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Organizational ambidexterity, open innovation and innovation outputs: How do followers and low-flyer eU countries innovate?

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International Journal of Innovation Studies 2024年第2期8卷 186-235页

作者： Joao Leitao Sonia de brito Dina Pereira Faculty of Social and Human Sciences NECE-Research Unit in Business SciencesUniversity of Beira Interior6200-001CovilhaPortugal Research Unit in business Sciences(NeCe) University of Beira InteriorCovilhaPortugal Centre for Management Studies of Instituto Superior Tecnico(CeG-IST) University of Lisbon1649-004LisboaPortugal Instituto de Ciencias Sociais ICsUniversity of Lisbon1649-004LisboaPortugal

This study analyses the role played by organizational ambidexterity and open innovation in innovation outputs,considering business units with different levels of technological intensity(medium-high and high tech,and medium-low and low tech)for countries with different inno-vation *** countries considered in this paper are i)estonia and Slovenia as innovation followers;i)Slovakia,Hungary,Spain,Czech Republic,Italy,Portugal,Norway,and Croatia as moderate innovators;and ii)bulgaria,Lithuania and Romania as modest *** the empirical approach,the research hypotheses arise from the literature review and are tested using secondary data collected from the Community Innovation Survey(CIS)*** conceptual model is tested using the logistic regression method,which indicates suitable accuracy and reliability for empirical testing *** evidence reveals that for innovation followers,ambidexterity has a greater influence on the practice of eco-innovation,marketing innovation,and product *** moderate innovators,ambidexterity has a greater influence on the practice of product innovation,process innovation,and *** modest in-novators,ambidexterity has a greater influence on the practice of product innovation,process innovation,and *** regard to open innovation,for innovation followers,this has a negative influence on product innovation in medium-high and high-tech *** moderate innovators,open innovation has a greater influence in process,organizational,and *** the case of modest innovators,open innovation is more significant for innovation outputs in product,organizational,and marketing *** is not always positively related to innovation outputs.

关键词： Organizational ambidexterity CIS Cooperation Open innovation Public innovation policies

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Analysis on the Impact of Cattle Fattening Technology on Farmer Households in Atabae Timor-Leste

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Agricultural Sciences 2024年第4期15卷 399-407页

作者： Marcolino estevão Fernandes e. brito Vicente de Paulo Correia Carlos da Conceicão de deus Mateus de Jesus Gomes Agro-Socio economic Faculty of Agriculture National University of Timor Lorosa&#8217e Dili Timor-Leste

Agriculture is one of the priority sectors in Timor-Leste. Introducing new agriculture technology is crucial to enhance agricultural production. Practicing cattle fattening can increase beef cattle body weight and generate income to the beef cattle farmers. As farmers face problems including agricultural production decline, lack of forages and information and weather unfavourable. The study’s purpose was to examine the impact of adoption of cattle fattening technology on farmer households in Atabae administrative post, bobonaro municipality in Timor-Leste. There were 200 beef cattle farmers households where randomly selected in four villages in Atabae. It consisted of 65 farmers practicing cattle fattening and 135 farmers non-practicing cattle fattening. Face to face interviews used structured questionnaire. Statistical analysis such as t-test and descriptive analysis were used to examine impact adoption of cattle fattening technology by farmers and factor constraints of cattle production and the solutions of it. The results indicated the average value of cattle and profit were significant different from zero and it is associated with practicing of cattle fattening. The average of labour used on cattle activities, the average of cattle sold, and total cost spent on cattle were not significant different from zero. The percentage of farmers said that factors constraints cattle production were shortage of water and forage (53%) and spend time on culture ceremony and lack of capital (33%). The number of farmers said that they collected water from river, feed cattle with sago and forage (55.3%) and cultivated forage (23.4%). This finding contributes information to the farmers, traders, and Timorese government to continue implementing cattle fattening activities as it enhances farmers’ income and developing cattle production.

关键词： Cattle Production Adoption of Cattle Fattening Technology and Cattle Farmer Households

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Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： Damián Sánchez-Ramírez Mónica G Mendoza-Rodríguez Omar R Alemán Fernando A Candanedo-González Miriam Rodríguez-Sosa Juan JoséMontesinos-Montesinos Mauricio Salcedo Ismael brito-Toledo Felipe Vaca-Paniagua Luis I Terrazas Unidad de Investigacion en biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico department of biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico department of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales Mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en biomedicina y Oncologia Genomica Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de Colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio Nacional en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CRC)remains one of the most commonly diagnosed and deadliest types of cancer *** displays a desmoplastic reaction(DR)that has been inversely associated with poor prognosis;less DR is associated with a better *** reaction generates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form a part of the tumor *** are directly involved in tumorigenesis through different ***,their role in immunosuppression in CRC is not well understood,and the precise role of signal transducers and activators of transcription(STATs)in mediating CAF activity in CRC remains *** the myriad chemical and biological factors that affect CAFs,different cytokines mediate their function by activating STAT signaling ***,the harmful effects of CAFs in favoring tumor growth and invasion may be modulated using STAT ***,we analyze the impact of different STATs on CAF activity and their immunoregulatory role.

关键词： Cancer-associated fibroblasts Signal transducer and activator of transcription signaling Colorectal cancer Immunity Immunosuppression

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epidemiology and Clinical Features of Mycobacterium avium Complex Pulmonary Disease in a brazilian Amazon Cohort

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Advances in Microbiology 2024年第6期14卷 287-302页

作者： Jose Tadeu Colares Monteiro Adriana Rodrigues barretto Ruan Seguin Azevedo Quaresma bianca Miranda Gouveia Ismari Perini Furlaneto Victória Menezes da Costa Yan Corrêa Rodrigues Layana Rufino Ribeiro Ricardo J. de Paula Souza e Guimarães Alex brito Souza Ana Roberta Fusco da Costa Karla Valéria batista Lima Joao de barros barreto University Hospital Federal University of Par Belm Brazil Center for biological and Health Sciences Ph.D. Program in Parasitic Biology in the Amazon Region (PPGBPA) State University of Par (UEPA) Belm Brazil department of Medicine Centro Universitrio do Par CESUPA Belm Brazil bacteriology and Mycology Section Evandro Chagas Institute (SABMI/IEC) Ministry of Health Ananindeua Brazil Geoprocessing Laboratory Evandro Chagas Institute/SVSA/MS Ananineua Brazil

The incidence of Mycobacterium avium complex pulmonary disease (MACPD) has been globally increasing. The present study aims to provide a comprehensive analysis of clinical characteristics and treatment response among patients in the Amazon region of brazil and conduct a retrospective cohort study at a prominent referral hospital in the State of Par, brazil, from 2012 to 2020. The M. avium group represented 58.9% of cases, followed by M. intracellulare (35.7%), M. colombiense (3.6%), and M. chimaera (1.8%). The majority of patients (73.2%) were female and with an average age of 63 years. Primary clinical manifestations included persistent cough and sputum production. The Charlson comorbidity index (CCI) averaged 2.47, with 36.3% of patients having a CCI score equal to higher than 3. Notably, over 70% of patients had received treatment for pulmonary tuberculosis before initiating treatment for MAC infection. The fibrocavitary radiologic form was the most prevalent (55.4%), frequently exhibiting a bilateral distribution (53.6%). Antimicrobial susceptibility revealed a significant prevalence of MAC resistance to drugs in the therapeutic regimen. despite this, most of the patients experienced clinical improvement (50%). In conclusion, this study highlights a higher prevalence of MAC infections among middle-aged women, with a history of pulmonary tuberculosis treatment and presenting the fibrocavitary radiological form was predominant.

关键词： MACDP Nontuberculous Mycobacteria Mycobacterium avium Lung Disease

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Can rainfall seasonality trigger soil water repellency in a tropical riparian forest?

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Journal of Forestry Research 2023年第3期34卷 773-780页

作者： Gleicon Queiroz de brito Johnny Rodrigues de Melo Murta Sérgio Fernandes Mendonca Filho Luiz Felippe Salemi Núcleo de estudos e Pesquisas Ambientais e Limnológicas(NePAL) Faculdade UnB de Planaltina(FUP)Universidade de Brasília(UnB)DFVila Nossa Senhora de FátimaÁrea Universitária 1Planaltina 73345-010Brazil

Though riparian areas generally have a shallow water table and higher soil moisture compared to up slope areas,climatic seasonality may trigger water repellency in tropical riparian forests,which,if persistent,could negatively affect essential ecosystem functions related to water resources protection such as reduced overland-flow,sediment transport,and nutrient *** objective of this study was to answer the following:can tropical riparian forests develop water repellency?If so,does water repellency affect infiltration on a seasonal basis?For this,water repellency and infiltration were measured in a grid of 72points during a dry and a wet month of a tropical riparian forest with a shallow water table in a region with highly marked climatic *** repellency and infiltration were significantly different between the wet and dry *** repellency affected negatively infiltration in the dry month,its effect in the wet month was *** a result,a higher infiltration capacity was observed over the wet *** research has claimed that the development and persistence of repellency in soils could promote other hydrological processes such as overland *** findings shown here demonstrate that such phenomenon does not persist longer than the dry season.

关键词： Hydrophobicity Gallery forest Aquifer recharge Climate change erosion

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Fluidized and vibrofluidized shallow beds of fresh leaves

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Particuology 2011年第2期9卷 139-147页

作者： Renata de Aquino brito Lima Maria do Carmo Ferreira Drying Center of Pastes Suspensions and SeedsChemical Engineering DepartmentFederal University of S o Carlos

The fluid dynamics behavior of shallow fluidized and vibrofluidized beds operating with fresh leaves was investigated with the aim of exploring drying applications in a modified conveyor belt （MCb） system, which may be operated in a fixed- or fluidized-bed mode. Leaves of the specimens Duranta repens, Schinus molle, Coleus barbatus, buxus sempervirens, and bougainvillea spectabilis were tested with a range of sphericities from 0.063 to 0.213, bulk densities from 0.038 to 0.251 g/cm3, apparent densities from 0.52 to 0.97 g/cm3 and ratios of total surface area to volume from 21 to 224 cm-1. Fluidization characteristic curves were obtained by measuring pressure drops versus air velocity in a rectangular column of 0.20 m - 0.11 m cross section. It was not possible to reach real fluidized regimes with the leaves due to strongly non-homogeneous beds. Nevertheless, the characteristic curves allowed for the identification of a transition regime from fixed- to expanded-beds, and parameters such as air velocity and pressure drop obtained from the experimental data at the transition were reproducible for specimens with lower surface area or lower specific gravity （i.e., Duranta repens, Schinus molle, and bougainvillea spectabilis）. The transition velocity and pressure drop could not be predicted by the literature developed for estimat- ing minimum fluidization conditions. The use of vibration at dimensionless vibration parameters （Γ） of 0.5 and 1.0 helped to reduce channeling and decrease the transition velocities from fixed to expanded regimes although it did not affect the pressure drops after the bed expansion. The results suggest that drying fresh leaves using the MCb dryer operating in a fluidized mode would not be feasible because none of the materials investigated attained a high-quality fluidization. Operation of the MCb dryer may be pos- sible by alternating between the fixed and vibrofluidized modes. For the specimens tested, the drying should be performed in a range

关键词： LeavesLow-sphericity particlesPressure dropsFluidizationVibration

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The brain as a source and a target of prolactin in mammals

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Neural Regeneration Research 2022年第8期17卷 1695-1702页

作者： Ana R.Costa-brito Isabel Gonçalves Cecília R.A.Santos CICS-UbI-Health Sciences Research Centre Universidade da Beira InteriorCovilhãPortugal C4-UbI-Cloud Computing Competence Centre Universidade da Beira InteriorCovilhãPortugal

Prolactin is a polypeptide hormone associated with an extensive variety of biological *** the roles of prolactin in vertebrates,some were preserved throughout *** is the case of its function in the brain,where prolactin receptors,are expressed in different structures of the central nervous *** the brain,prolactin actions are principally associated with reproduction and parental behavior,and involves the modulation of adult neurogenesis,neuroprotection,and neuroplasticity,especially during pregnancy,thereby preparing the brain to *** is mainly produced by specialized cells in the anterior pituitary ***,during vertebrate evolution many other extrapituitary tissues do also produce prolactin,like the immune system,endothelial cells,reproductive structures and in several regions of the *** review summarizes the relevance of prolactin for brain function,the sources of prolactin in the central nervous system,as well as its local production and secretion.A highlight on the impact of prolactin in human neurological diseases is also provided.

关键词： brain brain disease choroid plexus neurogenesis neuroplasticity neuroprotection prolactin prolactin receptor

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Supporting flexible regulation of crisis management by means of situated artificial institution

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Frontiers of Information Technology & electronic engineering 2016年第4期17卷 309-324页

作者： Maiquel de brito Lauren THeVIN Catherine GArbaY Olivier bOISSIeR Jomi Fred HUbNeR Federal University of Santa Catarina UFSC/CTC/DAS/PPGEAS-PO Box 476FlorianopolisSC 88040-900Brazil LIG/Universite de Grenoble Grenoble 38041France Laboratoire Hubert Curien UMR CNRS 5516 Institut Henri FayolMINES Saint-EtienneSaint-Etienne 42023France

This paper highlights the use of situated artificial institution(SAI) within a hybrid, interactive,normative multi-agent system to regulate human collaboration in crisis management. Norms regulate the actions of human actors based on the dynamics of the environment in which they are situated. This dynamics results from both environment evolution and actors' actions. Our objective is to situate norms in the environment in order to provide a context-aware crisis regulation. However, this coupling must be a loose one to keep both levels independent and easyto-change in order to face the complex and changing crisis situations. To that aim, we introduce a constitutive level between environmental and normative states providing a loose coupling of normative regulation with environment evolution. Norms are thus no more referring to environmental facts but to status functions, i.e., the institutional interpretation of environmental facts through constitutive rules. We present how this declarative and distinct SAI modelling succeeds in managing the crisis with a context-aware crisis regulation.

关键词： Situated artificial institutions(SAIs) Normative system Tangible interaction Crisis management

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Metabolic and nutritional triggers associated with increased risk of liver complications in SARS-CoV-2

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World Journal of Hepatology 2022年第1期14卷 80-97页

作者： Rosangela Passos de Jesus Jozélio Freire de Carvalho Lucivalda Pereira Magalhães de Oliveira Carla de Magalhães Cunha Thaisy Cristina Honorato Santos Alves Sandra Tavares brito Vieira Virginia Maria Figueiredo Allain Amador bueno Postgraduate Program in Food Nutrition and Health at the School of Nutrition of the Federal University of BahiaSalvador 40.110-150BahiaBrazil Institute of Health Sciences Federal University of BahiaSalvador 40231-300BahiaBrazil Institute of Life Sciences State University of BahiaSalvador 41.150-000BahiaBrazil department of Gastroenterology IPEMEDIpemed Faculty of Medical SciencesSalvador 40170-110BahiaBrazil College of Health Life and Environmental SciencesUniversity of WorcesterWorcester WR26AJUnited Kingdom

Obesity,diabetes,cardiovascular and respiratory diseases,cancer and smoking are risk factors for negative outcomes in severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which can quickly induce severe respiratory failure in 5%of *** disease-associated liver injury may occur during progression of SARS-CoV-2 in patients with or without pre-existing liver disease,and damage to the liver parenchyma can be caused by infection of *** patients may be particularly vulnerable to SARS-CoV-2 if suffering with cirrhosis-associated immune ***,pharmacotherapies including macrolide or quinolone antibiotics and steroids can also induce liver *** this review we addressed nutritional status and nutritional interventions in severe SARS-CoV-2 liver *** guidelines for SARS-CoV-2 in intensive care(IC)specifically are not yet available,strategies for management of sepsis and SARS are suggested in *** enteral nutrition(eN)should be started soon after IC admission,preferably employing iso-osmolar polymeric formula with initial protein content at 0.8 g/kg per day progressively increasing up to 1.3 g/kg per day and enriched with fish oil at 0.1 g/kg per day to 0.2 g/kg per *** is necessary to identify signs of intolerance,hemodynamic instability and metabolic disorders,and transition to parenteral nutrition should not be delayed when energy and protein targets cannot be met via *** including vitamins A,C,D,e,b6,b12,folic acid,zinc,selenium andω-3 fatty acids have in isolation or in combination shown beneficial effects upon immune function and inflammation *** and monitored supplementation up to upper limits may be beneficial in management strategies for SARS-CoV-2 liver patients.

关键词： COVID-19 SARS-CoV-2 enteral nutrition Parenteral nutrition Hepatic failure

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Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives

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World Journal of Clinical Pediatrics 2022年第2期11卷 105-119页

作者： Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior breno bittencourt de brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil

Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use.

关键词： Functional abdominal pain disorder Pediatrics Rome IV behavioral intervention Nonpharmacological treatment Complementary medicine

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