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Applications and advancements in animal models for antiviral research on mosquito-borne arboviruses

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Animal Models and Experimental Medicine 2024年第5期 673-684页

作者： Megan Caifeng Tang Ka Heng Wong Adzzie Shazleen azman Rafidah Lani School of Science Monash University Malaysia Department of Medical Microbiology Faculty of Medicine Universiti Malaya

Vector-borne diseases caused by arthropod-borne viruses(arboviruses) are a considerable challenge to public health globally. Mosquito-borne arboviruses, such as Chikungunya, Dengue, and Zika viruses, cause a range of human illnesses and may be fatal. Currently, efforts to control these diseases still face challenges due to growing vector resistance towards insecticides, urbanization, and limited effective antiviral treatments and vaccines. Animal models are crucial in antiviral research on mosquito-borne arboviruses, playing a role in understanding disease mechanisms,vaccine development, and toxicity testing, but the application of animal models still faces the challenges of ethical considerations and animal-to-human translational success. Genetically engineered mouse models, hamster models and non-human primate(NHP) are currently used in arbovirus research, but new models such as tree shrews and novel humanized mice are emerging. In the context of Malaysian research, the use of long-tailed macaques as potential NHP models for arbovirus research is possible;however, it faces the ethical dilemma of using an endangered species for scientific purposes. Overall, animal models play a crucial role in advancing infectious disease research, but a balance between medical research and species conservation must be upheld.

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Life Threatening Stridor Due to Primary Laryngeal Tuberculosis

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第1期13卷 62-69页

作者： Siti Aisyah Mohamed Azreen Zaira Abu Bakar Mawaddah azman Otorhinolaryngology Department Hospital Ampang Selangor Malaysia Otorhinolaryngology Department Faculty of Medicine Universiti Kebangsaan Malaysia Kuala Lumpur Malaysia Otorhinolaryngology Department Hospital Kuala Lumpur Kuala Lumpur Malaysia

Tuberculosis is a potentially serious infectious disease. In otorhinolaryngology practice, lymph node infection is the most common site of predilection followed by the larynx. Laryngeal tuberculosis (LTB) typically presents with dysphagia, odynophagia and hoarseness. We reported a case of primary LTB presenting with acute upper airway obstruction and respiratory distress mimicking acute supraglottitis which requires emergency tracheostomy. Therefore, in acute upper airway obstruction, the appropriate initial investigation should be done to rule out TB to make sure early treatment can be given and it may prevent complications of disease to the patient. .

关键词： Extra-Pulmonary Granulomatous Infection Malignancy Upper Airway

Determination of 14 Organophosphorus Pesticide Residues in Mutton by Gel Permeation Chromatography-Gas Chromatography-Mass Spectrometry(GPC-GC-MS)

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Agricultural Biotechnology 2024年第3期13卷 28-30,33页

作者： Junpeng ZHAO Richard Avoi azman Bin Atil@Azmi Jiao CHEN Ling YUN Tangshan Food and Drug Comprehensive Inspection and Testing Center Tangshan 063000China Hebei Agricultural Products Quality and Safety Testing Technology Innovation Center Tangshan 063000China Tangshan Institute of Industrial Technology for Functional Agricultural Products Tangshan 063000China Universiti Malaysia Sabah Faculty of Medicine and Health SciencesMalaysia Guizhou Forerunner College Guiyang 550000China Tangshan Center for Disease Prevention and Control Tangshan 063000China

[Objectives]This study was conducted to purify mutton samples by gel permeation chromatography(GPC).[Methods]Fourteen organophosphorus pesticide residues in samples were qualitatively and quantitatively analyzed by gas chromatography-mass spectrometry(GC-MS)in selective ion scanning mode(SIM).[Results]The organophosphorus pesticide standard solutions showed good linearity in the mass concentration range of 0.1-10.0μg/ml with correlation coefficients(r)not lower than 0.999,and the detection limits(S=3 N)ranged from 0.01 to 0.05 mg/*** average recovery values were in the range of 80.2%-99.7%,with relative standard deviations(RSDs,n=3)in the range of 1.8%-6.3%,at the addition levels of 0.5,1.0 and 2.0 mg/kg.[Conclusions]The method is simple,sensitive and accurate,and can be used for the determination of organophosphorus pesticide residues in mutton.

关键词： Mutton Gas chromatography-mass spectrometry Gel permeation chromatography Organophosphorus Pesticide residue

Function and Application Progress of Probiotics in Food

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Agricultural Biotechnology 2024年第4期13卷 63-64,69页

Probiotics have a long history of use in human production and *** the gradual deepening of the research on the functions of probiotics,their various nutritional and health benefits for the human body have also become increasingly *** research shows that probiotics can regulate intestinal flora,and improve immunity and even the symptoms of some ***,in the food industry,the application of probiotics from traditional fermented foods to functional foods has become more and more *** this paper,the research progress of nutritional function and application of probiotics in food at home and abroad was reviewed,in order to provide some reference for the safe application of probiotics in food.

关键词： Probiotics Physiological function Food Development and application

Stem cell therapy in neurodegenerative diseases From principles to practice

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Neural Regeneration Research 2012年第23期7卷 1822-1831页

作者： Rajalingham Sakthiswary azman Ali Raymond Department of Medicine Universiti Kebangsaan Malaysia Medical CentreBandar Tun Razak 56000Kuala LumpurMalaysia

The lack of curative therapies for neurodegenerative diseases has high economic impact and places huge burden on the *** contribution of stem cells to cure neurodegenerative diseases has been unraveled and explored extensively over the past few *** substitution of the lost neurons,stem cells act as immunomodulators and neuroprotectors.A large number of preclinical and a small number of clinical studies have shown beneficial outcomes in this *** this review,we have summarized the current concepts of stem cell therapy in neurodegenerative diseases and the recent advances in this field,particularly between 2010 and *** studies should be encouraged to resolve the clinical issues and vague translational findings for maximum optimization of the efficacy of stem cell therapy in neurodegenerative diseases.

关键词： stem cells neurodegenerative diseases Parkinson’s disease Huntington’s disease Alzheimer’s disease amyotrophic lateral sclerosis embryonic stem cells induced pluripotent stem cells mesenchymal stem cells neural stem cells

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A post-processing method for true random number generators based on hyperchaos with applications in audio-based generators

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Frontiers of Computer Science 2020年第6期14卷 85-95页

作者： Je Sen TEH Weijian TENG azman SAMSUDIN Jiageng CHEN School of Computer Sciences Universiti Sains MalaysiaPenang 11800Malaysia School of Engineering and Technology INTI International College PenangPenang 11900Malaysia School of Computer Central China Normal UniversityWuhan 430079China

True random number generators(TRNG)are important counterparts to pseudorandom number generators(PRNG).especially for high security applications such as *** produce unpredictable,non-repeatablerandom ***,most TRNGs require specialized hardware to extract entropy from physical phenomena and tend to be slower than *** generators usually require post-processing algorithms to eliminate biases but in *** *** this paper.a newpost-processing method based on hyperchaos is proposed forsoftware-based TRNGs which not only eliminates statisticalbiases but also provides amplification in order to improve the performance of *** proposed method utilizes the inherent characteristics of chaos such as hypersensitivity to input shanugeri,diffusisn,and csnfusion sapabilities to ushievethese *** bits of a physical entropy source areused to perturb the parameters of a hyperchaotic map,which is then iterated to produce a set of random output *** de-pict the feasibility of the proposed post-processing *** is applied in designing TRNGs based on digital *** are analyzed to identify statistical defects in addition to forward and backward *** indicate that the proposed generators are able to produce secure true random sequences at a high throughput,which in turn reflects on the effectiveness of the proposed post-processing method.

关键词： audio chaos theory chaotic map entropy hyperchaos post-processing random number generator security

Agrobacterium-Mediated Transformation of Rice: Constraints and Possible Solutions

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Rice science 2019年第3期26卷 133-146页

作者： Sulaiman MOHAMMED azman Abd SAMAD Zaidah RAHMAT Department of Biotechnology and Medical Engineering Faculty of Biosciences and Medical Engineering Universiti Teknologi Malaysia Department of Biological Sciences Faculty of Science Gombe State University

Genetic transformation of rice(Oryza sativa L.) by introducing beneficial traits is now a central research instrument in plant physiology and a practical tool for plant improvement. Many approaches are verified for stable introduction of foreign genes into the plant genome. The review examined the different constraints that limit the success of rice genetic transformation via Agrobacterium-mediated approach and suggested possible solutions. Explant identification, gene transfer technique and construct to tailor the integration, transgene expression without collateral to genetic damage and transformant selection are among the technical challenges affecting the rice transformation. Despite the contests, Agrobacteriummediated transformation system has been a better option for producing transgenic rice varieties because of its exact T-DNA processing and simple integration of low copy-number transgene. This information is necessary for improving the transformation system for recalcitrant rice varieties.

关键词： rice Agrobacterium-mediated transformation tissue culture gene transfer T-DNA integration

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A Review of Various Sources of Chitin and Chitosan in Nature

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Journal of Renewable Materials 2022年第4期10卷 1097-1123页

作者： Benedict Terkula Iber Nor azman Kasan Donald Torsabo Jenifer Wese Omuwa Higher Institution Center of Excellence(HICoE) Institute of Tropical Aquaculture and FisheriesUniversiti Malaysia TerengganuKuala Nerus21030Malaysia Department of Fisheries and Aquaculture Joseph Sarwuan Tarka University MakurdiMakurdi2373Nigeria

Chitin was first discovered by its name from the Greek word“chiton”,which means“mail coat”.It is indeed a polysaccharide made up of naturally occurring acetyl-D-glucosamine *** was the first researcher who extracted chitin from the shells of mollusks(crabs and lobsters),prawns,and crayfish in *** in 1811,Henri Braconnot discovered chitin in the cell walls of mushrooms and called it“fungine”.Chitin and chitosan are abundant in the biosphere as essential components of many organisms’exoskeletons and as by-products of the global seafood *** biopolymer must be deacetylated before chitosan can be *** can also be extracted using microbes in a biological extraction *** development of products that take advantage of the bioactivities of the existing primary commercial source of chitin(crustacean)has lagged ***,the disadvantages of the present commercial source such as seasonality and competition for other uses among others has been one of the driving forces towards seeking alternative sources of chitin and chitosan in *** review highlights some of the efforts made by environmental scholars to locate possible commercial sources of chitin and chitosan in nature over time.

关键词： Chitin chitosan crustaceans insects fungi

The Impact of Artificial Intelligence(AI) on the Low-Carbon Economy:A Prospective Study on the Long-Term Rental Housing Market in Guangxi, China

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Chinese Journal of Urban and Environmental Studies 2022年第4期10卷 56-69页

作者： LI Dandan Nik Hadiyan Nik azman School of Management Universiti Sains Malaysia Business School of Guilin University of Technology School of Management Universiti Sains Malaysia

In recent years, the tourism economy of Guangxi Zhuang Autonomous Region(hereinafter referred to as “Guangxi”), China, has been caught in the contradiction between infrastructure construction and natural environmental protection. By combing Guangxi’s tourism economy with its development path of smart long-term rental housing, this paper finds that the longterm rental market in Guangxi based on artificial intelligence(AI) technology can solve the development contradiction through accurate construction planning to improve *** long-term rental housing market in Guangxi has entered a low-carbon economy period since pilot programs were launched for the policy of managing public rental housing with AI and information technologies. From the perspective of AI, facts have proved that AI has the ability to re-adjust the competition order of an industry, which not only realizes the low-carbon development of the rental market, but also promotes the industrial upgrading of the tourist industry.

关键词： Artificial intelligence (AI) low carbon long-term rental housing Guangxi