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Impact of COVID-19 on liver transplant recipients: A nationwide cohort study evaluating hospitalization, transplant rejection, and inpatient mortality

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World Journal of Transplantation 2024年第2期14卷 62-75页

作者： Faisal Inayat Pratik Patel Hassam Ali Arslan Afzal Hamza Tahir Ahtshamullah Chaudhry Rizwan Ishtiaq Attiq ur rehman Kishan Darji Muhammad Sohaib Afzal Gul Nawaz Alexa Giammarino Sanjaya K Satapathy Department of Internal Medicine Allama Iqbal Medical CollegeLahorePunjab 54550Pakistan Division of Gastroenterology Mather Hospital and Zucker School of Medicine at Hofstra UniversityPort JeffersonNY 11777United States Division of Gastroenterology and Hepatology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal Medicine Jefferson Einstein HospitalPhiladelphiaPA 19141United States Department of Internal Medicine St.Dominic's HospitalJacksonMS 39216United States Department of Internal Medicine Saint Francis Hospital and Medical CenterHartfordCT 06105United States Division of Hepatology Geisinger Wyoming Valley Medical CenterWilkes-BarrePA 18711United States Department of Internal Medicine Campbell University and Cape Fear Valley Medical CenterFayettevilleNC 28301United States Department of Internal Medicine North Shore University Hospital and Zucker School of Medicine at Hofstra UniversityManhassetNY 11030United States Division of Hepatology North Shore University Hospital and Zucker School of Medicine at Hofstra UniversityManhassetNY 11030United States

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has posed a major public health concern *** with comorbid conditions are at risk of adverse outcomes following *** organ transplant recipients with concurrent immunosuppression and comorbidities are more susceptible to a severe COVID-19 *** could lead to higher rates of inpatient complications and mortality in this patient ***,studies on COVID-19 outcomes in liver transplant(LT)recipients have yielded inconsistent *** To evaluate the impact of the COVID-19 pandemic on hospital-related outcomes among LT recipients in the United *** We conducted a retrospective cohort study using the 2019–2020 National Inpatient Sample *** with primary LT hospitalizations and a secondary COVID-19 diagnosis were identified using the International Classi-fication of Diseases,Tenth Revision coding *** primary outcomes included trends in LT hospitalizations before and during the COVID-19 *** outcomes included comparative trends in inpatient mortality and transplant rejection in LT *** A total of 15720 hospitalized LT recipients were *** 0.8% of patients had a secondary diagnosis of COVID-19 *** both cohorts,the median admission age was 57 *** linear trends for LT hospitalizations did not differ significantly before and during the pandemic(P=0.84).The frequency of in-hospital mortality for LT recipients increased from 1.7% to 4.4% between January 2019 and December *** to the pre-pandemic period,a higher association was noted between LT recipients and in-hospital mortality during the pandemic,with an odds ratio(OR)of 1.69[95% confidence interval(CI):1.55-1.84),Puring the COVID-19 pandemic had a higher associ

关键词： Liver transplant recipients Solid organ transplantation COVID-19 Hospitalization Transplant rejection Mortality

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Mutations in wheat TaAPA2 gene result in pleiotropic effects on plant architecture

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Science China(Life Sciences) 2024年第9期67卷 2039-2042页

作者： Shengsheng Bai Guiping Wang Rui Song Yanna Liu Lei Hua Jinwei Yang Lijun Zhang Shams ur rehman Xiaohua Hao Lifeng Hou Chaozhong Zhang Hongna Li Yanyan Liang Lihua Zhao Yan Xue Zheng Wang Shisheng Chen National Key Laboratory of Wheat Improvement Peking University Institute of Advanced Agricultural SciencesShandong Laboratory of Advanced Agriculture Sciences in WeifangWeifang 261325China Department of Plant Sciences University of CaliforniaDavisCA 95616USA

Dear Editor,Bread wheat(Triticum aestivum L.)is a globally important cereal providing~20% of the calories and proteins for>4.5billion *** architecture,including morphologies of leaves,spikes,stems,and roots,has great impact on plant development and productivity,and thus has been extensively investigated in various plant species(Jiang et al.,2023;Zhang et al.,2017).

关键词： cereal globally roots

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Endoscopic treatment of scarred polyps with a non-thermal device(Endorotor):A review of the literature

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World Journal of Gastroenterology 2024年第12期30卷 1706-1713页

作者： Mariam Zaghloul Hameed rehman Stefano Sansone Konstantinos Argyriou Adolfo Parra-Blanco Department of Hepatology Gastroenterology and Infectious DiseasesKafrelsheikh UniversitKafr-Elshikh 33516Egypt Department of Gastroenterology Service Nottingham City Hospital CampusNottingham University Hospitals NHS TrustNottingham NG51PBUnited Kingdom Department of Gastroenterology University Hospital of LarissaLarissa 41334Greece NIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and University of NottinghamNottingham NG72UHUnited Kingdom

Endoscopic resection(ER)of colorectal polyps has become a daily practice in most endoscopic units providing a colorectal cancer screening program and requires the availability of local experts and high-end endoscopic *** procedures have evolved over the past few years from endoscopic mucosal resection(EMR)to more advanced techniques,such as endoscopic submucosal dissection and endo-scopic full-thickness *** resection and disease eradication are the ultimate goals of ER-based techniques,and novel devices have been developed to achieve these *** EndoRotor®Endoscopic Powered Resection System(Interscope Medical,Inc.,Northbridge,Massachusetts,United States)is one such *** EndoRotor is a powered resection tool for the removal of alimentary tract mucosa,including post-EMR persistent lesions with scarring,and has both CE Mark and FDA *** review covers available published evidence documenting the usefulness of EndoRotor for the management of recurrent colorectal polyps.

关键词： EndoRotor Scarred polyps Recurrent polyps Colorectal cancer Colorectal polyps

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BnaWRKY75 positively regulates the resistance against Sclerotinia sclerotiorum in ornamental Brassica napus

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Horticultural Plant Journal 2024年第3期10卷 784-796页

作者： Kexin Yu Yijie Zhang Xiaoyuan Fei Luyue Ma rehman Sarwar Xiaoli Tan Zheng Wang School of Life Sciences Jiangsu UniversityZhenjiangJiangsu 212013China School of Food and Biological Engineering Jiangsu University ZhenjiangJiangsu 212013China Key Laboratory for Theory and Technology of Intelligent Agricultural Machinery and Equipment Jiangsu UniversityZhenjiangJiangsu 212013China

With the development of tourism at home and abroad,Rapeseed(Brassica napus)has become an important ornamental ***,its ornamental value at the inflorescence stage is greatly reduced by Sclerotinia *** of important genes in the defense responses is critical for molecular breeding,which is an important strategy for controlling the *** this study,we isolated a *** WRKY transcription factor gene,***75 was found to encode a nucleus-localized protein and exhibited relatively high expression in the *** thaliana transgenic plants expressing BnaWRKY75 showed enhanced resistance to ***,and both ProBnaWRKY75:GUS and gene expression analyses showed that BnaWRKY75 was highly responsive to *** infection,indicating the involvement of BnaWRKY75 in response to this ***,overexpression(OE)of BnaWRKY75 in *** significantly enhanced the resistance to ***,whereas the resistance was reduced in RNAi transgenic *** ***,the BnaWRKY75-OE *** plants exhibited constitutive activation of salicylic acid-,jasmonic acid-,and ethylene-mediated defense responses and the inhibition of both H_(2)O_(2)and O_(2)·^(-)accumulation in response to this *** contrast,BnaWRKY75-RNAi plants showed a reverse pattern,suggesting that BnaWRKY75 is involved in hormonal signaling pathways and in the control of reactive oxygen species *** conclusion,these data indicate that BnaWRKY75,a regulator of multiple defense responses,positively regulates resistance against ***,which may guide the improvement of resistance in rapeseed.

关键词： Brassica napus BnaWRKY75 Defense response Sclerotinia sclerotiorum

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纳米材料制备及其电化学发光分析应用

纳米材料制备及其电化学发光分析应用

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中国化学会第29届学术年会

作者：祁文静张玲许敏赖建平 Anjum Saima aziz-ur-rehman Majeed Saadat 高文跃 Hanif Saima 徐国宝中国科学院长春应用化学研究所电分析化学国家重点实验室中国科学院研究生院

电致化学发光是一种电化学反应导致的化学发光现象。常见的电化学发光体系有钌配合物、鲁米诺、半导体量子点、纳米簇、光泽精和过氧化草酸酯等。其中钌配合物和鲁米诺电化学发光由于适用范围广、灵敏度高、重现性好、成本低等优点,而... 详细信息

电致化学发光是一种电化学反应导致的化学发光现象。常见的电化学发光体系有钌配合物、鲁米诺、半导体量子点、纳米簇、光泽精和过氧化草酸酯等。其中钌配合物和鲁米诺电化学发光由于适用范围广、灵敏度高、重现性好、成本低等优点,而成为研究最多的体系之一,特别是钌配合物电化学发光在临床分析中的广泛应用更使之成为重点的研究体系。电化学发光中常常用到纳米材料,如将含有发光试剂的纳米材料作为标记物用于免疫分析、核酸分析和基于适配子的分析、将纳米材料用作电化学发光的催化剂或将纳米材料作为电化学发光试剂等[1-3]。而电化学发光分析性能等与其所使用的纳米材料的组成和结构等密切相关。在这里我们介绍近一两年内开展的纳米材料制备及其在吡啶钌和鲁米诺电化学发光分析应用的部分工作,如纳米多面体电化学发光催化研究、基于功能化二氧化硅球的臭氧的检测方法、基于能量转移的TNT分析方法和基于重氮盐功能化纳米材料的电化学发光分析等[4-7]。

关键词：纳米材料电化学发光钌鲁米诺

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Early versus delayed necrosectomy in pancreatic necrosis:A population-based cohort study on readmission,healthcare utilization,and in-hospital mortality

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World Journal of Methodology 2024年第3期14卷 55-67页

作者： Hassam Ali Faisal Inayat Vinay Jahagirdar Fouad Jaber Arslan Afzal Pratik Patel Hamza Tahir Muhammad Sajeel Anwar Attiq ur rehman Muhammad Sarfraz Ahtshamullah Chaudhry Gul Nawaz Dushyant Singh Dahiya Amir H Sohail Muhammad aziz Division of Gastroenterology and Hepatology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Department of Internal Medicine Allama Iqbal Medical CollegeLahorePunjab 54550Pakistan Department of Internal Medicine University of Missouri-Kansas CityKansas CityMO 64108United States Division of Gastroenterology Mather Hospital and Zucker School of Medicine at Hofstra UniversityPort JeffersonNY 11777United States Department of Internal Medicine Jefferson Einstein HospitalPhiladelphiaPA 19141United States Department of Internal Medicine UHS Wilson Medical CenterJohnson CityNY 13790United States Division of Gastroenterology and Hepatology Geisinger Wyoming Valley Medical CenterWilkes-BarrePA 18711United States Department of Internal Medicine St.Dominic's HospitalJacksonMS 39216United States Division of Gastroenterology Hepatologyand MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Department of Surgery University of New Mexico School of MedicineAlbuquerqueNM 87106United States Division of Gastroenterology and Hepatology The University of ToledoToledoOH 43606United States

BACKGROUND Acute necrotizing pancreatitis is a severe and life-threatening *** poses a considerable challenge for clinicians due to its complex nature and the high risk of *** minimally invasive and open necrosectomy procedures have been *** advancements in treatment modalities,the optimal timing to perform necrosectomy lacks *** To evaluate the impact of necrosectomy timing on patients with pancreatic necrosis in the United *** A national retrospective cohort study was conducted using the 2016-2019 Nationwide Readmissions *** with non-elective admissions for pancreatic necrosis were *** participants were divided into two groups based on the necrosectomy timing:The early group received intervention within 48 hours,whereas the delayed group underwent the procedure after 48 *** various intervention techniques included endoscopic,percutaneous,or surgical *** major outcomes of interest were 30-day readmission rates,healthcare utilization,and inpatient *** A total of 1309 patients with pancreatic necrosis were *** propensity score matching,349 cases treated with early necrosectomy were matched to 375 controls who received delayed *** early cohort had a 30-day readmission rate of 8.6% compared to 4.8%in the delayed cohort(P=0.040).Early necrosectomy had lower rates of mechanical ventilation(2.9%vs 10.9%,Purred lower healthcare costs,with median total charges of $52202 compared to$147418 in the delayed *** in the early cohort also had a relatively shorter median length of stay(6 vs 16 days,Pur findings show that

关键词： Acute necrotizing pancreatitis Pancreatic necrosis Early necrosectomy Delayed necrosectomy Readmission,Healthcare costs Mortality

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The surveillance of arsenic levels in the drinking water of primary schools and the assessment of the potential cancer-related health risks of children in Multan, Pakistan

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Emerging Contaminants 2024年第1期10卷 17-23页

作者： Hidayatullah Mahar Abdul rehman Memon Aqsa Ishfaq Suhail Ahmed Soomro Mehran University of Engineering&Technology JamshoroPakistan NFC Institute of Engineering&Technology MultanPakistan

To investigate the levels of arsenic(As)in the groundwater and drinking water of primary schools and their potential impact on human health is main objective of this *** assess risk,the following parameters i.e.,carcinogenic indices(CI),hazardous indexes(HI),carcinogenic risk(CR),and hazardous quotient(HQ)have been measured for both dermal and oral arsenic *** study has been focused on primary schools located in four tehsils of Multan,where water samples were *** levels,with concentrations ranging from 3.31 to 191 mg/l,exceeding the safe limit set by the World Health Organization(WHO)have been detected in 99.9%of the *** results show that arsenic content ranged from 3.31 to 191 mg/l,with 99.9%of the samples exceeding the World Health Organization's safe limit of 10 mg/*** CR and CI exceeded the USEPA limit of 10–6 in all four tehsils ranged from 2.6×10^(-6) to 9.4×10^(-6) and 0.00023 to 0.0009 respectively in both dermal and oral cases.,Multan Sadar(1.51,1.39)and Multan City(1.76,1.71)exhibited HI and HQ values that surpassed the threshold of 1.0,signaling a significant likelihood of chronic and cancer-causing health consequences for individuals who are exposed to polluted water causing *** findings suggest that the groundwater in the Multan district poses a significant health risk to humans due to high levels of arsenic *** contamination is associated with an increased risk of mortality from internal cancers(including liver,kidney,lung,and bladder),as well as a higher HI&CI incidence of skin ***,pregnancy outcomes are affected,with associations found between arsenic exposure and lower birth weight,and infant *** researchers propose that water supply organizations and educational institutions promptly take measures to ensure that the affected areas have access to arsenic-free drinking water for the well-being of students and residents.

关键词： Risk assessment Drinking water contamination Arsenic Primary school Pakistan

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Deep Insight of Design,Mechanism,and Cancer Theranostic Strategy of Nanozymes

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Nano-Micro Letters 2024年第2期16卷 165-217页

作者： Lu Yang Shuming Dong Shili Gai Dan Yang He Ding Lili Feng Guixin Yang Ziaur rehman Piaoping Yang Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001People’s Republic of China Yantai Research Institute Harbin Engineering UniversityYantai 264000People’s Republic of China Key Laboratory of Green Chemical Engineering and Technology of Heilongjiang Province College of Material Science and Chemical EngineeringHarbin University of Science and TechnologyHarbin 150040People’s Republic of China Department of Chemistry Quaid-i-Azam UniversityIslamabad 45320Pakistan

Since the discovery of enzyme-like activity of Fe3O4 nanoparticles in 2007,nanozymes are becoming the promising substitutes for natural enzymes due to their advantages of high catalytic activity,low cost,mild reaction conditions,good stability,and suitable for large-scale ***,with the cross fusion of nanomedicine and nanocatalysis,nanozyme-based theranostic strategies attract great attention,since the enzymatic reactions can be triggered in the tumor microenvironment to achieve good curative effect with substrate specificity and low side ***,various nanozymes have been developed and used for tumor *** this review,more than 270 research articles are discussed systematically to present progress in the past five ***,the discovery and development of nanozymes are ***,classification and catalytic mechanism of nanozymes are ***,activity prediction and rational design of nanozymes are focused by highlighting the methods of density functional theory,machine learning,biomimetic and chemical ***,synergistic theranostic strategy of nanozymes are ***,current challenges and future prospects of nanozymes used for tumor theranostic are outlined,including selectivity,biosafety,repeatability and stability,in-depth catalytic mechanism,predicting and evaluating activities.

关键词： Nanozymes Classification Prediction and design Catalytic mechanism Tumor theranostics

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EfficientNetB1 Deep LearningModel for Microscopic Lung Cancer Lesion Detection and Classification Using Histopathological Images

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Computers, Materials and Continua 2024年第1期81卷 809-825页

作者： Javed, Rabia Saba, Tanzila Alahmadi, Tahani Jaser Al-Otaibi, Sarah AlGhofaily, Bayan rehman, Amjad Department of Computer Science Lahore College forWomen University Lahore 54000 Pakistan Artificial Intelligence & Data Analytics Lab. CCIS Prince Sultan University Riyadh 11586 Saudi Arabia Department of Information Systems College of Computer and Information Sciences Princess Nourah bint Abdulrahman University P.O. Box 84428 Riyadh 11671 Saudi Arabia Department of Computer Science College of Computer and Information Sciences King Saud University Riyadh 145111 Saudi Arabia

Cancer poses a significant threat due to its aggressive nature, potential for widespread metastasis, and inherent heterogeneity, which often leads to resistance to chemotherapy. Lung cancer ranks among the most prevalent forms of cancer worldwide, affecting individuals of all genders. Timely and accurate lung cancer detection is critical for improving cancer patients' treatment outcomes and survival rates. Screening examinations for lung cancer detection, however, frequently fall short of detecting small polyps and cancers. To address these limitations, computer-aided techniques for lung cancer detection prove to be invaluable resources for both healthcare practitioners and patients alike. This research implements an enhanced EfficientNetB1 deep learning model for accurate detection and classification using histopathological images. The proposed technique accurately classifies the histopathological images into three distinct classes: (1) no cancer (benign), (2) adenocarcinomas, and (3) squamous cell carcinomas. We evaluated the performance of the proposed technique using the histopathological (LC25000) lung dataset. The preprocessing steps, such as image resizing and augmentation, are followed by loading a pretrained model and applying transfer learning. The dataset is then split into training and validation sets, with fine-tuning and retraining performed on the training dataset. The model's performance is evaluated on the validation dataset, and the results of lung cancer detection and classification into three classes are obtained. The study's findings show that an enhanced model achieves exceptional classification accuracy of 99.8%. © 2024 The Authors.

关键词： Lung cancer

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Assessment of plastic degradation by indigenous bacteria from waste disposal sites

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Emerging Contaminants 2024年第3期10卷 111-123页

作者： Farzana Javid Ghadir Ali Abdul rehman Rehan Naeem Imran Ali Iffat Naz Department of Microbiology and Biotechnology Faculty of Life SciencesAbasyn University Peshawar CampusPeshawar25000Khyber PakhtunkhwaPakistan Department of Life Sciences School of ScienceUniversity of Management and Technology(UMT)Lahore54700Pakistan Department of Microbiology Kohat University of Science and Technology(KUST)Kohat26000Khyber PakhtunkhwaPakistan Department of Biotechnology and Genetic Engineering Kohat University of Science and Technology(KUST)Kohat26000Khyber PakhtunkhwaPakistan Department of Botany Kohat University of Science and Technology(KUST)Kohat26000Khyber PakhtunkhwaPakistan Department of Biology Deanship of Educational ServicesQassim UniversityBuraydah51452Kingdom of Saudi Arabia

The present study focuses on the isolation of bacterial pathogens from waste disposal sites,and examination of their efficiencies for degrading various *** bacterial isolates such as ***,Corynebacterium spp.,Micrococcus spp.,Azotobacter spp.,Pseudomonas spp.,Staphylococcus spp.,and Bacillus *** *** *** the highest percentage reduction in black plastic weight(47.46%),while Corynebacterium spp.,and *** achieved a maximum reduction of 45.76 and 46.42%for pink plastic *** *** Micrococcus *** notable reductions of 46.43%and 56.60%in white and Canteen Stores Department(CSD)biodegradable plastics,*** density(OD)measurements revealed that bacterial isolates achieved maximum OD values with CSD plastics,emphasizing their proficiency in plastic *** Transform Infrared Spectroscopy(FTIR)confirmed the degradation process,with a decrease in the peak value from 2916 to 2914 cm^(-1) for pink plastic,signifying alkane,and alkene *** new peaks at 1398,1371,and 1361 cm^(-1) in the FTIR spectrum of CSD plastic indicated presence of *** Electron Microscopic(SEM)micrographs illustrated bacterial colonization,cracks,and spots on plastic surfaces,while Xray Diffraction(XRD)spectra showed peaks at 4.083,3.705,3.020,and 1.909,suggesting plastic *** conclusion,soil of waste disposal site harbored diverse microbial species,and have highlighted their effectiveness in mitigating environmental pollution by degrading hazardous plastic waste.

关键词： Plastic degradation Bacterial isolates Waste disposal sites Fourier transform infrared spectroscopy Scanning electron microscopy X-ray diffraction Environmental pollution

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