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Synthesis,Characterization,Biological and Docking Simulations of 4-(Benzylideneamino) Benzoic Acids

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Chinese Journal of Structural Chemistry 2021年第3期40卷 291-300,271页

作者： HAMID aziz AAMER Saeed FARUKH Jabeen ABDul Basit IRFAN Zia Qureshi ABDul aziz ATIF Haroon ASHFAQ Ur Rehman Department of Chemistry Quaid-I-Azam University Islamabad 45320 Pakistan Computation ScienceResearch and Development Organization14012485 Hurontraio StreetMississaugaONCaL5A2G6 Department of Biology Laurentian University935 Ramsey Lake RoadSudburyONCanada P3E2C6 Department of Animal Sciences Quaid-I-Azam University Islamabad 45320 Pakistan Department of Microbiology Quaid-I-Azam University Islamabad 45320 Pakistan Department of Biochemistry Shankar CampusAbdul Wali Khan UniversityMardan 23200Khyber PukhtoonkhwaPakistan Department of Bioinformatics and Biostatistics Shanghai Jiaotong UniversityShanghai 200240China

The present research paper presents the synthesis, characterization, biological and computational studies of 4-(benzylideneamino) benzoic acid derivatives(3a~3g). Derivatives 3a~3c displayed best antidiabetic potential with a glucose-lowering effect compared to the reference drug Glibenclamide. Biochemical parameters including plasma glucose, serum triglycerides, cholesterol, alanine amino transferase and aspartate amino transferase levels showed significant alterations in concentrations relative to the control. Similarly, the derivatives 3a, 3d and 3e displayed potent in vitro antibacterial potential. Molecular docking simulations delineated that the ligands and complexes were stabilized at the active site by electrostatic and hydrophobic forces, consistent with the corresponding experimental results. In silico study of the binding pattern predicted that the synthesized ligands, 3d and 3a could serve as a potential surrogate for hit-to-lead generation and the design of novel antibacterial drugs.

关键词： antidiabetic biochemical cholesterol glibenclamide simulations

Evolution and application of in-seam drilling for gas drainage

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International Journal of Mining Science and Technology 2013年第4期23卷 534-544页

作者： Frank Hungerford Ting Ren Naj aziz Drilling Division Valley Longwall International Pty Ltd. School of Civil Mining & Environmental Engineering University of Wollongong

The presence of seam gas in the form of methane or carbon dioxide presents a hazard to underground coal mining ***-seam drilling has been undertaken for the past three decades for gas drainage to reduce the risk of gas outburst and lower the concentrations of seam gas in the underground *** drilling practices have reflected the standards of the times and have evolved with the development of technology and equipment and the needs to provide a safe mining environment *** practice was to adapt equipment from other felds,with rotary drilling being the only form of drilling *** form of drainage allowed various levels of gas drainage coverage but with changing emphasis,research and development within the coal industry has created specifc equipment,technology and practices to accurately place in-seam boreholes to provide effcient and effective gas *** into gas content determination established a standard for the process and safe levels for mining operations to *** technology improved from the wire-line,single-shot Eastman survey instruments which was time-dependent on borehole depth to electronic instruments located in the drill string which transmitted accurate survey data to the drilling crew without time *** allowed improved directional control and increased drilling *** drilling technology has now been established as the industry standard to provide effective gas drainage *** was identifed as an additional beneft with directional drilling as it has the ability to provide exploration data from long *** ability of the technology to provide safe and reliable means to investigate the need for inrush protection and water drainage ahead of mining has been *** drilling technology has now been introduced to the Chinese coal industry for gas drainage through a practice of auditing,design,supply,training and ongoing ***

关键词： Gas outbursts In-seam drilling Gas drainage Directional drilling technology Gas content determination Geological exploration

Response of Contrasting Rice Genotypes to Zinc Sources under Saline Condition

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Phyton-International Journal of Experimental Botany 2023年第5期92卷 1361-1375页

作者： Muhammad Jan Muhammad Anwar-ul-Haq Talha Javed Sadam Hussain Ilyas Ahmad Muhammad Ashraf Sumrah Javed Iqbal Babar Hussain Babar Aqsa Hafeez Muhammad Aslam Muhammad Tahir Akbar Marjan aziz Khadiga Alharbi Izhar ullah Department of Soil and Environmental Sciences Ghazi UniversityDera Ghazi Khan32200Pakistan Institute of Soil and Environmental Sciences University of AgricultureFaisalabad38040Pakistan Department of Agronomy University of AgricultureFaisalabad38040Pakistan College of Agronomy Northwest A&F UniversityYangling712100China Pesticide Quality Control Lab MultanPunjab59300Pakistan Barani Agricultural Research Institute Chakwal48800Pakistan Soil and Water Testing Laboratory for Research Dera Ghazi Khan32200Pakistan Agronomic Research Institute Ayub Agricultural Research InstituteFaisalabad38000Pakistan Department of Plant Sciences Quaid-i-Azam UniversityIslamabad45320Pakistan Soil Fertility(Field) Multan59300Pakistan Department of Biology College of SciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Queensland University of Technology QueenslandAustralia

Abiotic stresses are among the major limiting factors for plant growth and crop *** these,salinity is one of the major risk factors for plant growth and development in arid to semi-arid *** of salt tolerant crop genotypes is one of the imperative approaches to meet the food demand for increasing *** current experiment was carried out to access the performance of different rice genotypes under salinity stress and Zinc(Zn)*** rice genotypes were grown in a pot experiment and were exposed to salinity stress(7 dS m^(−1)),and Zn(15 mg kg^(-1)soil)was applied from two sources,ZnSO4 and Zn-EDTA.A control of both salinity and Zn was kept for *** showed that based on the biomass accumulation and K^(+)/Na^(+)ratio,KSK-133 and BAS-198 emerged as salt tolerant and salt sensitive,***,based on the Zn concentration,BAS-2000 was reported as Zn-in-efficient while IR-6 was a Zn-efficient *** results also revealed that plant growth,relative water content(RWC),physiological attributes including chlorophyll contents,ionic concentrations in straw and grains of all rice genotypes were decreased under salinity ***,salt tolerant and Zn-in-efficient rice genotypes showed significantly higher shoot K^(+)and Zn concentrations under saline *** application significantly alleviates the harmful effects of salinity by improving morpho-physiological attributes and enhancing antioxidant enzyme activities,and the uptake of K and *** beneficial effect of Zn was more pronounced in salt-tolerant and Zn in-efficient rice genotypes as compared with salt-sensitive and Zn-efficient *** sum,our results confirmed that Zn application increased overall plant’s performance under saline conditions,particularly in Zn in-efficient and tolerant genotypes as compared with salt-sensitive and Zn efficient rice genotypes.

关键词： Agronomic efficiency antioxidant enzymes:physiology Oryza sativa salinity Zn efficient

Seed Priming and Foliar Supplementation withβ-aminobutyric Acid Alleviates Drought Stress through Mitigation of Oxidative Stress and Enhancement of Antioxidant Defense in Linseed(Linum usitatissimum L.)

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Phyton-International Journal of Experimental Botany 2023年第11期92卷 3113-3131页

作者： Tauqeer Ahmad Yasir Muhammad Ateeq Allah Wasaya Mubshar Hussain Naeem Sarwar Khuram Mubeen Mudassir aziz Muhammad Aamir Iqbal Chukwuma COgbaga Ibrahim Al-Ashkar Md Atikur rahman Ayman El Sabagh Department of Agronomy University of LayyahLayyah31200Pakistan Department of Agronomy Bahauddin Zakariya UniversityMultan60000Pakistan State Key Lab of Crop Stress Biology for Arid Areas College of AgronomyNorthwest A&F UniversityYangling712100China Department of Agronomy MNS University of AgricultureMultan60000Pakistan Department of Agronomy Faculty of AgricultureUniversity of Poonch RawalakotRawalakot10250Pakistan Independent Researcher MiddlesbroughNorth YorkshireUK Plant Production Department College of Food and Agriculture SciencesKing Saud UniversityP.O.Box 2460Riyadh11451Saudi Arabia Grassland and Forage Division National Institute of Animal ScienceRural Development AdministrationCheonan31000Korea Department of Field Crops Faculty of AgricultureSiirt UniversitySiirt56100Turkey Department of Agronomy Faculty of AgricultureKafrelsheikh UniversityKafr El-Shaikh33516Egypt

Drought is one of the critical limitations to agricultural soils and crop *** of water is increasing due to climate change that lead to increasing threats to global food ***,ecofriendly and cost effective strategies are highly desirable for mitigating drought stress along with sustainable and smart agricultural *** aim of the study was to mitigate DS using seed priming and exogenous supplementation ofβ-aminobutyric acid(BABA)in linseed(Linum usitatissimum L.).Different doses(0,50,100 and 150μM)of BABA were used for seed priming agent and foliar spraying under three soil moisture levels viz.,25%(SM25),45%(SM45)and 65%(SM65).The response variables of both experiments included different agro-botanical traits and oxidative stress indicators such as melondialdehyde content,free proline accumulation,and antioxidant defense in *** linseed plants showed water stress at SM25 that reduced plant height,number of branches per plant,time taken to flower initiation and heading,and root and shoot dry ***,the number of capsules and seeds per capsule showed a significant decline at SM25,which led to a drastic reduction in 100-seed weight yield in linseed plants in both ***,seed priming and foliar supplementation with of BABA(50–100μM)significantly improved these morpho-agronomical attributes in linseed plants under *** results revealed that the BABA was fully active in linseed plants at ***,the combination of SM25 with BABA significantly improved the antioxidant enzymes superoxide dismutase(SOD),catalase(CAT),ascorbate peroxidase(APX),and peroxidase(POD)activity,which significantly enhanced DS tolerance in linseed *** findings might be useful to oil seed breeders and farmers linseed for breeding program in linseed plants as well as sustainable agricultural production of oil seed crop plants.

关键词： Linseed water stress signaling molecule climate change biostimulant ecofriendly approach sustainable agricultural

Fuzzy Genetic Sharing for Dynamic Optimization

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International Journal of Automation and computing 2012年第6期9卷 616-626页

作者： Khalid Jebari Abdelaziz Bouroumi aziz Ettouhami Conception and Systems Laboratory Faculty of SciencesMohammed V-Agdal University Modeling and Instrumentation Laboratory Ben Msik Faculty of SciencesHassan II Mohammedia-Casablanca University

Recently,genetic algorithms(GAs) have been applied to multi-modal dynamic optimization(MDO).In this kind of optimization,an algorithm is required not only to find the multiple optimal solutions but also to locate a dynamically changing *** fuzzy genetic sharing(FGS) approach is based on a novel genetic algorithm with dynamic niche sharing(GADNS).FGS finds the optimal solutions,while maintaining the diversity of the *** this,FGS uses several ***,an unsupervised fuzzy clustering method is used to track multiple optima and perform ***,a modified tournament selection is used to control selection ***,a novel mutation with an adaptive mutation rate is used to locate unexplored search *** effectiveness of FGS in dynamic environments is demonstrated using the generalized dynamic benchmark generator(GDBG).

关键词： Genetic algorithms unsupervised learning fuzzy clustering dynamic optimization evolutionary algorithms dynamic niche sharing Hill s diversity index multi-modal function optimization.

Darcy–Forchheimer Three-Dimensional Flow of Williamson Nanofluid over a Convectively Heated Nonlinear Stretching Surface

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Communications in Theoretical Physics 2017年第9期67卷 387-394页

作者： Tasawar Hayat Arsalan aziz Taseer Muhammad Ahmed Alsaedi Department of Mathematics Quaid-I-Azam University Nonlinear Analysis and Applied Mathematics (NAAM) Research Group Department of Mathematics Faculty of ScienceKing Abdulaziz University

The present study elaborates three-dimensional flow of Williamson nanoliquid over a nonlinear stretchable surface. Fluid flow obeys Darcy–Forchheimer porous medium. A bidirectional nonlinear stretching surface generates the flow. Convective surface condition of heat transfer is taken into consideration. Further the zero nanoparticles mass flux condition is imposed at the boundary. Effects of thermophoresis and Brownian diffusion are considered. Assumption of boundary layer has been employed in the problem formulation. Convergent series solutions for the nonlinear governing system are established through the optimal homotopy analysis method(OHAM). Graphs have been sketched in order to analyze that how the velocity, temperature and concentration distributions are affected by distinct emerging flow parameters. Skin friction coefficients and local Nusselt number are also computed and discussed.

关键词： three-dimensional flow Williamson fluid nanoparticles Darcy-Forchheimer porous medium con-vective boundary condition nonlinear stretching surface

Study of the degradation behavior and the biocompatibility of Mg-0.8Ca alloy for orthopedic implant applications

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Journal of Magnesium and Alloys 2019年第2期7卷 249-257页

作者： Aya Mohamed Ahmed MEl-aziz Hans-Georg Breitinger Materials Engineering Department German University in Cairo(GUC)11835 New CairoEgypt Department of Biochemistry German University in Cairo(GUC)11835 New CairoEgypt

Mg-Ca alloys have recently attracted great attention towards the research in the field of orthopedic biodegradable *** study presents an in vitro degradation assessment of Mg-0.8Ca(0.8 wt.%of Ca)alloy in Hank’s balanced salt solution(HBSS).Immersion,hydrogen evolution and electrochemical behavior was studied as well as the cytotoxicity of the degradation *** and phase composition of the corrosion products were studied using SEM,EDX and XRD *** in HBSS resulted in the formation of the needle-shaped carbonated hydroxyapatite which was similar to the biological apatite in the human *** kinetics showed that Mg-0.8Ca alloy had approximately 3-fold faster degradation rate than the pure Mg(1.08±0.38 mm/year for Mg-0.8Ca and 0.35±0.17 mm/year for pure Mg),as observed in two independent ***,pure Mg and Mg-0.8Ca alloy were biocompatible,generating no cytotoxic degradation products against human-derived HEK 293 ***,the Mg-0.8Ca alloy was found to be a promising biodegradable implant in terms of bioactivity and compatibility with human cell *** on the application of the implant and the estimated healing time of the bone,the desired degradation rate of an implant can be controlled by the Mg-Ca composition of such alloys.

关键词： Mg-Ca alloys Biodegradability Orthopedic implants Biocompatibility Toxicity Hydroxyapatite

Global geoepidemiology of gastrointestinal surgery rates in Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1835-1844页

作者： Simcha Weissman Muhammad aziz Ayrton Bangolo Vignesh K Nagesh Htat Aung Midhun Mathew Lino Garcia Shiva A Chandar Praveena Karamthoti Harinder Bawa Aseel Alshimari Yabets Kejela Nazish Mehdi Chrishanti A Joseph Athri Kodali Rohan Kumar Priya Goyal Sanya Satheesha Fnu Nivedita Nicole Tesoro Tanni Sethi Gurpreet Singh Areej Belal Alina Intisar Hirra Khalid Samuel Cornwell Suchith B Suresh Kareem Ahmed Karabo K Marole Om P Anand Rahat B Reshi Tej I Mehta Sameh Elias Joseph D Feuerstein Department of Medicine Hackensack Meridian Health Palisades Medical CenterNorth BergenNJ 07047United States Division of Gastroenterology and Hepatology University of Toledo Medical CenterToledoOH 43614United States Department of Medicine University of WashingtonSeattleWA 98195United States Department of Radiology Johns Hopkins University HospitalBaltimoreMD 21218United States Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215United States

BACKGROUND Data regarding the worldwide gastrointestinal surgery rates in patients with Crohn’s disease(CD)remains *** To systematically review the global variation in the rates of surgery in *** A comprehensive search analysis was performed using multiple electronic databases from inception through July 1,2020,to identify all full text,randomized controlled trials and cohort studies pertaining to gastrointestinal surgery rates in adult patients with *** included continent based demographic data,CD surgery rates over time,as well as the geoepidemiologic variation in CD surgery *** analyses were conducted using *** Twenty-three studies spanning four continents were *** median proportion of persons with CD who underwent gastrointestinal surgery in studies from North America,Europe,Asia,and Oceania were 30%(range:1.7%-62.0%),40%(range:0.6%-74.0%),17%(range:16.0%-43.0%),and 38%*** clear association was found regarding the proportion of patients undergoing gastrointestinal surgery over time in North America(R^(2)=0.035)and Europe(R^(2)=0.100).A moderate,negative association was seen regarding the proportion of patients undergoing gastrointestinal surgery over time(R^(2)=0.520)in *** There appears to be significant inter-continental variation regarding surgery rates in *** evidencebased guidelines accounting for the geographic differences in managing patients with CD is ***,as a paucity of data on surgery rates in CD exists outside the North American and European continents,future studies,particularly in less studied locales,are warranted.

关键词： Gastrointestinal surgery Crohn’s disease Geoepidemiology Inflammatory bowel disease Prevalence

A Robust Tuned Random Forest Classifier Using Randomized Grid Search to Predict Coronary Artery Diseases

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Computers, Materials & Continua 2023年第5期75卷 4633-4648页

作者： Sameh Abd El-Ghany A.A.Abd El-aziz Department of Information Systems College of Computer and Information SciencesJouf UniversityKSA Department of Information Systems Faculty of Computers and InformationMansoura UniversityEgypt Department of Information Systems and Technology Faculty of Graduate Studies for Statistical ResearchCairo UniversityEgypt

Coronary artery disease(CAD)is one of themost authentic cardiovascular afflictions because it is an uncommonly overwhelming heart *** breakdown of coronary cardiovascular disease is one of the principal sources of death all over *** deterioration is a challenge,especially in youthful and rural countries where there is an absence of humantrained *** heart diseases happen without apparent signs,high-level detection is *** paper proposed a robust and tuned random forest model using the randomized grid search technique to *** proposed framework increases the ability of CADpredictions by tracking down risk pointers and learning the confusing joint efforts between ***,the healthcare industry has a lot of data but needs to gain more *** proposed framework is used for extracting knowledge from data stores and using that knowledge to help doctors accurately and effectively diagnose heart disease(HD).We evaluated the proposed framework over two public databases,Cleveland and Framingham *** datasets were preprocessed by using a cleaning technique,a normalization technique,and an outlier detection ***,the principal component analysis(PCA)algorithm was utilized to lessen the feature dimensionality of the two ***,we used a hyperparameter tuning technique,randomized grid search,to tune a random forest(RF)machine learning(ML)*** randomized grid search selected the best parameters and got the ideal CAD *** proposed framework was evaluated and compared with traditional *** proposed framework’s accuracy,sensitivity,precision,specificity,and f1-score were 100%.The evaluation of the proposed framework showed that it is an unrivaled perceptive outcome with tuning as opposed to other ongoing existing frameworks.

关键词： Coronary artery disease tuned random forest randomized grid search classifier