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Dietary supplementation in patients with alcoholic liver disease: a review on current evidence

Hepatobiliary & Pancreatic Diseases International 2016年第4期15卷 348-360页

作者： Zeinab Ghorbani Masoomeh Hajizadeh azita hekmatdoost Department of Clinical Nutrition and Dietetics Faculty of Nutrition and Food TechnologyNational Nutrition and Food TechnologyResearch Institute Shahid Beheshti University of Medical Sciences

BACKGROUND：Alcoholic liver disease（ALD）is one of the main causes of liver disease *** the pathogenesis of ALD has not yet been well elucidated,the oxidative metabolites of ethanol such as acetaldehyde and reactive oxygen species play a pivotal role in the clinical and pathological spectrum of the *** review summarizes the existing evidences on dietary supplements considered to have antioxidant,and/or anti-inflammatory properties,and their role in the management of ALD and the proposed *** SOURCES：The present study reviewed all studies published in Pub Med,Science Direct and Scopus,from 1959 to2015,indicating the role of different dietary supplementation in attenuation of many pathophysiological processes involved in development and progression of ***-texts of citations were used except for those that were published in languages other than ***：Significant progress has been made to understand the key events and molecular players for the onset and progression of ALD from both experimental and clinical studies;however,there is no successful treatment currently *** present review discussed the role of a variety of dietary supplements（*** A,carotenoids,vitamins B3,C and E,in addition to antioxidants and anti-inflammatory agents）in treating *** has been shown that supplementation with some carotenoids,vitamin B3,vitamin C,silymarin,curcumin,probiotics,zinc,S-adenosylmethionine and garlic may havepotential beneficial effects in animal models of ALD;however,the number of clinical studies is very *** addition,supplementation should be accompanied with alcohol ***：Since oxidative stress and inflammation are involved in the pathogenesis of ALD,dietary supplements that can modulate these pathologies could be useful in the treatment of *** addition to alcohol cessation,these supplements have shown beneficial effects on animal models of *** trials are needed to validate t

关键词： alcoholic liver disease fatty liver dietary supplements antioxidants nutrition diet

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Effects of L-arginine supplementation on glycemic profile: Evidence from a systematic review and meta-analysis of clinical trials

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Journal of Integrative Medicine 2020年第4期18卷 284-291页

作者： Esmaeil Yousefi Rad Behzad Nazarian Somayeh Saboori Ebrahim Falahi azita hekmatdoost Nutritional Health Research Center Lorestan University of Medical SciencesKhorramabad ***Iran Student Research Committee Lorestan University of Medical SciencesKhorramabad ***Iran Department of Clinical Nutrition and Dietetics Faculty of Nutrition and Food TechnologyNational Nutrition and Food TechnologyResearch InstituteShahid Beheshti University of Medical SciencesTehran ***Iran Division of Gastroenterology Hepatology and NutritionBritish Columbia’s Children’s Hospital and Child and Family Research Institutethe University of British ColumbiaBritish Columbia ***Canada

Background:The effects of l-arginine supplementation on indices of glycemic control and the role of many factors influencing this intervention have been controversial in clinical ***:This meta-analysis was performed to assess the effects of l-arginine supplementation on indices of glycemic control,including fasting blood glucose(FBG),hemoglobin A1c(HbA1c),serum insulin and homeostatic model assessment of insulin resistance(HOMA-IR)levels in randomized controlled trials(RCTs).Search strategy:This study conducted a systematic review of RCTs published in PubMed,Scopus,Web of Science,Cochrane Library and Embase,up to 5 May,*** criteria:Studies were included in this meta-analysis if they were RCTs with parallel design and reported sufficient data on participants before and after intervention,and outcomes of glycemic profile parameters in both the arginine supplementation and control *** extraction and analysis:The screening of titles and abstracts was performed independently by two *** articles were considered if they met the study’s inclusion *** quality of included studies was assessed by using the Cochrane Collaboration modified *** 710 articles retrieved in the initial search,only 10 trials were suitable for pooling the effects of arginine supplementation on serum glucose,insulin,HOMA-IR and HbA1c levels,with effect sizes of nine,eight,five and five,***:Pooled random-effect analysis revealed that l-arginine supplementation could significantly decrease FBG level(weighted mean difference[WMD]:3.35 mg/dL;95%confidence interval[CI]=[−6.55,−0.16];P=0.04)and serum insulin level(WMD:−2.19μIU/mL;95%CI=[−3.70,−0.67];P=0.005).However,the effects of l-arginine supplementation on HOMA-IR and HbA1c were not *** of subgroup analysis showed that supplementation with l-arginine could significantly decrease serum insulin levels when the dosage of l-arginine is>6.5 g/d(WMD:−3.49μIU/mL;95%CI=

关键词： l-arginine Fasting blood glucose Insulin resistance Hemoglobin A1c Glycemic profile Meta-analysis

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Recent advances in dietary supplementation, in treating non-alcoholic fatty liver disease

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World Journal of Hepatology 2015年第2期7卷 204-212页

作者： Tannaz Eslamparast Sareh Eghtesad Hossein Poustchi azita hekmatdoost Department of Clinical Nutrition and Diet Therapy Faculty of Nutrition and Food Technology National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Science Liver and Pancreatobiliary Diseases Research Center Digestive Diseases Research Institute Tehran University of Medical Sciences

Nonalcoholic fatty liver disease(NAFLD) is currently known as the most common liver problem, characterized by excessive lipid accumulation in hepatocytes,which may progress to other liver diseases such as nonalcoholic steatohepatitis, hepatic tissue fibrosis, livercirrhosis, and failure or hepatocellular carcinoma. Since NAFLD is positively associated with the development of obesity, insulin resistance, and ultimately type 2 diabetes mellitus, it is often regarded as the hepatic manifestation of the metabolic syndrome. No pharmacologic treatment has yet been proven for this disease. For most patients with presumed or confirmed NAFLD, the only proven strategy is to offer lifestyle advice that can lead to sustained weight loss. Since insulin resistance, oxidative stress, inflammation, and necro-apoptosis are involved in NAFLD pathogenesis, it seems that every potential therapeutic agent should target one or some of these pathologic events. There are many well known anti-oxidants, anti-inflammatory, and insulin sensitizer dietary supplements which have shown beneficial effects on NAFLD improvement in animal and human studies. The purpose of this review is to explore the existing evidences on dietary supplements considered to have hepatoprotective properties, and to present some proposed mechanisms by which they may protect against NAFLD.

关键词： Nonalcoholic fatty liver disease Dietarysupplementation Treatment

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Egg consumption and risk of non-alcoholic fatty liver disease

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World Journal of Hepatology 2017年第10期9卷 503-509页

作者： Zeinab Mokhtari Hossein Poustchi Tannaz Eslamparast azita hekmatdoost Department of Clinical Nutrition and Dietetics Faculty of Nu-trition Sciences and Food TechnologyNational Nutrition and Food Technology Research InstituteShahid Beheshti University of Medical Sciences Liver and Pancreatobiliary Diseases Research Group Digestive Diseases Research InstituteTehran University of Medical Sciences

To evaluate the association between egg consumption and risk of non-alcoholic fatty liver disease (NAFLD) development. METHODSThis case-control study was conducted on individuals who were referred to two hepatology clinics in Tehran, Iran in 2015. The study included 169 patients with NAFLD and 782 controls. Egg consumption was estimated using a validated food frequency questionnaire. The participants were categorized according to the frequency of their egg consumption during the previous year: Less than two eggs per week, two to three eggs per week, and four or more eggs per week. RESULTSIn the crude model, participants who consumed 2 to 3 eggs per week, were 3.56 times more likely to have NAFLD in comparison to those who consumed less than 2 eggs per week (OR: 3.56; 95%CI: 2.35-5.31). Adjustment for known risk factors of NAFLD strengthened this significant association so that individuals have consumed two to three eggs per week had 3.71 times higher risk of NAFLD than those who have eaten less than two eggs per week (OR: 3.71; 95%CI: 1.91, 7.75). CONCLUSIONOur data indicate that higher egg consumption in common amount of usage is associated with higher risk of NAFLD.

关键词： Egg Diet Non-alcoholic fatty liver disease Dietary cholesterol

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Dietary supplements and pediatric non-alcoholic fatty liver disease: Present and the future

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World Journal of Hepatology 2015年第25期7卷 2597-2602页

作者： Mehran Rahimlou Hoda Ahmadnia azita hekmatdoost Department of Clinical Nutrition School of Nutritional Sciences and DieteticsTehran University of Medical Sciences Department of Clinical Nutrition School of Nutritional Sciences and DieteticsShiraz University of Medical Science Department of Clinical Nutrition and Dietetics Faculty of Nutrition and Food TechnologyNational Nutrition and Food TechnologyResearch Institute Shahid Beheshti University of Medical Science

Non-alcoholic fatty liver disease(NAFLD) is the most common chronic liver disease in *** prevalence of pediatric obesity and sedentary lifestyle has augmented the incidence of NAFLD in *** is associated with an increased risk of NAFLD through various mechanisms such as intensification of insulin resistance and increased levels of inflammatory *** is no approved medical intervention for treatment of pediatric NAFLD;the only proven strategy in management of pediatric NAFLD is lifestyle ***,the effects of nutritional supplements have been examined in the management of pediatric *** purpose of this review is to summarize the studies evaluating the effects of nutritional supplements on pediatric NAFLD and explain the future direction in this field.

关键词： Pediatric non-alcoholic fatty liver disease Diet Nutrition Dietary supplement Fatty liver

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A novel treatment for weight reduction by the recombinant "Pichia pastoris" yeast expressing the hybrid protein of "irisin-furin-transferrin"

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Journal of Integrative Medicine 2016年第1期14卷 1-4页

作者： Mahsa Jalili Zahra Bazi azita hekmatdoost Clinical Nutrition Department Nutrition FacultyShahid Beheshti University of Medical Sciences Medical Biotechnology Department Medicine FacultyShahid Beheshti University of Medical Sciences

Obesity is a major health problem across the world, but there are few ways to effectively treat or manage it in the long term. Researchers are searching for more convenient, cost-effective and noninvasive therapies for overweight and obese people. Recent studies have illustrated that the microbiome of the body＇s different organs can be used as a vehicle for in-situ gene therapy. We suggest that the recombinant form of ＂Pichia pastoris＂ yeast expressing the hybrid protein of ＂irisin-furin-transferrin＂ under the control of the enolase 1 promoter is a new nutraceutical strategy to absorb fewer calories from intestinal nutrients, and induce a higher metabolic rate to expend more calories, similar to that from engaging in physical activity. By comparison, this method can be a long-term, noninvasive treatment and can be used for obese patients who have movement limitations.

关键词： obesity nutrition biotechnology DNA, recombinant

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