A novel treatment for weight reduction by the recombinant "Pichia pastoris" yeast expressing the hybrid protein of "irisin-furin-transferrin"

作     者：Mahsa Jalili Zahra Bazi Azita Hekmatdoost 

作者机构：Clinical Nutrition DepartmentNutrition FacultyShahid Beheshti University of Medical Sciences Medical Biotechnology DepartmentMedicine FacultyShahid Beheshti University of Medical Sciences 

出 版 物：《Journal of Integrative Medicine》 (结合医学学报（英文版）)

年 卷 期：2016年第14卷第1期

页      面：1-4页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：obesity nutrition biotechnology DNA, recombinant 

摘      要：Obesity is a major health problem across the world, but there are few ways to effectively treat or manage it in the long term. Researchers are searching for more convenient, cost-effective and noninvasive therapies for overweight and obese people. Recent studies have illustrated that the microbiome of the body＇s different organs can be used as a vehicle for in-situ gene therapy. We suggest that the recombinant form of ＂Pichia pastoris＂ yeast expressing the hybrid protein of ＂irisin-furin-transferrin＂ under the control of the enolase 1 promoter is a new nutraceutical strategy to absorb fewer calories from intestinal nutrients, and induce a higher metabolic rate to expend more calories, similar to that from engaging in physical activity. By comparison, this method can be a long-term, noninvasive treatment and can be used for obese patients who have movement limitations.