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QCD sum rule study of J^(P)=1^(±)exotic states with two heavy quarks in the molecular picture

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Chinese Physics C 2024年第6期48卷 31-37页

作者： T.m.Aliev S.bilmis m.Savcı Department of Physics Middle East Technical UniversityAnkara06800Turkey TUbITAK ULAKbIm Ankara06510Turkey

In this study,the spectroscopic parameters of exotic molecular states composed of mesons containing two heavy quarks(scalar-axial and pseudoscalar-axial meson combinations)are investigated within the QCD sum *** findings reveal that molecular states containing charm quarks do not form bound states,whereas states with b-quarks can form exotic molecular *** observation has significant implications for understanding the structure of these exotic states.

关键词： QCD sum rules exotic mesons molecular states

Impact of increasing one-carbon metabolites on traumatic brain injury outcome using pre-clinical models

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Neural Regeneration Research 2024年第8期19卷 1728-1733页

作者： Sanika m.Joshi Theresa Currier Thomas Nafisa m.Jadavji College of Osteopathic medicine Midwestern UniversityGlendaleCAUSA Department of biomedical Sciences Midwestern UniversityGlendaleCAUSA Department of Child Health College of Medicine–PhoenixUniversity of ArizonaPhoenixAZUSA College of Veterinary medicine Midwestern UniversityGlendaleCAUSA Department of Neuroscience Carleton UniversityOttawaCanada

Traumatic brain injury is a major cause of death and disability worldwide,affecting over 69 million individuals ***-carbon metabolism has been shown to have beneficial effects after brain damage,such as ischemic ***,whether increasing one-carbon metabolite vitamins impacts traumatic brain injury outcomes in patients requires more *** aim of this review is to evaluate how one-carbon metabolites impact outcomes after the onset of traumatic brain ***,Web of Science,and Google Scholar databases were searched for studies that examined the impact of b-vitamin supplementation on traumatic brain injury *** search terms included combinations of the following words:traumatic brain injury,dietary supplementation,one-carbon metabolism,and *** focus of each literature search was basic science *** year of publication in the literature searches was not *** analysis of the literature has shown that dietary supplementation of b-vitamins has significantly improved the functional and behavioral recove ry of animals with traumatic brain injury compared to *** r,this improvement is dosage-dependent and is contingent upon the onset of supplementation and whether there is a sustained or continuous delive ry of vitamin supplementation post-traumatic brain *** details of supplementation post-traumatic brain injury need to be further ***,we conclude that b-vitamin supplementation improves behavioral outcomes and reduces cognitive impairment post-traumatic brain injury in animal model *** investigation in a clinical setting should be stro ngly considered in co njunction with current medical treatments for traumatic brain injury-affected individuals.

关键词： folic acid nicotinamide one-carbon metabolism riboflavin traumatic brain injury vitamin b12 vitamin b2 vitamin b3

A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

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bio-Design and manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.beeren G.Dos Santos P.J.Dijkstra C.mota J.bauer H.Ferreira Rui L.Reis N.Neves S.Camarero-Espinosa m.b.baker L.moroni Department of Complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3b’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3b’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal POLYmAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERbASQUE Basque Foundation for Science48009 BilbaoSpain

melt extrusion-based additive manufacturing(mE-Am)is a promising technique to fabricate porous scaffolds for tissue engi-neering ***,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell *** of biomolecules on polymeric surfaces of Am scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(PCL5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight PCL75k at different *** porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight PCL *** a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morphogenetic protein 2(bmP-2)-derived peptide was grafted onto the films comprising different blend compositions,and the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hmSCs)was *** two weeks of culturing in a basic medium,cells expressed higher levels of bmP receptor II(bmPRII)on films with the conjugated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface *** together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material ***,we have presented a viable strategy for mE-Am community that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive manufacturing blending Surface functionalization Surface density Click chemistry Human

Trust-based Intelligent Scheme for mitigating black Hole Attacks in IoT

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Journal of Harbin Institute of Technology(New Series) 2024年第3期31卷 39-50页

作者： Feroz Khan A.b Weslin D Dilli babu m mohammed muzaffar Hussain Department of Computer Science Syed Hameedha Arts and Science CollegeKilakarai 623806Tamil NaduIndia Department of Information Technology Mohamed Sathak AJ College of EngineeringSiruseriChennai 603103India Department of Information Technology Panimalar Engineering CollegeChennai 600123India Department of Information Technology C.Abdul Hakeem College of Engineering and TechnologyMelvisharam 632509India

Internet of Things(IoT)networks are characterized by a multitude of wireless,interconnected devices that can dynamically join or exit the network without centralized administration or fixed infrastructure for *** multipath routing in IoT networks can improve data transmission reliability and load balancing by establishing multiple paths between source and destination nodes,these networks are susceptible to security threats due to their wireless *** security solutions developed for conventional networks are often ill-suited to the unique challenges posed by IoT *** response to these challenges,this paper proposes the integration of the Ad hoc On-demand multipath Distance Vector(AOmDV)routing protocol with a trust model to enhance network *** findings from this research demonstrate the successful fusion of AOmDV with a trust model,resulting in tangible improvements in network *** assessment of trustworthiness bolsters both security and routing capabilities in IoT *** trust model plays a crucial role in mitigating black hole attacks in IoT networks by evaluating the trustworthiness of nodes and helping in the identification and avoidance of malicious nodes that may act as black *** results validate the efficacy of the proposed trust-based routing mechanism in achieving its *** plays a pivotal role in decision-making and in the creation of secure distribution *** assessing the trustworthiness of nodes,both network security and routing efficiency can be *** effectiveness of the proposed trust-based routing mechanism is scrutinized through simulations,offering insights into its potential advantages in terms of improved network security and routing performance in the context of the IoT.

关键词： mobile ad-hoc network(mANET) routing Ad hoc On-demand multipath Distance Vector(AOmDV) trust model security

A Review on the Advancement of Renewable Natural Fiber Hybrid Composites: Prospects, Challenges, and Industrial Applications

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Journal of Renewable materials 2024年第7期12卷 1237-1290页

作者： mohammed mohammed Jawad K.Oleiwi Aeshah m.mohammed Anwar Ja’afar mohamad Jawad Azlin F.Osman Tijjani Adam bashir O.betar Subash C.b.Gopinath Center of Excellence Geopolymer&Green Technology(CEGeoGTech) Universiti Malaysia PerlisArau02600Malaysia Faculty of Chemical Engineering Technology Universiti Malaysia Perlis(UniMAP)Arau02600Malaysia Department of materials Engineering University of TechnologyBaghdad10070Iraq Department of Chemical materials University of Bagdad College of Education for Pure Science Ibn-AlhaithamBaghdad10001Iraq Department of Computer Techniques Engineering Al-Rafidain University CollegeBaghdad10001Iraq Faculty of Electronics Engineering Technology Universiti Malaysia PerlisKampus Uniciti Alam Sg.ChuchuhPerlis02100Malaysia Research Center(NANOCAT) University of MalayaKuala Lumpur50603Malaysia Institute of Nano Electronic Engineering Universiti Malaysia PerlisPerlis01000Malaysia Center for Global Health Research Saveetha Medical College&HospitalSaveetha Institute of Medical and Technical Sciences(SIMATS)Tamil Nadu602105India

Naturalﬁbre(NFR)reinforced functional polymer composites are quickly becoming an indispensable sustainable material in the transportation industry because of their lightweight,lower cost in manufacture,and adaptability to a wide variety of ***,the major difﬁculties of using theseﬁbres are their existing poor dimensional stability and the extreme *** assessing the mechanical properties(mP)of composites,the interfacial bonding(Ib)happening between the NFR and the polymer matrix(Pm)plays an incredibly signiﬁcant *** compared to NFR/syntheticﬁbre hybrid composites,hybrid composites(HC)made up of two separate NFR are less prevalent;yet,these hybrid composites also have the potential to be valuable materials in terms of environmental issues.A new dimension to theﬂexibility of composites reinforced with NFR is added by the cost-effective manufacture of hybrid composites utilising *** purpose of this study is to offer an over-view of the keyﬁndings that were presented on hybrid *** emphasis was focused on the factors that inﬂuence the performance of the naturalﬁber composites,diverse approaches to enhancing mP,physical,electri-cal,and thermal characteristics of the *** study in polymer science gains interest for applications in con-struction and automotive industries.

关键词： Renewable naturalﬁber hybrid composites sustainability nanomaterial greener material

major,trace element and Sr-Nd isotope evidence for a sublithospheric mantle source for the Umkondo large igneous province

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Geoscience Frontiers 2024年第1期15卷 263-285页

作者： ben Hayes Lewis D.Ashwal Khulekani b.Khumalo Linda m.Iaccheri School of Geosciences University of the WitwatersrandJohannesburg2050South Africa

The mesoproterozoic(1.11 Ga)Umkondo large igneous province(LIP)in southern Africa and Antarctica was emplaced in<5 myr and is dominated by low-Ti tholeiitic doleritic-gabbroic *** is of particular interest because it ... 详细信息

The mesoproterozoic(1.11 Ga)Umkondo large igneous province(LIP)in southern Africa and Antarctica was emplaced inmyr and is dominated by low-Ti tholeiitic doleritic-gabbroic *** is of particular interest because it is the least studied LIP in southern Africa with both sublithospheric and lithospheric mantle sources proposed and it coincides with the early assembly of Rodinia,so it has importance in understanding the nature of magmatism and tectonics in and around the Kalahari craton during the *** this study,we compiled a large database of existing(~750)and new(~100)major and trace element data for the Umkondo province,as well as 42 new Sr-Nd isotopic measurements,to provide constraints on its magma sources and geochemical *** element compositional variations in the low-Ti tholeiites are explained by low-pressure(1 kbar)three-phase fractional crystallisation(olivine,clinopyroxene and plagioclase)of a parent magma with~10 wt.%mgO in oxidising conditions(QFm+1).Inverse models show that the low-Ti tholeiitic magmas were derived as residual melts after the crystallization of 12%-33%olivine from primary komatiitic-basaltic magmas(up to~20 wt.%mgO)in equilibrium with mantle olivine(Fo90).Low Sm/Yb and TiO2/Yb-Nb/Yb indicate that the primary magmas were derived by 2%-20%shallow(40-50 km)partial melting of spinel *** Sm/Yb is restricted to dyke swarms and may imply limited magma production from deeper(up to~70 km)garnet lherzolite-like *** low-Ti tholeiites of the Umkondo province are enriched in large ion lithophile elements(Rb-Sr-Cs-K)and depleted in high-field strength elements(Zr-Hf-Nb-Ta),indicating the involvement of crustal material and/or the subcontinental lithospheric *** is supported by covariations in Th/Nb,Nb/Yb,Nb/La and Ce/Sm with generally negativeΔ***-Nd isotopes lend support to the notion that the Umkondo magmas were derived from depleted and/or enriched sublithospheric mantle sources and subs

关键词： Umkondo large igneous province Low-Ti magma Continental tholeiites Sublithospheric mantle sources Kalahari craton Rodinia

A Retrospective Analysis of Intoxicated Patients Admitted to the Intensive Care Unit: A Single-Institution Assessment in the Post-Pandemic Period

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Journal of biosciences and medicines 2024年第3期12卷 159-167页

作者： müge Arikan Abdullah Yeşilkaya büşra Nur Taşdelen İbrahim Özyiğit Department of Anesthesia and Intensive Care Faculty of Medicine Karabuk University Karabuk Turkey

background: The aim of this study was to evaluate the clinical and epidemiological characteristics of patients with acute intoxication admitted to the Intensive Care Unit (ICU). material and methods: An observational retrospective study was conducted on intoxicated patients who admitted to ICU between January 2022 and January 2024. Data were collected from the patients medical records. The demographic characteristics, causes of intoxications, clinical parameters, the mean stay in the ICU, treatment modalities and prognosis were recorded. Results: A total of 2875 critically ill patients were admitted during the study period, and 109 (3.79%) of them were acute intoxications. Their mean of ages was 38.09 ± 12.29. The female-to-male ratio was 1.37/1. Drugs were found to be the primary cause (62.39%) of intoxications, and analgesics, antidepressants, and antibiotics were the most frequent agents. Suicidal attempts were present in 66 patients, most of them were female (62.13%) and between 17 - 24 years (40.91%). The other common causes of intoxications were carbon monoxide (CO) (22.02%), methyl/ethyl alcohol (8.26%) and mushroom (5.50%). The mean stay in the ICU was 2.69 ± 0.89 days. mechanical ventilation was applied to 10 of our patients. Renal replacement therapy was required in 6 patients. Despite all treatments, 6 of our patients died, and we found the mortality rate to be 5.50%. Conclusion: Intoxications were more frequent in young female patients and drugs were the most common cause with suicidal intent. Unfortunately, CO poisoning continues to be a very important problem in our city. These findings provided significant information about the characteristics of intoxications in Karabuk.

关键词： Intoxication Intensive Care Unit Suicidal mortality

Pelleting and particle size reduction of corn increase net energy and digestibility of fiber,protein,and fat in corn-soybean meal diets fed to group-housed pigs

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Journal of Animal Science and biotechnology 2024年第4期15卷 1751-1760页

作者： Su A Lee Diego A.Rodriguez Chad b.Paulk Hans H.Stein Department of Animal Sciences University of IllinoisUrbanaIL 61801USA Department of Grain Sciences and Industry Kansas State UniversityManhattanKS 66506USA

background Reduction of the particle size of corn increases energy digestibility and concentrations of digestible and metabolizable *** may also reduce particle size of grain,but it is not known if there are interactions between particle size reduction and *** objective of this experiment was to test the hypothesis that particle size reduction and pelleting,separately or in combination,increase N balance,apparent total tract digestibility(ATTD)of fiber and fat,and net energy(NE)in corn-soybean meal diets fed to group-housed *** Six corn-soybean meal-based diets were used in a 3×2 factorial design with 3 particle sizes of corn(i.e.,700,500,or 300μm)and 2 diet forms(i.e.,meal or pelleted).Pigs were allowed ad libitum access to feed and ***-four castrated male pigs(initial weight:29.52 kg;standard diviation:1.40)were allotted to the 6 diets using a 6×6 Latin square design with 6 calorimeter chambers(i.e.,4 pigs/chamber)and 6 *** consumption and CO_(2)and CH_(4)productions were measured during fed and fasting states and fecal and urine samples were *** Regardless of particle size of corn,the ATTD of gross energy(GE),N,and acid-hydrolyzed ether extract(AEE),and the concentration of NE were greater(Pmeal *** of diet form,the ATTD of GE,N,and AEE,and the concentration of NE were increased(linear;Pby reducing the particle size of corn,but the increase was greater in meal diets than in pelleted diets(interaction;Pboth pelleting and reduction of corn particle size increased nutrient digestibility and NE,but increases were greater in meal diets than in pelleted diets.

关键词： Corn Digestibility Feed technology Net energy Particle size Pelleting

The role of N-glycosylation in cancer

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Acta Pharmaceutica Sinica b 2024年第3期14卷 1098-1110页

作者： Yu Lin David m.Lubman Department of Surgery University of Michigan Medical CenterAnn ArborMI 48109USA

Despite advances in understanding the development and progression of cancer in recent years,there remains a lack of comprehensive characterization of the cancer *** play an important role in medicine and are involved in various human disease conditions including ***-moieties participate in fundamental cancer processes like cell signaling,invasion,angiogenesis,and *** N-glycosylation significantly impacts cancer processes and targeted therapies in ***,understanding N-glycosylation in a tumor is essential for comprehending disease progression and discovering anti-cancer targets and biomarkers for therapy monitoring and *** review presents the fundamental process of protein N-glycosylation and summarizes glycosylation changes in tumor cells,including increased terminal sialylation,N-glycan branching,and ***,the role of N-glycosylation in tumor signaling pathways,migration,and metabolism are *** and glycopeptides as potential biomarkers for early detection of cancer based on site specificity have been ***,understanding and exploring the cancer glycoproteome,along with its role in medicine,implication in cancer and other human diseases,highlights the significance of N-glycosylation in tumor processes,necessitating further research for potential anticancer targets and biomarkers.

关键词： N-Glycosylated proteins Cancer signaling Cancer angiogenesis Cancer metabolism Cancer biomarkers