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Nigella sativa oil alleviates doxorubicin-induced cardiomyopathy and neurobehavioral changes in mice:In vivo and in-silico study

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Asian Pacific Journal of Tropical Biomedicine 2022年第7期12卷 312-322页

作者： Md Jamir Anwar Sattam Khulaif Alenezi Faizul azam Danish Mahmood Faisal Imam Khalid Saad Alharbi Department of Pharmacology and Toxicology Unaizah College of PharmacyQassim UniversityAl-QassimSaudi Arabia Department of Pharmaceutical Chemistry&Pharmacognosy Unaizah College of PharmacyQassim UniversityAl-QassimSaudi Arabia Department of Pharmacology and Toxicology College of PharmacyKing Saud UniversityRiyadhSaudi Arabia Department of Pharmacology College of PharmacyJouf UniversitySakakahSaudi Arabia

Objective:To investigate the effect of Nigella sativa oil on cardiomyopathy and neurobehavioral changes induced by doxorubicin in ***:Swiss strain of albino female mice were divided into 6 groups of 5 animals in each:GroupⅠ(control group),groupⅡ(doxorubicin,10 mg/kg,i.v.),groupⅢ,Ⅳ,andⅤ(Nigella sativa oil;1.5,3,and 6 mL/kg,respectively),groupⅥ(Nigella sativa oil per se;6 mL/kg,p.o.).The duration of treatment was 15 d(10 days’pre-treatment and 5 days’post-treatment)and doxorubicin was administered on day 11th of the treatment *** Nigella sativa oil treatment,neurobehavioral tests,cardiac hypertrophy tests,and biochemical tests in serum and tissues were *** tests included assessment of anxiety-like behavior in the elevated plus maze,spontaneous alternation behavior in the cross maze,and depression-like behavior in modified forced swim *** tests included serum lactate dehydrogenase and creatinine kinase-MB,malondialdehyde and reduced glutathione in ***,molecular docking was used to estimate the affinity of the phytoconstituents of Nigella sativa oil with histone ***:Nigella sativa oil treatment significantly(P<0.001)restored doxorubicin-induced neurobehavioral changes,decreased lactate dehydrogenase and creatinine kinase-MB in the plasma,malondialdehyde contents in tissues,and increased reduced glutathione ***,no significant alteration was observed in Nigella sativa oil per se group as compared to the *** docking showed that Nigella sativa oil components had appreciable binding affinitiy with the protein cavities of HDAC1 and ***:The result shows that Nigella sativa oil exerts anxiolytic,antidepressant,and memory-enhancing effects in addition to cardioprotective effect against doxorubicin-induced cardiomyopathy in *** modulatory effect of Nigella sativa oil on oxidative stress could contribute to the cardioprotective effect and associated neuro

关键词： Nigella sativa oil Doxorubicin Cardiomyopathy Neurobehavioral changes Lactate dehydrogenase Creatinine kinase-MB Malondialdehyde Reduced glutathione Mice HDAC docking

Effects of the nitrification inhibitor nitrapyrin and the plant growth regulator gibberellic acid on yield-scale nitrous oxide emission in maize fields under hot climatic conditions

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Pedosphere 2021年第2期31卷 323-331页

作者： Khadim DAWAR Kamil SARDAR Mohammad ZAMAN Christoph MÜLLER Alberto SANZ-COBENA Aamir KHAN azam BORZOUEI Ana Gabriela PÉREZ-CASTILLO Department of Soil and Environmental Science University of Agriculture PeshawarPeshawa 25000(Pakistan) Soil and Water Management&Crop Nutrition Joint FAO/IAEA Division of Nuclear Techniques in Food&AgricultureP.O.Box 100Vienna A-1400(Austria) Institute of Plant Ecology Justus Liebig UniversityHeinrich-Buff-Ring 26Giessen D-35392(Germany) School of Biology and Environmental Science University College DublinBelfieldD04 V1W8(Ireland) Management of Environment and Agricultural Risks(CEIGRAM) ETSIAABUniversidad Poliécnica de MadridMadrid 28040(Spain) Agricultural Research School Nuclear Science and Technology Research InstituteP.O.Box 31465/1498Karaj(Iran) Environmental Pollution Research Center(CICA) University of Costa RicaMontes de Oca 11501(Costa Rica)

Nitrification inhibitors are widely used in agriculture to mitigate nitrous oxide(N_(2)O)emission and increase crop ***,no concrete information on their mitigation of N_(2)O emission is available under soil and environmental conditions as in Pakistan.A field experiment was established using a silt clay loam soil from Peshawar,Pakistan,to study the effect of urea applied in combination with a nitrification inhibitor,nitrapyrin(2-chloro-6-tri-chloromethyl pyridine),and/or a plant growth regulator,gibberellic acid(GA_3),on N_(2)O emission and the nitrogen(N)uptake efficiency of *** experimental design was a randomized complete block with five treatments in four replicates:control with no N(CK),urea(200 kg N ha^(-1))alone,urea in combination with nitrapyrin(700 g ha^(-1)),urea in combination with GA_3(60 g ha^(-1)),and urea in combination with nitrapyrin and GA_*** N_(2)O emission,yield,N response efficiency,and total N uptake were measured during the experimental *** treatment with urea and nitrapyrin reduced total N_(2)O emission by 39%–43%and decreased yield-scaled N_(2)O emission by 47%–52%,relative to the treatment with urea *** maize plant biomass,grain yield,and total N uptake increased significantly by 23%,17%,and 15%,respectively,in the treatment with urea and nitrapyrin,relative to the treatment with urea alone,which was possibly due to N saving,lower N loss,and increased N uptake in the form of ammonium;they were further enhanced in the treatment with urea,nitrapyrin,and GA_3 by 27%,36%,and 25%,respectively,probably because of the stimulating effect of GA_3 on plant growth and development and the reduction in biotic and abiotic *** results suggest that applying urea in combination with nitrapyrin and GA_3 has the potential to mitigate N_(2)O emission,improve N response efficiency,and increase maize yield.

关键词： fertilizer use efficiency greenhouse gas emission mitigation N response efficiency N uptake efficiency N_(2)O flux plant growth hormone urea

Missed estradiol determination resulting in oocyte retrieval and embryo development following controlled ovarian hyperstimulation at early pregnancy: Case report

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Asian pacific Journal of Reproduction 2018年第3期7卷 143-144页

作者： Maryam Eftekhar azam Agha-Rahimi Mohammad Ali Khalili Marjan Omidi Department of Obstetrics and Gynecology Shahid Sadoughi University of Medical SciencesYazdIran Research and Clinical Center for Infertility Yazd Reproductive Sciences InstituteShahid Sadoughi University of Medical SciencesYazdIran Department of Reproductive Biology Shahid Sadoughi University of Medical SciencesYazdIran

This paper is a case report on the success of oocyte retrieval and good quality embryo development following controlled ovarian hyperstimulation at early pregnancy. A 30-year-old patient underwent controlled ovarian hyperstimulation by gonadotropin-releasing hormone agonist long protocol. On the day of oocyte collection, a 5-week gestational sac was observed by exact sonography monitoring. However, via ultrasound guided follicle puncture, 7 oocytes were collected. After intarcytoplasmic sperm injection, 3 developed good quality embryos were cryopreserved. Moreover, the natural pregnancy was continued and finally a healthy live birth was achieved. Despite physiological hormonal changes during pregnancy, the follicular growth occurred and followed by oocyte retrieval and embryo development, subsequently.

关键词： Controlled ovarian hyperstimulation Oocyte Embryo Pregnancy

Evolving paradigms in biological carbon cycling in the ocean

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National Science Review 2018年第4期5卷 481-499页

作者： Chuanlun Zhang Hongyue Dang Farooq azam Ronald Benner Louis Legendre Uta Passow Luca Polimene Carol Robinson Curtis A.Suttle Nianzhi Jiao Department of Ocean Science and Engineering Southern University of Science and Technology State Key Laboratory of Marine Environmental Science Institute of Marine Microbes and Ecospheres College of Ocean and Earth Sciences Xiamen University Scripps Institution of Oceanography University of California San Diego Department of Biological Sciences and School of the Earth Ocean and EnvironmentUniversity of South Carolina Sorbonne Université Laboratoired' Océanographie de Villefranche LOV 6. Marine Science Institute University of California Santa Barbara 7. Plymouth Marine Laboratory 8. School of Environmental SciencesUniversity of East Anglia 9. Departments of Earth Ocean and Atmospheric SciencesBotany and Microbiology and Immunology and the Institute for the Oceans and Fisheries University of British Columbia

Carbon is a keystone element in global biogeochemical *** plays a fundamental role in biotic andabiotic processes in the ocean,which intertwine to mediate the chemistry and redox status of carbon in the ocean and the *** interactions between abiotic and biogenic carbon(***2,Ca CO3,organic matter)in the ocean are complex,and there is a half-century-old enigma about the existence of a huge reservoir of recalcitrant dissolved organic carbon(RDOC)that equates to the magnitude of the pool of atmospheric *** concepts of the biological carbon pump(BCP)and the microbial loop(ML)shaped our understanding of the marine carbon *** more recent concept of the microbial carbon pump(MCP),which is closely connected to those of the BCP and the ML,explicitly considers thesignificance of the ocean’s RDOC reservoir and provides a mechanistic framework for the exploration of its formation and *** of the MCP has benefited from advanced‘omics’and novel research in biological oceanography and microbial *** need to predict the ocean’sresponse to climate change makes an integrative understanding of the BCP,ML and MCP a high *** this review,we summarize and discuss progress since the proposal of the MCP in 2010 and formulate research questions for the future.

关键词： biological carbon pump microbial loop microbial carbon pump ocean carbon cycle global climate change

In Vitro Synthetic Seed Production of Potato under Different Fungicide Levels and Storage Intervals

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Phyton-International Journal of Experimental Botany 2023年第8期92卷 2429-2450页

作者： Tahira Kalsoom Touqeer Ahmed Muhammad azam Khan Mirza Hasanuzzaman Mukhtar Ahmed Stefaan P.O.Werbrouck Department of Horticulture PMAS-Arid Agriculture UniversityRawalpindi46300Pakistan Department of Agronomy Sher-e-Bangla Agricultural UniversityDhaka1207Bangladesh Department of Agronomy PMAS-Arid Agriculture UniversityRawalpindi46300Pakistan Department of Plants and Crops Ghent UniversityGhent9000Belgium

Potato propagation through tubers and seed is an inefﬁcient way of propagation thus we propose an alternative method in this study which is in vitro *** were raised from True Potato Seeds(TPS)in test tubes containing 10 mL of Murashige Skoog(MS)*** was done after every 21 days and after four subsequent subculturing,when there was an adequate quantity of stock material,uninodal cuttings of about 3-4 mm in length were prepared from in vitro proliferated potato plants by excising leaves of 1-2 mm on each side of the *** uninodal cuttings were cultured on 1/2 strength MS medium for root primordia *** selected uninodal cuttings with root primordia were encapsulated with sodium alginate solution(3.5%(w/v)),mixed with 1.25%charcoal and different concentration of fungicide(thiophanate methyl,sigma)to enhance the viability percentage of synthetic ***,these encapsulated uninodal cuttings were subjected to different storage intervals to check maximum *** showed that optimum dose for fungicide is 150 mg/L as it resulted in good viability percentage,shoot number,shoot length,rooting percentage,root number,root length and ideal for bead formation with sodium ***,results revealed that encapsulated uninodal cuttings can be stored at a temperature of 4℃ up to 45 days with a survival rate of 63.33%.Encapsulated uninodal cutting stored for 60 days showed a poor viability percentage of about 43.03%.It can be concluded that optimum dose of 150 mg/L with storage time of 45 days should be used to get a better outcome for synthetic potato seed production.

关键词： Synthetic seeds potato storage charcoal sodium alginate fungicide

Phytochemical analysis of Berberis lyceum methanolic extract and its antiviral activity through the restoration of MAPK signaling pathway modulated by HCV NS5A

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Asian Pacific Journal of Tropical Biomedicine 2021年第3期11卷 132-140页

作者： Koloko Brice Landry Shafiq azam Sidra Rehman Somayya Tariq Bushra Iqbal Mateen Abbas Dieudonné Massoma Lembè Bushra Ijaz Laboratory of Applied and Functional Genomic Centre of Excellence in Molecular BiologyUniversity of the PunjabLahorePakistan Department of Biosciences COMSATS University IslamabadIslamabadPakistan Quality Operations Laboratory University of Veterinary and Animal SciencesLahorePakistan Laboratory of Animal Biology and Physiology Faculty of ScienceUniversity of DoualaDoualaCameroon

Objective:To evaluate the antiviral activity and phytochemicals of selected plant extracts and their effect on the mitogen-activated protein kinase(MAPK)signaling pathway modulated by hepatitis C virus(HCV)nonstructural protein 5 A(NS5A).Methods:A total of ten plant extracts were initially screened for their toxicities against Hep G2 *** non-toxic plants were tested for their inhibitory effect on the expression of HCV NS5A at both m RNA and protein levels using real-time PCR and Western blotting assays,*** differential expression of the genes associated with MAPK pathway in the presence of NS5A gene and plant extract was measured through real-time ***,the identification of secondary metabolites was carried out by phytochemical and HPLC ***:The phytochemical profiling of Berberis lyceum revealed the presence of alkaloids,phenols,saponins,tannins,flavonoids,carbohydrates,terpenoids,steroids,and ***,quercetin,myricetin,gallic acid,caffeic acid,and ferulic acid were identified through HPLC *** methanolic extract of Berberis lyceum strongly inhibited HCV RNA replication with an IC50 of 11.44μg/m ***-PCR and Western blotting assays showed that the extract reduced the expression of HCV NS5A in a dosedependent *** lyceum extract also attenuated NS5A-induced dysregulation of the MAPK signaling ***:Our findings suggest that Berberis lyceum extract strongly inhibits HCV propagation by reducing HCV NS5A-induced perturbation of MAPK signaling.

关键词： Anti-HCV HCV NS5A Berberis lyceum MAPK pathway Phytochemicals HPLC

Baseline Isolated Printed Text Image Database for Pashto Script Recognition

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Intelligent Automation & Soft Computing 2023年第7期37卷 875-885页

作者： Arfa Siddiqu Abdul Basit Waheed Noor Muhammad Asfandyar Khan M.Saeed H.Kakar azam Khan Department of Computer Science&Information Technology University of BalochistanQuetta87300Pakistan

The optical character recognition for the right to left and cursive languages such as Arabic is challenging and received little attention from researchers in the past compared to the other Latin ***,the absence of a standard publicly available dataset for several low-resource lan-guages,including the Pashto language remained a hurdle in the advancement of language *** that,a clean dataset is the fundamental and core requirement of character recognition,this research begins with dataset generation and aims at a system capable of complete language *** in view the complete and full autonomous recognition of the cursive Pashto *** first achievement of this research is a clean and standard dataset for the isolated characters of the Pashto *** this paper,a database of isolated Pashto characters for forty four alphabets using various font styles has been *** order to overcome the font style shortage,the graphical software Inkscape has been used to generate sufficient image data samples for each *** dataset has been pre-processed and reduced in dimensions to 32×32 pixels,and further converted into the binary format with a black background and white text so that it resembles the Modified National Institute of Standards and Technology(MNIST)*** benchmark database is publicly available for further research on the standard GitHub and Kaggle database servers both in pixel and Comma Separated Values(CSV)formats.

关键词： Text-image database optical character recognition(OCR) pashto isolated characters visual recognition autonomous language understanding deep learning convolutional neural network(CNN)

Insight into the growth behaviors of MoS_(2)nanograins influenced by step edges and atomic structure of the substrate

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Nano Research 2022年第8期15卷 7646-7654页

作者： Shuangyue Wang Ni Yang Mengyao Li Ji Zhang Ashraful azam Yin Yao Xiaotao Zu Liang Qiao Peter Reece John Stride Jack Yang Sean Li School of Materials Science and Engineering UNSW SydneyNSW 2052Australia School of Physics University of Electronic Science and Technology of ChinaChengdu 610054China School of Physics UNSW SydneyNSW 2052Australia School of Chemistry UNSW SydneyNSW 2052Australia

The step edges and intrinsic atomic structure of single-crystal substrate play a critical role in determining the growth pathways of transition metal dichalcogenide(TMD)grains,particularly whether the TMDs will grow into wafer-scale single-crystal or anisotropic ***,we investigate the growth behaviours of the MoS_(2)nanograins on(0001)and()sapphire *** one hand,the step edges formed on the(0001)surface after thermal treatment are found to promote the macroscopic aggregation of MoS_(2)nanograins and to form unidirectional large triangular islands along with thesteps in the annealing process,while on the pristine(0001)surface,the MoS_(2)nanograins grow into a random network-like ***,oxygen treatment on the substrate can further enhance the growth of MoS_(2)*** electron microscopy and fast Fourier transform patterns reveal that the substrate could modulate the orientation of MoS_(2)nanograins during their growing *** the other hand,the MoS_(2)nanograins on the surface could self-assemble into one-dimensional nanoribbons due to the strong structural anisotropy of the *** addition,the ratio of Raman intensities for peaks that correspond to the and A1g phonon modes shows a linear relationship with the grain size due to the change of the“phonon confinement”.Moreover,new peaks located at 226 and 280 cm−1 can be observed in the off-resonant and resonant Raman spectra for the MoS_(2)nanograin samples,respectively,which can be attributed to the scatterings from the edges of as-fabricated MoS_(2)nanostructures.

关键词： MoS_(2)nanograins growth behaviors step edges atomic structure Raman spectra evolution UV-vis absorption

Efficacy of Static and Intermittent Gravity Inverted Therapy Techniques in Improvement of Motor Apraxia and Cognitive Abilities in Autism Spectrum Disorder (ASD)

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World Journal of Neuroscience 2018年第2期8卷 314-331页

作者： Ahmed M. azam Department of Physiotherapy for Developmental Disturbance and Pediatric Surgery Faculty of Physical Therapy Cairo University Giza Egypt

This work was carried out to investigate the efficacy of static and intermittent gravity inverted therapy techniques in improvement of motor apraxia and cognitive abilities in Autism Spectrum Disorder (ASD). 30 children were randomly joined in this study into two groups;Group A (sensory integration therapy approach plus static and intermittent inversion therapy techniques) and Group B (sensory integration therapy approach only). Block design test was used to locate and follow constructional apraxia, computerized information processing speed test to locate and follow cognitive processing and grooved pegboard test was used to locate and follow fine motor skills. The variance between pre- and post-treatment results was highly significant in the study group in all variables. By comparison of the two groups in constructional apraxia variables test at post-treatment, there was a highly representative elevation in favour to study groups (p < 0.05). By comparison of the two groups in cognitive processing variable at post-treatment, there was a highly representative elevation in favour to study group (p < 0.05). By comparison of the two groups in fine motor skills variable at post-treatment, there was a highly representative elevation in favor to study group (p < 0.05). According to the outcomes of this study, it can be terminated that the sensory integration therapy approach plus static and intermittent inversion therapy techniques can be recommended in improvement constructional apraxia and cognitive processing abilities in autism spectrum disorder (ASD) children.

关键词： Inversion Therapy Motor Apraxia Autism Spectrum Disorder (ASD) Children