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A simple method for inducing nonalcoholic steatohepatitis with fibrosis

Animal Models and Experimental Medicine 2019年第4期2卷 282-290页

作者： Leyla Yahaghi azadeh ebrahim-habibi Nasim Hayati-Roodbari Shiva Irani Parichehreh Yaghmaei Department of Biology Science and Research BranchIslamic Azad UniversityTehranIran Biosensor Research Center Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical SciencesTehranIran Endocrinology and Metabolism Research Center Tehran University of Medical SciencesTehranIran

Background: Nonalcoholic fatty liver disease(NAFLD) is increasingly occurring in sedentary people, and may progress to NASH and hepatocellular carcinoma. It is essential to design affordable animal models for the study of various diseases, including fatty liver, which was the aim of the study. In this study, a high-fat diet was devised that triggers NASH’s animal model quickly and easily. High-fat diet(HFD) was used both with intra-mouth oral gavage and in combination with animal ***: Twenty-four male C57 BL/6 J mice were divided into HFD and ND groups, which received a high-fat diet and a normal diet, respectively. At the end of the experiment(fourth week of treatment), body and liver weights, biochemical parameters, PPAR-α gene expression and histopathologic characteristics of the liver were ***: During 4 weeks, body weight of mice did not show a significant increase in the HFD group compared to the ND group, while weight gain of the liver was significant. Histological assessment of the HFD group’s liver confirmed NASH symptoms. In the HFD group, HDL-c, SOD, catalase, FRAP, adiponectin, and PPAR-α decreased significantly, and lipid profiles, hepatic enzymes, MDA, leptin, and TNF-α showed a significant increase compared to the ND ***: Our high-fat diet has successfully induced all aspects of NASH with fibrosis in 4 weeks, and with low cost.

关键词： animal model nonalcoholic fatty liver disease(NAFLD) nonalcoholic steatohepatitis(NASH) PPAR‐α

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Effectiveness of the Combination of Solution-Focused Therapy and Narrative Therapy in Marital Adjustment among Incompatible Iranian Women

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Open Journal of Psychiatry 2017年第2期7卷 79-89页

作者： azadeh Shirashiani ebrahim Namani MA in Counseling Department of Psychology Department of Psychological Sciences Faculty of Humanities Neyshabur Branch Islamic Azad University Neyshabur Iran Assistant Professor of Counseling Department of Educational Sciences Hakim Sabzevari University Sabzevar Iran

The present study aims to examine the effectiveness of the combination of solution-focused therapy and narrative therapy in marital adjustment of incompatible women. This research is a pretest-posttest quasi-experimental study design with a nonequivalent control group. The statistical population comprises all the incompatible women who referred to the counseling clinics of Neyshabour in May 2016 (1500 admission per month). The research sample consists of 24 incompatible women who were selected through Randomand available sampling method. For data collection, Marital Adjustment Scale by Spinner was applied. The data were analyzed using the analysis of covariance test and with the aid of SPSS-22 software. The findings demonstrated that the combination of solution-focused therapy and narrative therapy is significantly effective in marital adjustment of incompatible women (P < 0.05). Thus, it can be stated that the combination of solution-focused therapy and narrative therapy can help to promote adjustment among incompatible women.

关键词： Solution-Focused Therapy Narrative Therapy Marital Adjustment Incompatible Women

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