检索结果-南通市图书馆

World Journal of Experimental Medicine 2024年第4期14卷 170-173页

作者： ayrton I bangolo Nikita Wadhwani Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States

This comprehensive analysis by Saeed and Faeq investigates the impact of primary percutaneous coronary intervention(pPCI)on mortality among patients with ST-segment elevation myocardial infarction(STEMI)at the Erbil Cardiac *** data from 96 consecutive STEMI patients,the study identified significant predictors of in-hospital mortality,emphasizing the critical impact of time of hospital arrival post-symptom onset on overall *** indicate that factors such as atypical presentation,cardiogenic shock,chronic kidney disease,and specific coronary complications are associated with higher mortality *** study underscores the necessity of prompt medical intervention for improving survival outcomes in STEMI patients,especially in the high-risk *** research offers valuable insights into optimizing STEMI management and enhancing patient survival rates through effective and timely pPCI.

关键词： ST-segment elevation myocardial infarction Primary percutaneous coronary intervention Mortality predictors Timely hospital arrival Cardiogenic shock

Impact of gut microbiome in the development and treatment of pancreatic cancer:Newer insights

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第25期29卷 3984-3998页

作者： ayrton I bangolo Chinmay Trivedi Ishan Jani Silvanna Pender Hirra Khalid Budoor Alqinai Alina Intisar Karamvir Randhawa Joseph Moore Nicoleta De Deugd Shaji Faisal SuchithBoodgere Suresh Parva Gopani Vignesh K Nagesh Tracy Proverbs-Singh Simcha Weissman Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Gastrointestinal Malignancies John Theurer Cancer CenterHackensackNJ 07601United States

The gut microbiome plays an important role in the variation of pharmacologic *** aspect is especially important in the era of precision medicine,where understanding how and to what extent the gut microbiome interacts with drugs and their actions will be key to individualizing *** impact of the composition of the gut microbiome on the efficacy of newer cancer therapies such as immune checkpoint inhibitors and chimeric antigen receptor T-cell treatment has become an active area of *** adenocarcinoma(PAC)has a poor prognosis even in those with potentially resectable disease,and treatment options are very *** studies have concluded that there is a synergistic effect for immunotherapy in combination with cytotoxic drugs,in the treatment of PAC.A variety of commensal microbiota can affect the efficacy of conventional chemotherapy and immunotherapy by modulating the tumor microenvironment in the treatment of *** review will provide newer insights on the impact that alterations made in the gut microbial system have in the development and treatment of PAC.

关键词： Pancreatic cancer Gut microbiome Chemotherapy Dysbiosis Intratumoral microbiome Gut flora

Management of gastrointestinal bleed in the intensive care setting,an updated literature review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Critical Care Medicine 2025年第1期14卷 20-41页

作者： Vignesh K Nagesh Sai Priyanka Pulipaka Ruchi Bhuju Emelyn Martinez Shruthi Badam Gomathy Aarthy Nageswaran Hadrian Hoang-Vu Tran Daniel Elias Charlene Mansour Jaber Musalli Sanket Bhattarai Lokeash Subramani Shobana Tannishtha Sethi Ritvik Sethi Namrata Nikum Chinmay Trivedi Amer Jarri Colin Westman Nazir Ahmed Shawn Philip Simcha Weissman Jonathan Weinberger ayrton I bangolo Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Internal Medicine University of Arkansas for Medical SciencesLittle RockAR 72205United States Department of Internal Medicine Hackensack Palisades Medical CenterNorth BergenNJ 07047United States Department of Gastroenterology Hackensack University Medical CenterHackensackNJ 07061United States Department of Pulmonology and Critical Care HCA Florida Bayonet Point HospitalHudsonFL 34667United States Department of Hematology&Oncology John Theurer Cancer Center at Hackensack University Medical CenterHackensackNJ 07601United States

Gastrointestinal(GI)bleeding is a critical and potentially life-threatening condition frequently observed in the intensive care unit(ICU).This literature review consolidates current insights on the epidemiology,etiology,management,and outcomes of GI bleeding in critically ill *** bleeding remains a significant concern,especially among patients with underlying risk factors such as coagulopathy,mechanical ventilation,and renal *** GI bleeding in the ICU requires a multidisciplinary approach,including resuscitation,endoscopic intervention,pharmacologic therapy,and sometimes surgical *** with enhanced management strategies,GI bleeding in the ICU is associated with considerable morbidity and mortality,particularly when complicated by multi-organ *** review reiterates the need for adequate resuscitation and interventions in managing GI bleeding in critically ill patients,aiming to enhance survival rates and improve the quality of care within the ICU setting.

关键词： Gastrointestinal bleed Varices Variceal bleeding Diverticular bleed Angiodysplasia Ulcer Hemorrhoids Endoscopy Enteroscopy Embolization

Epidemiologic risk factors for patients admitted with chronic pancreatitis and pancreatic ductal adenocarcinoma in the United States

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2022年第11期13卷 907-917页

作者： Daniel Lew Fatima Kamal Khiem Phan Karamvir Randhawa Sam Cornwell ayrton I bangolo Simcha Weissman Stephen J Pandol Department of Gastroenterology Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Internal Medicine Hackensack Meridian Health/Palisades Medical CenterNorth BergenNJ 07047United States

BACKGROUND Epidemiological studies of chronic pancreatitis(CP)and its association with pancreatic ductal adenocarcinoma(PDAC)are *** demographic and ethno-racial factors may help identify patients at the highest risk for CP and *** To evaluate the ethno-racial risk factors for CP and its association with *** secondary aim was to evaluate hospitalization outcomes in patients admitted with CP and *** This retrospective cohort study used the 2016 and 2017 National Inpatient Sample *** included in the study had ICD-10 codes for CP and *** ethnic,socioeconomic,and racial backgrounds of patients with CP and PDAC were *** Hospital admissions for CP was 29 per 100000,and 2890(0.78%)had ***[adjusted odds ratio(aOR)1.13],men(aOR 1.35),age 40 to 59(aOR 2.60),and being overweight(aOR 1.34)were significantly associated with CP(all with P<0.01).In patients with CP,Whites(aOR 1.23),higher income,older age(aOR 1.05),and being overweight(aOR 2.40)were all significantly associated with PDAC(all with P<0.01).Men(aOR 1.81)and Asians(aOR 15.19)had significantly increased mortality(P<0.05).Hispanics had significantly increased hospital length of stay(aOR 5.24)(P<0.05).CONCLUSION Based on this large,nationwide analysis,black men between 40-59 years old and overweight are at significantly increased risk for admission with *** men older than 40 years old and overweight with higher income were found to have significant associations with CP and *** discrepancy may reflect underlying differences in healthcare access and utilization among different socioeconomic and ethno-racial groups.

关键词： Chronic pancreatitis Pancreatic cancer Ethno-racial Risk factors Hospitalization outcomes Adult

Innovation in pathogenesis and management of aortic aneurysm

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Experimental Medicine 2024年第2期14卷 35-45页

作者： Maryam Barkhordarian Hadrian Hoang-Vu Tran Aiswarya Menon Sai Priyanka Pulipaka Izage Kianifar Aguilar Axel Fuertes Shraboni Dey Angel Ann Chacko Tanni Sethi ayrton bangolo Simcha Weissman Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States

Aortic aneurysm(AA)refers to the persistent dilatation of the aorta,exceeding three *** the pathophysiology of this condition is important for its prevention and management,given its responsibility for more than 25000 deaths in the United *** are classified based on their location or *** pathophysiologic pathways including inflammation,the immune system and atherosclerosis have been implicated in its *** markers such as transforming growth factorβ,interleukin-1β,tumor necrosis factor-α,matrix metalloproteinase-2 and many more may contribute to this *** genetic disorders such as Marfan syndrome,Ehler-Danlos syndrome and Loeys-Dietz syndrome have also been associated with this *** years has seen the investigation of novel management of AA,exploring the implication of different immune suppressors,the role of radiation in shrinkage and prevention,as well as minimally invasive and newly hypothesized surgical *** this narrative review,we aim to present the new contributing factors involved in pathophysiology of *** also highlighted the novel management methods that have demonstrated promising benefits in clinical outcomes of the AA.

关键词： Aortic aneurysm Abdominal aneurysm Thoracic aneurysm Immunotherapy Surgical management Pathophysiology Inflammation and molecular pathways

Proportion of thyroid cancer and other cancers in the democratic republic of Congo

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Experimental Medicine 2023年第3期13卷 17-27页

作者： John Bukasa-Kakamba ayrton I bangolo Pascal Bayauli Branly Mbunga Francis Iyese Aliocha Nkodila Ali Atoot Gaurav Anand Stacy H Lee Maimona Chaudhary Pamela Q Fernandes Hari PSS Mannam Adithya Polavarapu Merajunissa Merajunnissa Abdullah Azhar Mohan N Alichetty Gauravdeep Singh Georgemar V Arana Jr Imranjot Sekhon Manbir Singh JoséD Rodriguez-Castro Adam Atoot Simcha Weissman Jean Rene M’buyamba Endocrine and Metabolic Disorders Department University of KinshasaKinshasa KinshasaCongo Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States School of Public Health University of KinshasaKinshasa KinshasaCongo Family Medicine Protestant University of CongoKinshasa KinshasaCongo Department of Medicine Hackensack University-Palisades Medical CenterNorth BergenNJ 07047United States

BACKGROUND Cancer diagnosis is increasing around the world and in the Democratic Republic of the Congo(DRC).The proportion of thyroid cancer has increased over the past three *** are very few studies on cancer epidemiology,and in particular on thyroid cancer in the *** To establish the most recent proportion of thyroid cancer in the DRC compared to other *** This is a retrospective and descriptive study of 6106 consecutive cancer cases listed in the pathological registers of 4 Laboratories in the city of *** study included all cancer cases recorded in the registers between 2005 and *** From a sample of 6106 patients,including all cancer types,68.3%cases were female and 31.7%were *** and cervical cancer were the most common types of cancer in women and,prostate and skin cancer were the most common types in *** cancer was sixth in proportion in women and eleventh in men compared to all *** carcinoma was the most common of thyroid *** cancers such as anaplastic and medullary thyroid carcinomas had a proportion of 7%and 2%,*** Newer diagnostic tools led to a surge in cancer diagnoses in the *** cancer has more than doubled its proportion over the last several decades in the country.

关键词： Thyroid cancer Papillary carcinoma Cancer Democratic Republic of the Congo Africa Proportion

Global geoepidemiology of gastrointestinal surgery rates in Crohn’s disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第6期16卷 1835-1844页

作者： Simcha Weissman Muhammad Aziz ayrton bangolo Vignesh K Nagesh Htat Aung Midhun Mathew Lino Garcia Shiva A Chandar Praveena Karamthoti Harinder Bawa Aseel Alshimari Yabets Kejela Nazish Mehdi Chrishanti A Joseph Athri Kodali Rohan Kumar Priya Goyal Sanya Satheesha Fnu Nivedita Nicole Tesoro Tanni Sethi Gurpreet Singh Areej Belal Alina Intisar Hirra Khalid Samuel Cornwell Suchith B Suresh Kareem Ahmed Karabo K Marole Om P Anand Rahat B Reshi Tej I Mehta Sameh Elias Joseph D Feuerstein Department of Medicine Hackensack Meridian Health Palisades Medical CenterNorth BergenNJ 07047United States Division of Gastroenterology and Hepatology University of Toledo Medical CenterToledoOH 43614United States Department of Medicine University of WashingtonSeattleWA 98195United States Department of Radiology Johns Hopkins University HospitalBaltimoreMD 21218United States Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215United States

BACKGROUND Data regarding the worldwide gastrointestinal surgery rates in patients with Crohn’s disease(CD)remains *** To systematically review the global variation in the rates of surgery in *** A comprehensive search analysis was performed using multiple electronic databases from inception through July 1,2020,to identify all full text,randomized controlled trials and cohort studies pertaining to gastrointestinal surgery rates in adult patients with *** included continent based demographic data,CD surgery rates over time,as well as the geoepidemiologic variation in CD surgery *** analyses were conducted using *** Twenty-three studies spanning four continents were *** median proportion of persons with CD who underwent gastrointestinal surgery in studies from North America,Europe,Asia,and Oceania were 30%(range:1.7%-62.0%),40%(range:0.6%-74.0%),17%(range:16.0%-43.0%),and 38%*** clear association was found regarding the proportion of patients undergoing gastrointestinal surgery over time in North America(R^(2)=0.035)and Europe(R^(2)=0.100).A moderate,negative association was seen regarding the proportion of patients undergoing gastrointestinal surgery over time(R^(2)=0.520)in *** There appears to be significant inter-continental variation regarding surgery rates in *** evidencebased guidelines accounting for the geographic differences in managing patients with CD is ***,as a paucity of data on surgery rates in CD exists outside the North American and European continents,future studies,particularly in less studied locales,are warranted.

关键词： Gastrointestinal surgery Crohn’s disease Geoepidemiology Inflammatory bowel disease Prevalence

Impact of artificial intelligence in the management of esophageal,gastric and colorectal malignancies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Artificial Intelligence in Gastrointestinal Endoscopy 2024年第2期5卷 1-14页

作者： ayrton bangolo Nikita Wadhwani Vignesh K Nagesh Shraboni Dey Hadrian Hoang-Vu Tran Izage Kianifar Aguilar Auda Auda Aman Sidiqui Aiswarya Menon Deborah Daoud James Liu Sai Priyanka Pulipaka Blessy George Flor Furman Nareeman Khan Adewale Plumptre Imranjot Sekhon Abraham Lo Simcha Weissman Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Medicine Palisades Medical CenterNorth BergenNJ 07047United States

The incidence of gastrointestinal malignancies has increased over the past decade at an alarming *** and gastric cancers are the third and fifth most commonly diagnosed cancers worldwide but are cited as the second and third leading causes of *** institution of appropriate therapy from timely diagnosis can optimize patient *** intelligence(AI)-assisted diagnostic,prognostic,and therapeutic tools can assist in expeditious diagnosis,treatment planning/response prediction,and post-surgical *** can intercept neoplastic lesions in their primordial stages,accurately flag suspicious and/or inconspicuous lesions with greater accuracy on radiologic,histopathological,and/or endoscopic analyses,and eliminate over-dependence on ***-based models have shown to be on par,and sometimes even outperformed experienced gastroenterologists and *** neural networks(state-of-the-art deep learning models)are powerful computational models,invaluable to the field of precision *** models not only reliably classify images,but also accurately predict response to chemotherapy,tumor recurrence,metastasis,and survival rates *** this systematic review,we analyze the available evidence about the diagnostic,prognostic,and therapeutic utility of artificial intelligence in gastrointestinal oncology.

关键词： Artificial intelligence Gastrointestinal malignancies Machine learning Helicobacter pylori State-of-the-art deep learning models

Therapeutics involved in managing initial and recurrent Clostridium difficile infection:An updated literature review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第5期15卷 1-14页

作者： Vignesh K Nagesh Hadrian Hoang-Vu Tran Daniel Elias Izage Kianifar Aguilar Tanni Sethi AiswaryaMenon Charlene Mansour Florchi Furman Kylie Tsotsos Talia Subar Auda Auda Aman Sidiqui JevonLamar Nikita Wadhwani Shraboni Dey Abraham Lo Adam Atoot Simcha Weissman Humberto Sifuentes ayrton I bangolo Department of Internal Medicine Hackensack Palisades Medical CenterNorth BergenNJ 07047United States Department of Gastroenterology Augusta UniversityAugustaGA 30912United States

Clostridium difficile infection(CDI)has been increasing due to the effect of recurrent *** use of antibiotics has been shown to alter the gut microbiome and lead to *** treatment is limited to three major antibiotics;however,the incidence of recurrent CDIs has been increasing and drug resistance is a major *** aspect is a growing concern in modern medicine especially in the elderly population,critical care patients,and immunocompromised individuals who are at high risk of developing *** difficile can lead to various complications including septic shock and fulminant colitis that could prove to be lethal in these *** modalities of treatment have been developed including bezlotoxumab,a monoclonal antibody and fecal microbiota *** have been studies showing asymptomatic carriers and drug resistance posing a major threat to the healthcare *** treatment options are being studied to treat and prevent *** review will provide an insight into the current treatment modalities,prevention and newer modalities of treatment and challenges faced in the treatment of CDIs.

关键词： Clostridium difficile Antibiotics Vancomycin Fidaxomicin Prevention Bezlotoxumab Fecal microbiota transplant

Relationships of hospitalization outcomes and timing to endoscopy in non-variceal upper gastrointestinal bleeding:A nationwide analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2023年第4期15卷 285-296页

作者： Simcha Weissman Muhammad Aziz ayrton I bangolo Dean Ehrlich Arnold Forlemu Anthony Willie Manesh K Gangwani Danish Waqar Hannah Terefe Amritpal Singh Diego MC Gonzalez Jayadev Sajja Fatma L Emiroglu Nicholas Dinko Ahmed Mohamed Mark A Fallorina David Kosoy Ankita Shenoy Anvit Nanavati Joseph D Feuerstein James H Tabibian Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States Department of Gastroenterology University of Toledo Medical CenterToledoOH 43614United States Division of Digestive Diseases David Geffen School of Medicine at University of California at Los AngelesLos AngelesCA 90095United States Department of Internal Medicine Creighton University School of MedicinePhoenixAZ 85012United States Division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215United States Division of Gastroenterology Department of MedicineOlive View-University of California at Los Angeles Medical CenterSylmarCA 91342United States

BACKGROUND The optimal timing of esophagogastroduodenoscopy(EGD)and the impact of clinico-demographic factors on hospitalization outcomes in non-variceal upper gastrointestinal bleeding(NVUGIB)remains an area of active *** To identify independent predictors of outcomes in patients with NVUGIB,with a particular focus on EGD timing,anticoagulation(AC)status,and demographic *** A retrospective analysis of adult patients with NVUGIB from 2009 to 2014 was performed using validated ICD-9 codes from the National Inpatient Sample *** were stratified by EGD timing relative to hospital admission(≤24 h,24-48 h,48-72 h,and>72 h)and then by AC status(yes/no).The primary outcome was all-cause inpatient *** outcomes included healthcare *** Of the 1082516 patients admitted for NVUGIB,553186(51.1%)underwent *** mean time to EGD was 52.8 ***(<24 h from admission)EGD was associated with significantly decreased mortality,less frequent intensive care unit admission,shorter length of hospital stays,lower hospital costs,and an increased likelihood of discharge to home(all with P<0.001).AC status was not associated with mortality among patients who underwent early EGD(aOR 0.88,P=0.193).Male sex(OR 1.30)and Hispanic(OR 1.10)or Asian(aOR 1.38)race were also independent predictors of adverse hospitalization outcomes in *** Based on this large,nationwide study,early EGD in NVUGIB is associated with lower mortality and decreased healthcare usage,irrespective of AC *** findings may help guide clinical management and would benefit from prospective validation.

关键词： Upper gastrointestinal bleeding Esophagogastroduodenoscopy Outcomes Mortality Anticoagulation