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Embracing different languages and local differences:Coconstructive patient simulation strengthens host countries’clinical training in psychiatry

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World Journal of Psychiatry 2024年第1期14卷 111-118页

作者： Şafak ErayÇamlı Büşra Ece Yavuz Meliha Feyza Gök Idil Yazgan Yanki Yazgan ayelet Brand-Gothelf Doron Gothelf Doron Amsalem Andrés Martin Department of Child and Adolescent Psychiatry Bursa UludağUniversity Faculty of MedicineBursa 16059 Turkey Yale University School of Medicine New HavenCT 06510United States Güzel Günler Clinic Beşiktaş/İstanbul 34335 Turkey Child Study Center Yale School of MedicineNew HavenCT 06520United States The Feinberg Child Study Center Schneider Children's Medical Center of IsraelTel Aviv UniversityPetach Tikvah 4920235Israel The Child Psychiatry Division Edmond and Lily Safra Children’s HospitalSheba Medical CenterTel HashomerRamat Gan 52561Israel Faculty of Medicine and Sagol School of Neuroscience Tel Aviv UniversityTel Aviv 6997801Israel Department of Psychiatry Columbia University Vagelos College of Physicians and SurgeonsNew YorkNY 10032United States

BACKGROUND Global education in psychiatry is heavily influenced by knowledge from Western,high-income countries,which obscures local voices and *** To adapt a human simulation model to psychiatric education in a context that is specific to local languages and *** We conducted an observational study consisting of six human simulation sessions with standardized patients from two host countries,speaking their native languages,and following an adaptation of the co-constructive patient simulation(CCPS)*** local faculty became increasingly familiar with the CCPS approach,they took on the role of facilitators—in their country’s native *** Fifty-three learners participated:19 child and adolescent psychiatry trainees and 3 faculty members in Türkiye(as a group that met online during 3 consecutive months);and 24 trainees and 7 faculty in Israel(divided into 3 groups,in parallel in-person sessions during a single training day).Each of the six cases reflected local realities and clinical challenges,and was associated with specific learning goals identified by each case-writing *** Human simulation has not been fully incorporated into psychiatric education:The creation of immersive clinical experiences and the strengthening of reflective practice are two areas ripe for *** adaptations of CCPS can also strengthen local and regional networks and psychiatric communities of ***,the model can help question and press against hegemonies in psychiatric training that overshadow local expertise.

关键词： Human simulation Standardized patients Medical education Psychiatric education Capacity building Local languages

Feature engineering methodology for congestion forecasting

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Journal of Traffic and Transportation Engineering(English Edition) 2022年第6期9卷 1055-1068页

作者： ayelet Gal-Tzur Shlomo Bekhor Yana Barsky Department of Industrial Engineering and Management Ruppin Academic CenterEmek Hefer 40250Israel Faculty of Civil and Environmental Engineering Israel Institute of TechnologyHaifa 32000Israel Transportation Research Institute Israel Institute of TechnologyHaifa 32000Israel

Short-term traffic forecasting is a key element in proactive traffic management,e.g.,mitigating the negative effect of impending congestion through appropriate capacity allocation at signalized *** this study,we develop a data-driven methodology for reliably and robustly predicting impending stable *** incorporating feature engineering techniques into an iterative machine learning process,we develop a prediction model that can be intuitively understood by traffic experts and is amenable to diagnostics during *** iterative machine learning process combines the embedded and filter approaches for feature selection with the use of expert knowledge to create aggregative input *** embedded approach is represented by application of a decision tree algorithm,while the filter approach is reflected in use of the mean decrease in accuracy output of a random forest algorithm for identifying expressive *** tested the methodology by applying it to field data from a sub-network in Tel *** demonstrated a reduction in the number of decision tree input variables from 66 raw variables to the five most effective aggregative ones,while achieving statistically significant improvement in all performance *** identification rate of stable congestion increased from 65%to 74%while the robustness of the results was enhanced:the standard deviations of the identification and false alarm rates fell from 8%to 3%,respectively,to 5%and 2%.

关键词： Intelligent transportation systems Advanced traffic management systems Congestion forecasting Data mining Feature engineering

A Novel Facial Cream Based on Skin Penetrable Hemp Oil Microparticles

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Journal of Cosmetics, Dermatological Sciences and Applications 2023年第3期13卷 165-178页

作者： Rachel Lubart Inbar Yariv Dror Fixler ayelet Rothstein Arie Gruzman Anat Lipovsky Department of Chemistry Bar Ilan University Ramat-Gan Israel Physics Department of Faculty of Exact Sciences Bar Ilan University Ramat-Gan Israel Faculty of Engineering Bar Ilan University Ramat-Gan Israel Institute of Nanotechnology and Advanced Materials Bar-Ilan University Ramat-Gan Israel Hava Zingboim Ltd. Ramat-Gan Israel

Objective: Hemp seed oil is perfect for most skin types;it moisturizes skin and protects it from inflammation, oxidation, and other causes of aging. The problem is that the Hemp oil-based products do not penetrate the skin;they remain on the skin’s surface. Recently researchers have been trying to prepare nano emulsions of hemp oil to facilitate its permeation to deep skin layers. In all techniques used today, surfactants are added to the emulsification process. These surfactants may cause unwanted skin side effects. In the present study, we prepare micronized Hemp (m-Hemp) without using any surfactants in the micronization process, thus avoiding the side effects associated with surfactant addition. Methods & Results: Particles size of m-Hemp was evaluated using electron microscopy. Various sizes of m-Hemp were found, the smallest being 100 nm in diameter. The antioxidation properties of m-Hemp were measured using the Electron Spin Resonance (ESR) technique and were found to be enhanced. Skin topography and morphology following a cream containing m-Hemp treatment were visualized by Optical Profilometry and ESEM respectively. The results show a marked improvement in skin topography in all measured parameters. In addition, human keratinocytes (HaCaT) were exposed to inflammatory conditions and were then treated using Hemp. As a result, one of the key inflammatory factors (IL-2) was significantly reduced after treatment with m-Hemp (p ≤ 0.0001). The skin penetration of the cream containing m-Hemp was tested on human skin using the IMOPE (Iterative Multi-plane Optical Property Extraction) system. The results indicate that m-Hemp penetrates both the stratum corneum and the deep epidermal layers towards the dermis. Conclusion: The new cream prepared with micronized Hemp shows significant anti-inflammatory and antioxidative effects and demonstrates the entrance of m-Hemp to the skin epidermal layer.

关键词： Hemp Microparticles Anti-Inflammatory Antioxidant Skin Penetration

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The art of leaving

The art of leaving

Effect of a specialized injury prevention program on static balance, dynamic balance and kicking accuracy of young soccer players

作者： ayelet Tsabari.

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World Journal of Orthopedics 2017年第4期8卷 317-321页

作者： ayelet Dunsky Ido Barzilay Orly Fox Department of Bio-mechanics the Zinman College of Physical Education and Sport SciencesWingate Institute

AIM To study the effect of balance intervention program using the "FIFA 11+" program on static and dynamic balance and kicking accuracy of young soccer *** Twenty young soccer players were allocated to experimental(n = 10) or control(n = 10) groups. The experimental group performed the "FIFA 11+" program three times a week for six weeks. The control group performed their normal warm-up routine. The primary outcomes were measured pre and post intervention, and assessed kicking accuracy, static balance and dynamic *** No differences were found in kicking accuracy following intervention, for both groups, however, static balance improved significantly among the experimental group with significant interaction with the control group, and with high effect size. In addition, the dynamic balance of the left leg of the experimental group, with medium effect size for interaction between *** The large effect size of balance improvement that was observed following six weeks of intervention sessions, implies that soccer trainers and coaches should consider the inclusion of "FIFA 11+" as components of programs aimed at improving balance ability/control in young soccer players, as improvement in balance abilities may prevent injuries.

关键词： Soccer Injury prevention Balance Warmup Kicking accuracy

Germline BRCA2 variants in advanced pancreatic acinar cell carcinoma:A case report and review of literature

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World Journal of Gastroenterology 2022年第45期28卷 6421-6432页

作者： Cha Len Lee Spring Holter ayelet Borgida Anna Dodd Stephanie Ramotar Robert Grant Kristy Wasson Elena Elimova Raymond W Jang Malcolm Moore Tae Kyoung Kim Korosh Khalili Carol-Anne Moulton Steven Gallinger Grainne M O’Kane Jennifer J Knox Division of Medical Oncology and Hematology Wallace McCain Center for Pancreatic CancerPrincess Margaret Cancer CentreToronto M5G1Z5ONCanada Department of Medical Imaging Wallace McCain Center for Pancreatic CancerPrincess Margaret Cancer CentreToronto M5G1Z5ONCanada Hepatobiliary/Pancreatic Surgical Program Wallace McCain Center for Pancreatic CancerPrincess Margaret Cancer CentreToronto M5G1Z5ONCanada

BACKGROUND Pancreatic acinar cell carcinoma(PACC)is a rare *** to 45%of PACCs have alterations in the DNA damage repair pathway and 23%harbor rearrangements in the BRAF or RAF1 *** present a PACC case with a germline BRCA2 likely pathogenic variant(LPV)to highlight the impact of genomic testing on treatment decisions and patient *** our larger case series,we provide clinic-based information on additional 10 PACC patients treated in our *** SUMMARY A 70-year-old male was diagnosed with advanced *** presentation,he was cachectic with severe arthralgia despite prednisolone and a skin rash that was later confirmed to be *** was treated with modified FOLFIRINOX(mFFX)with the knowledge of the germline BRCA2 *** 11 cycles of mFFX,a computed tomography(CT)scan demonstrated significant tumor response in the pancreatic primary and hepatic metastases,totaling 70%from baseline as per Response Evaluation Criteria in Solid *** of the skin panniculitis was also *** identified two additional PACCs with druggable targets in our case *** data contribute to practical evidence for the value of germline and somatic profiling in the management of rare diseases like *** This patient and others in our larger case series highlight the importance of genomic testing in PACC with potential utility in personalized treatment.

关键词： Pancreatic acinar carcinoma BRCA Polyadenosine diphosphate-ribose polymerase inhibitor Case report

MicroRNAs as a potential prognostic factor in gastric cancer

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World Journal of Gastroenterology 2011年第35期17卷 3976-3985页

作者： Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld ayelet Chajut Yaron Niv Michal Kushnir Institute of Oncology Davidoff CenterRabin Medical CenterBeilinson HospitalPetach Tikva 49100Israel Sackler Faculty of Medicine Tel Aviv UniversityTel Aviv 69978Israel Rosetta Genomics Ltd. Rehovot 76706Israel Clalit Research Institute Clalit Medical ServicesTel Aviv 69978Israel Institute of Oncology Rabin Medical CenterGolda-Hasharon HospitalPetach Tikva 49100Israel Institute of Oncology Rabin Medical CenterBeilinson HospitalPetach Tikva 49100Israel Institute of Pathology Rabin Medical CenterBeilinson HospitalPetach Tikva 49100Israel Institute of Pathology Rabin Medical CenterGolda-Hasharon HospitalPetach Tikva 49100Israel Cancer Research UK Cambridge Research InstituteCambridge CB2 OREUnited Kingdom Department of Gastroenterology Rabin Medical CenterBeilinson HospitalPetach Tikva 49100Israel Sackler Faculty of Medicine Tel Aviv UniversityTel Aviv 69978 Israel

AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric ***:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was *** RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA *** profiling using miR microarrays was performed to identify potential biomarkers of recurrence after *** expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and *** miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis ***:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric *** these,miR-451 had the strongest prognostic impact.

关键词：小分子RNA 预后胃癌 microRNA 肿瘤患者聚合酶链反应辅助治疗手术切除

Evaluation of a Pediatric Mock Code Educational Training Program at a Large, Tertiary Care Pediatric Hospital

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Open Journal of Pediatrics 2015年第4期5卷 314-319页

作者： ayelet Rimon Amit Hess Dennis Scolnik Oren Tavor Shirley Friedman Miguel Glatstein Pediatric Emergency Medicine Dana-Dwek Children’s Hospital Tel-Aviv Israel Sackler School of Medicine Tel Aviv University Tel-Aviv Israel Divisions of Pediatric Emergency Medicine and Clinical Pharmacology and Toxicology Department of Pediatrics The Hospital for Sick Children University of Toronto Toronto Canada Pediatric Intensive Care Dana-Dwek Children’s Hospital Tel-Aviv Israel

Background: Management of the acutely ill children represents one of the more complex clinical skills required of pediatric physicians. Our goal was to develop and evaluate a multidisciplinary pediatric mock code training program for the pediatric residents in our institution. Methods: We performed a before and after evaluation of pediatric residents. The residents were educated by attending five mock code scenarios, followed by debriefing. Before and after the five sessions, the residents completed a self-assessment questionnaire. Results: Residents reported a significant improvement in their comfort in all aspects of managing pediatric resuscitations, with notable improvement seen in running a resuscitation requiring airway management, managing fluid resuscitation and performing endotracheal intubation. The most prominent change was demonstrated in the comfort level of the overall management of a pediatric resuscitation. Conclusion: The pediatric mock code educational training program improved residents’ self-reported knowledge and comfort level in managing pediatric emergency situations.

关键词： Education Mock Code Pediatric Residents Emergency Medicine

Recent advances in bone regeneration using adult stem cells

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World Journal of Stem Cells 2015年第3期7卷 630-640页

作者： Hadar Zigdon-Giladi Utai Rudich Gal Michaeli Geller ayelet Evron Department of Periodontology School of Graduate Dentistry Rambam Health Care Campus Research Institute for Bone Repair Rambam Health Care Campus the Rappaport Family Faculty of Medicine Technion-Israel Institute of Technology Orthopedic Department Rambam Health Care Campus Evolutionary Developmental Biology Faculty of Natural Sciences Haifa University

Bone is a highly vascularized tissue reliant on the close spatial and temporal association between bloodvessels and bone cells. Therefore, cells that participate in vasculogenesis and osteogenesis play a pivotal role in bone formation during prenatal and postnatal periods. Nevertheless, spontaneous healing of bone fracture is occasionally impaired due to insufficient blood and cellular supply to the site of injury. In these cases, bone regeneration process is interrupted, which might result in delayed union or even nonunion of the fracture. Nonunion fracture is difficult to treat and have a high financial impact. In the last decade, numerous technological advancements in bone tissue engineering and cell-therapy opened new horizon in the field of bone regeneration. This review starts with presentation of the biological processes involved in bone development, bone remodeling, fracture healing process and the microenvironment at bone healing sites. Then, we discuss the rationale for using adult stem cells and listed the characteristics of the available cells for bone regeneration. The mechanism of action and epigenetic regulations for osteogenic differentiation are also described. Finally, we review the literature for translational and clinical trials that investigated the use of adult stem cells(mesenchymal stem cells, endothelial progenitor cells and CD34+ blood progenitors) for bone regeneration.

关键词： Bone tissue Mesenchymal stem cells Tissueengineering Osteogenesis Angiogenesis Endothelialprogenitor cells