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Induction heating for desorption of surface contamination for high-repetition laser-driven carbon-ion acceleration

Matter and Radiation at Extremes 2023年第5期8卷 19-25页

作者： Sadaoki Kojima Tatsuhiko Miyatake Hironao Sakaki Hiroyoshi Kuroki Yusuke Shimizu Hisanori Harada Norihiro Inoue Thanh Hung Dinh Masayasu Hata Noboru Hasegawa Michiaki Mori Masahiko Ishino Mamiko Nishiuchi Kotaro kondo Masaharu Nishikino Masaki Kando Toshiyuki Shirai Kiminori kondo Kansai Institute for Photon Science National Institutes for Quantum Science and Technology(QST)8-1-7 UmemidaiKizugawaKyoto 619-0215Japan Interdisciplinary Graduate School of Engineering Sciences Kyushu University6-1Kasuga-KoenKasugaFukuoka 816-8580Japan Hitachi Zosen Corporation 7-89 Nanko-Kita 1-chomeSuminoe-kuOsaka 559-8559Japan Department of Accelerator and Medical Physics Institute for Radiological ScienceNational Institutes for Quantum Science and Technology(QST)4-9-1 AnagawaInage-kuChiba 263-8555Japan

This study reports the first experimental demonstration of surface contamination cleaning from a high-repetition supply of thin-tape targets for laser-driven carbon-ion *** adsorption of contaminants containing protons,mainly water vapor and hydrocarbons,on the surface of materials exposed to low vacuum(>10^(−3)Pa)suppresses carbon-ion *** newly developed contamination cleaner heats a 5-μm-thick nickel tape to over 400℃in 100 ms by induction *** the future,this heating method could be scaled to laserdriven carbon-ion acceleration at rates beyond 10 *** contaminant hydrogen is eliminated from the heated nickel surface,and a carbon source layer—derived from the contaminant carbon—is spontaneously formed by the catalytic effect of *** species of ions accelerated from the nickel film heated to various temperatures have been observed *** the nickel film is heated beyond∼150℃,the proton signal considerably decreases,with a remarkable increase in the number and energy of carbon *** Langmuir adsorption model adequately explains the temperature dependence of desorption and re-adsorption of the adsorbed molecules on a heated target surface,and the temperature required for proton-free carbon-ion acceleration can be estimated.

关键词： acceleration heated nickel

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颗粒弥散增强型核辐射屏蔽材料强度模型研究

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应用数学和力学 2015年第12期36卷 1306-1314页

作者：何铮王绪伟 D.孔多国核华清(北京)核电技术研发中心有限公司北京102209 巴黎第六大学法国巴黎75005

基于微观力学的均匀化理论,旨在从核辐射屏蔽材料的微观结构、物理特性的角度出发,通过多尺度方法研究了材料宏观的机械力学性质.主要研究对象为颗粒弥散增强的孔隙基体材料,推导出了此类复合材料(金属基材料、非金属类材料)的强度准则... 详细信息

基于微观力学的均匀化理论,旨在从核辐射屏蔽材料的微观结构、物理特性的角度出发,通过多尺度方法研究了材料宏观的机械力学性质.主要研究对象为颗粒弥散增强的孔隙基体材料,推导出了此类复合材料(金属基材料、非金属类材料)的强度准则模型,可预测微观孔隙率与颗粒相体积分数对材料宏观强度的影响.在塑性极限分析法的理论框架下,在介观上成功引入了速度场跳动来描述两相界面间的力学特性,利用刚性核的球体胞元模型进行求解.最后,选用了界面速度为0的速度场对模型进行研究,并初步探讨了界面效应对材料性能的影响.

关键词：屏蔽材料颗粒增强孔隙多尺度强度塑性极限

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18F-fluciclovine的Ⅱa期临床试验:用于脑肿瘤PET显像的效能和安全性

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中华核医学与分子影像杂志 2017年第6期37卷 382-383页

作者：唐军 Akihide kondo Hisato Ishii Shigeki Aoki Masaru Suzuki Hidekazu Nagasawa Kazuo Kubota Ryogo Minamimoto Atsushi Arakawa Masato Tominaga Hajime Arai 苏州大学附属第二医院核医学科 Department of Neurosurgery Juntendo University School of Medicine

目的;F-fluciclovine(anti-;F-FACBC)氨基酸代谢显像诊断脑肿瘤的效能较好,而;FFDG诊断脑肿瘤存在局限性。该研究通过Ⅱa期临床研究来评价anti-;F-FACBC在脑胶质瘤患者肿瘤中的分布和安全性。方法 5例脑胶质瘤拟行手术切除的患者术前静... 详细信息

目的;F-fluciclovine(anti-;F-FACBC)氨基酸代谢显像诊断脑肿瘤的效能较好,而;FFDG诊断脑肿瘤存在局限性。该研究通过Ⅱa期临床研究来评价anti-;F-FACBC在脑胶质瘤患者肿瘤中的分布和安全性。方法 5例脑胶质瘤拟行手术切除的患者术前静脉注射anti-;F-FACBC后行PET显像,同时行钆增强T;加权（CE-T;W）MRI。根据CE-T;MRI和anti-;F-FACBC PET显像结果,取术中标本行组织病理学分析。比较MRI和PET/CT图像上的肿瘤范围。Anti-;F-FACBC显像时绘制肿瘤和正常脑组织的时间-放射性曲线,在肿瘤、对侧正常脑组织和小脑部位勾画ROI,并计算上述部位SUV。根据患者主观症状、客观体征、心电图、生命体征、实验室检查结果和不良反应发生情况评价anti-;F-FACBC的安全性。结果所有患者的胶质瘤病灶均摄取anti-;F-FACBC,CE-T;W MRI也可显示病灶,但前者显像的病灶范围大于后者。组织病理学结果证实,有2例患者的病灶在anti-;F-FACBC显像的病灶范围内,但在CE-T;W MRI显示的范围外。2例患者出现轻度不良反应:1例头部隐痛到轻度头痛,1例全身不适;上述症状均自行缓解。轻度头痛和anti-;F-FACBC的因果关系无法排除。该研究还发现,肿瘤与正常组织存在较高的T/N比值。结论 Anti-;F-FACBC PET/CT显像可以显示胶质瘤的病灶范围,其准确性比CE-T;W MRI高。Anti-;F-FACBC用于脑胶质瘤患者显像有较好的安全性。

关键词：临床试验 F-fluciclovine 脑胶质瘤 PET MRI

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Current status of predictive biomarkers for neoadjuvant therapy in esophageal cancer

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World Journal of Gastrointestinal Pathophysiology 2014年第3期5卷 322-334页

作者： Norihisa Uemura Tadashi kondo Department of Gastroenterological Surgery Aichi Cancer Center Hospital Division of Pharmacoproteomics National Cancer Center Research Institute

Neoadjuvant therapy has been proven to be extremely valuable and is widely used for advanced esophageal cancer. However, a significant proportion of treated patients(60%-70%) does not respond well to neoadjuvant treatments and develop severe adverse effects. Therefore, predictive markers for individualization of multimodality treatments are urgently needed in esophageal cancer. Recently, molecular biomarkers that predict the response to neoadjuvant therapy have been explored in multimodal approaches in esophageal cancer and successful examples of biomarker identification have been reported. In this review, promising candidates for predictive molecular biomarkers developed by using multiple molecular approaches are reviewed. Moreover, treatment strategies based on the status of predicted biomarkers are discussed, while considering the international differences in the clinical background. However, in the absence of adequate treatment options related to the results of the biomarker test, the usefulness of these diagnostic tools is limited and new effective therapies for biomarker-identified nonresponders to cancer treatment should be concurrent with the progress of predictive technologies. Further improvement in the prognosis of esophageal cancer patients can be achieved through the introduction of novel therapeutic approaches in clinical practice.

关键词： Esophageal cancer Neoadjuvant therapy Response prediction Molecular biomarker Chemoradiation

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Photocatalytic Degradation of Ibuprofen Using TiO<sub>2</sub>and Ecotoxicological Assessment of Degradation Intermediates against <i>Daphnia similis</i>

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Journal of Environmental Protection 2014年第7期5卷 620-626页

作者： Farley S. Braz Milady R. A. Silva Flávio S. Silva Sandro J. Andrade Ana L. Fonseca Márcia M. kondo Natural Resource Institute Universidade Federal de Itajubá Itajubá Brazil Physic and Chemistry Institute Universidade Federal de Itajubá Itajubá Brazil

Several pharmaceutical compounds have been detected in natural aqueous systems and ibuprofen (IBF), one of the most consumed medicament, has been detected in many countries. The degradation efficiency of IBF under TiO2/UV radiation was evaluated. Optimum degradation results were observed using 20 mg·L-1 of TiO2, pH 7.8 and 5 mg·L-1 of IBF. Under these experimental conditions total IBF removal was achieved in less than 60 min of irradiation. Although total IBF concentration was observed, the total mineralization of the compound was not achieved. The by-products generated during TiO2/UV reaction showed to be more toxic against Daphnia similis than the initial IBF present in aqueous solution.

关键词： Photodegradation TiO2 Ibuprofen Acute Toxicity

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日本长期不同施肥稻田N_2O和CH_4排放特征及其环境影响

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应用生态学报 2010年第12期21卷 3200-3206页

作者：罗良国近藤始彦伊藤纯雄中国农业科学院农业环境与可持续发展研究所农业部农业环境与气候变化重点实验室北京100081 日本国立农业研究中心土壤肥料部

观测了75年长期连续不施肥、施硫酸铵、施熟制水稻秸秆与豆饼混合堆肥、施绿肥苜蓿4种处理下日本单季稻田温室气体N2O和CH4的排放特征及其环境影响.结果表明:在水稻生长季节,不同处理间N2O排放无显著差异,但CH4排放差异显著;长期连续施... 详细信息

观测了75年长期连续不施肥、施硫酸铵、施熟制水稻秸秆与豆饼混合堆肥、施绿肥苜蓿4种处理下日本单季稻田温室气体N2O和CH4的排放特征及其环境影响.结果表明:在水稻生长季节,不同处理间N2O排放无显著差异,但CH4排放差异显著;长期连续施用有机肥虽然没有增加N2O排放却促进了CH4排放.各系统排放N2O和CH4所产生的累积全球增温潜势(GWP)以绿肥处理最大(310.7gCO2e·m-2),熟制有机堆肥次之(151gCO2e·m-2),硫酸铵处理最小(60.6gCO2e·m-2).稻田系统的GWP主要来自CH4排放,控制和减少稻田系统CH4排放是稻田温室气体减排的核心问题.长期连续施用熟制有机堆肥既能增加土壤有机质,改善地力,满足水稻高产,又能实现CH4减排,是实践中值得推荐的水稻生产模式.

关键词：长期施肥管理水稻温室气体排放静态箱法

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巴金研究在日本

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大连大学学报 2020年第2期41卷 28-41页

作者：近藤光雄神田外语大学亚洲语言系日本千叶市2610014

在日本,巴金的代表作品几乎已被译成日文,在学术研究方面也有丰硕的成果。然而,至今很少有人对这些研究成果的整体倾向进行梳理与分析。本文将从有关巴金六部作品的研究成果中选出发表于1935年至2019年的具有代表性的文章,围绕“巴金思... 详细信息

在日本,巴金的代表作品几乎已被译成日文,在学术研究方面也有丰硕的成果。然而,至今很少有人对这些研究成果的整体倾向进行梳理与分析。本文将从有关巴金六部作品的研究成果中选出发表于1935年至2019年的具有代表性的文章,围绕“巴金思想研究”与“巴金作品研究”这两个层面来介绍日本巴金研究的整体面貌,阐明巴金革命思想的理想化、观念性倾向,文学创作的真实性问题以及这两种因素之间的关系。

关键词：日本巴金研究巴金思想巴金作品

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Distinct Gene Expression Profile Distinguishes Increased Metabolic Activity in Spontaneously Hyperactive Rats While Sedentary from That Induced by Exercise

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Advances in Biological Chemistry 2018年第1期8卷 1-14页

作者： Manami Abe Yuki Matsuo Akiko Harada-Sukeno Takayuki Uchida Kanako Kitahata Chisato Tomida Katsuya Hirasaka Shigetada Teshima-kondo Nagakatsu Harada Yutaka Nakaya Hiroshi Sakaue Reiko Nakao Takeshi Nikawa Departments of Nutritional Physiology Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan Laboratory of Fishery Nutritional Science Graduate School of Fisheries and Environmental Sciences Nagasaki University Nagasaki Japan Department of Medical Nutrition Graduate School of Comprehensive Rehabilitation Osaka Prefecture University Osaka Japan Departments of Nutrition and Metabolism Institute of Biomedical Sciences Tokushima University Graduate School To-kushima Japan

The Spontaneously-Running Tokushima Shikoku (SPORTS) strain is an original line derived from Wistar rats, which spontaneously runs >6 km/day on wheels, and has better glucose tolerance and less fat than Wistar rats. However, the molecular mechanism that contributes to the increased metabolic activity in SPORTS rats is unknown. The present study aimed to characterize the gene expression profiles of skeletal muscles in SPORTS rats housed under sedentary (SED) conditions. We found that the expression levels of genes encoding mitochondrial respiratory chain enzymes such as ATP synthase 6 (mt-Atp6) and cytochrome c oxidase subunit 6c (Cox6c), were higher in the soleus (SOL) muscles of SED SPORTS than in SED Wistar rats. The ratio of type IIa myofibers was higher and glucose tolerance was better in SED SPORTS than in Wistar rats that were sedentary and trained daily on treadmills, respectively. We then investigated candidate genes that might contribute to the better glucose tolerance of SED SPORTS rats using DNA microarray analysis. Among 116 upregulated genes in the SOL muscles of SED SPORTS rats, only 19 were also increased in trained Wistar rats. We focused on v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (Erbb3), which was associated with glucose transport in myocytes, and found higher expression levels in the SOL muscles of SED SPORTS than in SED Wistar rats. The SOL muscles of SED SPORTS rats also contained more activity of β-hydroxyacylCoA dehydrogenase, a key enzyme of β-oxidation, indicating enhanced lipid oxidation. These findings suggest that increased metabolic activity in skeletal muscle (especially the SOL muscle) of SPORTS rats is congenital and that gene expression profiles of SPORTS rats and Trained Wistar rats are different.

关键词： Mitochondria Myofiber Type Microarray Metabolism

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玩转缤纷色彩引人注目新法则

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国际服装技术 2007年第4期 56-67页

作者： Masako kondo Xiyanfeng（翻译） Hideyo Fukuda（models）（摄影） Hideyuki Watanabe（still）（摄影）申广云（摄影）

本季欢快活泼的色彩成为时尚的焦点，LUCi精心从各大时装发布会中的获得显出时尚的穿着秘诀。打造出适合日常的装束，你不容错过！

关键词：色彩法则时装发布会时尚穿着

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Pegylated interferon plus ribavirin for genotype Ib chronic hepatitis C in Japan

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World Journal of Gastroenterology 2008年第47期14卷 7225-7230页

作者： Takayuki Kogure Yoshiyuki Ueno Koji Fukushima Futoshi Nagasaki Yasuteru kondo Jun Inoue Yasunori Matsuda Eiji Kakazu Takeshi Yamamoto Hiroyoshi Onodera Yutaka Miyazaki Hiromasa Okamoto Takehiro Akahane Tomoo Kobayashi Yutaka Mano Takao Iwasaki Motoyasu Ishii Tooru Shimosegawa Division of Gastroenterology Tohoku University HospitalSendai 980-8574Japan Department of Gastroenterology Tohoku Rosai HospitalSendai 980-8574Japan Department of Gastroenterology Miyagi Cancer CenterNatori 981-1293Japan Department of Internal Medicine Tohoku Kosai HospitalSendai 980-0803Japan Department of Internal Medicine Shirakawa Kosei General HospitalShirakawa 961-0005Japan Department of Gastroenterology Ishinomaki Municipal HospitalIshinomaki 986-0835Japan Department of Gastroenterology Osaki Citizen HospitalFurukawa 989-6183Japan Department of Gastroenterology Sendai Medical CenterSendai 983-8520Japan Department of Internal Medicine Miyagi Social Insurance HospitalSendai 981-1103Japan

AIM:To evaluate the efficacy of pegylated interferon α-2b(peg-IFNα-2b) plus ribavirin(RBV) therapy in Japanese patients with chronic hepatitis C(CHC) genotype Ib and a high viral ***:One hundred and twenty CHC patients(58.3% male) who received peg-IFNα-2b plus RBV therapy for 48 wk were *** virological response(SVR) and clinical parameters were ***:One hundred(83.3%) of 120 patients completed 48 wk of treatment.53 patients(44.3%) achieved *** virological response(EVR) and end of treatment response(ETR) rates were 50% and 73.3%,*** clinical parameters(SVR vs non-SVR) associated with SVR,ALT(108.4 IU/L vs 74.5 IU/L,P = 0.063),EVR(76.4% vs 16.4%,P 56 years),SVR in females was significantly lower than that in males(17% vs 50%,P = 0.0262).EVR and adherence to Peg-IFN were demonstrated to be the main factors associated with ***:Peg-IFNα-2b plus RBV combination therapy demonstrated good tolerability in Japanese patients with CHC and resulted in a SVR rate of 44.3%.Treatment of elderly female patients is still challenging and maintenance of adherence to peg-IFNα-2b is important in improving the SVR rate.

关键词： Chronic hepatitis C Pegylated interferon Ribavirin

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