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Feasibility of gastric endoscopic submucosal dissection in elderly patients aged≥80 years

World Journal of Gastrointestinal Endoscopy 2022年第1期14卷 49-62页

作者： Yasuhiro Inokuchi ayaka ishida Kei Hayashi Yoshihiro Kaneta Hayato Watanabe Kazuki Kano Mitsuhiro Furuta Kosuke Takahashi Hirohito Fujikawa Takanobu Yamada Kouji Yamamoto Nozomu Machida Takashi Ogata Takashi Oshima Shin Maeda Department of Gastroenterology Kanagawa Cancer CenterYokohama 241-8515KanagawaJapan Department of Gastrointestinal Surgery Kanagawa Cancer CenterYokohama 241-8515KanagawaJapan Department of Biostatics Yokohama City University School of Medicine.Yokohama 236-0004KanagawaJapan Department of Gastroenterology Yokohama City UniversityYokohama 236-0004KanagawaJapan

BACKGROUND Endoscopic resection,especially endoscopic submucosal dissection(ESD),is increasingly performed in elderly patients with early gastric cancer,and lesions beyond the expanded indications are also resected endoscopically in some *** is essential to assess whether gastric ESD is safe and suitable for elderly patients and investigate what type of lesions carry an increased risk of ESD-related *** To assess the efficacy and feasibility of gastric ESD for elderly patients,and define high-risk lesions and prognostic *** Among a total of 1169 sessions of gastric ESD performed in Kanagawa Cancer Center Hospital from 2006 to 2014,179 sessions(15.3%)were performed in patients aged≥80 years,and 172 of these sessions were done in patients with a final diagnosis of gastric *** patients were studied retrospectively to evaluate short-term outcomes and *** short-term outcomes included the rates of en bloc resection and curative resection,complications,and procedurerelated *** was assessed according to the Japanese Gastric Cancer Treatment Guidelines ***’s exact test was used to statistically analyze risk *** characteristics of each group were compared using Fisher’s exact test and Mann-Whitney U *** rates at each time point were based on Kaplan-Meier *** survival rates were compared between patients with gastric cancer in each group with use of the log-rank *** identify prognostic factors that jointly predict the hazard of death while controlling for model overfitting,we used the least absolute shrinkage and selection operator(LASSO)Cox regression model including factors curative/noncurative,age,gender,body mass index,prognostic nutritional index,Charlson comorbidity index(CCI),Glasgow prognostic score,neutrophil-to-lymphocyte ratio,and antithrombotic agent *** selected the LASSO Cox regression model that resulted in minimal prediction error in 10-f

关键词： Endoscopic submucosal dissection Elderly Charlson comorbidity index Early gastric cancer Complications Prognostic indicators

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Laser speckle flowgraphy findings in a patient with radiation retinopathy

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 172-174页

作者： Satoru Kase ayaka Hasegawa Kiriko Hirooka Hiroaki Endo Kousuke Noda Susumu ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan Department of Ophthalmology Teine Keijinkai HospitalSapporo 006-0811Japan

Dear Editor,I am Satoru Kase, from Hokkaido University Hospital, Japan. Choroidal melanoma is a serious intraocular tumor, which threatens patients’ vision and life. Treatments for choroidal melanoma consist of surge... 详细信息

关键词： melanoma surgery intraocular

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High Ethanol Production by Marine-Derived Yeasts-<i>Saccharomyces cerevisiae</i>under Stress Pressures

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Advances in Microbiology 2017年第5期7卷 349-357页

作者： Naoto Urano ayaka Shirao Masahiko Okai Masami ishida Laboratory of Marine Biochemistry Department of Ocean Sciences Tokyo University of Marine Science and Technology Tokyo Japan

For practical applications of bioethanol, the uses of both highly concentrated biomass materials and their effective fermentation by yeasts are indispensable in order to produce ethanol at low costs. However, as the saccharified products of those biomass generally contain abundant sugars, the yeasts are affected by the compounds and are inclined to decrease their physiological activities. In the process of fermentation, ethanol is gradually produced by the yeasts in the culture;the concentrated metabolic product also damages itself, and inhibition of the fermentation frequently occurs. The application of yeasts with high fermentative activities under stress pressures such as sugars and ethanol is thus desired for bioethanol production. In this study, various types of high-fermentative yeasts under stress pressures were isolated mainly from coastal waters in Japan and characterized. All yeast strains with high fermentative activities under 20% v/v ethanol were found to be Saccharomyces cerevisiae. The HK21 strain isolated from Tokyo Bay and identified as S. cerevisiae had the highest fermentation activity under 30% w/v sorbitol and under 20% v/v ethanol, and it produced approx. 70 g/l (9% v/v) ethanol from the 15% w/v glucose solution at 25 oC within 5 days.

关键词： Marine-Derived Yeast Fermentation Bioethanol Coastal Water Saccharomyces cerevisiae Stress Pressure

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HsfAld, a Protein Identified via FOX Hunting Using Thellungiella salsuginea cDNAs Improves Heat Tolerance by Regulating Heat-Stress-Responsive Gene Expression

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Molecular Plant 2013年第2期6卷 411-422页

作者： Yukari Higashi Naohiko Ohama Tomoko Ishikawa Taku Katori ayaka Shimura Kazuya Kusakabe Kazuko Yamaguchi-Shinozaki Junko ishida Maho Tanaka Motoaki Seki Kazuo Shinozaki Yoichi Sakata Takahisa Hayashi Teruaki Taji Department of Bio-Science Tokyo University of Agriculture 1-1-1 Sakuragaoka Setagaya Tokyo 156-8502 Japan Graduate School of Agriculture and Life Sciences University of Tokyo Tokyo 113-8657 Japan RIKEN Yokohama Institute 1-7-22 Suehiro-cho Tsururni-ku Yokohama 230-0045 Japan

Thellungiella salsuginea （formerly T. halophila）, a species closely related to Arabidopsis （Arabidopsis thali-ana）, is tolerant not only to high salt levels, but also to chilling, freezing, and ozone. Here, we report that T. salsuginea also shows greater heat tolerance than Arabidopsis. We identified T. salsuginea HsfAld （TsHsfAld） as a gene that can confer marked heat tolerance on Arabidopsis. TsHsfAld was identified via Full-length cDNA Over-eXpressing gene （FOX） hunt-ing from among a collection of heat-stress-related T. salsuginea cDNAs. Transgenic Arabidopsis overexpressing TsHsfAld showed constitutive up-regulation of many genes in the Arabidopsis AtHsfA1 regulon under normal growth tempera-ture. in Arabidopsis mesophyll protoplasts, TsHsfAld was localized in both the nucleus and the cytoplasm. TsHsfAld also interacted with AtHSP90, which negatively regulates AtHsfAls by forming HsfA1-HSP90 complexes in the cytoplasm. It is likely that the partial nuclear localization of TsHsfAld induced the expression of the AtHsfAld regulon in the transgenic plants at normal temperature. We also discovered that transgenic Arabidopsis plants overexpressing AtHsfAldwere more heat-tolerant than wild-type plants and up-regulated the expression of the HsfAld regulon, as was observed in TsHsfAld-overexpressing plants. We propose that the products of both TsHsfAld and AtHsfAld function as positive regulators of Arabidopsis heat-stress response and would be useful for the improvement of heat-stress tolerance in other plants.

关键词： Thellungiella salsuginea heat-stress tolerance HsfA1 FOX hunting.

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Molecular Phylogeny and Phenotypic Characterization of Yeasts with a Broad Range of pH Tolerance Isolated from Natural Aquatic Environments

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Advances in Microbiology 2019年第1期9卷 56-73页

作者： Naoto Urano ayaka Shirao Yuka Naito Masahiko Okai Masami ishida Masachika Takashio Department of Ocean Sciences Laboratory of Marine Biochemistry Tokyo University of Marine Science and Technology Tokyo Japan Zensho Laboratories of Food Technology Zensho Holdings Co. Ltd. Tokyo Japan

In this study, yeasts with broad range of pH tolerance were isolated and characterized from natural aquatic environments in Japan. Only a few basic and application studies of alkali-tolerant yeasts have been reported, despite the unmet industrial needs. First, we surveyed alkali-tolerant yeasts from natural aquatic environments at pH 7.6 - 9.4. We isolated 35 yeast strains that grew in pH 9.0 medium, from seven genera and nine species: 25 strains (N1, N2, through N6, N9, K1, K3 through K19) were Rhodotorula mucilaginosa;one (N7) was Rhodosporidium fluvial;one (N8) was Scheffersomyces spartinae;two (N10 and N13) were Wicherhamonyces anomalus;one (N11) was Cyberlindnera saturnus;one (S1) was Candida sp.;two (S2 and S4) were Candida intermedia;one (S3) was Candida quercuum;and one (K2) was Cryptococcus liquefacience. We examined the effects of pH on the growth of representative yeast strains. Strains K12 and S4 showed high growth at pH 3 - 10. Strains N7, N8, N10, N11, and S3 showed high growth at pH 3 - 9. Strains K2 and S1 showed high growth at pH 4 - 8. All nine of these strains had neutralizing activities from acidic media at pH 3 - 5 to pH 6 - 8. We previously isolated acid-tolerant yeasts (Cryptococcus sp. T1 [1] and Candida intermedia CeA16 [2]) from extremely acidified environments;they showed high growth at pH 3 - 9 and neutralizing activities of acidic media by releasing ammonium ions. Thus, alkali-tolerant yeasts and acid-tolerant yeasts were found to be similar species and have both high growth at a broad range of pH and neutralizing activities of acid media. Previously, we also isolated acid-tolerant, acid-neutralizing yeasts from neutral natural environments (26 strains, 12 species) [3]. Next, we constructed the phylogenetic trees of both acid-tolerant yeasts and alkali-tolerant yeasts. All were situated in the same classification position. Similar yeast species with a broad range of pH tolerance were living in natural aquatic environments at pH values fr

关键词： pH Tolerance Yeast Species Aquatic Environment Phylogenetic Tree Fermentation

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