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Journal of Integrative Nursing 2023年第1期5卷 27-32页

作者： ayşe taştekin ouyaba Şehadet taŞKIN Obstetrics and Gynecology Nursing Faculty of Health SciencesAfyonkarahisar Health Sciences UniversityAfyonkarahisarTurkey Department of Nursing Balıklıgöl State HospitalSanliurfaTurkey

Background:Risk perception and COVID‑19 anxiety in pregnant women restrict access to health services,cause pregnant women to resort to alternative channels such as the Internet,and affect prenatal care quality(PCQ)***:The purpose of this study was to examine the effect of risk perception and COVID‑19 anxiety in pregnancy on decision‑making via the Internet(DMI)and PCQ with multivariate *** and Methods:This cross‑sectional study was conducted with 406 pregnant women selected using the convenience sampling method in a training and research hospital,in *** data were collected using the information form,the perception of pregnancy risk questionnaire,the Coronavirus Anxiety Scale,the DMI Scale,and the PCQ *** data obtained were subject to descriptive analysis and the multivariate analysis of ***:Approximately 24.9%of the pregnant women were found to have a high perception of risk and 18%had symptoms of COVID‑19 *** women with high COVID‑19 anxiety and a higher perception of risk perceived the Internet as less influential for decision‑making(Pegnant women with a high‑risk perception had lower PCQ(Pe findings can be used to enhance mental health and resilience in pregnant women and to formulate appropriate intervention strategies.

关键词： COVID-19 anxiety decision-making via the Internet perception of risk pregnancy prenatal care quality

Simplified seismic scenario analysis of existing masonry buildings accounting for local site effects

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Frontiers of Structural and Civil engineering 2024年第2期18卷 309-318页

作者： ayşe e.ÖZSOYÖZBay Işıl SANRI KARAPINAR Zehra N.KUTLU İsmail e.KILIÇ Department of Civil engineering Maltepe UniversityIstanbul 34857Turkey School of engineering and Construction Oryx Universal CollegeDoha 12253Qatar

This study discusses the effects of local sites and hazard amplification on the seismic vulnerability assessment of existing masonry *** this context,a rapid seismic evaluation procedure was implemented on an old masonry building stock in the historical center Galata,located inİstanbul,to determine the seismic risk priority of the built *** scenarios were generated for all soil classes,different moment magnitudes,and source-to-site distances to obtain more accurate results for the seismic vulnerability assessment of the studied building ***,damage distributions estimated under nine different scenarios with/without site effects were compared and illustrated in maps to discuss changes in vulnerability owing to amplification *** this study,by re-examining the rapid seismic evaluation procedure by including geo-hazard-based assessment,the importance of site effects on the vulnerability and risk assessment of built heritage was *** proposed framework integrating field data and local site effects is believed to advance the current applications for vulnerability assessment of masonry buildings and provide an improvement in the application of rapid seismic assessment procedures with more reliable results.

关键词： masonry buildings seismic vulnerability assessment cultural heritage local site effect

Latest Carboniferous-early Permian Rifting of the Northern Gondwanan Margin and the Opening of the Northern Neotethys: New evidence from the Carboniferous and Permian Foraminiferal Assemblages from the Beyşehir-Hoyran Nappes, Central taurides(Southern Turkey)

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Journal of earth Science 2024年第2期35卷 394-415页

作者： Cengiz Okuyucu U.Kagan tekin Cagri Guzgun Kaan Sayit Department of Geological engineering Konya Technical UniversityKonya42250Turkey Department of Geological engineering Hacettepe UniversityAnkara06800Turkey Department of Geological engineering Middle East Technical UniversityAnkara06800Turkey

The Beyşehir-Hoyran Nappes,one of the tectonostratigraphic units of the taurides,are thought to be originated from the Izmir-Ankara Ocean(northern branch of Neotethys).In this study,Late Paleozoic rock units from the blocks of Beyşehir-Hoyran Nappes were studied in detail using foraminiferal assemblages in two different locations from the southwest of Karaman City(southern Turkey).In both places,blocks/slices and pebbles of various origins are embedded within a highly sheared matrix of Late Cretaceous Age,and the whole unit can be regarded as a sedimentary mé*** ages of the blocks from the southwest of Karaman City range from the Late Serpukhovian(Late Mississippian)to Late Capitanian(Middle Permian)with some depositional breaks(e.g.,Bashkirian,Kasimovian).Combined with the previous data from the Mersin Mélange,which also include the remnants of the Beyşehir-Hoyran Nappes,our new findings suggest that a shallowing-upward sequence,characterized by a shallow water environment with foraminifera-bearing limestones,was deposited over the Tournaisian pelagic sequence in the Beyşehir-Hoyran Nappes till the early Moscovian(early Middle Pennsylvanian).This shallowing-upward sequence in the Beyşehir-Hoyran Nappes could be related to the Late Paleozoic Glaciation on the Gondwana supercontinent(Glacial Ⅱ),which resulted in a sea-level drop and deposition of platform carbonates during the Viséan–early Moscovian(Middle Mississippian to early Middle Pennsylvanian)time *** absence of the main part of the Middle-Upper Pennsylvanian deposits(continental phase during the Middle Moscovian–Middle Gzhelian)in the Beyşehir-Hoyran Nappes can be mainly attributed to the occurrence of a mantle plume and partially to the effect of Late Paleozoic Gondwanan Glaciation(Glacial Ⅲ).Progressive uplifting by the buoyant mantle plume material has resulted in rifting at the center of the basin where the Beyşehir-Hoyran Nappes have *** rifting process led to tectonic destabiliz

关键词： foraminifera Carboniferous and Permian Beyşehir-Hoyran Nappes plume rifting Neotethys paleontology

emerging role of galectin 3 in neuroinflammation and neurodegeneration

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Neural Regeneration Research 2024年第9期19卷 2004-2009页

作者： Brian M.Lozinski Khanh ta Yifei Dong Department of Clinical Neuroscience University of CalgaryCalgaryABCanada Deparment of Biochemistry Microbiology&ImmunologyUniversity of SaskatchewanSaskatoonSKCanada

Neuroinflammation and neurodegeneration are key processes that mediate the development and progression of neurological ***,the mechanisms modulating these processes in different diseases remain incompletely *** in single cell based multi-omic analyses have helped to identify distinct molecular signatures such as Lgals3 that is associated with neuroinflammation and neurodegeneration in the central nervous system(CNS).Lgals3 encodes galectin-3(Gal3),aβ-galactoside and glycan binding glycoprotein that is frequently upregulated by reactive microglia/macrophages in the CNS during various neurological *** Gal3 has previously been associated with non-CNS inflammatory and fibrotic diseases,recent studies highlight Gal3 as a prominent regulator of inflammation and neuroaxonal damage in the CNS during diseases such as multiple sclerosis,Alzheimer’s disease,and Parkinson’s *** this review,we summarize the pleiotropic functions of Gal3 and discuss evidence that demonstrates its detrimental role in neuroinflammation and neurodegeneration during different neurological *** also consider the challenges of translating preclinical observations into targeting Gal3 in the human CNS.

关键词： Alzheimer’s disease Galectin 3 microglia multiple sclerosis neurodegeneration neuroinflammation Parkinson’s disease therapeutics

exponentially Bounded C-semigroup and the Cauchy Initial Value Problems in Complete Random Normed Modules

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Acta Mathematica Sinica,english Series 2024年第9期40卷 2195-2212页

作者： Son ta CONG Thang Dang HUNG Oanh Le THI Department of Mathematics University of ScienceVietnam National University 334 Nguyen TraiThanh XuanHanoiVietnam Faculty of Natural Sciences Hong Duc University565 Quang TrungDong VeThanh HoaVietnam

In this paper,the notion of C-semigroup of continuous module homomorphisms on a complete random normal(RN)module is introduced and *** existence and uniqueness of solution to the Cauchy problem with respect to exponen... 详细信息

关键词： C-semigroup Cauchy problem random normed modules L^(0)-Lipschitz

A robust vector tracking loop structure based on potential bias analysis

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Chinese Journal of Aeronautics 2024年第4期37卷 405-420页

作者： Qiongqiong JIA Yiran LUO Bing XU Li-ta HSU Renbiao WU Tianjin Key Lab for Advanced Signal Processing Civil Aviation University of ChinaTianjin 300300China Interdisciplinary Division of Aeronautical and Aviation engineering The Hong Kong Polytechnic University999077Hong KongChina Department of Geomatics engineering University of CalgaryCalgary T2N1N4Canada

This paper proposes a robust vector tracking loop structure based on potential bias analysis. The influence of four kinds of biases on the existing two implementations of Vector Tracking Loops(VTLs) is illustrated by theoretical analysis and numerical simulations, and the following findings are obtained. Firstly, the initial user state bias leads to steady navigation solution bias in the relative VTL, while new measurements can eliminate it in the absolute VTL. Secondly, the initial code phase bias is transferred to the following navigation solutions in the relative VTL, while new measurements can eliminate it in the absolute VTL. Thirdly, the user state bias induced by erroneous navigation solution of VTLs can be eliminated by both of the two VTLs. Fourthly,the multipath/NLOS likely affects the two VTLs, and the induced tracking bias in the duration of the multipath/NLOS would decrease the performance of VTLs. Based on the above analysis,a robust VTL structure is proposed, where the absolute VTL is selected for its robustness to the two kinds of initialization biases;meanwhile, the instant bias detection and correction method is used to improve the performance of VTLs in the duration of the multipath/NLOS. Numerical simulations and experimental results verify the effectiveness of the proposed robust VTL structure.

关键词： Global Navigation Satellite System(GNSS) Vector Tracking Loop(VTL) Multipath Non-Line-of-Sight(NLOS) Tracking bias propagation Least Absolute Shrinkage and Selection Operator(LASSO)

The Influence of Significant Public Health events on Offline Consumption and Its Pathways

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Journal of Systems Science and Systems engineering 2024年第5期33卷 627-648页

作者： Baile Lu Kewei Zhou Shuai Hao La ta Hongyan Dai Weihua Zhou College of Systems engineering National University of Defense TechnologyChangsha 410073China Business School Central University of Finance and EconomicsBeijing 100081China Department of Marketing and Operations Management College of BusinessSouthern University of Science and TechnologyShenzhen 518055China School of Management Zhejiang UniversityHangzhou 310058China

In the face of a significant public health event,consumers may either increase their panic buying or decrease their willingness to make *** study focuses on the impact of a significant public health event on offline store sales and consumer consumption,utilizing data from chain convenience stores in Hefei and Wuhu during early 2019 and early 2020 in *** a difference-in-differences model,the study investigates the effect of the significant public health event outbreak on weekly store sales,order numbers,and consumer consumption in terms of product quantities,transaction amount,average amount per order,and transaction *** from prior literature that finds hoarding behavior of consumers online,the findings of this paper indicate a significant reduction in stores’offline weekly sales and order numbers,as well as consumers’offline weekly consumption across the four dimensions,as a result of the significant public health event ***,employing a mediation model,the study explores the pathway of population mobility through which the significant public health event adversely affects offline ***,subset analysis is conducted for stores located in different areas and consumers with varying characteristics,revealing that the aforementioned conclusions predominantly apply to stores situated in office areas and residential areas,as well as consumers with either no apparent preference for different product categories or a noticeable preference for food.

关键词： Significant public health event offline consumption population mobility mediating effect

The impact of broad glutamine metabolism inhibition on the tumor microenvironment

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Genes & Diseases 2024年第3期11卷 2-4页

作者： Tianhe Li Yun-ta Chuang Tian-Li Wang Departments of Pathology Oncologyand Gynecology and ObstetricsThe Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21231USA

Glutamine is an importantα-amino acid that provides carbon and nitrogen sources for the biosynthesis of nucleotides,proteins,and *** also generates metabolites that fuel the tricarboxylic acid cycle and maintain intracellular redox *** cells have a heightened metabolic dependence on glutamine to support incessant tumor growth and mitigate tumor microenvironmental stresses including hypoxia,nutrient depletion.

关键词： metabolism tumor microenvironment

In vitro engineered models of neurodegenerative diseases

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BIOCeLL 2024年第1期48卷 79-96页

作者： ZeHRA GÜL MORÇIMeN ŞeYMA taŞDeMIR ayLIN ŞeNDeMIR Bioengineering Department Graduate School of Natural and Applied SciencesEge UniversityIzmir35040Türkiye Bioengineering Department Faculty of Engineering and Natural ScienceCelal Bayar UniversityManisa45110Türkiye Bioengineering Department Ege UniversityIzmir35040Türkiye Department of Biomedical Technologies Graduate School of Natural and Applied SciencesEge UniversityIzmir35040Türkiye

Neurodegeneration is a catastrophic process that develops progressive damage leading to functional andstructural loss of the cells of the nervous system and is among the biggest unavoidable problems of our *** do not reflect the pathophysiology observed in humans due to distinct differences between the neuralpathways,gene expression patterns,neuronal plasticity,and other disease-related mechanisms in animals *** in vitro cell culture models are also not sufficient for pre-clinical drug testing in reflecting thecomplex pathophysiology of neurodegenerative ***,modern,engineered techniques are applied to developmulticellular,intricate in vitro models and to create the closest microenvironment simulating biological,biochemical,and mechanical characteristics of the in vivo degenerating *** THIS review,the capabilities and shortcomings ofscaffold-based and scaffold-free techniques,organoids,and microfluidic models that best reflect neurodegeneration invitro in the biomimetic framework are discussed.

关键词： Neurodegenerative diseases In vitro models Scaffolds Organoids Microfluidic devices

Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer:A systematic review

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Journal of Integrative Medicine 2024年第2期22卷 137-162页

作者： Bizhar Ahmed Tayeb Ikhwan Yuda Kusuma Alaa A.M.Osman Renáta Minorics Institute of Pharmacodynamics and Biopharmacy Faculty of PharmacyUniversity of Szeged6720 SzegedHungary Institution of Clinical Pharmacy Faculty of PharmacyUniversity of Szeged6725 SzegedHungary Department of Clinical Pharmacy and Pharmacy Practice Faculty of PharmacyUniversity of Gezira20 Wad MadaniSudan Pharmacy Study Program Facuity of HealthUniversitas Harapan BangsaPurwokerto 53182Indonesia

Background:The field of personalized medicine has gained increasing attention in cancer care,with the aim of tailoring treatment strategies to individual patients for improved *** medicine,with its long-standing historical use and extensive bioactive compounds,offers a rich source of potential treatments for various diseases,including ***:To provide an overview of the current knowledge and evidence associated with incorporating herbal compounds into precision medicine strategies for cancer ***,to explore the general characteristics of the studies included in the analysis,focusing on their key features and *** strategy:A comprehensive literature search was conducted from multiple online databases,including Pub Med,Scopus,Web of Science,and *** search strategy was designed to identify studies related to personalized cancer medicine and herbal *** criteria:Publications pertaining to cancer research conducted through in vitro,in vivo,and clinical studies,employing natural products were included in this *** extraction and analysis:Two review authors independently applied inclusion and inclusion criteria,data extraction,and assessments of methodological *** quality assessment and biases of the studies were evaluated based on modified Jadad scales.A detailed quantitative summary of the included studies is presented,providing a comprehensive description of their key features and ***:A total of 121 studies were included in this review for *** of them were considered as comprehensive experimental investigations both in vitro and in *** majority(n=85)of the studies included in this review were conducted in vitro,with 44 of them specifically investigating the effects of herbal medicine on animal ***,7 articles with a combined sample size of 31,271 patients,examined the impact of herbal medicine in clinical ***:Personal

关键词： Cancer Herbal medicine Personalized medication Active phytochemicals Natural compound