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neCAB family of neuronal calcium-binding proteins in health and disease

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neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The n-terminal eF-hand calcium-binding proteins 1–3(neCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. neCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. neCAB2 interacts with predominantly striatal G-protein-coupled receptors, while neCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. neCAB proteins exhibit distinct subcellular localizations: neCAB1 is found in the nucleus and cytosol, neCAB2 resides in endosomes and the plasma membrane, and neCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in neCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of neCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel e.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA national Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain eAAT-1/GLAST eAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Improvements in quality of life in septuagenarians versus octogenarians undergoing trans-catheter aortic valve replacement

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Journal of Geriatric Cardiology 2016年第5期13卷 439-443页

作者： nuray Kahraman ay Yasin ay Osman Sonmez Mehmet Akif Vatankulu Omer Goktekin Department of Cardiology Bezmialem Vakif University Fatih Istanbul Turkey Department of Cardiovascular Surgery Bezmialem Vakif University Fatih Istanbul Turkey

Background Very elderly patients represent a distinct patient group in clinical setting in terms of a decision for trans-catheter aortic valve replacement （TAVR） when one considers the potential improvement in the quality of life （QoL） on one hand and the benefit to risk ratio on the other. This study aimed to compare functional and QoL outcomes of TAVR between octogenarians and septuagenarians. Methods This prospective cohort study included 136 elderly patients （70 to 89 years of age）, who tmderwent Wansfemoral TAVR due to degenerative aortic stenosis. Patients were allocated into one of the following age groups： septuagenarians （n = 67） and octogenarians （n = 69）. Preoperative and early postoperative clinical parameteT：s were recorded. In addition, QoL of the patients was evaluated using SF-36 questionnaire preoperatively and six month postoperatively. Results Groups were similar in terms of early postoperative mortality and morbidity parameters. The mean new York Heart Association （nYHA） class improved after TAVR in both groups. In addition, all SF-36 norm-based scale and SF-36 summary scale scores improved significantly in both groups during the postoperative period. Postoperatively, physical functioning, general health and physical component summary scores were significantly better in the septuagenarian group （P = 0.02, 0.01, 0.03, respectively）. ConcLusion Although the improvement in the QoL in terms of physical health was more marked in septuagenarians than in octogenarians, substantial benefits on the QoL and particularly on mental health seem to justify re-consideration of TAVR indications in the very elderly.

关键词： elderly Octogenarians Quality of life Septuagenarian Trans-catheter aortic valve replacement

Dendritic spine degeneration:a primary mechanism in the aging process

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neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores Leonardo Aguilar-Hernández Fernado García-Dolores Humberto nicolini Andrea Judith Vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(InCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto nacional de Medicina Genómica(InMeGen) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

Influence of oxygen partial pressure on properties of n-doped ZnO films deposited by magnetron sputtering

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Transactions of nonferrous Metals Society of China 2010年第12期20卷 2326-2330页

作者：王金忠 e.elAnGOVAn n.FRAnCO A.ALVeSe A.ReGO R.MARTInS e.FORTUnATO School of Materials Science and engineering Harbin Institute of Technology Material Science Department CENIMAT/I3N and CEMOP/UNINOVAFCT-UNLCampus de Caparica2829-516 CaparicaPortugal Ion Beam Laboratory Physics DepartmentInstitute of Technology and Nuclear EN.102686-953 SacavemPortugal Center of Molecular Chemistry-Physics Institute of Nanoscience and NanotechnologyComplexo InterdisciplinarIST 1049-001 LisboaPortugal

n-doped ZnO films were radio frequency(RF)sputtered on glass substrates and studied as a function of oxygen partial pressure(OPP)ranging from 3.0×10-4 to 9.5×10-3 Pa.X-ray diffraction patters confirmed the polycrystalline nature of the deposited *** crystalline structure is influenced by the variation of *** force microscopy analysis confirmed the agglomeration of the neighboring spherical grains with a sharp increase of root mean square(RMS)roughness when the OPP is increased above 1.4×10-3 Pa.X-ray photoelectron spectroscopy analysis revealed that the incorporation of n content into the film is decreased with the increase of OPP,noticeably n 1s XPS peaks are hardly identified at 9.5×10-3 *** average visible transmittance(380-700 nm) is increased with the increase of OPP(from～17%to 70%),and the optical absorption edge shifts towards the shorter *** films deposited with low OPP(≤3.0×10-4 Pa)show n-type conductivity and those deposited with high OPP(≥9.0×10-4 Pa)are highly resistive(>105Ω·cm)

关键词： ZnO oxygen partial pressure magnetron sputtering transmittance

nano-enhanced Dairy Scum Biodiesel Blends:Unleashing the Power of Aluminium Oxide for Sustainable and efficient engine Performance

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Journal of Thermal Science 2025年第1期34卷 283-302页

作者： Veeranna MODI Prasad B.RAMPURe Sunil Kumar SHeTTY Madeva nAGARAL Channa Keshava nAIK n Johar MGM Muhammad Irsyad ABDULLAH Abdullah I.AL-MAnSOUR Shamshad ALAM KLe College of engineering and Technology ChikodiVisvesvaraya Technological University nitte (Deemed to be University) NMAM Institute of Technology (NMAMIT)Department of Mechanical Engineering Aircraft Research and Design Centre HAL Department of Mechanical engineering BGS College of Engineering and TechnologyBengaluruAffiliated to Visvesvaraya Technological University Management and Science University Department of Civil engineering College of EngineeringKing Saud University

This study investigates the effect of aluminium oxide nanoparticlesaddition to biodiesel blends made from dairy milk scum on performance and combustion characteristics of the diesel *** dispersion of Al2O3nanoparticles in B20 blends at different concentrations was done with the help of *** number of blends were prepared for the *** Machine learning algorithms(Random Forest（RF）and CatBoost) was used for the *** results show that in comparison to biodiesel blends without nanoparticles,the kinematic viscosity and density is higher for fuel blends with *** these Fuel blends have higher calorific *** blends exhibited reduced Brake Specific Fuel Consumption（BSFC） of2.85% than the blends without nano particles(Dairy Scum Methyl ester Biodiesel 20%+neat Diesel 80%（in volume）,DSMeB20),57.14% less CO,40.8% less hydrocarbon,and increased nOxemissions compared to conventional diesel,contributing to the development of environmentally friendly and renewable biofuel blends with *** B20nP30 is the optimal blend for performance and emission *** study concludes with findings on enhanced Brake Thermal efficiency（BTe） of 26.29% in 3×10-5（in volume） Al2O3nanoparticle-blended DSMe B20 and other DSMe B20 fuel blends,emphasizing the importance of optimal nanoparticle *** correlation matrix shows how engine load,efficiency measures（BTe,BSFC）,and emissions（CO,CO2,nOx,Smoke） are connected in complex *** results help us understand the complicated dynamics of engine performance and emission characteristics ***'s diagram for BTe and BSFC shows that CatBoost-based BTe models perform superior to RF-based models during the training as well as testing *** results were obtained for CO and CO2emission results.

关键词： Al2O3 concentration CI engine Dairy Scum Methyl ester Biodiesel

Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.Spicer Jianqi Yang Daniel Fu Alison n.DeVore Marisol Lauffer nilufer S.Atasoy Deniz Atasoy Rory A.Fisher Department of neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWe) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWe) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWe) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWe) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

Calculation of electron Swarm Parameters of SF_6/n_2 in a Uniform Field Using an Improved Monte Carlo Collision Simulation Method

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Plasma Science and Technology 2008年第1期10卷 39-42页

作者：汪沨 W.PFeIFFeR n.KOUZICHIne 邱毓昌 e.KUFFeL 李肯立 School of electrical and Information engineering Hunan University Changsha 410082. China Technische Universitt Darmstadt 64283 Darmstadt Germany School of electrical engineering Xi'an Jiaotong University Xi'an 710049 China Department of electrical engineering and Computer Science University of Manitoba Winnipeg Canada School of Computor and Communication Huna University Changsha 410084 China

The electron swarm parameters of SF6/n2 are calculated in the present study using an improved Monte Carlo collision simulation method （MCS）. And some improved sampling techniques are also adopted. The simulation res... 详细信息

关键词： Monte Carlo collision simulation gas discharge swarm parameter

A Galerkin-Type Fractional Approach for Solutions of Bagley-Torvik equations

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Computer Modeling in engineering & Sciences 2020年第6期123卷 941-956页

作者： Şuayip Yüzbaşı Murat Karaçayır Department of Mathematics Akdeniz UniversityAntalya07070Turkey

In this study,we present a numerical scheme similar to the Galerkin method in order to obtain numerical solutions of the Bagley Torvik equation of fractional order 3/*** this approach,the approximate solution is assumed to have the form of a polynomial in the variable t=xα,whereαis a positive real parameter of our *** problem is firstly expressed in vectoral form via substituting the matrix counterparts of the terms present in the *** taking inner product of this vector with nonnegative integer powers of t up to a selected positive parameter n,a set of linear algebraic equations is *** incorporation of the boundary conditions,the approximate solution of the problem is then computed from the solution of this linear *** present method is illustrated with two examples.

关键词： Bagley-Torvik equation fractional derivative Galerkin method numerical solutions.