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Chaetomium-like fungi causing opportunistic infections in humans:a possible role for extremotolerance

Fungal Diversity 2016年第1期76卷 11-26页

作者： Sarah A.Ahmed Ziauddin Khan Xue-wei Wang Tarek A.A.moussa Hassan S.Al-Zahrani Omar A.A.lmaghrabi Deanna A.Sutton S.Ahmad Johannes Z.Groenewald A.Alastruey-Izquierdo Anne van Diepeningen S.B.J.menken m.J.Najafzadeh Pedro W.Crous Oliver Cornely axel Hamprecht maria J.G.T.Vehreschild A.J.Kindo G.Sybren de Hoog Faculty of medical Laboratory Sciences University of KhartoumKhartoumSudan CBS-KNAW Fungal Biodiversity Centre P.O.Box 851673508 AD UtrechtThe Netherlands Institute for Biodiversity and Ecosystem Dynamics University of AmsterdamAmsterdamThe Netherlands Department of microbiology Faculty of MedicineKuwait UniversityKuwaitKuwait State Key Laboratory of mycology Institute of MicrobiologyChinese Academy of SciencesBeijingChina Biological Sciences Department Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Botany and microbiology Department Faculty of ScienceCairo UniversityGizaEgypt Fungus Testing Laboratory Department of PathologyUniversity of Texas Health Science Center at San AntonioSan AntonioTXUSA mycology Reference Laboratory National Centre for MicrobiologyCarlos III Institute of Health(Servicio deMicologíaCentro Nacional de MicrobiologíaInstituto de Salud Carlos III)MadridSpain Department of Parasitology and mycology Mashhad University of Medical SciencesMashhadIran German Centre for Infection Research(DZIF)at Cologne/Bonn First Department of Internal MedicineUniversity Hospital of CologneCologneGermany Institute for medical microbiology Immunology and HygieneUniversity of CologneCologneGermany Department of microbiology Sri Ramachandra UniversityPorurChennaiIndia Peking University Health Science Center Research Center for Medical MycologyBeijingChina Sun Yat-Sen memorial Hospital Sun Yat-Sen UniversityGuangzhouChina Shanghai Institute of medical mycology Changzheng HospitalSecond Military Medical UniversityShanghaiChina 17 Basic Pathology DepartmentFederal University of ParanáStateCuritibaParanáBrazil

members of the family Chaetomiaceae are ubiquitous ascosporulating fungi commonly,which reside in soil enriched with manure or cellulosic *** role as human pathogens is largely ***,the ability of some species to grow at high temperature enables them to play an important role as opportunistic *** family contains several genera and species that have never been reported to cause human ***,three new species are described;two belong to the genus Subramaniula and one represents a Chaetomium *** asteroides was isolated from various sources including eye and skin infections as well as from the natural environment,and *** was isolated from a toe *** anamorphosum was isolated from a kidney transplant patient suffering from fungal *** species described were previously misidentified as Papulaspora *** to the formation of cellular clumps or bulbil-like structures,which are characteristic of *** isolates failed to form sexual fruit bodies and ascospores remained absent,which is an unusual feature for the generally ascosporulating genera Chaetomium and Subramaniula;minute conidia from phialides were sometimes observed.

关键词： Chaetomium Desert fungi Keratitis Papulaspora Peritonitis Sterile fungi Subramaniula

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双套冠固位可摘局部义齿的临床长期成功率研究间隙配合型双套冠的重要性

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中国口腔医学继续教育杂志 2006年第3期9卷 25-31页

作者： Hans-Jurgen Wenz Katrin Hertrampf axel Sonnenschein Klaus m. Lehmann 陈俊（译）冯海兰（校）不详北京大学口腔医学院北京海淀区中关村南大街22号100081

双套冠作为可摘义齿的固位装置已有十余年的历史。根据固位方式的不同可将双套冠分为以下3种：套筒冠（摩擦固位）、锥形双套冠（楔力固位）及间隙配合型双套冠（附加的固位装置）。尽管双套冠在临床上已得到广泛深入的应用．但迄今为... 详细信息

双套冠作为可摘义齿的固位装置已有十余年的历史。根据固位方式的不同可将双套冠分为以下3种：套筒冠（摩擦固位）、锥形双套冠（楔力固位）及间隙配合型双套冠（附加的固位装置）。尽管双套冠在临床上已得到广泛深入的应用．但迄今为止仅有少量的文献报道了双套冠修复体的长期成功率。本文对间隙配合型的marburg双套冠原理进行了研究。相对于其它类型的双套冠．marburg双套冠义齿是一种弹性支持型修复体。长期成功率研究表明．marburg双套冠系统的基牙脱落率5年为6％．10年为18％。如果基牙数量足够，所有不同类型的双套冠系统都可以达到这样好的预后效果。然而．刚性就位双套冠系统会增高基牙脱落率。研究表明．按照牙周病修复治疗理论设计的弹性支持型可摘义齿没有显著增高基牙脱落率．因此该设计可能有利于口内余留牙数量较少的情况。

关键词：双套冠修复体可摘局部义齿固位装置配合型 marburg双套冠系统间隙功率临床可摘义齿理论设计

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SmTA华南高科技技术研讨会论文浓度监控和闭环控制技术的优势

SMTA华南高科技技术研讨会论文浓度监控和闭环控制技术的优势

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2014中国高端SmT学术会议

作者： Umut Tosun m.S.Chem.Eng. axel Vargas 纪建光 ZESTRON America ManassasVirginiaUSA Pressure Products Company Inc.CharlestonWest VirginiaUSA ZESTRON中国

正如电子制造业中的其他生产流程一样,对清洗工艺中各个参数进行监控非常重要,只有在准确控制了工艺参数的前提下,方可确保工艺的可靠性、可重复性以及成本效率。清洗设备供应商们可以确保设备内液体的温度、压力、流量和清洗时间都得... 详细信息

正如电子制造业中的其他生产流程一样,对清洗工艺中各个参数进行监控非常重要,只有在准确控制了工艺参数的前提下,方可确保工艺的可靠性、可重复性以及成本效率。清洗设备供应商们可以确保设备内液体的温度、压力、流量和清洗时间都得到有效控制,但是目前的技术却很难实现对清洗液的浓度进行监控,如何有效控制清洗液浓度成为了业界一项难度极高的挑战。以往,手持式或是自动化的折光率测试仪经常被用来测试溶液的浓度。不可置否的是,当新鲜清洗液还未受到污染时,折光率的测试结果的确可以作为参考,但是随着污染物不断积累,清洗液中的残留物质越来越多,污染物将会对光的折射率产生影响使测试结果产生偏差,错误的读数进一步将影响整体工艺的稳定性。本文将阐述如何利用一种激动人心的新技术来构建闭环的浓度控制系统并精确测试混有助焊剂残留的水基清洗液的浓度。笔者将引用大量对比性的数据来说明这种新的工艺控制技术与传统测试相比展现出的优越性。

关键词：折光率清洗液浓度监控创新精确

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Diagnostic Performance of Five Rapid Serological Tests for SARS-CoV-2

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Open Journal of Epidemiology 2022年第4期12卷 470-480页

作者： Gilbert Ndziessi Jospeh axel Ngatse Fabien Roch Niama Henriette Poaty mayengue Pembe Issamou Fresnovie Geladore mbele Laure Stella Ghoma Linguissi Francine Ntoumi Department of Public Health Faculty of Health Sciences University Marien Ngouabi Brazzaville Republic of the Congo National Laboratory of Public Health Brazzaville Republic of the Congo National Research Institute on Health Sciences Brazzaville Republic of the Congo Fondation Congolaise pour la Recherche médicale Brazzaville Republic of the Congo

We conducted a study to evaluate the sensitivity (Se), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV) of five serologic tests. Subjects with negative or positive COVID-19 polymerase chain reaction (PRC) test results were tested with each of the serological tests. The results were compared with the reference PCR test. For the five tests evaluated, the Se ranged from 55.0% to 70.0% and the Sp ranged from 67.2% to 86.2%. PPV ranged from 53.2% to 80% and NPV from 75.0% to 86.2%. One test, the Wantai, had better specificity and sensitivity. None of the five tests had performance values of more than 90% in the entire sample. In symptomatic positive cases, the Wantai test reported excellent sensitivity. Overall, the low level of diagnostic performance of these tests does not support their use as an alternative to PCR for COVID-19 diagnostic. Test with better performance can be used for mass screening in low prevalence populations, to limit the indiscriminate use of PCR in context of resource-limited countries. Given the excellent sensitivity of Wantai in symptomatic cases, this test could be used as a referral test only in health facilities to discriminate suspected cases before PCR confirmation.

关键词： SARS-Cov-2 Seroprevalence Antibodies COVID-19 Congo

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A reference-guided TILLING by amplicon-sequencing platform supports forward and reverse genetics in barley

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Plant Communications 2022年第4期3卷 37-53页

作者： Congcong Jiang miaomiao Lei Yu Guo Guangqi Gao Lijie Shi Yanlong Jin Yu Cai axel Himmelbach Shenghui Zhou Qiang He Xuefeng Yao Jinhong Kan Georg Haberer Fengying Duan Lihui Li Jun Liu Jing Zhang manuel Spannagl Chunming Liu Nils Stein Zongyun Feng martin mascher Ping Yang Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijingChina College of Agronomy Sichuan Agricultural UniversityChengduChina Leibniz Institute of Plant Genetics and Crop Plant Research(IPK) SeelandGermany Institute of Botany Chinese Academy of SciencesBeijingChina Plant Genome and Systems Biology(PGSB) Helmholtz Center MunichGerman Research Center for Environmental HealthNeuherbergGermany

Barley is a diploid species with a genome smaller than those of other members of the Triticeae tribe,making it an attractive model for genetic studies in Triticeae *** recent development of barley genomics has created a need for a high-throughput platform to identify genetically uniform mutants for gene function *** this study,we report an ethyl methanesulfonate(EmS)-mutagenized population consisting of 8525m_(3) lines in the barley landrace“Hatiexi”(HTX),which we complement with a high-quality de novo assembly of a reference genome for this *** mutation rate within the population ranged from 1.51 to 4.09 mutations per megabase,depending on the treatment dosage of EmS and the mutation discrimination platform used for genotype *** implemented a three-dimensional DNA pooling strategy combined with multiplexed amplicon sequencing to create a highly efficient and cost-effective TILLING(targeting induced locus lesion in genomes)platform in *** were successfully identified from 72 mixed amplicons within a DNA pool containing 64 individual mutants and from 56 mixed amplicons within a pool containing 144 *** discovered abundant allelic mutants for dozens of genes,including the barley Green Revolution contributor gene Brassinosteroid insensitive 1(BRI1).As a proof of concept,we rapidly determined the causal gene responsible for a chlorotic mutant by following the mutmap strategy,demonstrating the value of this resource to support forward and reverse genetic studies in barley.

关键词： barley mutagenesis TILLING amplicon-seq genetics

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基于最大剩余能量的簇头选取方法(英文)

基于最大剩余能量的簇头选取方法(英文)

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2005年中国农业工程学会学术年会

作者：王卫星 axel Jantsch 宋淑然华南农业大学工程学院瑞典皇家工学院电子与计算机系统实验室华南农业大学工程学院

考虑在测量作物冠层温度,进行基于作物水分胁迫指数（CWSI）的研究时,红外测温仪的安装高度应是作物冠层上方 1m 处,因此本文提出一种正六边形的传感器节点分布方案。为了获得无线传感器网络的最大寿命,提出了基于节点最大剩余能量的竞... 详细信息

考虑在测量作物冠层温度,进行基于作物水分胁迫指数（CWSI）的研究时,红外测温仪的安装高度应是作物冠层上方 1m 处,因此本文提出一种正六边形的传感器节点分布方案。为了获得无线传感器网络的最大寿命,提出了基于节点最大剩余能量的竞选簇头方法。通过 ns-2 程序模拟,得到了不同节点电能损耗下的簇头竞选参数θ,以及第一个节点死亡和最后一个节点死亡两种情况下的网络生存时间。结果表明,θ值虽节点能量消耗速度降低而减小。

关键词：无线传感器网络剩余能量簇头生存时间作物水分胁迫指数(CWSI)

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Preclinical Evaluation of CD40-Directed Immunotherapy in B-Cell Lymphoma Using [<sup>18</sup>F]Fluorothymidine-PET

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Advances in molecular Imaging 2015年第2期5卷 17-28页

作者： Nicolas Graf Zhoulei Li Ken Herrmann michaela Aichler Jolanta Slawska axel Walch Christian Peschel markus Schwaiger Andreas K. Buck Tobias Dechow Ulrich Keller III. medical Department of Hematology and medical Oncology Technische Universitat München Munich Germany Department of Nuclear medicine Technische Universitat München Munich Germany Department of Nuclear medicine Universitat Sklinikum Würzburg Würzburg Germany Institute of Pathology—Analytical Pathology Helmholtz Zentrum München Neuherberg Germany German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ) Heidelberg Germany

Background: Inhibition of the lymphoma surface antigen CD40 by the antagonistic CD40 antibody NVP-HCD122 (HCD122) demonstrates activity in various lymphoma subtypes. In this preclinical in vivo study we examined the suitability of positron emission tomography (PET) using the thymidine analogue 3’-deoxy-3’-[18F]fluorothymidine (FLT) for early response assessment upon HCD122 treatment in diffuse large B cell lymphoma (DLBCL). methods: Immunodeficient mice bearing human DLBCL xenografts (SU-DHL-4) received weekly intraperitoneal injections of HCD122. Tumor growth was followed up until Day 14. molecular imaging with FLT-PET was performed before (Day 0) and after start of therapy (Day 2 and Day 7). On Day 14 lymphoma xenografts were explanted for immunohistochemical analysis to correlate PET findings with CD40 surface expression on tumor tissue. Results: Treatment with HCD122 significantly delayed tumor growth resulting in a tumor growth inhibition of 45% on Day 14. Significant reduction of tumor-to-background ratio (TBR) of FLT-PET was seen in treated animals on Day 7 and preceded change of tumor volume, thus predicting therapy response to HCD122. Immunohistochemical analysis of xenografts revealed significantly higher CD40 expression on treated than on untreated tissue. moreover, we found a significant correlation between CD40 expression and FLT-PET response for xenograft tumor treated with HCD122. Conclusions: Treatment of DLBCL with the antagonistic CD40 antibody HCD122 can be monitored with FLT-PET as early as seven days after commencement of therapy and seems to increase CD40 expression on tumor tissue.

关键词： CD40 Antibody FLT-PET Lymphoma Therapy monitoring

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塔里木中奥陶瓶筐石-微生物礁格架之剖析

塔里木中奥陶瓶筐石-微生物礁格架之剖析

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2015年全国沉积学大会

作者：李启剑李越张元动 axel munnecke 埃尔朗根-纽伦堡大学中国科学院南京地质古生物研究所

含瓶筐石(Calathiμm)的生物礁在早奥陶世的浅海广泛分布,但在随后的的中奥陶世迅速衰落。在我国西北的塔里木巴楚地区,达瑞威尔阶(Darriwilian)的一间房组中部保存了同时代鲜见的瓶筐石-微生物礁。在一间房组的标准剖面(40°08’37"N,7... 详细信息

含瓶筐石(Calathiμm)的生物礁在早奥陶世的浅海广泛分布,但在随后的的中奥陶世迅速衰落。在我国西北的塔里木巴楚地区,达瑞威尔阶(Darriwilian)的一间房组中部保存了同时代鲜见的瓶筐石-微生物礁。在一间房组的标准剖面(40°08’37"N,78°49’31"E),出露了保存良好的几个点礁,高1m,直径28m。围岩由生屑颗粒灰岩(bioclastic grainstones)构成。采自礁核的样品显示,其礁灰岩可分为3大类:(1)瓶筐石-微生物格架岩(Calathiμm–microbial floatstone),(2)棘皮类-瓶筐石障积岩(echinoderm-Calathiμm bafflestone),和(3)苔藓虫-微生物粘结岩(bryozoan–microbial bindstone)。瓶筐石-微生物格架岩作为主导类型,是由瓶筐石构建并被微生物加固的三维礁格架。虽然大量瓶筐石个体程倒伏状态保存,但是个体间由发达的壁外结构(outgrowths)相连,显示其高效的造架能力。连续切片揭示瓶筐石的出芽生殖(budding reproduction)现象,表明其海绵动物的属性。与早奥陶的石海绵-瓶筐石相比,此礁内石海绵十分罕见,苔藓虫虽然丰度也不高,但却是附着于瓶筐石表面最重要的包壳动物(non-microbial encrusters)。巴楚这一瓶筐石-微生物礁的案例证明瓶筐石类(calathids)海绵至少在中奥陶之末仍在局部地区发挥着重要的造礁作用。

关键词：瓶筐石微生物岩塔里木中奥陶生物礁

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Honey Dressing of Cutaneous Wounds on Limbs in the Traumatology Orthopaedics Department of Bouaké University Hospital

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Open Journal of Orthopedics 2024年第9期14卷 411-420页

作者： Achié Jean-Régis Akobe Aya Adélaide Natacha Kouassi Ibrahim Soumahoro Zolopégué marcel Soro Sedy Louess De Randolphe Akpro Bakary Traoré Almamy Kamate axel Fabrice Essehin Yao Aboh Ganyn Robert Arnaud Assere Lanciné Kaba Kouamé Innocent m’bra Loukou Blaise Yao Bada Justin Léopold Niaoré Sery Koffi Léopold Krah michel Kodo Orthopaedics-Traumatology Department of the University Hospital of Bouak Bouak Ivory Coast Plastic and Reconstructive Surgery Department of the University Hospital of Bouak Bouak Ivory Coast

The study evaluated the effectiveness of honey dressings in healing recent skin wounds with soft tissue loss on limbs. Conducted over a year with 60 patients, results showed a significant reduction in wound size and early healing, with complete recovery on average within 29 days. The study supports honey as a viable wound treatment.

关键词： Healing Honey Limbs Loss of Substances

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Neoadjuvant Therapy for Locally Advanced Renal Cell Carcinoma with Sorafenib in a Reference Center in mexico

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Surgical Science 2011年第6期2卷 356-359页

作者： axel Costilla-montero Benjamín Guadarrama-Benítez marco A. Aragón-Castro Omar morales-Ordaz Rubén Gutiérrez-Rosales Claudia Carrillo-Ponce marcela Janka-Zires Luis Gabriel Vázquez-Lavista Departament of Urology Centro médico ISSEmYm Toluca Toluca México

Background: neo - adjuvant therapy is usually indicated in locally advanced tumors, the aim is to decrease the tumoral burden and enhance overall survival. Renal cell carcinoma is a chemo and radio resistant neoplasm and this type of approach is not as effective as in other solid tumors. On the other hand immunotherapy is indicated in metastatic disease, demonstrating a better overall survival. Sorafenib is an antiangiogenic drug approved for locally advanced or metastatic RCC. We postulated that it can be used in a neoadjuvant way to decrease the vascularization of selected tumors. Report of the case: 57 years old male referred to our service with a right renal mass and metastatic disease to lumbar spine and suprarenal gland. He was treated with three months of sorafenib previous to the surgery. Results: The patient went into surgery three months after initiating the antiangiogenic drug, during the surgery we found less neo-formance vessels;the dissection was subjectively easier, due to peri-renal edema. The pathologic analysis of the specimen was renal cell carcinoma. Interestingly, 40% of central ischemic (coagulative) necrosis was found. Conclusion: There are no neoadjuvant drugs accepted for the treatment of renal cell carcinoma;using an antiagiogenic drug to decrease the vascular burden characteristic of this type of tumors could be a viable option in selected cases. We used a lower dose of the drug with an acceptable safety profile.

关键词： Renal Cell Carcinoma Antiagiogenic Drugs Neoadyvant Therapy Sorafenib

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