Diagnostic Performance of Five Rapid Serological Tests for SARS-CoV-2
Diagnostic Performance of Five Rapid Serological Tests for SARS-CoV-2作者机构：Department of Public Health Faculty of Health Sciences University Marien Ngouabi Brazzaville Republic of the Congo National Laboratory of Public Health Brazzaville Republic of the Congo National Research Institute on Health Sciences Brazzaville Republic of the Congo Fondation Congolaise pour la Recherche Médicale Brazzaville Republic of the Congo
出 版 物：《Open Journal of Epidemiology》 (流行病学期刊（英文）)
年 卷 期：2022年第12卷第4期
页 面：470-480页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：SARS-Cov-2 Seroprevalence Antibodies COVID-19 Congo
摘 要：We conducted a study to evaluate the sensitivity (Se), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV) of five serologic tests. Subjects with negative or positive COVID-19 polymerase chain reaction (PRC) test results were tested with each of the serological tests. The results were compared with the reference PCR test. For the five tests evaluated, the Se ranged from 55.0% to 70.0% and the Sp ranged from 67.2% to 86.2%. PPV ranged from 53.2% to 80% and NPV from 75.0% to 86.2%. One test, the Wantai, had better specificity and sensitivity. None of the five tests had performance values of more than 90% in the entire sample. In symptomatic positive cases, the Wantai test reported excellent sensitivity. Overall, the low level of diagnostic performance of these tests does not support their use as an alternative to PCR for COVID-19 diagnostic. Test with better performance can be used for mass screening in low prevalence populations, to limit the indiscriminate use of PCR in context of resource-limited countries. Given the excellent sensitivity of Wantai in symptomatic cases, this test could be used as a referral test only in health facilities to discriminate suspected cases before PCR confirmation.
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