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Traditional uses,phytochemistry and pharmacology of Clerodendron glandulosum Coleb - a review

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Asian Pacific Journal of Tropical Medicine 2012年第1期5卷 1-6页

作者： Ravirajsinh N Jadeja Menaka C Thounaojam Thouchom Brojendro Singh Ranjitsinh v Devkar av Ramachandran Division of Phytotherapeutics and Metabolic Endocrinology Department of ZoologyFaculty of ScienceThe MS University of BarodaVadodara-390002GujaratIndia Department of Chemistry Oriental CollegeImphal-795001ManipurIndia

Present review for the first time provides a complete botanical description and information on ethnomcdicinal uses of Clerodendron ***(CG:***).Recent studies conducted from our laborator) provide pharmacological evidence for its anti-hypertensive,antidiabetic and anti-obesity ***,its beneficial potential in preventing in vitro and in vivo non-alcoholic steatohepatitis and atherosclerosis and potent hcpatoprotective and free radical scavenging abilities along with its acute and sub- chronic toxicologiesl evaluations are also reported from our *** keeping with its traditional uses,CG extract was capable of ameliorating experimentally induced hypertension,diabetes and *** beneficial potential against NASH induced oxidative stress and atherosclerosis can be attributed to its potent free radical scavenging ***—toxic nature of CG leaf extract further provides added merit to its reported pharmacological *** present review summarizes the pioneering scientific evidence for the pharmacological effects of CG against related metabolic disorders like hypertension,diabetes and obesity along with anti oxidant potential and beneficial elicits against non alcoholic steatohepatitis.

关键词： Clerodendron glandulosum.Coleb Hypertension Hyperlipidemia Insulin resistance Obesity Atherosclerosis

Machine learning for predicting the outcome of terminal ballistics events

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Defence Technology（防务技术） 2024年第1期31卷 14-26页

作者： Shannon Ryan Neeraj Mohan Sushma Arun Kumar av Julian Berk Tahrima Hashem Santu Rana Svetha venkatesh Applied Artificial Intelligence Institute(A2I2) Deakin University75 Pigdons RdWaurn PondsVIC3216Australia

Machine learning(ML) is well suited for the prediction of high-complexity,high-dimensional problems such as those encountered in terminal *** evaluate the performance of four popular ML-based regression models,extreme gradient boosting(XGBoost),artificial neural network(ANN),support vector regression(SvR),and Gaussian process regression(GP),on two common terminal ballistics’ problems:(a)predicting the v50ballistic limit of monolithic metallic armour impacted by small and medium calibre projectiles and fragments,and(b) predicting the depth to which a projectile will penetrate a target of semi-infinite *** achieve this we utilise two datasets,each consisting of approximately 1000samples,collated from public release *** demonstrate that all four model types provide similarly excellent agreement when interpolating within the training data and diverge when extrapolating outside this *** extrapolation is not advisable for ML-based regression models,for applications such as lethality/survivability analysis,such capability is *** circumvent this,we implement expert knowledge and physics-based models via enforced monotonicity,as a Gaussian prior mean,and through a modified loss *** physics-informed models demonstrate improved performance over both classical physics-based models and the basic ML regression models,providing an ability to accurately fit experimental data when it is available and then revert to the physics-based model when *** resulting models demonstrate high levels of predictive accuracy over a very wide range of projectile types,target materials and thicknesses,and impact conditions significantly more diverse than that achievable from any existing analytical *** with numerical analysis tools such as finite element solvers the ML models run orders of magnitude *** provide some general guidelines throughout for the development,application,and reporting of ML models in terminal ballist

关键词： Machine learning Artificial intelligence Physics-informed machine learning Terminal ballistics Armour

Treatment of children with neurogenic bladder dysfunctions using dynamic nero-electrostimulation(DENS) and M-Cholinolytic therapy

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中国现代医学杂志 2013年第2期23卷 13-16页

作者： Zubarenko av Stoeva Nv Godlevska TL Department of Pediatrics Odessa National Medical University(rector-academic of NAMS in UkraineProfessor Zaporozhan V.N.)Valikhovsky lane 2Kyiv 65082Ukraine

【Objective】 To investigate effects of combined usage of dynamic neuro-electric stimulation(DNES) and M-cholynolytic therapy(oxybutynin) upon manifestations of neurogenic bladder dysfunctions(NBD) in children.【Method】 Urodynamics examination included registration of extemporaneous urinary excretion,urofluometry,and retrograde cytometry in horizontal and vertical position by example of urodynamic system(UDS) ACS 180 Plus(MENFIS BioMed.,USA).In accordance to severity of clinician manifestations,three groups of patients have been defined(27-highest one,49-middle and 51 low levels).Dynamic neuro-electrostimulation(DNES) procedures were conducted using the"DiaDNES-PKM"device(Russian Federation).The children were exposed to juxtaspinal stimulation on S1-S3 level-altogether 10 sessions have been ***(driptan) was used in dosage of 2.5 mg per diem.【Result】It was established that combined usage of DNES and oxybutynin in the group with highest severity caused the reduction of manifestations by 3.1 times while separately given DNES and basic therapy were followed by 34.1% and 28.0% reduction ***,DNES and oxybutynin reduced severity in patients with pronounced disturbances by 7.5 *** usage of oxybutynin and DNES in severely manifested NBD increased the effective volume of bladder by 2.3 *** significant reduction of both intrabladder pressure(by 48.0%) and compliance of the bladder(by 4.8 times) were detected under condition of combined usage of DNES and *** mentioned indices were modified to less extent in case of separate usage of DNES or oxybutynin when compared with the one registered after the combined their usage(P ve in most severe cases in children suffered from neurogenic overactive bladder.

关键词：医学临床诊断疾病

中低收入国家中,从乡村到城市人口迁移对心血管风险因子的影响

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中华高血压杂志 2012年第3期20卷 285-286页

作者： Hernández av Pasupuleti v Deshpande A Bernabé-Ortiz A Miranda JJ 叶鹏机构不详

以往关于中低收入国家人口迁移的研究在试验设计和患者特征方面大不相同,难以就迁移对心血管病风险的影响达成一致性结论。目前尚不知这种迁移对各种心血管风险因子的影响是否一致。

关键词：中低收入国家人口迁移风险因子心血管病乡村城市试验设计一致性

Bedrock outcropping in the accumulation zone of the largest glacier in Mexico(Glaciar Norte of Citlaltépetl),as evidence of a possible accelerated extinction

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Journal of Mountain Science 2023年第2期20卷 338-354页

作者： SOTO víctor Colegio de Geografía Facultad de EconomíaUniversidad VeracruzanaAv.Xalapa s/nObrero Campesina91020XalapaVer.México

The highest volcano in Mexico,at the same time the third largest mountain in North America(Citlaltépetl,5610 m a.s.l.),is home to the largest glacier in the *** of the extinction of the Popocatépetl glacier(5500 m a.s.l.)caused by eruptive activity,and the almost disappearance of the Iztaccíhuatl glaciers(5220 m a.s.l.)due to the lower elevation of the mountain,the Glaciar Norte of Citlatépetl has been the only glacier that has shown a certain degree of stability as a response to the altitude in which it is ***,as occurs in almost all glaciers on the planet,the retreat of its glacier terminus has been ***,during the last years the thickness of its upper part began to decrease rapidly until its bedrock was exposed for the first time in *** to its ecosystem importance and because it is the main glacier in Mexico,as well as the only one in the world located at latitude 19°N,in this work its current dimensions are updated,as well as the local climatology that governs the current state of the glacier is pointed *** study was based on the analysis of high-resolution Sentinel-2 optical images,as well as through Sentinel-1 SAR images,with the support of climatological information from the study ***,the outcropping of the bedrock in the accumulation zone and the consequent horizontal retreat of the upper part of the glacier are documented;at the same time,the decrease in the thickness of the ice along it is *** rocky outcrop in the accumulation zone suggests that the flow dynamics of the ice towards the ablation zone will be considerably less,accelerating the retreat of the glacier ***,the ascent of the glacial front to 5102 m *** the modelled altitude of the equilibrium line to 5276 m *** reported as a warning signal in terms of snow catchment and mass balance;likewise,the decrease of 23%of its surface is also indicated regarding the surface reduction monitoring that has been done

关键词： Bedrock outcrop Citlaltépetl glacier Glacial accumulation zone Glacier retreat Glacial thickness

Cladophora mats in a Crimean hypersaline lake:structure,dynamics,and inhabiting animals

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Journal of Oceanology and Limnology 2018年第6期36卷 1930-1940页

作者： Alexandr v.PRAZUKIN Elena v.ANUFRIIEvA Nickolai v.SHADRIN The A.O.Kovalevsky Institute of Marine Biological Research of RAS 2 Nakhimov Av.Sevastopol 299011Russia

Filamentous green algae play an important functional role in element cycling and productivity in the diff erent water bodies. In hypersaline lakes and lagoons of the Crimea, filamentous green algae are present and form bottom and floating mats that occupy large areas with high biomass, up to 4–5 kg(wet biomass)/m2. Cladophora spp. dominated in those mats. Five species of filamentous green algae(Chlorophyta) in Lake Chersonesskoye: C ladophora vadorum(Aresch.) Kütz., C. siwaschensis C. Meyer, C. echinus(Biasol.) Kütz., Ulothrix implexa(Kütz.) Kütz., Rhizoclonium tortuosum(Dillw.) Kütz., and seagrass(Angiospermae) R uppia cirrhosa(Petagna) Grande were found. Cladophora spp. and R. cirrhosa were found in the lake throughout the year, other types of algae were encountered episodically. In most cases the biomass of bottom mat exceeded that of the floating mat. In general, the total biomass of the bottom and floating mats in the lake areas at depths up to 30 cm was in a stable range of values from 100 to 290 mg(dry weight)/cm2. Animal and infusorian average abundance in mats reach high values: infusorians—up to 15 000 000 ind./m2, Cletocamptus retrogressus(Copepoda, Harpacticoida)—up to 730 000 ind./m2, Eucypris mareotica(Ostracoda)—up to 91 000 ind./m2 and Chironomidae larvae(Insecta, Diptera)—up to 140 ind./m2. Those values were much higher than in the plankton.

关键词： green algae mats hypersaline lake photosynthesis invertebrates

青少年和青年肿瘤患者的化疗：远期副作用的管理

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英国医学杂志中文版 2017年第1期20卷 42-50页

作者： Saif S Ahmad Marika av Reinius Helen M Hatcher Thankamma vAjithkumar 黎立喜马飞 Department of Oncology Addenbrooke's Hospital Cambridge University Hospitals NHS Foundation Trust MRC Cancer Unit University of Cambridge Cambridge Biomedical Campus 中国医学科学院肿瘤医院

癌症是西方国家青少年和青年中与疾病相关死亡的主要原因。在英国，癌症分别占青少年和青年中男性和女性死亡人数的9％和15％，并且从20世纪90年代中期以来，癌症发病率上升了19％，从2011年至2013年平均每年新增2300例癌症患者。在日... 详细信息

癌症是西方国家青少年和青年中与疾病相关死亡的主要原因。在英国，癌症分别占青少年和青年中男性和女性死亡人数的9％和15％，并且从20世纪90年代中期以来，癌症发病率上升了19％，从2011年至2013年平均每年新增2300例癌症患者。在日本，从2000年至2006年，因癌症死亡的人数达到近7000人。

关键词：青少年肿瘤患者化疗

Incretin manipulation in diabetes management

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World Journal of Diabetes 2015年第6期6卷 774-781页

作者： Joseph M Pappachan av Raveendran Rajagopalan Sriraman Department of Endocrinology and Diabetes New Cross Hospital the Royal Wolverhampton Hospital NHS Trust Department of Medicine Kottayam Medical College Department of Endocrinology Lincoln County Hospital

Incretin-based therapies have revolutionized the medical management of type 2 diabetes mellitus(T2DM) in the 21 st century. Glucagon-like peptide-1(GLP-1) suppresses appetite and gastric motility, and has trophic effects on pancreas, cardio-protective and renal effects. GLP-1 analogues and dipeptidyl peptidase-4 inhibitors form the incretin-based therapies. Significant reduction of hemoglobin A1 c when used as monotherapy and in combination regimens, favorable effects on body weight, and low risk of hypoglycemia are their unique therapeutic benefits. Their safety and tolerability are comparable to other anti-diabetic medications. Concern about elevated risk of pancreatitis has been discarded by two recent meta-analyses. This article discusses the therapeutic manipulation of incretin system for the management of T2 DM.

关键词： Incretin hormones Incretin-based therapies Glucagon-like peptide-1 analogues Dipeptidyl peptidase-4inhibitors Pancreatitis

A-site ordered state in manganites with perovskite-like structure based on optimally doped compounds Ln0.70Ba0.30MnO3（Ln=Pr,Nd）

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Journal of Rare Earths 2019年第11期37卷 1242-1249页

作者： S.v.Trukhanov vA Khomchenko D.v.Karpinsky M.v.Silibin A.v.Trukhanov L.S.Lobanovsky H.Szymczak C.E.Botez I.O.Troyanchuk National University of Science and Technology MISiS 119049 MoscowLeninsky Av.4Russia South Ural State University 454080 ChelyabinskLenin Av.76Russia Scientific-Practical Materials Research Centre of NASB 220072 MinskBelarus CFisUC Department of PhysicsUniversity of Coimbra3004-516 CoimbraPortugal National Research University of Electronic Technology"MIET 124498 ZelenogradMoscowRussia Institute for Bionic Technologies and Engineering I.M.Sechenov First Moscow State Medical University2-4 Bolshaya Pirogovskaya St.119991 MoscowRussia Institute of Physics Polish Academy of Sciences02-668 WarsawPoland The University of Texas at El Paso El PasoTX 79968-0515USA

In this paper,we report on the crystal structure and magnetic properties of the nano structured Baordered phases of rare-earth manganites obtained from the optimally doped solid solutions Ln0.70Ba0.30MnO3(Ln=Pr,Nd).The materials were studied by X-ray diffraction,scanning electron microscopy,energy dispersive spectroscopy and SQUID-magnetometry *** is found that states with different degrees of cation ordering in the A-sublattice of the ABO3 perovskite can be obtained by employing special conditions of chemical *** particular,reduction of the parent compounds results in the formation of a nanocomposite containing ferrimagnetic anion-deficient ordered phase *** of the composite does not change an average size of the nanocrystallites,but drastically alters their phase composition to stabilize ferromagnetic stoichiometric ordered phase LnBaMn2O6 and ferromagnetic superstoichiometric disordered phase Ln0.90Ba0.10MnO3+δ.It is shown that the magnetic properties of the materials are determined by the joint action of chemical(cation ordering)and external(surface tension)pressures.

关键词： Ionic order Magnetic transition Perovskite Manganite Rare earths