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Zwitterionic peptides:Tunable next-generation stealth nanoparticle modifications

Bioactive Materials 2023年第9期27卷 113-124页

作者： Clyde Overby Soomin Park austin summers Danielle S.W.Benoit Department of Biomedical Engineering University of Rochester RochesterNYUSA Center for Musculoskeletal Research University of RochesterRochesterNYUSA Department of Biology University of Rochester RochesterNYUSA Department of Biology Duquesne UniversityPAUSA Department of Chemical Engineering University of RochesterRochesterNYUSA Materials Science Program University of RochesterRochesterNYUSA Knight Campus for Accelerating Scientific Impact Department of BioengineeringUniversity of OregonEugeneORUSA

Adsorption of proteins to nanoparticles(NPs),a complex process that results in a protein corona,is controlled by NP surface properties that define NP interactions in *** to control adsorbed protein quantity through surface modification have led to improvements in circulation time or ***,current approaches have yet to be identified to control adsorbed protein identities within the ***,we report the development and characterization of diverse zwitterionic peptides(ZIPs)for NP anti-fouling surface functionalization with specific and controllable affinity for protein adsorption profiles defined by ZIP *** serum exposure of ZIP-conjugated NPs and proteomics analysis of the resulting corona,we determined that protein adsorption profiles depend not on the exact composition of the ZIPs but on the sequence and order of charges along the sequence(charge motif).These findings pave the way for developing tunable ZIPs to orchestrate specific ZIP-NP protein adsorption profiles as a function of ZIP charge motif to better control cell and tissue specificity and pharmacokinetics and provide new tools for investigating relationships between protein corona and biological ***,overall ZIP diversity enabled by the diversity of amino acids may ameliorate adaptive immune responses.

关键词： Nanoparticles Protein corona Surface functionalization Peptide design Cellular uptake

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A virtual framework of robotic SWARM testbed

A virtual framework of robotic SWARM testbed

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2009中国控制与决策会议

作者： Tyler H.summers The University of Texas at austin AustinTexas78712USA

＜正＞A robotic SWARM testbed is presented in a companion paper,as complementarities,we present a virtual framework of this robotic SWARM testbed for the same *** similarities of these two approaches are both trying to implement formation control algorithms onto robots and generate certain criteria to adapt the algorithms to the dynamics of the *** to the physical testbed,this virtual framework has a lot of *** instance, the agents can be either any kind of commercialized robots or even the ones not existing that we can design by our own, which means it could have some advanced features,such as self localization capability and global knowledge of their *** are demonstrated using an example of coordinated standoff tracking ***,a virtual framework enables provision of co-simulation capability which is critical for SWARM testbed

关键词： Robotic testbed Formation Control

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Testing for selection on color and pattern in a mimetic radiation

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Current Zoology 2012年第4期58卷 668-676页

作者： Justin YEAGER Jason L. BROWN Victor MORALES Molly CUMMINGS Kyle summers Department of Biology East Carolina University Greenville NC 27858 Department of Ecology and Evolutionary Biology Tulane University New Orleans LA 70118 Department of Biology Duke University Durham NC 27708 Universidad de Ricardo Palma Lima Peru Department of Integrative Biology University of Texas Austin Texas 78712

In this paper, we analyze variation in spectral reflectance and color pattern among populations to demonstrate dra-matic divergence between four distinct morphs of the mimic poison frog Ranitomeya imitator. We also analyze genetic diver-gence in d-loop mtDNA sequences between populations. We then use coalescent-based simulations to demonstrate that the high levels of observed phenotypic divergence are not consistent with levels of genetic divergence expected under neutral drift among populations, implying an important role for selection in driving divergence between these populations .

关键词： Mullerian Mimicry Natural Selection Population Divergence Coalescent

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