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Identification of JAK2(V617F) Mutation in Myeloproliferative Neoplasms by Using Allele Specific Polymerase Chain Reaction (AS-PCR)

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American Journal of Molecular Biology 2020年第4期10卷 273-282页

作者： Khin La Pyae Tun aung zaw latt Win Pa Pa Naing San San Htwe Yamin Ko Ko Win Win Mar San Yu Hlaing Wai Wai Han Sein Win Department of Medical Research Yangon Myanmar Department of Clinical Haematology Yangon General Hospital Ministry of Health and Sports Nay Pyi Taw Myanmar

Myeloproliferative neoplasms (MPNs) are a group of clonal haematopoietic stem cell disorders characterized by the proliferation of one or more myeloid cell lineages. According to WHO classification, the Janus associated kinase 2 (JAK2) V617F mutation is one of the major diagnostic criteria in BCR-ABL1 negative myeloproliferative neoplasms. The aim of this study is to detect the JAK2 (V617F) mutation in patients with myeloproliferative neoplasms to get accurate diagnosis and proper management. A total of 90 clinically diagnosed MPN patients attending to Department of Clinical Haematology, Yangon General Hospital were enrolled in this study. The mean age was 53.4 ± 14 years which ranged from 16 to 81 years old and male and female ratio was 2.4:1. The identification of JAK2 (V617F) point mutation was found to be positive in 44/90 MPN patients (48.9%). According to MPN subtypes, the JAK2 mutation positivity was found in 19 out of 46 polycythemia vera patients (41.3%), 17 out of 25 essential thrombocythemia patients (68%), 8 out of 15 primary myelofibrosis patients (53.3%), 0 of 4 others myeloproliferative neoplasms (0%). Confirmation of each of nine JAK2 mutation positive and negative samples was done by Sanger sequencing. The arterial or venous thrombotic attack was found in 32/44 JAK2 mutation positive cases (72.7%) and 12/44 JAK2 mutation negative cases (27.3%). The association between thrombotic attack and presence of JAK2 mutation was statistically significance with p = 0.000. The diagnosis of myeloproliferative neoplasms mainly relies on the molecular genetics according to WHO classification. The Allele specific PCR reaction is sensitive, simple test and relatively cost-effective. Therefore, the identification of JAK2 (V617F) somatic point mutation by AS-PCR should be implemented as

关键词： Myeloproliferative Neoplasms JAK2 (V617F) Allele-Specific PCR

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Qualitative Analysis of a Belousov–Zhabotinskii Reaction Model

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Acta Mathematica Sinica,English Series 2018年第6期34卷 975-991页

作者： aung zaw MYINT Li LI Ming Xin WANG Department of Mathematics Harbin Institute of Technology

This paper deals with one kind of Belousov-Zhabotinskii reaction model. Linear stability is discussed for the spatially homogeneous problem firstly. Then we focus on the stationary problem with diffusion. Non-existence and existence of non-constant positive solutions are obtained by using implicit function theorem and Leray-Sehauder degree theory, respectively.

关键词： Belousov-Zhabotinskii reaction stability positive stationary solutions

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The effect of pharmaceutical care in the elderly patients with type 2 diabetes mellitus

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 93-94页

作者： Win Myat Maw Mi Mi Saw Theingi Kyaw Khin Ohnmar Kyaing zaw Min latt Kyawzaw Lin aung PyaePhyo No(2)Military Hospital(500-Bedded) YangonMyanmar University of Pharmacy YangonMyanmar Defence Services Medical Academy YangonMyanmar Military Institute of Nursing and Paramedical Sciences YangonMyanmar

Pharmaceutical care plays a crucial role in reducing mortality and morbidities of the patients.A hospital based quasiexperimental study was conducted with elderly patients with type 2 diabetes who attended at the diabetes clinic of No.(2)Military Hospital(500-Bedded)in Myanmar from April 2013 to February *** aim of this study was to evaluate the effect of pharmaceutical care in elderly patients with type 2 diabetes mellitus.A total of 52 respondents enrolled in this *** clinical outcomes and quality of life of patients before and eight months after intervention were *** care program was implemented as *** the total number of respondents,52 drug related problems were identified.

关键词： Pharmaceutical care Type 2 diabetes mellitus Quality of life Clinical outcomes

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Effects of Integrated Organic and Inorganic Fertilizers on Yield and Growth Parameters of Rice Varieties

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Rice science 2019年第5期26卷 309-318页

作者： Kyi MOE Seinn Moh MOH aung zaw HTWE Yoshinori KAJIHARA Takeo YAMAKAWA Plant Nutrition Laboratory Graduate School of Bioresource and Bioenvironmental SciencesFaculty of AgricultureKyushu University6-10-1 HakozakiHigashi-kuFukuoka 812-8581Japan Department of Agronomy Yezin Agricultural UniversityYezinNay Pyi Taw 15013Myanmar University Farm School of AgricultureKyushu UniversityFukuoka 812-8581Japan Plant Nutrition Laboratory Division of Molecular BiosciencesDepartment of Biosciences and BiotechnologyFaculty of AgricultureKyushu University6-10-1 HakozakiHigashi-kuFukuoka 812-8581Japan

We investigated the effects of integrated organic and inorganic fertilizers on the growth and yield of indica rice variety Manawthukha and japonica rice variety *** a split-plot design,the two rice varieties were assigned as main plot factors,and the integrated treatments were the subplot factors,including no-N fertilizer(N0),50%chemical fertilizer(CF)(CF50),100%CF(CF100),50%CF+50%poultry manure(PM)(CF50PM50),50%CF+50%cow manure(CM)(CF50CM50),and 50%CF+50%compost(CP)(CF50CP50).CF100 was equivalent to N at 85 kg/*** was applied based on the estimated mineralizable nitrogen(EMN)level,which is dependent on total N(%)of each manure *** rice plants were taller with higher tiller number and dry matter ***,higher soil-plant analysis development(SPAD)values were measured in Genkitsukushi throughout the crop growth period,resulting in higher seed-setting rate(%)and greater *** the same N level,CF50PM50 application in both rice varieties resulted in higher SPAD values,plant height and tiller number than ***50PM50 containing total N more than 4%supplied synchronized N for the demands of the rice plants,resulting in maximum dry matter,yield and yield ***50CM50 and CF50CP50 treatments containing total N less than 4%resulted in lower yields which were similar to *** results indicated that integrating organic and inorganic fertilizers enhanced growth parameters and yields of Manawthukha and Genkitsukushi,while reducing the dose of chemical fertilizer.

关键词： estimated mineralizable nitrogen growth parameter inorganic fertilizer organic manure rice yield

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双体量子系统的算子权并发度

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北京理工大学学报 2020年第6期40卷 687-690页

作者： aung Khaing zaw 刘锴蒋立宁北京理工大学数学与统计学院北京100081

在Hilbert空间算子理论基础上,通过量子态的约化密度矩阵给出了双体量子系统中算子权并发度的定义,并讨论了其在判断量子态可分性上的有效性.同时研究了此类加权并发度和系统信道的相容性及相关性质.

关键词：量子纠缠算子权并发度量子信道

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Low-Density Co-Inoculation with Bradyrhizobium japonicum SAY3-7 and Streptomyces griseoflavus P4 Promotes Plant Growth and Nitrogen Fixation in Soybean Cultivars

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American Journal of Plant Sciences 2016年第12期7卷 1652-1661页

作者： aung zaw Htwe Takeo Yamakawa Laboratory of Plant Nutrition Graduate School of Bioresource and Bioenvironmental Sciences Faculty of Agriculture Kyushu University Fukuoka Japan Department of Agronomy Yezin Agricultural University Yezin Myanmar

Inoculation density has a marked effect on nodulation and N fixation in soybean (Glycine max L.). Therefore, we conducted this study to determine the optimal inoculation density of Bradyhizobium japonicum SAY3-7 (SAY3-7) and Streptomyces griseoflavus P4 (P4) for plant growth, nodulation, and N fixation, and to investigate the effect of co-inoculation on selected soybean cultivars, using the optimal inoculation density. Nitrogen fixation, in terms of an acetylene reduction activity value, was measured using a flame ionization gas chromatograph. In this study, low-density single inoculation with P4 (105 or 106 cells mL-1) was associated with the highest plant biomass, compared with normal- and high-density single inoculation with P4 (107 or 108 cells mL-1). Moreover, low-density single or co-inoculations with SAY3-7 and/or P4 produced the highest nodule biomass and highest nitrogenase activity, compared with single or dual inoculation at other inoculation densities. Therefore, we evaluated low-density co-inoculation with P4 and SAY3-7, at the rate of 105 cells mL-1, on selected soybean cultivars. Low-density co-inoculation increased the plant biomass, compared with un-inoculated plants. The effects of single and co-inoculation on nodulation did not differ significantly for any of the cultivars, except “Yezin-9” in the first experiment and “Shan Seine” in the second experiment. Low-density inoculation with both bacteria increased N fixation by 15% - 75% for seven of the cultivars in the first experiment and by 15% - 39% for three of the cultivars in the second experiment, compared with single inoculation with SAY3-7. Based on the overall results, we concluded that low-density co-inoculation with P4 and SAY3-7 gave improved plant growth and N fixation.

关键词： Brayrhizobium japonicum SAY3-7 Streptomyces griseoflavus P4 Inoculation Densities Co-Inoculation Soybean Nitrogen Fixation

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Different challenges,different approaches and related expenditures of communitybased tuberculosis activities by international non-governmental organizations in Myanmar

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Infectious Diseases of Poverty 2017年第1期6卷 506-513页

作者： Wai Wai Han Saw Saw Petros Isaakidis Mohammed Khogali Anthony Reid Nguyen Hoa Ko Ko zaw Si Thu aung Department of Medical Research Ministry of Health and SportsNo 5Ziwaka RoadDagon Township11191 YangonMyanmar Mddecins sans Frontieres Operational Research UnitLuxembourg cityLuxembourg Centre for Operational Research International Union Against Tuberculosis and Lung DiseaseParisFrance National Tuberculosis Programme Ministry of Health and SportsNay Pyi TawMyanmar National Tuberculosis Programme HanoiVietnam

Background:International non-governmental organizations(INGOs)have been implementing community-based tuberculosis(TB)care(CBTBC)in Myanmar since *** the National TB Programme(NTP)ultimately plans to take over CBTBC,there have been no evaluations of the models of care or of the costs of providing CBTBC in Myanmar by ***:This was a descriptive study using routinely-collected programmatic and financial data from four INGOs during 2013 and 2014,adjusted for *** analysis was performed from the provider *** for sputum examination were not included as it was provided free of charge by *** calculated the average cost per year of each programme and cost per patient completing ***:Four INGOs assisted the NTP by providing CBTBC in areas where access to TB services was *** INGO faced different issues in their contexts and responded with a diversity of *** total costs ranged from US$140754 to US$550221 during the study *** cost per patient completing treatment ranged from US$215 to US$1076 for new cases and US$354 to US$1215 for retreatment cases,depending on the targeted area and the package of services *** INGO appeared less costly,more sustainable and patient oriented than ***:This study revealed a wide variety of models of care and associated costs for implementing CBTBC in diverse and challenging populations and contexts in ***,we recommend a more comprehensive evaluation,including development of a cost model,to estimate the costs of scaling up CBTBC country-wide,and cost-effectiveness studies,to best inform the NTP as it prepares to takeover CBTBC activities from *** awaiting evidence from these studies,model of CBTBC that have higher sustainability potential and allocate more resources to patient-centered care should be given priority support.

关键词： Operational research Cost Sustainability Budget allocation

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Incompatible Nodulation of Bradyrhizobium elkaniiStrains BLY3-8 and BLY6-1 with Rj3 Gene-Harboring Soybean Cultivars

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American Journal of Plant Sciences 2017年第2期8卷 178-190页

Bradyrhizobia are known symbiotic partners of soybean. However, some soybean cultivars restrict nodulation by some Bradyrhizobium bacterial strains. These restrictions are related to compatibility between the Rj genes of soybean cultivars and nodulation types of inoculated bacteria. The objective of this study was to determine nodulation incompatibility of Type B strains with Rj3 soybean cultivars. Newly isolated B. elkanii strains BLY3-8 and BLY6-1 from Myanmar and specific strain Bradyrhizobium elkanii USDA33, which are incompatible with Rj3 soybean cultivars, and B. japonicum USDA110 were used as inoculants to check compatibility or incompatibility with Rj3 soybean cultivars. Nitrogen fixation activity was measured by the acetylene reduction method. Ethylene concentration (reduction of acetylene) was determined by flame ionization gas chromatography. According to the inoculation test results, USDA110 was compatible with all soybean cultivars because it formed effective nodules (Figure S1 in Appendix) and possessed nitrogenase activity. Similarly, B. elkanii strains BLY3-8, BLY6-1, and USDA33 were highly compatible with non-Rj and Rj4-gene harboring soybean cultivars because they had the ability to form functional nodules and possessed nitrogenase activity. Inversely, BLY3-8, BLY6-1, and USDA33 were incompatible with Rj3 soybean cultivars because they produced ineffective nodules. Consequently, the ratio of ineffective nodule number to total nodule number was >0.5. Therefore, nodule formation by the newly isolated B. elkanii strains BLY3-8 and BLY6-1 was restricted by the Rj3 soybean cultivars potentially making them useful as specific strains to detect the Rj3 gene in soybean cultivars.

关键词： Bradyrhizobium elkanii Nodulation Incompatibility Rj3 Soybean

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Fucoidan and topography modification improved in situ endothelialization on acellular synthetic vascular grafts

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Bioactive Materials 2023年第4期22卷 535-550页

作者： Yuan Yao aung Moe zaw Deirdre E.J.Anderson YeJin Jeong Joshua Kunihiro Monica T.Hinds Evelyn K.F.Yim Department of Chemical Engineering University of Waterloo200 University Avenue WestWaterlooONN2L 3G1Canada Department of Biomedical Engineering Oregon Health&Science UniversityPortlandOR97239USA Waterloo Institute for Nanotechnology University of Waterloo200 University Avenue WestWaterlooONN2L 3G1Canada Center for Biotechnology and Bioengineering University of Waterloo200 University Avenue WestWaterlooONN2L 3G1Canada

Thrombogenesis remains the primary failure of synthetic vascular *** coverage is crucial to provide an antithrombogenic ***,most synthetic materials do not support cell adhesion,and transanastomotic endothelial migration is ***,a surface modification strategy using fucoidan and topography was developed to enable fast in situ endothelialization of polyvinyl alcohol,which is not endothelial *** three different immobilization approaches compared,conjugation of aminated-fucoidan promoted endothelial monolayer formation while minimizing thrombogenicity in both in vitro platelet rich plasma testing and ex vivo non-human primate shunt *** of six topographical patterns showed that 2μm gratings increased endothelial cell migration without inducing inflammation responses of endothelial *** studies demonstrated that fucoidan could attract fibronectin,enabling integrin binding and focal adhesion formation and activating focal adhesion kinase(FAK)signaling,and 2μm gratings further enhanced FAK-mediated cell *** a clinically relevant rabbit carotid artery end-to-side anastomosis model,60%in situ endothelialization was observed throughout the entire lumen of 1.7 mm inner diameter modified grafts,compared to 0%of unmodified graft,and the four-week graft patency also *** work presents a promising strategy to stimulate in situ endothelialization on synthetic materials for improving long-term performance.

关键词： Blood-contacting devices Small diameter vascular graft Endothelialization Topography Fucoidan

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Contributions to the flora of Myanmar from 2000 to 2019

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Plant Diversity 2020年第4期42卷 292-301页

作者： Bin Yang Min Deng Ming-Xia Zhang aung zaw Moe Hong-Bo Ding Mya Bhone Maw Pyae Pyae Win Richard TCorlett Yun-Hong Tan Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw05282Myanmar Center for Integrative Conservation Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunMenglaYunnan666303PR China Center of Conservation Biology Core Botanical GardensChinese Academy of SciencesMenglunMenglaYunnan666303PR China School of Ecology and Environmental Science Yunnan UniversityKunmingYunnan650091PR China Forest Research Institute Forest DepartmentMinistry of Environmental Conservation and ForestryYezinNay Pyi Taw05282Myanmar

Myanmar is botanically rich and floristically diverse:one of the world's biodiversity ***,Myanmar is still very unevenly explored,and until a plant checklist was published in 2003,relatively little work was done on its *** checklist included 11,800 species of spermatophytes in 273 *** this checklist was published,the botanical exploration of Myanmar has accelerated and there have been many additional *** therefore surveyed the literature of taxonomic contributions to Myanmar’s vascular flora over the last 20 years(2000e2019)and compiled a list of new and newly described *** list includes 13 genera,193 species,7 subspecies,19 varieties,and 2 forms new to science;and 3 families,34 genera,347 species,4 subspecies,7 varieties,and 1 form newly recorded in ***,they represent 91 families and 320 *** of the new discoveries belong to 15 families,with more than 25%(146 taxa)belonging to *** new discoveries are unevenly distributed in the country,with about 41%of the newly discovered species described from Kachin State in northeast *** reflects the incompleteness of our current knowledge of the flora of Myanmar and the urgent need for a greatly expanded *** completion of the flora of Myanmar requires more fieldwork from north to south,taxonomic studies on new and existing collections,and some mechanism that both coordinates the efforts of various international institutions and initiatives and encourages continued international *** addition,producing modern taxonomic treatments of the flora of Myanmar requires the participation of experts on all vascular plant families and *** is also an urgent need to attract young scientists to plant taxonomy,to work on inventories,identification,nomenclature,herbarium work,and comparative studies.

关键词： Flora New species Taxonomy Plant diversity Specimens

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