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Journal of Materials Science & Technology 2020年第6期41卷 209-218页

作者： Bassem Barkia Pascal Aubry Paul Haghi-Ashtiani Thierry auger Lionel gosmain Frédéric Schuster Hicham Maskrot DEN-Service d’Etudes Analytiques et de Réactivitédes Surfaces CEAUniversitéParis-Saclay91191France Laboratoire de Mécanique des Sols Structures et MatériauxCentralesupélecUMR CNRS 8579UniversitéParis-Saclay92295France Arts et Métiers ParisTech PIMMUMR CNRS 800675013 ParisFrance CEA Cross-Cutting Program on Materials and Processes Skills 91191Gif-sur-YvetteFrance

We report that 316L austenitic stainless steel fabricated by direct laser deposition(DLD),an additive manufacturing(AM)process,have a higher yield strength than that of conventional 316L while keeping high *** interestingly,no clear anisotropy in tensile properties was observed between the building and the scanning direction of the 3D printed *** examination of the as-built parts shows a heterogeneous solidification cellular *** electron microscopy observations coupled with Energy Dispersive X-ray Spectrometry(EDS)reveal the presence of chemical micro-segregation correlated with high dislocation density at cell boundaries as well as the in-situ formation of well-dispersed oxides and transition-metal-rich *** hierarchical heterogeneous microstructure in the AM parts induces excellent strength of the 316L stainless steel while the low staking fault energy of the as-built 316L promotes the occurrence of abundant deformation twinning,in the origin of the high ductility of the AM *** additional post-process treatments,the AM 316L proves that it can be used as a structural material or component for repair in mechanical construction.

关键词： Additive manufacturing Austenitic stainless steel Dislocation structure Twinning Mechanical behavior Anisotropy

Integrative rodent models for assessing male reproductive toxicity of environmental endocrine active substances

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Asian Journal of Andrology 2014年第1期16卷 60-70页

作者： Jacques auger Florence Eustache Virginie Rouiller-Fabre Marie Chantal Canivenc-Lavier gabriel Livera Service d'Histologie-Embryologie Biologie de la Reproduction/CECOS Site Port-Royal - Cochin/Broca/H6tel Dieu H6pitaux Universitaires Paris Centre Paris France Departement de genetique et Developpement INSERM U 567 and Institut Cochin Universite Paris Descartes Paris and Service d'Histologie-Embryologie-Cytogen6tique 8iologie de la Reproduction/CECOS H6pital Jean Verdier Bondy France 1NRA/UMR 1324 CNRS/UMR6265 Centre des Sciences du GoOt et de I'Atimentation Dijon France. Laboratoire de Developpement des gonades UMR 967 INSERM CEA DSV IRCM SCSR Universit Paris Diderot Sorbonne Paris Cite Universit Paris Sud Fontenay-aux Roses France and

In the present review, we first summarize the main benefits, limitations and pitfalls of conventional in vivo approaches to assessing male reproductive structures and functions in rodents in cases of endocrine active substance （EAS） exposure from the postulate that they may provide data that can be extrapolated to humans. Then, we briefly present some integrated approaches in rodents we have recently developed at the organism level. We particularly focus on the possible effects and modes of action （MOA） of these substances at low doses and in mixtures, real-life conditions and at the organ level, deciphering the precise effects and MOA on the fetal testis. It can be considered that the in vivo experimental EAS exposure of rodents remains the first choice for studies and is a necessary tool （together with the epidemiological approach） for understanding the reproductive effects and MOA of EASs, provided the pitfalls and limitations of the rodent models are known and considered. We also provide some evidence that classical rodent models may be refined for studying the multiple consequences of EAS exposure, not only on the reproductive axis but also on various hormonally regulated organs and tissues, among which several are implicated in the complex process of mammalian reproduction. Such models constitute an interesting way of approaching human exposure conditions. Finally, we show that organotypic culture models are powerful complementary tools, especially when focusing on the MOA. All these approaches have contributed in a combinatorial manner to a better understanding of the impact of EAS exposure on human reproduction.

关键词： endocrine active substance endocrine disruptor exposure gonad in culture low dose mixture mouse rat rodent strain

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.R.groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton g.R.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

Present status and future directions:Apexification

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World Journal of Methodology 2025年第1期15卷 26-32页

作者： Sachin Chauhan Radha Chauhan Prashant Bhasin Bhavna g Sharaf Department of Conservative Dentistry and Endodontics Sudha Rustagi College of Dental Sciences and ResearchFaridabad 121002HaryanaIndia Department of Prosthodontics and Crown and Bridge and Oral Implantology Mahatma Gandhi Dental College&HospitalJaipur 302022RajasthanIndia Department of Pedodontics and Preventive Dentistry Sudha Rustagi College of Dental Sciences and ResearchFaridabad 121002HaryanaIndia

The success rate of apexification is primarily determined by multiple factors,including the material used,the size of the open apex compared to the length of the root,and the technique used in each *** main objective of this review was to provide an update on the present management of open apex to identify factors and circumstances that may influence the success of apexification using different materials and *** research on apexification should focus on how to treat open apices with wide periapical lesions without ***,the predictability of these parameters with non-surgical procedures was uncertain,but now,with the use of a dental operating microscope,it has become more *** reason could be that extra visits are no longer required due to major advances in the armamentarium and materials used for apexification.

关键词： Bioceramics Magnification Biodentine Mineral trioxide aggregate Apexification Open apex

Advancement in utilization of magnetic resonance imaging and biomarkers in the understanding of schizophrenia

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World Journal of Clinical Cases 2025年第1期13卷 11-15页

作者： Aidan K Tirpack Danyaal g Buttar Mandeep Kaur Department of Psychiatry Campbell University School of Osteopathic MedicineBuies CreekNC 27506United States Department of Psychiatry and Behavioral Health Mercyhealth Hospital and Trauma CenterJanesvilleWI 53548United States

Historically,psychiatric diagnoses have been made based on patient’s reported symptoms applying the criteria from diagnostic and statistical manual of mental *** utilization of neuroimaging or biomarkers to make the diagnosis and manage psychiatric disorders remains a distant *** have been several studies that examine brain imaging in psychiatric disorders,but more work is needed to elucidate the complexities of the human *** this editorial,we examine two articles by Xu et al and Stoyanov et al,that show developments in the direction of using neuroimaging to examine the brains of people with schizo-phrenia and *** et al used magnetic resonance imaging to examine the brain structure of patients with schizophrenia,in addition to examining neurotransmitter levels as *** et al used functional magnetic resonance imaging to look at modulation of different neural circuits by diagnostic-specific scales in patients with schizophrenia and *** two studies provide crucial evidence in advancing our understanding of the brain in prevalent psychiatric disorders.

关键词： Schizophrenia Magnetic resonance imaging Biomarkers Neurotransmitters Psychiatric disorders

A Text in Search of an Author: “Quelques remarques sur la Chine que j’ay tirées des conversations que j’ay eües avec Mr Ouanges”

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World History Studies 2016年第1期3卷 17-32页

作者： Catherine Volpilhac–auger (E)cole normale supérieure de LyonUMR 5317CNRS

The twenty–two volume edition of Montesquieu’s OEuvres complètes is a long–term project that requires the input of specializations and energies throughout the *** by Jean Ehrard in the late 1980s, it is now under the direction of Pierre Rétat and myself, who have also taken direct responsibility for several of the volumes;among these, the first volume devoted to reading notes and extracts under the title geographica II. Published in 2007,1 this volume will soon be re–issued in the form of an electronic edition.2 We expect much interest from many scholars in this document, which provides evidence of Montesquieu’s interest in Chinese history and culture. In this context, the contribution of Professor Xu Minglong3 on part of this publication is welcome.

关键词： of des edition sur this under notes the

Analysis of Autopilot Disengagements Occurring During Autonomous Vehicle Testing

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IEEE/CAA Journal of Automatica Sinica 2018年第1期5卷 58-68页

作者： Chen Lv Dongpu Cao Yifan Zhao Daniel J. auger Mark Sullman Huaji Wang Laura Millen Dutka Lee Skrypchuk Alexandros Mouzakitis School of Aerospace Transport and Manufacturing Cranfield University Cranfield Bedford MK430AL UK Jaguar Land Rover Coventry CV3 4LF UK IEEE

In present-day highly-automated vehicles, there are occasions when the driving system disengages and the human driver is required to take-over. This is of great importance to a vehicle's safety and ride comfort. In the U.S state of California, the Autonomous Vehicle Testing Regulations require every manufacturer testing autonomous vehicles on public roads to submit an annual report summarizing the disengagements of the technology experienced during testing. On 1 January 2016,seven manufacturers submitted their first disengagement reports:Bosch, Delphi, google, Nissan, Mercedes-Benz, Volkswagen, and Tesla Motors. This work analyses the data from these disengagement reports with the aim of gaining abetter understanding of the situations in which a driver is required to takeover, as this is potentially useful in improving the Society of Automotive Engineers(SAE) Level 2 and Level 3 automation *** events from testing are classified into different groups based on attributes and the causes of disengagement are investigated and compared in detail. The mechanisms and time taken for take-over transition occurred in disengagements are studied. Finally, recommendations for OEMs, manufacturers, and government organizations are also discussed.

关键词： Automated vehicle Disengagement humanvehicle interactions take-over operation vehicle testing

基于贝叶斯信息准则的非侵入式负荷事件检测算法

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电力系统保护与控制 2018年第22期46卷 8-14页

作者：肖江 Francois auger 荆朝霞 Sarra HOUIDI 华南理工大学电力学院广东广州510640 法国南特大学南特44600

用户负荷数据监测是实现需求侧管理的基础,非侵入式负荷监测技术是负荷监测的重要发展方向,而事件检测是非侵入式负荷监测中的一个关键环节。对适用于模型选取问题的贝叶斯信息准则进行建模,将贝叶斯信息准则首次运用到事件检测当中,利... 详细信息

用户负荷数据监测是实现需求侧管理的基础,非侵入式负荷监测技术是负荷监测的重要发展方向,而事件检测是非侵入式负荷监测中的一个关键环节。对适用于模型选取问题的贝叶斯信息准则进行建模,将贝叶斯信息准则首次运用到事件检测当中,利用快速事件检测算法降低贝叶斯信息准则检测算法的误检率,并能解决CUSUM算法中产生的漏检问题。最后采用真实数据集进行测试。实验结果表明,相比于CUSUM算法,基于贝叶斯信息准则的事件检测算法能达到更好的检测准确性,并且能明显提高计算运行的速度。

关键词：贝叶斯信息准则累积和非侵入式负荷监测事件检测

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让微笑展示健康牙齿

父母必读 2004年第3期 80-80页

作者： Catherine auger

不要认为乳牙早晚要掉,就掉以轻心。健康乳牙为健康恒牙奠定了良好的基础。

关键词：六龄齿

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl Lászlógál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNgCs). However, the use of tNgCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNgC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNgCs and compared the various features of these improved silk^(+) tNgCs with the tubes without holes(silk^(–) tNgCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNgCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNgCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNgCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNgCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization