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Food Bioscience 2022年第3期47卷 1016-1022页

作者： Swati tiwari Neelam Upadhyay Ashish kumar Singh Dairy Technology Division ICAR-National Dairy Research InstituteKarnal132001HaryanaIndia

The research was conducted on the stability assessment of emulsion of carotenoids extracted from carrot-pomace in omega-3 rich flaxseed oil,followed by converting this emulsion into freeze-dried powder,and its application as natural functional colorant in the preparation of flavored milk.The study indicated that emulsion was stable over a range of pH (5–9),temperature (forewarming to HTST pasteurization) and ionic strength (0.1–0.75 M NaCl) except at pH 4,sterilization temperature and 1.0 M NaCl based on zeta potential and particle size of emulsion analysed at these conditions.Ten percent (out of 8,10 and 12%) of freeze-dried emulsion was selected for addition as a natural functional ingredient in flavored milk on the basis of organoleptic evaluation.The fat,protein,total solids,total carotenoid content and antioxidant value (in terms of ABTS and reducing power assay) of developed product were significantly higher (p < 0.05) than control.The whiteness index of control was significantly higher (p < 0.05) than the developed product,while reverse was true for yellowness index.However,both the products showed total color difference of 34.65.The research concludes that carotenoid-rich emulsion can be efficiently freeze-dried and used as a functional natural colorant in flavored milk for providing it better bio-functional attributes over control.

关键词： Carotenoids Carrot bio-waste Nano-emulsion Stability studies Flavored milk

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太阳能电池纳米技术

国外科技新书评介 2014年第4期 17-18页

作者： atul tiwari 吴永礼不详中国科学院力学研究所

人类文明的发展伴随着能源的消耗。因此，材料科学家和工程师已经面临必须减少人类对化石燃料资源依赖的挑战。在过去的几十年里，已开发了太阳能电池技术，

关键词：太阳能电池纳米技术人类文明材料科学家燃料资源电池技术工程师

Bianchi type-I cosmological models with perfect fluid in general relativity

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Research in Astronomy and Astrophysics 2010年第4期10卷 291-300页

作者： Rishi kumar tiwari Department of Mathematics Govt.Model Science College

Einstein＇s field equations with variable gravitational and cosmological constants are considered in the presence of perfect fluid for the Bianchi type-I universe by assuming that the cosmological term is proportional to R-m （R is a scale factor and m is a constant）.A variety of solutions are presented.The physical significance of the respective cosmological models are also discussed.

关键词： cosmological parameters - cosmology： theory - relativity

Novel targeting approaches and signaling pathways of colorectal cancer: An insight

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World Journal of Gastroenterology 2018年第39期24卷 4428-4435页

作者： Ankita tiwari Shivani Saraf Amit Verma Pritish kumar Panda Sanjay K Jain Pharmaceutics Research Projects Laboratory Department of Pharmaceutical SciencesDr. Hari Singh Gour Central University

Colorectal cancer(CRC) is the third most common cancer of mortality in the world. Chemotherapy based treatment leads to innumerable side effects as it delivers the anticancer drug to both normal cells besides cancer cells. Sonic Hedgehog(SHH), Wnt wingless-type mouse mammary tumor virus/β-catenin, transforming growth factor-β/SMAD, epidermal growth factor receptor and Notch are the main signaling pathways involved in the progression of CRC. Targeted therapies necessitate information regarding the particular aberrant pathways. Advancements in gene therapies have resulted in the recognition of novel therapeutic targets related with these signal-transduction cascades. CRC is a stepwise process where mutations occur over the time and activation of oncogenes and deactivation of tissue suppressor genes takes place. Genetic changes which are responsible for the induction of carcinogenesis include loss of heterozygosity in tumor suppressor genes such as adenomatous polyposis coli, mutation or deletion of genes like p53 and K-ras. Therefore, many gene-therapy approaches like gene correction, virusdirected enzyme-prodrug therapy, immunogenetic manipulation and virotherapy are currently being explored. Development of novel strategies for the safe and effective delivery of drugs to the cancerous site is the need of the hour. This editorial accentuates different novel strategies with emphasis on gene therapy and immunotherapy for the management of CRC.

关键词： Colorectal cancer Immunotherapy Gene therapy Signaling Targeted therapy

Robust Optimization Method of Cylindrical Roller Bearing by Maximizing Dynamic Capacity Using Evolutionary Algorithms

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Journal of Harbin Institute of Technology(New Series) 2022年第5期29卷 20-40页

作者： kumar Gaurav Rajiv tiwari Twinkle Mandawat Department of Mechanical Engineering Indian Institute of Technology GuwahatiGuwahati 781039India

Optimization of cylindrical roller bearings(CRBs)has been performed using a robust design.It ensures that the changes in the objective function,even in the case of variations in design variables during manufacturing,have a minimum possible value and do not exceed the upper limit of a desired range of percentage variation.Also,it checks the feasibility of design outcome in presence of manufacturing tolerances in design variables.For any rolling element bearing,a long life indicates a satisfactory performance.In the present study,the dynamic load carrying capacity C,which relates to fatigue life,has been optimized using the robust design.In roller bearings,boundary dimensions(i.e.,bearing outer diameter,bore diameter and width)are standard.Hence,the performance is mainly affected by the internal dimensions and not the bearing boundary dimensions mentioned formerly.In spite of this,besides internal dimensions and their tolerances,the tolerances in boundary dimensions have also been taken into consideration for the robust optimization.The problem has been solved with the elitist non-dominating sorting genetic algorithm(NSGA-II).Finally,for the visualization and to ensure manufacturability of CRB using obtained values,radial dimensions drawing of one of the optimized CRB has been made.To check the robustness of obtained design after optimization,a sensitivity analysis has also been carried out to find out how much the variation in the objective function will be in case of variation in optimized value of design variables.Optimized bearings have been found to have improved life as compared with standard ones.

关键词： cylindrical roller bearing optimization robust design elitist non-dominating sorting genetic algorithm(NSGA-II) fatigue life dynamic load carrying capacity

Computational interaction analysis of organophosphorus pesticides with different metabolic proteins in humans

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The Journal of Biomedical Research 2011年第5期25卷 335-347页

作者： Amit kumar Sharma Karuna Gaur Rajeev kumar tiwari Mulayam Singh Gaur Pesticides Research & Sensors Laboratory Department of PhysicsHindustan College of Science and Technology Department of Bioscience R.D.Govt.Girls College

Pesticides have the potential to leave harmful effects on humans, animals, other living organisms, and the environment. Several human metabolic proteins inhibited after exposure to organophosphorus pesticides absorbed through the skin, inhalation, eyes and oral mucosa, are most important targets for this interaction study. The crystal structure of five different proteins, PDBIDs： 3LII, 3NXU, 4GTU, 2XJ1 and 1YXA in Homo sapiens （H. sapiens）, interact with organophosphorus pesticides at the molecular level. The 3-D structures were found to be of good quality and validated through PROCHECK, ERRAT and ProSA servers. The results show that the binding energy is maximum -45.21 relative units of cytochrome P450 protein with phosmet pesticide. In terms of H-bonding, methyl parathion and parathion with acetylcholinesterase protein, parathion, methylparathion and phosmet with protein kinase C show the highest interaction. We conclude that these organophosphorus pesticides are more toxic and inhibit enzymatic activity by interrupting the metabolic pathways in H. sapiens.

关键词： docking organophosphorus pesticides comparative analysis modeling toxicity analysis acetylcholinesterases Homo sapiens

Evaluating role of bone marrow-derived stem cells in dry age-related macular degeneration using multifocal electroretinogram and fundus autofluorescence imaging

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International Journal of Ophthalmology(English edition) 2017年第10期10卷 1552-1558页

作者： atul kumar Neha Midha Sujata Mohanty Annu Chohan Tulika Seth Varun Gogia Shikha Gupta Dr.Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical Sciences Stem Cell Facility All India Institute of Medical Sciences Department of Hematology All India Institute of Medical Sciences

AIM：To evaluate the role of bone marrow-derived stem cells in the treatment of advanced dry age-related macular degeneration（AMD）using multifocal electroretinogram（mf-ERG）and fundus autofluorescence imaging.METHODS：Thirty patients（60 eyes）with bilateral central geographic atrophy（GA）were recruited.Worse eye of each patient received autologous bone marrow-derived hematopoietic stem cells（BM-HSCs）（group 1）and the fellow eye with better visual acuity served as control（group2）.The effect of stem cell therapy was determined in terms of visual acuity,amplitude and implicit time in mf-ERG and size of GA on fundus autofluorescence imaging.These tests were performed at presentation and first,third and sixth month follow up.Adverse events（if any）were also monitored.RESULTS：At 6mo follow-up there was no statistically significant improvement in median log MAR best corrected visual acuity（BCVA）in either group.Mf-ERG revealed significant improvement in amplitude and implicit time in the intervention group.A significant decrease was also noted in greatest linear dimension（GLD）of GA in the eyes receiving stem cells[6.78±2.60 mm at baseline to 6.56±2.59 mm at 6mo（P=0.021）].However,no such improvement was noted in the control group.CONCLUSION：Electrophysiological and anatomical improvement in the intervention group sheds light on the therapeutic role of BM-HSCs.Further studies are required to determine the stage of disease at which the maximal benefit can be achieved and to standardize the dose andfrequency of stem cell injection.

关键词： dry age-related macular degeneration multifocal electroretinogram stem cells fimdus autofluorescence imaging

First contact investigations and compliance to treatment in patients with uveitis

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International Journal of Ophthalmology(English edition) 2023年第11期16卷 1820-1826页

作者： Anuja Patil Sanjeev Gupta Pradeep Venkatesh Mousumi Banerjee Vinod kumar Rohan Chawla Shorya Vardhan Azad atul kumar Dr.Rajendra Prasad Centre for Ophthalmic Sciences All India Institute of Medical SciencesNew Delhi 110029India

AIM:To ascertain the pattern of investigations at first contact in uveitic patients and evaluate compliance to treatment.METHODS:An observational study comprised of 201 uveitic patients presenting for the first time to our centre from January 2019 to June 2020.Detailed information regarding systemic investigations undertaken by specialists at the time of first contact and the cost of these investigations were reviewed on the first visit to our centre.Compliance with the treatment was determined and reasons behind non-compliance were evaluated on the first follow-up in patients who had no improvement in clinical signs and symptoms.RESULTS:The mean age of the study group was 35.35±14.1y and gender composition was 59.7%males and 40.3%females.Anterior uveitis was observed in 45.3%of patients,intermediate uveitis in 31.8%of patients,posterior uveitis in 14.9%of patients and panuveitis in 8.0%of patients.Association with a systemic disease was evident in 17.9%of patients.When compared with standard guidelines and uveitis patterns,systemic investigations were identified to be relevant only in 38.3%of patients.Non-compliance to treatment was documented in 22.4%of patients.Common reasons for non-compliance were inadequate counselling by the treating physician about treatment in 26.7%of patients and a busy schedule at work/school in 22.2%of patients.CONCLUSION:Significant number of investigations performed at first contact is found to be contrary to standard guidelines and are not contributory to the care.About a quarter of patients in this study are found to be non-compliant with the treatment.Compliance is more challenging to achieve in school-going children and working adults.The availability of comprehensive,periodically updated,evidence-based guidelines on the role of investigations and the use of trained counsellors may help to channelize proper evaluation and improve compliance to treatment,respectively,in patients with uveitis.

关键词： uveitis compliance investigations first contact

Reducing shoulder dislocation without anaesthesia or assistant:Validation of a new reduction manoeuvre

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Chinese Journal of Traumatology 2019年第5期22卷 274-277页

作者： Rashid Anjum Subodh Pathak atul Rai Sharma Jatin Aggarwal Aryan Sharma Vineet Pruthi Anil kumar Chaudhary MM Institute of Medical Sciences&Research Ambala13320乙India

Purpose:Shoulder dislocation comprises 60%of all major joint dislocations worldwide and a number of reduction techniques are described in the literature w让h varying degrees of success.The description of a large number of techniques speaks for itself that no method is effective all the times and one should be acquainted with more than one technique.An ideal method of reduction should be simple,easily reproducible,relatively painless that can be performed unassisted without sedation or anaesthesia w让h minimal or no further complications.We report our results of using a novel method of anterior shoulder reduction described recently in the literature that claims to fulfil most of the characteristics of an ideal method if not all.Methods:This prospective study was conducted in a tertiary care centre.All the cases of primary anterior shoulder dislocation presenting within three days of injury without any associated fracture or spine trauma with or without greater tuberosity fracture were included.The reduction was done using a novel method by orthopaedic residents in all cases.The need for a second reduction attempt or anaesthesia was considered a treatment failure.Time taken for reduction,pain felt during reduction and complications if any were noted.Results:There were 47(77.04%)males and 14(22.95%)females with a mean age of(37.04±12.63)years.The new technique was effective in locating a shoulder dislocation on the first attempt in 58 of the 61 dislocated shoulders(95.08%).The remaining three shoulders were reduced on second attempt by the same technique.Sedative,pre-medication or anaesthesia was not used in any case.The average time taken for the shoulder reductio n was(130.5±25.8)sec onds and con fide nee interval(95%)124-137 s.Iatrogenic complications were not seen in any of the patients.Conclusion:This relatively painless technique of shoulder reduction is easy to acquire and practice in emergency department.The advantages of this manoeuvre and its associated safety may justly lead surgeons to select it as their p

关键词： Shoulder dislocation External rotation manoeuvre Prakash's manoeuvre

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Upper ocean high resolution regional modeling of the Arabian Sea and Bay of Bengal

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Acta Oceanologica Sinica 2019年第5期38卷 32-50页

作者： Dwivedi Suneet Mishra Alok kumar Srivastava atul K Banerjee Centre of Atmospheric and Ocean Studies and M N Saha Centre of Space Studies University of Allahabad

In this paper, effort is made to demonstrate the quality of high-resolution regional ocean circulation model in realistically simulating the circulation and variability properties of the northern Indian Ocean(10°S–25°N,45°–100°E) covering the Arabian Sea(AS) and Bay of Bengal(BoB). The model run using the open boundary conditions is carried out at 10 km horizontal resolution and highest vertical resolution of 2 m in the upper ocean.The surface and sub-surface structure of hydrographic variables(temperature and salinity) and currents is compared against the observations during 1998–2014(17 years). In particular, the seasonal variability of the sea surface temperature, sea surface salinity, and surface currents over the model domain is studied. The highresolution model's ability in correct estimation of the spatio-temporal mixed layer depth(MLD) variability of the AS and BoB is also shown. The lowest MLD values are observed during spring(March-April-May) and highest during winter(December-January-February) seasons. The maximum MLD in the AS(BoB) during December to February reaches 150 m (67 m). On the other hand, the minimum MLD in these regions during March-April-May becomes as low as 11–12 m. The influence of wind stress, net heat flux and freshwater flux on the seasonal variability of the MLD is discussed. The physical processes controlling the seasonal cycle of sea surface temperature are investigated by carrying out mixed layer heat budget analysis. It is found that air-sea fluxes play a dominant role in the seasonal evolution of sea surface temperature of the northern Indian Ocean and the contribution of horizontal advection, vertical entrainment and diffusion processes is small. The upper ocean zonal and meridional volume transport across different sections in the AS and BoB is also computed. The seasonal variability of the transports is studied in the context of monsoonal currents.

关键词： Indian Ocean modeling Arabian Sea and Bay of Bengal mixed layer depth transport