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Asian Journal of Andrology 2010年第5期12卷 753-759页

作者： Rieko Matsuura Takumi Takeuchi atsumi Yoshida The Reproduction Center Kiba Park Clinic Tokyo 135-0042 Japan

Appropriate semen processing and assessment are critical for successful infertility treatment. We investigated whether laboratory procedures including semen preparation and incubation affect sperm DNA integrity. A total of 153 infertile men were involved. Conventional semen parameters and sperm chromatin structure assay （SCSA） parameters, that is, DNA fragmentation index （%DFI） and high DNA stainability （%HDS）, were assessed on the flesh ejaculated semen samples, which were treated and incubated under different conditions. Negative correlations were identified between the %DFI and sperm concentration, motility, progressive motility and morphology. A lower percentage of DFI was detected in spermatozoa when density gradient centrifugation （DGC） was followed by swimup treatment in comparison with DGC alone （P 〈 0.01）. Although the %DFI increased in a time-dependent manner with incubation both at room temperature （RT） and at 37℃ in air, the %DFI after 24 h at RT was significantly lower than that at 37℃ （P 〈 0.05）. Incubation with 5% CO2 was effective in maintaining sperm motility （P 〈 0.01）; however, it induced further elevation of %DFI （P 〈 0.001）. Thus, sperm DNA damage was associated with longer incubation periods. Interestingly, common culture conditions, such as maintaining pH and temperature, compromised the sperm DNA integrity.

关键词： density gradient centrifugation DNA damage male infertility sperm chromatin structure assay spermatozoa

Decreased hemoglobin after initial treatment is associated with treatment resistance in Kawasaki disease in Kobayashi risk stratification

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World Journal of Pediatrics 2020年第6期16卷 623-628页

作者： Yukari atsumi Hiroshi Sakakibara Yoshihiko Morikawa Koichi Miyata Hiroyuki Yamagishi Masahiro Misawa Masaru Miura Department of General Pediatrics Tokyo Metropolitan Children's Medical Center.TokyoJapan Clinical Research Support Center.Tokyo Metropolitan Children's Medical Center TokyoJapan Department of Cardiology.Tokyo Metropolitan Children's Medical Center.Tokyo Japan Department of Pediatrics Keio University School of MedicineTokyo.Japan Department of Pediatrics Tokyo Metropolitan Bokutoh HospitalTokyoJapan National Center for Global Health and Medicine.1-21-1.Toyama Shinjuku-kuTokyo 162-8655.Japan

Background Although Kawasaki disease(KD)is known to cause anemia,the relationship between its prognosis and hemoglobin level is less well *** We herein performed a secondary analysis of data from a previous study(Post-RAISE).Children aged 6 months to 2 years at the time of KD diagnosis were *** hemoglobin was defined as a decrease>10%on post-treatment day 2 compared with the level prior to the initial *** Of 1253 KD cases,treatment resistance was observed in 209(17%)and was significantly more frequent in the decreased hemoglobin group(37/167 vs.172/1086,P=0.041).Multivariable logistic regression analysis revealed that decreased hemoglobin was associated with resistance to the initial treatment(odds ratio 1.53;95%confidence interval 1.00-2.33;P=0.048).Conclusions Decreased hemoglobin was significantly associated with resistance to initial treatment in patients with KD.

关键词： Anemia Inflammation Hepcidin Kawasaki disease

Characteristics of In-Hospital Patients with Congenital Heart Disease Requiring Rapid Response System Activations: A Japanese Database Study

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Congenital Heart Disease 2022年第1期17卷 31-43页

作者： Taiki Haga Tomoyuki Masuyama Yoshiro Hayashi Takahiro atsumi Kenzo Ishii Shinsuke Fujiwara Department of Pediatric Critical Care Medicine Osaka City General HospitalOsaka534-0021Japan Department of Emergency and Critical Care Medicine Jichi Medical University Saitama Medical CenterSaitama330-8503Japan Department of Intensive Care Medicine Kameda Medical CenterChiba296-8602Japan Department of Emergency Medicine Seirei Hamamatsu General HospitalShizuoka430-8558Japan Department of Anesthesiology Intensive Care UnitFukuyama City HospitalHiroshima721-8511Japan Department of Emergency Medicine NHO Ureshino Medical CenterSaga843-0393Japan

Objectives:This study aimed to study the characteristics of in-hospital deterioration in patients with congenital heart disease who required rapid response system activation and identify risk factors associated with 1-month ***:We retrospectively analysed data from a Japanese rapid response system registry with 35 participating *** included consecutive patients with congenital heart disease who required rapid response system activation between January 2014 and March *** regression analyses were performed to examine the associations between 1-month mortality and other patient-specific ***:Among 9,607 patients for whom the rapid response system was activated,only 82(0.9%)had congenital heart *** few patients with congenital heart disease were being treated at the cardiology and cardiovascular surgery departments(12.3%and 9.9%,respectively).Moreover,the incidences of rapid-response events after intensive care unit discharge or surgery were low(6.8% and 12.2%,respectively).The most common reason for rapid response system activation was respiratory dysfunction(desaturation:35.4%,tachypnoea:25.6%,and new dyspnoea:19.5%).Rapid response system interventions and intensive care unit transfers were required for 65.9% and 20.7%of patients,*** mortality rate was 1.2% at the end of the rapid response system intervention and 11.0% after 1 ***,decreased respiratory rate and decreased heart rate at rapid response system activation were associated with increased 1-month *** adjusted odds ratio was 1.10(95% confidence interval 1.02–1.19)and 1.02(95% confidence interval,1.00–1.04) for respiratory rate and heart rate,***:Rapid response systems were rarely activated after cardiac surgery and intensive care unit discharge,which were situations with a high risk of sudden deterioration in patients with congenital heart ***,encouraging the use of the rapid response sys

关键词： Heart defects congenital emergencies clinical deterioration hospital rapid response team critical care This

Attention-Guided Organized Perception and Learning of Object Categories Based on Probabilistic Latent Variable Models

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Journal of Intelligent Learning Systems and Applications 2013年第2期5卷 123-133页

作者： Masayasu atsumi Department of Information Systems Science Faculty of Engineering Soka University Tokyo Japan.

This paper proposes a probabilistic model of object category learning in conjunction with attention-guided organized perception. This model consists of a model of attention-guided organized perception of object segments on Markov random fields and a model of learning object categories based on a probabilistic latent component analysis. In attention guided organized perception, concurrent figure-ground segmentation is performed on dynamically-formed Markov random fields around salient preattentive points and co-occurring segments are grouped in the neighborhood of selective attended segments. In object category learning, a set of classes of each object category is obtained based on the probabilistic latent component analysis with the variable number of classes from bags of features of segments extracted from images which contain the categorical objects in context and an object category is represented by a composite of object classes. Through experiments using two image data sets, it is shown that the model learns a probabilistic structure of intra-categorical composition and inter-categorical difference of object categories and achieves high performance in object category recognition.

关键词： Attention Perceptual Organization Probabilistic Learning Object Categorization

Preliminary prospective study of real-time post-gastrectomy glycemic fluctuations during dumping symptoms using continuous glucose monitoring

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World Journal of Gastroenterology 2021年第23期27卷 3386-3395页

作者： Motonari Ri Souya Nunobe Satoshi Ida Naoki Ishizuka Shinichiro atsumi Rie Makuuchi Koshi Kumagai Manabu Ohashi Takeshi Sano Department of Gastroenterological Surgery Cancer Institute HospitalJapanese Foundation for Cancer ResearchTokyo 135-8550Japan Clinical Trial Planning and Management Cancer Institute HospitalJapanese Foundation for Cancer ResearchTokyo 135-8550Japan

BACKGROUND Although dumping symptoms constitute the most common post-gastrectomy syndromes impairing patient quality of life,the causes,including blood sugar fluctuations,are difficult to elucidate due to limitations in examining dumping symptoms as they *** To investigate relationships between glucose fluctuations and the occurrence of dumping symptoms in patients undergoing gastrectomy for gastric *** Patients receiving distal gastrectomy with Billroth-I(DG-BI)or Roux-en-Y reconstruction(DG-RY)and total gastrectomy with RY(TG-RY)for gastric cancer(March 2018-January 2020)were prospectively *** tissue glycemic profiles were measured every 15 min,up to 14 d,by continuous glucose *** episodes were recorded on 5 patient-selected days by *** 3 h postprandially,dumping-associated glycemic changes were defined as a dumping profile,those without symptoms as a control *** profiles were *** Thirty patients were enrolled(10 DG-BI,10 DG-RY,10 TG-RY).The 47 early dumping profiles of DG-BI showed immediately sharp rises after a meal,which 47 control profiles did not(P<0.05).Curves of the 15 late dumping profiles of DG-BI were similar to those of early dumping profiles,with lower glycemic *** and TG-RY late dumping profiles(7 and 13,respectively)showed rapid glycemic decreases from a high glycemic state postprandially to hypoglycemia,with a steeper drop in TG-RY than in *** Postprandial glycemic changes suggest dumping symptoms after standard gastrectomy for gastric ***,glycemic profiles during dumping may differ depending on reconstruction methods after gastrectomy.

关键词： Gastric cancer Gastrectomy Billroth-I reconstruction Roux-en-Y reconstruction Dumping syndrome Continuous glucose monitoring

How to improve the ART outcome in patients with poor prognosis and/or repeated failures

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How to improve the ART outcome in patients with poor prognos...

中华医学会第六次全国生殖医学学术会议

作者： atsumi Yoshida Kiba Park Clinic TokyoJapan

1)Key elements to determine the ART outcome Six mainstays responsible for the successful results in ART are:1)throughout evaluation of both partners including physical,hormonal and genetic assessments prior to ART;2)selection of an appropriate ovarian stimulation according to each patients ovarian reserve;3)effecti ve follicular monitoring and oocyte retrieval procedure,4)intensive embryology laboratory work;5)proper embryo selection and relia-

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用欧诺连续铸造法生产镁铸造毛料

轻合金加工技术 1989年第1期17卷 16-18页

作者： atsumi Ohno 郭华

1978年,一种被称作欧诺(Ohno)连续铸造法(以下简称OCC法)的新工艺问世了.这种方法的优点是,生产出的铸料无杂质的宏观偏析、无气孔和无晶界. 由这种铸造法生产的任何金属和合金,都可成为性能高、质量好的新材料,即OCC法能生产出先进的... 详细信息

1978年,一种被称作欧诺(Ohno)连续铸造法(以下简称OCC法)的新工艺问世了.这种方法的优点是,生产出的铸料无杂质的宏观偏析、无气孔和无晶界. 由这种铸造法生产的任何金属和合金,都可成为性能高、质量好的新材料,即OCC法能生产出先进的工业材料(简称AIM). OCC法适用于纯镁线材或板材的水平铸造.由这种方法生产的铸料几乎全是单向凝固组织.

关键词：镁铸料欧诺法连续铸造 OCC法