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Prognostic Significance of Hematologic Markers in Patients with Head and Neck Squamous Cell Carcinomas

International Journal of Otolaryngology and Head & Neck Surgery 2018年第2期7卷 55-65页

作者： Ryohei Oya Yukinori Takenaka Kengo Aoki Hiroko Hamaguchi Kazuya Takemura Masayuki Nozawa Takahiro Kitamura Yoshifumi Yamamoto atsuhiko uno Department of Otorhinolaryngology-Head and Neck Surgery Osaka General Medical Center Osaka Japan Department of Otorhinolaryngology-Head and Neck Surgery Osaka University Graduate School of Medicine Osaka Japan Department of Otorhinolaryngology-Head and Neck Surgery Kansai Medical Hospital Osaka Japan

Aim: To assess the prognostic value of hematologic markers for cancers of the head and neck region, according to tumor site. Methods: We reviewed the data of 441 patients diagnosed with head and neck squamous cell carcinomas (HNSCC) between 2006 and 2014. Overall survival rates were estimated using the Kaplan-Meier method and Cox proportional hazards models were used to assess the hazard ratio (HR) for death, according to hematologic markers. Results: In the univariate analyses, hemoglobin concentration;leukocyte, neutrophil, monocyte, and platelet counts;and the platelet-lymphocyte ratio were associated with overall survival. In the multivariate analyses, hemoglobin concentration (HR 0.55, 95% confidence interval [CI] 0.38 - 0.78, p Conclusions: Several hematologic markers have prognostic significance for patients with HNSCC, however, the magnitude of the effect depends on the tumor site.

关键词： Biomarkers Head and Neck Cancer Hematologic Marker

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Analysis of Endoscopic Sphenopalatine Artery Surgery for Refractory Epistaxis

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International Journal of Otolaryngology and Head & Neck Surgery 2020年第2期9卷 78-85页

作者： Takahiro Kitamura Yukinori Takenaka Kengo Aoki Takuma Shimada Hiroko Hamaguchi Ayaka Nakatani Masayuki Nozawa Ryohei Oya Yoshifumi Yamamoto atsuhiko uno Department of Otorhinolaryngology-Head and Neck Surgery Osaka General Medical CenterOsakaJapan

Background: This study aimed to determine the safety and efficacy of sphenopalatine artery (SPA) surgery in patients with refractory epistaxis and to identify factors associated with the indications for surgery to assist clinicians in making prompt and appropriate decisions regarding SPA surgery for refractory epistaxis. Methods: We analyzed 97 consecutive patients with nasal bleeding hospitalized in our institution between April 2009 and March 2018. Clinicopathological characteristics and clinical outcomes were analyzed from retrospective chart reviews. Results: Of the 97 patients, 28 (29 sides) required SPA surgery. There were no differences in sex, anti-coagulant drug or antiplatelet use, hemoglobin concentration, or platelet count between Group A (patients who required surgery) and Group B (patients who did not require surgery). Age (58 vs. 67 years, p = 0.038) and severity of comorbidity (0 vs. 1, p = 0.039) were significantly lower in the surgery group. Patients who were younger and had lower Charlson Comorbidity Index (CCI) scores had more requirements for surgery than those who were older and had higher CCI scores. There was no significant difference between the groups with respect to the proportion of patients receiving blood transfusions;however, the length of hospitalization was significantly longer in Group A than in Group B (8.9 vs. 8 days, p = 0.038). Success rate (non-rebleeding rate) was 89%, comparable to that reported in previous studies. Conclusions: Endoscopic SPA surgery was found safe and effective method with few complications. Younger patients with lower CCI scores were found appropriate for SPA surgery for refractory epistaxis due in part to a lower risk of anesthesia.

关键词： Epistaxis Sphenopalatine Artery Emergency Admission Cauterization Ligation Endoscope

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