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Association of breastfeeding with tidal breathing analysis in infants with bronchiolitis

World Journal of Clinical Pediatrics 2021年第6期10卷 168-176页

作者： Evanthia Perikleous Sotirios Fouzas athina karageorgiou Paschalis Steiropoulos Evangelia Nena Athanasios Chatzimichael Aggelos Tsalkidis Emmanouil Paraskakis Department of Pediatrics University General Hospital of AlexandroupolisDemocritus University of ThraceAlexandroupoli 68100Greece Department of Paediatrics University Hospital of PatrasUniversity of PatrasPatra 26504Greece Department of Pneumonology University General Hospital of AlexandroupolisDemocritus University of ThraceAlexandroupoli 68100Greece Laboratory of Hygiene and Environmental Protection Medical SchoolDemocritus University of ThraceAlexandroupoli 68100Greece Paediatric Respiratory Unit Paediatric DepartmentUniversity of CreteHeraklion 71500Greece

BACKGROUND Tidal breathing flow-volume(TBFV)analysis provides important information about lung mechanics in *** To assess the effects of breastfeeding on the TBFV measurements of infants who recover from acute *** In this cross-sectional study,TBFV analysis was performed in infants with bronchiolitis prior to hospital *** ratio of time to peak expiratory flow to total expiratory time(tPEF/tE)at baseline and after the administration of 400 mcg salbutamol was *** A total of 56 infants(35 boys),aged 7.4±2.8 mo,were *** them,12.5%were exposed to tobacco smoke and 41.1%were breastfed less than 2 *** were no differences in baseline TBFV measurements between the breastfeeding groups;however,those who breastfed longer than 2 mo had a greater change in tPEF/tE after bronchodilation(12%±10.4%vs 0.9%±7.1%;P<0.001).Moreover,there was a clear dose-response relationship between tPEF/tE reversibility and duration of breastfeeding(P<0.001).In multivariate regression analysis,infants who breastfed less(regression coefficient-0.335,P=0.010)or were exposed to cigarette smoke(regression coefficient 0.353,P=0.007)showed a greater change in tPEF/tE after bronchodilation,independent of sex,prematurity,and family history of asthma or *** Infants who recover from bronchiolitis and have a shorter duration of breastfeeding or are exposed to cigarette smoke,have TBFV measurements indicative of obstructive lung disease.

关键词： Tidal breathing analysis Lung function Bronchiolitis Breastfeeding Cigarette smoke Infants

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Complications of modern pancreaticoduodenectomy:A systematic review and meta-analysis

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 527-537页

作者： Stamatios Kokkinakis Evangelos I Kritsotakis Neofytos Maliotis Ioannis karageorgiou Emmanuel Chrysos Konstantinos Lasithiotakis Department of General Surgery University General Hospital of HeraklionHeraklionCrete 71110Greece Laboratory of Biostatistics Division of Social MedicineSchool of MedicineUniversity of CreteHeraklionCrete 71110Greece

Background:In the past decades,the perioperative management of patients undergoing pancreaticoduo-denectomy(PD)has undergone major changes *** review aimed to systematically determine the burden of complications of PD performed in the last 10 *** sources:A systematic review was conducted in PubMed for randomized controlled trials and ob-servational studies reporting postoperative complications in at least 100 PDs from January 2010 to April *** of bias was assessed using the Cochrane RoB2 tool for randomized studies and the method-ological index for non-randomized studies(MINORS).Pooled complication rates were estimated using random-effects *** was investigated by subgroup analysis and ***:A total of 20 randomized and 49 observational studies reporting 63229 PDs were *** MINORS score showed a high risk of bias in non-randomized studies,while one quarter of the ran-domized studies were assessed to have high risk of *** incidences of 30-day mortality,overall complications and serious complications were 1.7%(95%CI:0.9%-2.9%;I 2=95.4%),54.7%(95%CI:46.4%-62.8%;I 2=99.4%)and 25.5%(95%CI:21.8%-29.4%;I 2=92.9%),***-relevant postopera-tive pancreatic fistula risk was 14.3%(95%CI:12.4%-16.3%;I 2=92.0%)and mean length of stay was 14.8 days(95%CI:13.6-16.1;I 2=99.3%).Meta-regression partially attributed the observed heterogeneity to the country of origin of the study,the study design and the American Society of Anesthesiologists ***:Pooled complication rates estimated in this study may be used to counsel patients scheduled to undergo a PD and to set benchmarks against which centers can audit their ***,cautious interpretation is necessary due to substantial heterogeneity.

关键词： Pancreaticoduodenectomy Postoperative complications Meta-analysis Postoperative pancreatic fistula

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Connections Between Insomnia and Cognitive Aging

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Neuroscience Bulletin 2020年第1期36卷 77-84页

作者： Claire E.Sexton Konstantina Sykara Elissaios karageorgiou Jenny Zitser Talita Rosa Kristine Yaffe Yue Leng Global Brain Health Institute Memory and Aging CenterDepartment of NeurologyUniversity of CaliforniaSan FranciscoCAUSA Department of Psychiatry University of OxfordOxfordUK Neurological Institute of Athens AthensGreece Department of Psychiatry Neurology and EpidemiologyUniversity of CaliforniaSan FranciscoCAUSA

Insomnia is a common sleep disorder among older adults,and a risk factor for poor physical and mental ***,the relationship between insomnia and cognitive health is not well ***,we review observational studies that have investigated whether insomnia is associated with deficits in objective cognitive performance and an increased risk of dementia,magnetic resonance imaging studies that have assessed grey matter volumes and white matter microstructure,and interventional studies that have explored whether the treatment of insomnia can improve cognitive *** are inconsistent findings regarding impaired performance in objective cognitive tests and reduced grey matter volumes,and limited,emerging,evidence that suggests that insomnia is associated with an increased risk of dementia and reduced white matter *** the interventional literature is still in its infancy,there is some indication that treatment may have an impact on ***-powered studies examining sources of heterogeneity are warranted.

关键词： Insomnia Sleep Dementia Cognition

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