Association of breastfeeding with tidal breathing analysis in infants with bronchiolitis

作     者：Evanthia Perikleous Sotirios Fouzas Athina Karageorgiou Paschalis Steiropoulos Evangelia Nena Athanasios Chatzimichael Aggelos Tsalkidis Emmanouil Paraskakis 

作者机构：Department of PediatricsUniversity General Hospital of AlexandroupolisDemocritus University of ThraceAlexandroupoli 68100Greece Department of PaediatricsUniversity Hospital of PatrasUniversity of PatrasPatra 26504Greece Department of PneumonologyUniversity General Hospital of AlexandroupolisDemocritus University of ThraceAlexandroupoli 68100Greece Laboratory of Hygiene and Environmental ProtectionMedical SchoolDemocritus University of ThraceAlexandroupoli 68100Greece Paediatric Respiratory UnitPaediatric DepartmentUniversity of CreteHeraklion 71500Greece 

出 版 物：《World Journal of Clinical Pediatrics》 (世界临床儿科杂志)

年 卷 期：2021年第10卷第6期

页      面：168-176页

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：Tidal breathing analysis Lung function Bronchiolitis Breastfeeding Cigarette smoke Infants 

摘      要：BACKGROUND Tidal breathing flow-volume(TBFV)analysis provides important information about lung mechanics in *** To assess the effects of breastfeeding on the TBFV measurements of infants who recover from acute *** In this cross-sectional study,TBFV analysis was performed in infants with bronchiolitis prior to hospital *** ratio of time to peak expiratory flow to total expiratory time(tPEF/tE)at baseline and after the administration of 400 mcg salbutamol was *** A total of 56 infants(35 boys),aged 7.4±2.8 mo,were *** them,12.5%were exposed to tobacco smoke and 41.1%were breastfed less than 2 *** were no differences in baseline TBFV measurements between the breastfeeding groups;however,those who breastfed longer than 2 mo had a greater change in tPEF/tE after bronchodilation(12%±10.4%vs 0.9%±7.1%;P0.001).Moreover,there was a clear dose-response relationship between tPEF/tE reversibility and duration of breastfeeding(P0.001).In multivariate regression analysis,infants who breastfed less(regression coefficient-0.335,P=0.010)or were exposed to cigarette smoke(regression coefficient 0.353,P=0.007)showed a greater change in tPEF/tE after bronchodilation,independent of sex,prematurity,and family history of asthma or *** Infants who recover from bronchiolitis and have a shorter duration of breastfeeding or are exposed to cigarette smoke,have TBFV measurements indicative of obstructive lung disease.