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Biocompatible silver nanoparticles: An investigation into their protein binding efficacies, anti-bacterial effects and cell cytotoxicity studies

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Journal of Pharmaceutical Analysis 2021年第4期11卷 422-434页

作者： Sourav Das Leader Langbang Mahabul Haque Vinay Kumar Belwal Kripamoy Aguan atanu singha roy Department of Chemistry National Institute of Technology MeghalayaShillong793003India Department of Biotechnology&Bioinformatics North-Eastern Hill UniversityShillong793022India Department of Bioscience and Bioengineering Indian Institute of Technology GuwahatiAssam781039India

Green synthesis of silver nanoparticles(AgNPs)has garnered tremendous interest as conventional methods include the use and production of toxic chemicals,products,by-products and *** this regard,the synthesis of AgNPs using green tea(GT)extract and two of its components,(-)-epigallocatechin gallate(EGCG)and(+)-catechin(Ct)as capping/stabilizing agents,is *** synthesized AgNPs showed antibacterial activity against the bacterial strains Staphylococcus aureus and Escherichia coli,along with anticancer activity against HeLa *** administering nanoparticles to the body,they come in contact with proteins and results in the formation of a protein corona;hence we studied the interactions of these biocompatible AgNPs with hen egg white lysozyme(HEWL)as a carrier *** quenching mechanism was accountable for the quenching of HEWL fluorescence by the *** binding constant(Kb)was found to be higher for EGCG-AgNPs((2.309±0.018)×104 M-1)than for GT-AgNPs and Ct-AgNPs towards ***-AgNPs increased the polarity near the binding site while Ct-AgNPs caused the opposite effect,but GT-AgNPs had no such observable *** dichroism studies indicated that the AgNPs had no such appreciable impact on the secondary structure of *** key findings of this research included the synthesis of AgNPs using GT extract and its constituent polyphenols,and showed significant antibacterial,anticancer and protein-binding ***-OH groups of the polyphenols drive the in situ capping/stabilization of the AgNPs during synthesis,which might offer new opportunities having implications for nanomedicine and nanodiagnostics.

关键词： Green tea Polyphenols Silver nanoparticles Anti-bacterial Cytotoxicity Hen egg white lysozyme(HEWL)

A spectroscopic study of the interaction of the antioxidant naringin with bovine serum albumin

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Journal of Biophysical Chemistry 2010年第3期1卷 141-152页

作者： atanu singha roy Debi Ranjan Tripathy Angshuman Chatterjee Swagata Dasgupta 不详

The interaction of naringin with bovine serum albumin has been performed using fluorescence, circular dichroism and fourier transform infrared spectroscopy in 20 mM phosphate buffer of pH 7.0 as well as molecular docking studies. The changes in enthalpy (ΔH°) and entropy (ΔS°) of the interaction were found to be +18.73 kJ/mol and +143.64 J mol-1 K-1 respectively, indicating that the interaction of naringin with bovine serum albumin occurred mainly through hydrophobic interactions. Negative values of free energy change (ΔG°) at different temperatures point toward the spontaneity of the interaction. Circular dichroism studies reveal that the helical content of bovine serum albumin decreased after interaction with naringin. According to the F?rster non-radiative energy transfer theory the distance between Trp 213 residue and naringin was found to be 3.25 nm. Displacement studies suggest that naringin binds to site 1 (subdomain IIA) of bovine serum albumin (BSA) which was also substantiated by molecular docking studies.

关键词： Naringin Bovine Serum Albumin Fluorescence Binding Warfarin Docking

Forecasting of Software Reliability Using Neighborhood Fuzzy Particle Swarm Optimization Based Novel Neural Network

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IEEE/CAA Journal of Automatica Sinica 2019年第6期6卷 1365-1383页

作者： Pratik roy Ghanshaym singha Mahapatra Kashi Nath Dey Department of Computer Science and Engineering University of CalcuttaKolkata-700106India Department of Mathematics National Institute of TechnologyPuducherryKaraikal-609609India

This paper proposes an artificial neural network(ANN) based software reliability model trained by novel particle swarm optimization(PSO) algorithm for enhanced forecasting of the reliability of software. The proposed ANN is developed considering the fault generation phenomenon during software testing with the fault complexity of different levels. We demonstrate the proposed model considering three types of faults residing in the software. We propose a neighborhood based fuzzy PSO algorithm for competent learning of the proposed ANN using software failure data. Fitting and prediction performances of the neighborhood fuzzy PSO based proposed neural network model are compared with the standard PSO based proposed neural network model and existing ANN based software reliability models in the literature through three real software failure data sets. We also compare the performance of the proposed PSO algorithm with the standard PSO algorithm through learning of the proposed ANN. Statistical analysis shows that the neighborhood fuzzy PSO based proposed neural network model has comparatively better fitting and predictive ability than the standard PSO based proposed neural network model and other ANN based software reliability models. Faster release of software is achievable by applying the proposed PSO based neural network model during the testing period.

关键词： Artificial neural network(ANN) fuzzy particle swarm optimization(PSO) reliability prediction software reliability

A Review on Phylogenetic Analysis: A Journey through Modern Era

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Computational Molecular Bioscience 2014年第3期4卷 39-45页

作者： Sourav singha roy Rakhi Dasgupta Angshuman Bagchi Department of Biochemistry and Biophysics University of Kalyani Kalyani India

Phylogenetic analysis may be considered to be a highly reliable and important bioinformatics tool. The importance of phylogenetic analysis lies in its simple manifestation and easy handling of data. The simple tree representation of the evolution makes the phylogenetic analysis easier to comprehend and represent as well. The varied applications of phylogenetics in different fields of biology make this analysis an absolute necessity. The different aspects of phylogenetic analysis have been described in a comprehensive manner. This review may be useful to those who would like to have a firsthand knowledge of phylogenetics.

关键词： Phyllogeny Tree Structure Evolutionary Time Evolution of Function

Effects of 42-year long-term fertilizer management on soil phosphorus availability, fractionation,adsorption–desorption isotherm and plant uptake in flooded tropical rice

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The Crop Journal 2015年第5期3卷 387-395页

作者： Pratap Bhattacharyya Amaresh Kumar Nayak Mohammad Shahid Rahul Tripathi Sangita Mohanty Anjani Kumar Rajagounder Raja Bipin Bihari Panda Banwari Lal Priyanka Gautam Chinmaya Kumar Swain Koushik singha roy Pradeep Kumar Dash Division of Crop Production Central Rice Research Institute

Soil phosphorus(P) fractionation, adsorption, and desorption isotherm, and rice yield and P uptake were investigated in flooded tropical rice(Oryza sativa L.) following 42-year fertilizer and manure application. The treatments included low-input [unfertilized control without N, P, or K(C0N0)], farmyard manure(FYM)(C1N0), NP(C0NP), NPK(C0NPK), FYM + NP(C1NP), and high-input treatment, FYM + NPK(C1NPK). Grain yield was increased significantly by 74%over the control under the combined application of FYM + NPK. However, under low- and high-input treatments, yield as well as P uptake was maintained at constant levels for 35 *** the same period, high yield levels and P uptake were maintained under the C0 NP, C0 NPK,and C1 NPK treatments. These are unique characteristics of a tropical flooded ecosystem, which is a self-sustaining system for rice production. The Fe–P fraction was highest compared to the Ca–P and Al–P fractions after 42 years of fertilizer application and was significantly higher under FYM + NPK treatment. The P adsorption capacity of soil was highest under the low-input treatment and lowest under long-term balanced fertilization(FYM + NPK). In contrast, P desorption capacity was highest under NPK and lowest in the control treatment. Long-term balanced fertilization in the form of FYM + NPK for 42 years lowered the bonding energy and adsorption capacity for P in soil but increased its desorption potential, increasing P availability to the plant and leading to higher P uptake and yield maintenance.

关键词： Long-term fertilization Phosphorus adsorption Phos

Efficacy of oxytetracycline and potentiated sulphonamide oral therapies against Aeromonas hydrophila infection in Nile tilapia Oreochromis niloticus

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Journal of Coastal Life Medicine 2017年第9期5卷 371-374页

作者： Thangapalam Jawahar Abraham Anwesha roy roy Beryl Julinta Jasmine singha Prasanna Kumar Patil Department of Aquatic Animal Health Faculty of Fishery SciencesWest Bengal University of Animal and Fishery SciencesChakgariaKolkataWestBengalIndia Central Institute of Brackishwater Aquaculture Indian Council of Agricultural ResearchRaja Annamalai PuramChennaiTamil NaduIndia

Objective: To assess the efficacy of feeds containing approved antibiotics, viz., oxytetracycline (OTC) or potentiated sulphonamide [(sulphamethoxazole-trimethoprim) SMZ-TMP] at 1 g, 2 g, 3 g and 4 g of respective antibiotics/kg feed at 2% body weight ration in preventing the Aeromonas hydrophila (A. hydrophila) infection in Oreochromis niloticus. Methods: Commercial pellet feed was top dressed with respective antibiotics using 5 mL vegetable oil as a binder. Fish were injected intramuscularly with A. hydrophila at ≈ 6.0 × 107–8.6 × 107 CFU/fish, and fed subsequently with OTC and SMZ-TMP feeds for 10 and 5 days, respectively. Fish mortalities were recorded during the pre-treatment, treatment and post-treatment periods. Results: Highest mortalities (7.42%–8.33%) were observed in challenged and untreated fish. The mortalities observed in fish fed with OTC or SMZ-TMP were 0%–6.66% with decreasing concentrations of antibiotics from 4 to 1 g/kg feed. Significant differences existed in the mortalities among fish fed with different doses of antibiotics (P < 0.05). The relative percent survival values were 20, 40, 40 and 60 for 1 g, 2 g, 3 g and 4 g OTC/kg feed groups, respectively;while in SMZ-TMP fed fish, the respective relative percent survival values were 10, 100, 100, and 100. Conclusions: The fish fed with feed containing 2 g antibiotic/kg at 2% body weight was the lowest concentration that recorded significantly lower mortality (P < 0.05), which could be the treatment of choice for the control of A. hydrophila in Oreochromis niloticus in tropical condition.

关键词： Aeromonas hydrophila Oreochromis niloticus Oxytetracycline Potentiated sulphonamide

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羧化丁腈橡胶和丙烯酸酯橡胶的特种共混体

橡胶参考资料 1996年第9期26卷 41-47页

作者： S.K.singha roy C.K.Das 姚联国

前言起始于传统聚合物的聚合物共混在聚合物相间存在有利相互作用并能共硫化的条件下能以较低的成本获得高性能。羧化丁腈橡胶(XNBR)是一种易加工的耐磨特种弹性体。Bryant 指出。

关键词：丁腈橡胶丙烯酸酯橡胶橡塑共混共混体