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Organic Chemistry Frontiers 2022年第2期9卷 420-427页

作者： marta Gil-Ordonez Alicia maestro Pablo Ortega Pablo G.Jambrina jose m.Andres GIR-SintACat-Instituto Universitario CInQUImA y Departamento de Química Orgánica Facultad de CienciasUniversidad de ValladolidPaseo Belén 747011 ValladolidSpain Departamento de Química Física University of Salamanca37008 SalamancaSpain

Chiral pyrazolones with a spirocyclic centre at the C4-position are widely found in a large family of medically relevant *** recent years,organocatalysis,particularly that performed with quiral n-heterocyclic carbenes(nHCs),has allowed the enantioselective synthesis of these spirocyclic compounds despite its inherent *** this work,we describe the fully diastereo-and highly enantioselective synthesis of novel spirocyclic pyrazolone γ-butyrolactones via nHC-catalysed[3+2]annulation reaction of enals and 1H-pyrazol-4,*** understand the catalytic mechanism and origin of stereoselectivity,electronic structure calculations were carried *** considering various pathways,we concluded that the stereoselectivity-determining step is the formation of the lactone that proceeds after addition of the nHC derived homoenolate to the electrophilic carbonyl group of pyrazolin-4,*** calculations predict that the free energy barrier is lower for the(RS)product,which is also the main product experimentally obtained.

关键词： synthesis spiro mechanism

Chronic model of tympanic perforation in rats with mitomycin C and dexamethasone

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Journal of Otology 2019年第1期14卷 12-16页

作者： Tomás Esteban noemí m.Atucha jose maría moraleda Joaquín Garcia-Esta? Carmen L.Insausti Javier moraleda-Deleyto Servicio de Otorinolaringologia Hospital General Universitario Santa Lucia Departamento de Fisiologia Facultad de Medicina Universidad de Murcia Instituto Murciano de Investigacion Biosanitaria Departamento de medicina Facultad de Medicina Universidad de MurciaInstituto Murciano de Investigacion Biosanitaria EnT Service University Hospital of Lewisham

A rat model of chronic tympanic membrane perforation was developed to be used in the search of new materials for the sealing of these perforations. A longitudinal study was carried out in rats subjected to incisional myr-ingotomy followed by the application of mitomycin C alone or with dexamethasone. Rats were checked at days 3, 7,1 0,1 4 and weekly thereafter until perforation closure, for up to 6 months. The addition of dexamethasone is a key component in order to obtain a chronic opening. myringotomies treated w ith saline had a mean healing time of 8.5 days. At 8 weeks, between 62.5% and 77.7% of tympanic membranes treated w ith mitomycin C and dexamethasone remained perforated and at 6 months this number fell to 21.4%. This technique is able to maintain most tympanic membrane perforations patent for at least 8 weeks. This rat model is adequate for its use in preclinical or translational research.

关键词： Animal model Chronic tympanic membrane perforation mitomycin C myringotomy Dexamethasone

Remediation of amide pesticide-polluted soils by combined solarization and ozonation treatment

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Pedosphere 2024年第3期34卷 641-651页

作者： Isabel GARRIDO Carmen mmARTInEZ Pilar FLORES Pilar HELLIn Fulgencio COnTRERAS jose FEnOLL Department of Sustainability and Quality Group of Fruit and Vegetable Products Instituto Murciano de Investigacion y Desarrollo Agrario y MedioambientalLa Alberca 30150(Spain)

Agriculture has a close relationship with nature,but it can also be the source of negative and permanent environmental *** use of pesticides in modern agriculture is a common practice,but their side effects on the environment cannot be *** this study,we evaluated a combination of solarization and ozonation techniques for the elimination of six amide pesticides(boscalid,chlorantraniliprole,cyflufenamid,fluopyram,napropamide,and propyzamide)in *** experiments were performed with four different soils to assess the efficiency of this methodology at different soil temperatures and ozone dosages under laboratory conditions,and then a greenhouse pot experiment was conducted under controlled conditions during *** days after the onset of the experiments,higher degradation percentages of amide pesticides were observed in ozonized soils than in other treated soils,particularly when ozone was applied at 10 cm soil *** results show that the utilization of ozonation,along with solarization,represents a valid method for degrading residues of the studied pesticides and suggest that this combined technology may be a promising tool for remediating pesticide-polluted soils.

关键词： intermediate ozone pesticide degradation pesticide residue polyethylene film remediation technique

Film cooling effects on the tip flow characteristics of a gas turbine blade

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Propulsion and Power Research 2015年第1期4卷 9-22页

作者： jin Wang Bengt Sundén min Zeng Qiuwang Wang Key Laboratory of Thermo-Fluid Science and Engineering Ministry of EducationXi’an Jiaotong UniversityXi’anShaanxi 710049China School of Energy and Environmental Engineering Hebei University of TechnologyTianjin 300401China Department of Energy Sciences Division of Heat TransferLund UniversityLund SE-22100Sweden

An experimental investigation of the tip flow characteristics between a gas turbine blade tip and the shroud was conducted by a pressure-test system and a particle image velocimetry(PIV)system.A three-times scaled profile of the GE-E3 blade with five film cooling holes was used as *** effects on flow characteristics by the rim width and the groove depth of the squealer tip were *** rim widths were(a)0.9%,(b)2.1%,and(c)3.0%of the axial chord,and the groove depths were(a)2.8%,(b)4.8%,and(c)10%of the blade *** pressure taps on the top plate above the blades were connected to pressure *** a CCD camera the PIV system recorded the velocity field around the leading edge zone including the five cooling *** flow distributions both in the tip clearance and in the passage were revealed,and the influence of the inlet velocity was *** this work,the tip flow characteristics with and without film cooling were *** effects of different global blowing ratios of m=0.5,1.0,1.3 and 2.5 were *** was found that decreasing the rim width resulted in a lower mass flow rate of the leakage flow,and the pressure distributions from the leading edge to the trailing edge showed a linearly increasing *** was also found that if the inlet velocity was less than 1.5 m/s,the flow field in the passage far away from the suction side appeared as a stagnation zone.

关键词： Film cooling Squealer tip Rim Vorticity Particle image velocimetry(PIV)

Predicting the clothing insulation through machine learning algorithms:A comparative analysis and a practical approach

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Building Simulation 2024年第5期17卷 839-855页

作者： Pablo Aparicio-Ruiz Elena Barbadilla-martin jose Guadix Jesus munuzuri Grupo de Ingenieria de Organizacion Escuela Tecnica Superior de IngenieriaUniversidad de SevillaCamino de los Descubrimientos S/N41092SevilleSpain

Since indoor clothing insulation is a key element in thermal comfort models,the aim of the present study is proposing an approach for predicting it,which could assist the occupants of a building in terms of recommendations regarding their *** that,a systematic analysis of input variables is exposed,and 13 regression and 12 classification machine learning algorithms were developed and *** results are based on data from 3352 questionnaires and 21 input variables from a field study in mixed-mode office buildings in *** temperature at 6 a.m.,indoor air temperature,indoor relative humidity,comfort temperature and gender were the most relevant features for predicting clothing *** comparing machine learning algorithms,decision tree-based algorithms with Boosting techniques achieved the best *** proposed model provides an efficient method for forecasting the clothing insulation level and its application would entail optimising thermal comfort and energy efficiency.

关键词： clothing insulation simulation adaptive thermal comfort behavioural adaptive actions machine learning

Flat Zn deposition at battery anode via an ultrathin robust interlayer

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nano Research 2024年第9期17卷 8104-8111页

作者： yizhou Wang Jianyu Chen Zibo Chen Qian He Zhengnan Tian jin Zhao yanwen ma Husam n.Alshareef materials Science and Engineering King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia State Key Laboratory of Organic Electronics and Information Displays(KLOEID)and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Suzhou Vocational Institute of Industrial Technology Suzhou 215104China

Rechargeable aqueous zinc(Zn)ion batteries(AZIBs)using low-cost and safe Zn metal anodes are considered promising candidates for future grid-scale energy storage systems,but the Zn dendrite problem severely hinders the further prospects of *** Zn depositing behaviors toward horizontal alignment is highly effective and thus has received huge ***,such a strategy is usually based on previous substrate engineering,which requires complex preparation or expensive ***,it is essential to develop a novel solution that can realize horizontally aligned Zn flake deposition via easy operation and low ***,we report an ultrathin and robust Kevlar membrane as the interlayer to mechanically suppress Zn dendrite *** to the randomly distributed flaky dendrites in the control group,the deposited Zn sheets would grow into parallel alignment with the existence of such *** the dendrites are effectively suppressed,Zn||Cu asymmetric,Zn||Zn symmetric,and Zn||mnO_(2)full batteries using Kevlar interlayer deliver significantly improved cycling ***,the Zn||mnO_(2)pouch cell using a Kevlar interlayer delivers stable cycling performance and shows stable operation during multi-angle *** believe this work provides a new possibility for regulating Zn deposition from a crystallographic perspective.

关键词： Zn metal anodes Zn dendrites aqueous Zn ion batteries dendrite suppression (002)crystal plane

Generalized B（m, n）, C（n）, D（m, n）-graded Lie superalgebras arising from fermionic-bosonic representations

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Frontiers of mathematics in China 2016年第6期11卷 1451-1470页

作者： jin CHEnG Department of mathematics University of Science and Technology of China Hefei 230026China

We construct fermionic-bosonic representations for a class of generalized B（m, n）, C（n）, D（m, n）-graded Lie superalgebras coordinatized by quantum tori with nontrivial central extensions.

关键词： Root system graded Lie superalgebras quantum tori fermionic- bosonic reoresentations

Commitment of human mesenchymal stromal cells to skeletal lineages is independent of their morphogenetic capacity

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World Journal of Stem Cells 2023年第7期15卷 701-712页

作者： Jessica Cristina marín-Llera Damián García-García Estefania Garay-Pacheco Victor Adrian Cortes-morales Juan jose montesinos-montesinos Jesus Chimal-monroy medicina Genómica y Toxicología Ambiental Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCoyoacan 04510Mexico Laboratorio de Células Troncales mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Departamento de medicina Genómica y Toxicología Ambiental Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCoyoacan 04510Mexico

BACKGROUnD mesenchymal stromal cells(mSCs)are multipotent cell populations obtained from fetal and adult *** share some characteristics with limb bud mesodermal cells such as differentiation potential into osteogenic,chondrogenic,and tenogenic lineages and an embryonic mesodermal *** mSCs differentiate into skeletal-related lineages in vitro,they have not been shown to selforganize into complex skeletal structures or connective tissues,as in the *** this work,we demonstrate that the expression of molecular markers to commit mSCs to skeletal lineages is not sufficient to generate skeletal elements in *** To evaluate the potential of mSCs to differentiate into skeletal lineages and generate complex skeletal structures using the recombinant limb(RL)*** We used the experimental system of RLs from dissociated-reaggregated human placenta(PL)and umbilical cord blood(UCB)*** being harvested and reaggregated in a pellet,cultured cells were introduced into an ectodermal cover obtained from an early chicken limb ***,this filled ectoderm was grafted into the back of a donor chick *** these conditions,the cells received and responded to the ectoderm’s embryonic signals in a spatiotemporal manner to differentiate and pattern into skeletal *** response to differentiation and morphogenetic signals was evaluated by quantitative poly-merase chain reaction,histology,immunofluorescence,scanning electron microscopy,and in situ *** We found that human PL-mSCs and UCB-mSCs constituting the RLs expressed chondrogenic,osteogenic,and tenogenic molecular markers while differentially committing into limb lineages but could not generate complex structures in ***-RL from PL or UCB were committed early to chondrogenic ***,the UCB-RL osteogenic commitment was favored,although preferentially to a tenogenic cell *** findings suggest that the commitment of mSCs to differentiate int

关键词： Human mesenchymal stromal cells Recombinant limbs mesenchymal stromal cell morphogene-sis mesenchymal stromal cell in vivo differentiation Skeletal tissues

Topical Applications of Thiosulfinate-Enriched Allium sativum Extract Accelerates Acute Cutaneous Wound Healing in murine model

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Chinese Journal of Integrative medicine 2020年第11期26卷 812-818页

作者： Juan Luis Santiago Eva maria Galan-moya jose Ramon munoz-Rodriguez miguel Angel de la Cruz-morcillo Francisco Javier Redondo-Calvo Ignacio Gracia-Fernandez Peter m.Elias jose manuel Perez-Ortiz mao-Qiang man Dermatology Service Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Research Unit Hospital General Universitario de Ciudad RealCiudad Real(13004)Spain Translational Oncology Laboratory Centro Regional de Investigaciones BiomedicasUniversidad de Castilla-La ManchaAlbacete(02008)Spain Instituto de Tecnologia Quimica y medioambiental Universidad de Castilla-La ManchaCiudad Real(13004)Spain Dermatology Service Vetera ns Affairs Medical Centerand Department of DermatologyUniversity of CaliforniaSan FranciscoCA(94121)USA Dermatology Hospital Southern Medical UniversityGuangzhou(510091)China

Objective To determine whether topical applications of thiosulfinate-enriched Allium sativum extract(TASE)can accelerate acute cutaneous wound healing(WH)in a murine *** Keratinocyte viability and in vitro wound closure were assessed in keratinocyte *** of topical TASE(0.5μg/mL of allicin in 97%ethanol)on acute cutaneous WH were determined in a murine model of acute cutaneous *** mice were alternately assigned to the vehicle-and TASE-treated groups(n=6 per group).Expression levels of mRnA for keratinocyte differentiation marker-related proteins(filaggrin,loricrin and involucrin)and lipid synthetic enzymes(elongation of very long chain fatty acids protein 4(ELOVL4),fatty acid synthase(FA2H),3-hydroxy-3-methyl-glutaryl-coenzyme A reductase(HmGCoA),and serine palmitoyltransferase(SPT))were assessed using real-time quantitative polymerase chain reaction on day 3 and 8 after wounding,while transepidermal water loss(TEWL)rates were measured in wounded *** TASE accelerated WH both in vivo(40%vs.22%reduction in wound area,Pnd in vitro(90%vs.65%reduction in wound area,Pmoreover,topical applications of TASE upregulated the expression levels of epidermal mRnA for ELOVL4,HmGCoA,SPT,filaggrin,loricrin and involucrin(Pntrols)on day 3 after ***,TASE significantly lowered TEWL rates in comparison with vehicle alone on day 8(33.06±2.09 g/(m^2·h)vs.24.60±2.04 g/(m^2·h),Pnclusions Topical applications of TASE stimulated keratinocyte proliferation and formation of epidermal permeability barrier function,leading to acceleration of acute cutaneous *** products containing TASE could be used to manage acute cutaneous WH.

关键词： Allium sativum thiosulfinate wound healing permeability barrier keratinocytes proliferation

Global Solvability,Pattern Formation and Stability to a Chemotaxis-haptotaxis model with Porous medium Diffusion

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Acta mathematica Sinica,English Series 2023年第8期39卷 1597-1623页

作者： Chun Hua jin School of mathematical Sciences South China Normal UniversityGuangzhou 510631P.R.China

In this paper,we deal with the following chemotaxis-haptotaxis system modeling cancer invasion with nonlinear diffusion,ut=Δum−χ∇·(u∇v)−ξ∇·(u∇ω)+μu(1−u−ω),inΩ×R^(+),vt−Δv+v=u,inΩ×R+,ωt=−vω,inΩ×R+,whereΩ⊂R^(n)is a bounded *** first supplement the results of global existence and uniform boundedness of solutions for the case m=2n n+*** for any m>0 and any spatial dimension,we consider the stability of equilibrium,and find that the chemotaxis has a destabilizing effect,that is for the ODEs,or the diffusion-ODE system without chemotaxis,the solutions tend to a linearly stable uniform steady state(1,1,0).When the chemotactic coefficientχis large,the equilibrium(1,1,0)become *** we study the existence of nontrivial stationary solutions via bifurcation techniques withχbeing the bifurcation parameter,and obtain nonhomogeneous *** last,we also investigate the stability of these bifurcation solutions.

关键词： Chemotaxis-haptotaxis porous medium diffusion pattern formation stability