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Food and Nutrition Sciences 2020年第6期11卷 509-522页

作者： astha dwivedi Sandeep Kumar Sharmistha Singh Poonam Chandra Mittal Department of Biochemistry Faculty of Science University of Allahabad Allahabad India

Aims: Obesity is the major contributor of the metabolic syndrome (MetS), but a unique phenotype of obesity known as metabolically healthy obese (MHO) shows healthier metabolic profile; however understanding of their biochemical correlates is poorly understood. Obesity is defined by Body mass index (BMI), but controversy exists regarding ethnic-specific BMI cut-offs. The present study used the Asian Indian BMI cut-offs to assess relationships of MHO phenotypes with oxidative stress (OS) and inflammation. Methods: In this case-control study, 299 metabolically-healthy (MH) respondents were divided into four groups as per Asian criteria for obesity: MH non-obese (MHNO), MH overweight (MHOW), MHO and MH severely obese (MHSO). Their oxidative stress and pro-inflammatory markers were measured. Results: Levels of hydroxyl radicals (·OH), fluorescent oxidation products (FLOP), MDA, PCO and inflammatory markers CRP, TNF-α, IL-6 were highest in MHSO pheno

关键词： Metabolically Healthy Obesity Metabolic Syndrome Risk Factors Oxidative Stress Inflammatory Markers

Total Antioxidant Status and Other Markers to Distinguish Severely Obese Volunteers with and without Metabolic Syndrome

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Food and Nutrition Sciences 2019年第6期10卷 648-663页

作者： Sharmistha Singh astha dwivedi Sandeep Kumar Poonam Chandra Mittal Department of Biochemistry Faculty of Science University of Allahabad Allahabad India

Obesity (Ob) is an accepted major risk factor for the metabolic syndrome (MetS), a combination of at least three of five risk factors, which predispose to high oxidative stress (OS), but all obese do not show symptoms of MetS. There is dearth of data comparing OS homeostasis of severely obese adults with and without MetS, and need for biomarkers to help in differential diagnosis. Erythrocytic lipid and protein damage markers, malondialdehyde (MDA) and protein carbonyl (PCO), antioxidant enzymes erythrocytic superoxide dismutase(SOD), catalase (CAT), plasma glutathione peroxidase (GPX), and total antioxidant capacity (TAC) as ferric-reducing-ability-of-plasma (FRAP) were compared to understand OS homeostasis among 102 severely Ob (body mass index > 30), 102 Ob with severe (z-score > 2) MetS as per National Cholesterol Education Program-Adult Treatment Panel III guidelines and 100 healthy non-obese Controls. MDA/PCO and all antioxidant enzymes were lowest for ObMetS, followed by Ob, indicating greater damage to protein moieties of the erythrocytic membrane. Multiple regression analysis confirmed z-scores > 2 as significant predictor of lowered enzymes and TAC. Receiver Operator Curve analysis predicted that TAC was the most potential biomarker for the diagnosis and prognosis of MetS with an Odds Ratio of 88.5 indicating the high probability that FRAP would be low for ObMetS (z-score > 2) than for Ob with BMI > 30, but z-scores < 1. TAC is qualified as the most effective biomarker to distinguish between severely obese respondents with and without metabolic syndrome, and as a useful candidate for study of homeostatic breakdown in metabolic syndrome and the importance of z-score in assessment of MetS in obese respondents.

关键词： Obesity Body Mass Index Metabolic Syndrome Z-Score Total Antioxidant Capacity Biomarker

Randomized controlled trial of topical EMLA and vapocoolant spray for reducing pain during wDPT vaccination

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World Journal of Pediatrics 2017年第3期13卷 236-241页

作者： Navratan Kumar Gupta Amit Upadhyay Ajeet Kumar dwivedi astha Agarwal Vijay Jaiswal Abhishek Singh Department of Pediatrics LLRMMedical CollegeMeerut(UP)India

Background:Intramuscular vaccination is among the most common source of iatrogenic pain in *** sprays are rapid-acting alternative to topical *** provide transient anesthesia via evaporation induced skin cooling,and reduce pain due to vaccine injection in children and *** objective was to compare the synergistic analgesic effect of eutectic mixture of local anesthetics (EMLA) with breastfeeding (EB group) and vapocoolant spay with breastfeeding (VB group) to that of only breastfeeding (BO group) during whole cell diptheria,pertussis and tetanus (wDPT) ***:A double blind randomized controlled trial was done to include infants up to 3 months of age who came for their first wDPT *** primary outcome variable was the duration of cry after *** outcome variables were Modified Facial Coding Score,Neonatal Infant Pain Scale and latency of onset of ***:Of the 201 eligible participants,111 babies were excluded and remaining 90 babies were randomized into three groups of thirty *** groups did not differ significantly in baseline *** (interquartile range,IQR) of duration of cry was lesser [35.86 (21.07-107.75) seconds] in babies receiving EMLA cream with breast feeding (EB group) and in babies receiving vapocoolant spray with breast feeding (VB group) [32.58 (21.25-106.21) seconds] as compared to babies receiving only breast feeding (BO group) [67.5 (27.6-180) seconds] (P=-0.147).Difference in median (IQR) of latency of cry was not statistically *** Facial Coding Score and Neonatal Infant Pain Scale at 1 minute and 3 minutes was significantly lower in the EB and VB group,as compared to the BO group (P<0.05).Conclusions:Addition of topical EMLA application or vapocoolant spray to breastfeeding during wDPT vaccination does not reduce duration of cry in infants up to 3 months of ***,they are able to show reduction in pain score and further studi

关键词： diptheria,pertussis and tetanus vaccine eutectic mixture of local anesthetics Modified Facial Coding Score Neonatal Infant Pain Scale

Ten-year review of trends in children with type 1 diabetes in England and Wales

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World Journal of Diabetes 2023年第8期14卷 1194-1201页

作者： Sze M Ng astha Soni Department of Paediatrics Mersey and West Lancashire Teaching Hospitals NHS TrustOrmskirk L392AZUnited Kingdom Department of Women's and Children's Health University of LiverpoolLiverpool L693BXMerseysideUnited Kingdom Faculty of Health Social Care&MedicineEdge Hill UniversityOrmskirk L394QPLancashireUnited Kingdom Department of Paediatrics Sheffield Children's HospitalSheffield S102THUnited Kingdom

This review describes the prevalence,incidence,and demographics of children and young people(CYP)with type 1 diabetes in England and Wales using data from the United Kingdom National Paediatric Diabetes Audit(NPDA)and has almost 100%submission from all paediatric diabetes centres *** is a powerful benchmarking tool and is an essential part of a long-term quality improvement programme for CYP with *** characteristics of this population by age,insulin regimen,complication rates,health inequalities,access to diabetes technology,socioeconomic deprivation and glycaemic outcomes over the past decade is described in the *** NPDA for England and Wales is commissioned by the United Kingdom Healthcare Quality Improvement Partnership as part of the National Clinical Audit for the United Kingdom National Service Framework for *** rising incidence of Type 1 diabetes is evidenced in the past *** in national median glycated hemoglobin for CYP with diabetes is observed over the last 10 years and the improvement sustained by various initiatives and quality improvement programmes implemented with universal health coverage.

关键词： Paediatric Type 1 Trends Outcomes Glycated hemoglobin

Digital reconstruction of fragmented tooth remains in forensic context

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Forensic Sciences Research 2022年第1期7卷 88-93页

作者： Abraham Johnson Gargi Jani Joe Adserias Garriga astha Pandey Institute of Forensic Science Gujarat Forensic Sciences UniversityGandhinagarIndia Department of Applied Forensic Sciences Mercyhurst UniversityEriePAUSA

Forensic odontology majorly focuses on the identification of victims through the analyses of oral and para-oral *** to high temperatures and trauma can occur in mass disasters and may lead to the fracturing and fragmentation of *** fragments may become very fragile and easily damaged while *** methodologies such as the use of transparent nail polish,hair spray,cyanoacrylate or adhesives have been used to stabilise the fragmented *** study introduces a new and innovative digital technique that utilises three-dimensional surface scanning(3DSS)and rapid prototyping techniques to reconstruct fractured portions of the *** results of qualitative congruency analysis suggest that over all variance of morphological error(0.0526±0.05)*** results imply that the reconstructed 3D model can be used for various morphometric analyses.

关键词： Forensic sciences forensic odontology forensic reconstruction threedimensional surface scanning threedimensional printing

Inorganic/organic combination:Inorganic particles/polymer composites for tissue engineering applications

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Bioactive Materials 2023年第6期24卷 535-550页

作者： astha Sharma Ganesh R.Kokil Yan He Baboucarr Lowe Arwa Salam Tariq A.Altalhi Qingsong Ye Tushar Kumeria School of Materials Science and Engineering University of New South WalesKensingtonSydneyNSW2052Australia Australian Centre for Nanomedicine University of New South WalesKensingtonSydneyNSW2052Australia Institute of Regenerative and Translational Medicine Department of StomatologyTianyou HospitalWuhan University of Science and TechnologyWuhan430030China Chemistry Department College of ScienceTaif UniversityTaif21944Saudi Arabia Center of Regenerative Medicine Department of StomatologyRenmin Hospital of Wuhan UniversityWuhan430060China School of Pharmacy University of QueenslandWoolloongabbaQLD4102Australia

Biomaterials have ushered the field of tissue engineering and regeneration into a new era with the development of advanced *** these,the composites of inorganic materials with organic polymers present unique structural and biochemical properties equivalent to naturally occurring hybrid systems such as bones,and thus are highly *** last decade has witnessed a steady increase in research on such systems with the focus being on mimicking the peculiar properties of inorganic/organic combination composites in *** this review,we discuss the recent progress on the use of inorganic particle/polymer composites for tissue engineering and regenerative *** have elaborated the advantages of inorganic particle/polymer composites over their organic particle-based composite *** the inorganic particles play a crucial role in defining the features and regenerative capacity of such composites,the review puts a special emphasis on the various types of inorganic particles used in inorganic particle/polymer *** inorganic particles that are covered in this review are categorised into two broad types(1)solid(e.g.,calcium phosphate,hydroxyapatite,etc.)and(2)porous particles(e.g.,mesoporous silica,porous silicon etc.),which are elaborated in detail with recent *** review also covers other new types of inorganic material(e.g.,2D inorganic materials,clays,etc.)based polymer composites for tissue engineering ***,we provide our expert analysis and opinion of the field focusing on the limitations of the currently used inorganic/organic combination composites and the immense potential of new generation of composites that are in development.

关键词： Composites Regenerative medicine Inorganic nanomaterials Mesoporous silica Porous silicon

Biological Management of Damping-Off, Buckeye Rot and Fusarial Wilt of Tomato (cv. Solan Lalima) under Mid-Hill Conditions of Himachal Pradesh

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Agricultural Sciences 2015年第5期6卷 535-544页

作者： Nitika Thakur astha Tripathi Department of Microbiology Shoolini University of Biotechnology and Management Sciences Bajhol Campus Solan (Himachal pradesh) India

Disease management is often complicated by the presence of multiple types of pathogens;in an organic system, it is appropriate to develop disease control strategies. The available literature so far reflects that the management of important disease of tomato is through the integrated approaches and very few organic approaches have been tried with various degree of success. Boiopriming of seeds with biocontrol agents (Trichoderma viridae, Trichoderma harzianum and Pseudomonas fluorescens) in combination with different biofertilizers (Azotobacter, Azospirillum and PSB) and organic manures (FYM and vermi-compost) were tested against disease incidence and health management of tomato seedling under nursery as well as field conditions. The studies were conducted during two successive years (2012-2013) at farmer’s field with the objective to combat with the increasing disease incidence of three major disease damping-off, fusarium wilt and buckeye rot from nursery stage to the final harvesting. The study focused on the use of biocontrol agents as the suitable alternative to chemical pesticides with sustainable disease management without pesticide residues in foodstuff. The bio priming of seeds with fungal antagonist Trichoderma viridae and harzianum and bacterial antagonist Pseudomonas fluorescens significantly improved the germination behavior of tomato seeds as compared to untreated control. Highest mean germination (93.1%) and seedling vigour (953.33) was recorded in Treatment 3 (FYM @ 200 q/ ha + Azospirillum + PSB + Trichoderma herzianum (4 kg/ha each) and lowest in control (60.3%) and (304.83), thus indicating a significant per cent increase in seedling emergence (54.4%) and seedling vigour (95.23%). A considerable reduction in disease incidence (pre and post) of damping off was observed in treatment T? and T? (VC @ 50 q/ha + Azospirillum + PSB + Trichoderma herzianum @ (4 kg/ha) with 45.6% and 35.4% respectively). Treatment T? proved highest in terms of yield (665 Kg/

关键词： Biocontrol Agents Biofertilizers Disease Incidence Organic Manure Tomato Yield

Malignant hyperthermia in severe COVID-19:2 case reports

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Emergency and Critical Care Medicine 2021年第1期1卷 45-48页

作者： Solmaz Ehteshami-Afshar Roozbeh Nikooie Pranav Reddy astha Chichra Mark D.Siegel Department of Medicine Yale University School of MedicineNew HavenConnecticut

Malignant hyperthermia is a rare but potentially fatal *** present 2 cases of young patients with coronavirus disease 2019(COVID-19)requiring intubation for hypoxic respiratory failure who both developed significant hyperthermia post intubation and were suspected to have malignant ***,the 2 patients had different responses to conservative management and *** cases highlight the increased challenge imposed by intubation complications when managing patients with COVID-19.

关键词： Case report COVID-19 Malignant hyperthermia

Intensive diabetes management and goal setting are key aspects of improving metabolic control in children and young people with type 1 diabetes mellitus

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World Journal of Diabetes 2014年第6期5卷 877-881页

作者： astha Soni Sze May Ng Department of Paediatrics Southport and Ormskirk NHS Trust Department of Women’s and Children’s Health Institute of Translational MedicineUniversity of Liverpool

Diabetes control in children remains poor in spite of advances in treatment for last 10 years. The aim of this review was to look at various aspects of intensive therapy in the management of type 1 diabetes such as insulin regimes, role of target setting, psycho-educational approaches and self-management. To achieve good metabolic control, clear goal setting with adequate support for self-management are essential. Psycho-educational and behavioural interventions aimed at specific areas of management have shown significant improvement in quality of life and diabetes control.

关键词： Type 1 diabetes Children Metabolic control Intensive Management Goal setting

Giant Angiomyolipoma Masquerading as Perinephric Abscess: A Diagnostic Conundrum

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Open Journal of Urology 2021年第10期11卷 351-357页

作者： Sudhir Jain Adiba Nizam Tariq Hameed astha Nayyar Department of Surgery Maulana Azad Medical College and Associated Lok Nayak Hospital New Delhi India

Renal angiomyolipomas are the most common benign tumours of the kidney accounting for up to 1% of all renal masses. Giant angiomyolipomas which have a size greater than 10 centimetres are rare entities with few cases reported in literature. Small angiomyolipomas are usually a symptomatic and increasing size correlates with symptomatology. These are usually incidentally detected or when symptomatic may present with an abdominal lump, flank pain or hemorrhage. Herein, we report a rare case of 45-year-old lady with giant angiomyolipoma with clinical presentation indistinguishable from perinephric abscess. The case is rare with regards to the large size of tumour and the discordant presentation unusual for an angiomyolipoma.

关键词： Angiomyolipoma Giant Angiomyolipoma Perinephric Abscess