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Engineering of ovarian tissue for ovarian dysfunctions:A review

Asian pacific Journal of Reproduction 2024年第1期13卷 3-11页

作者： Aliya Zhylkybekova Gulbakit KKoshmaganbetova Myltykbay SRysmakhanov Nurgul Abdullayevna Abenova Nadiar Maratovich Mussin asset askerovich kaliyev Mahdi Mahdipour Amin Tamadon Department of Evidence-Based Medicine and Scientific Management West Kazakhstan Marat Ospanov Medical UniversityAktobeKazakhstan Department of Surgery and Urology No.2 West Kazakhstan Medical UniversityAktobeKazakhstan Department of Surgery and Transplantation Aktobe Medical CenterAktobeKazakhstan Department of Internal Diseases West Kazakhstan Marat Ospanov Medical UniversityAktobeKazakhstan Stem Cell Research Center Tabriz University of Medical SciencesTabrizIran Department of Reproductive Biology Faculty of Advanced Medical SciencesTabriz University of Medical SciencesTabrizIran Department for Scientific Work West-Kazakhstan Marat Ospanov Medical UniversityAktobeKazakhstan

This review explores tissue engineering as a potential solution for reproductive health issues in women caused by genetic or acquired diseases,such as premature ovarian failure or *** loss of ovarian function can lead to infertility,osteoporosis,and cardiovascular *** replacement therapy is a common treatment,but it has limitations and *** review focuses on two main approaches in tissue engineering:scaffold-based(3D printing,electrospinning,decellularization)and scaffold-free(stem cell transplantation,organoid cultivation).Both approaches show promise in preclinical studies for creating functional ovarian *** include vascularization,innervation,long-term function,and *** these challenges,tissue engineering offers a potential avenue for restoring fertility and hormone balance in women with ovarian dysfunction.

关键词： Female gonads Tissue engineering Estrogen Reproductive system

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Impact of alcoholic extract from sea cucumber(Holothuria parva)on letrozole-induced polycystic ovary syndrome in adult female rats

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Asian pacific Journal of Reproduction 2024年第6期13卷 261-270页

作者： Samaneh Askari Mohammad Reza Jafarzadeh Shirazi Masoumeh Ahmadi Arezoo Khoradmehr Nadiar M.Mussin asset A.kaliyev Farzad Mohammad Rezazadeh Mohammad Dadpasand Taromsari Ali Bustani Nader Tanideh Kulyash R.Zhilisbayeva Amin Tamadon Department of Animal Science College of AgricultureShiraz UniversityShirazIran The Persian Gulf Marine Biotechnology Research Center The Persian Gulf Biomedical Sciences Research InstituteBushehr University of Medical SciencesBushehrIran Department of Surgery No.2 West Kazakhstan Marat Ospanov Medical UniversityAktobe030019Kazakhstan Department of Animal Science Science and Research BranchIslamic Azad UniversityTehranIran Department of Pharmacology Medical SchoolShiraz University of Medical SciencesShirazIran Stem Cells Technology Research Center Shiraz University of Medical SciencesShirazIran PerciaVista R&D Co. ShirazIran Department of Scientific Work West Kazakhstan Marat Ospanov Medical UniversityAktobeKazakhstan Department of Natural Resources West Kazakhstan Marat Ospanov Medical UniversityAktobeKazakhstan

Objective:To explore the potential therapeutic impact of an alcoholic extract derived from the sea cucumber(Holothuria parva)on letrozole-induced polycystic ovary syndrome(PCOS)in adult female Sprague-Dawley ***:Sixteen female rats,aged 8 to 10 weeks,with a mean weight of(200±20)g,were randomly assigned to four groups:the control,PCOS,and two treatment groups receiving sea cucumber extract and metformin,*** was induced by administering letrozole at a dose of 1 mg/kg to initiate the treatment period at 60 days of *** study spanned four weeks,during which ovarian and uterine tissues were collected for histological examination,and blood samples were collected for hormonal ***:Significant decreases in luteinizing hormone/follicle stimulating hormone(LH/FSH)and testosterone and increases progesterone levels among groups treated with sea cucumber extract were *** no significant differences were observed in follicle-stimulating hormone(FSH)and testosterone levels,the distinctive variations in key hormones suggested a potential role for sea cucumber alcoholic extract in ameliorating PCOS ***:This research highlights the moderate efficacy of sea cucumber extract as a therapeutic intervention for PCOS,providing a novel perspective in the search for effective *** observed hormonal alterations,particularly in LH,estradiol,and progesterone,underscore the need for further exploration into the underlying mechanisms and for optimizing the application of sea cucumber extract in PCOS management.

关键词： Polycystic ovary syndrome Sea cucumber Letrozole Metformin Rats

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