检索结果-南通市图书馆

Hepatotoxicity induced by cyproterone acetate:A report of three cases

World Journal of Gastroenterology 2006年第46期12卷 7551-7555页

作者： Ioanna savidou Melanie Deutsch aspasia s soultati Dimitrios Koudouras Georgia Kafiri spyridon P Dourakis 2nd Department of Medicine University of Athens Medical School Hippokration General Hospital 114 Vas Sofias Avenues 11527 Athens Greece Department of Pathology Hippokration General Hospital Greece

Cyproterone acetate (CPA) is a steroidal synthetic progestagen and anti-androgenic compound widely administered in prostate cancer which has been evidentially correlated with a severe hepatotoxic potency. Three male patients aged 78-83 years are presented, in whom severe hepatotoxic reactions emerged after CPA administration. Patients were treated with CPA at the doses of 200-300 mg/d for malignant prostate disease for 3-12 mo prior to the acute manifestation of the hepatic disease. Clinical features compatible with mixed hepatocellular and cholestatic liver disease including jaundice, white stools and dark urine, manifested in all three cases whereas encephalopathy and ascites were present in two of the patients. Other primary causes of hepatotoxicity (alcohol consumption and viral hepatitis) were also verified in two cases, and in those patients biopsy findings revealed the presence of cirrhotic lesions in liver parenchyma. Discontinuation of the therapeutic agent led to the amelioration of the clinical profile in all the patients whereas a patient died 40 d after hospital admission due to sepsis, despite acute liver disease improvement. The current article highlights the hepatotoxic potency of a widely administered therapeutic agent and illustrates the importance of clinical surveillance especially in patients with previous hepatic diseases. Three relevant cases are reported and a review of the published literature is made.

关键词： Cyproterone acetate Drug induced hepatotoxicity Prostate cancer Idiosyncratic drug reaction Hepatomitogen action

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

simultaneous development of diabetic ketoacidosis and Hashitoxicosis in a patient treated with pegylated interferon-alpha for chronic hepatitis C

引用

World Journal of Gastroenterology 2007年第8期13卷 1292-1294页

作者： aspasia s soultati spyridon P Dourakis Alexandra Alexopoulou Melanie Deutsch Athanasios J Archimandritis 2nd Department of Internal Medicine University of Athens Medical School Hippokration General Hospital 114 Vas Sofias Avenues Athens 11527 Greece

Classical interferon-alpha has been shown to be correlated with the development of a variety of autoimmune disorders. A 38 year-old female patient developed simultaneously diabetic ketoacidosis and hyperthyroidism 5 mo following initiation of treatment with pegylated interferon-α and ribavirin for chronic hepatitis C. High titers of glutamic acid decarboxylase, antinuclear and thyroid (thyroid peroxidase and thyroglobulin) antibodies were detected. Antiviral treatment was withdrawn and the patient was treated with insulin for insulin-dependent diabetes mellitus and propranolol for hyperthyroidism. Twelve months after cessation of pegylated interferon-α therapy the patient was euthyroid without any medication but remained insulin-dependent.

关键词： Autoimmune thyroiditis Insulin dependent diabetes mellitus Pegylated interferon-alpha Chronic hepatitis C

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Predicting utility of a model for end stage liver disease in alcoholic liver disease

引用

World Journal of Gastroenterology 2006年第25期12卷 4020-4025页

作者： aspasia s soultati spyridon P Dourakis Alexandra Alexopoulou Melanie Deutsch Larissa Vasilieva Athanasios J Archimandritis 2nd Department of Internal Medicine University of Athens Medical school Hippokration General Hospital114 Vas Sofias AvenuesAthens 11527Greece

AIM： To validate the statistic utility of both the Maddrey Discriminant Function score and the Model for End-stage Liver Disease as predictors of short term （30 d and 90 d） mortality in patients with alcoholic hepatitis and to assess prognostic factors among clinical characteristics and laboratory variables of patients with alcoholic hepatitis. METHODs： Thirty-four patients with the diagnosis of alcoholic hepatitis admitted to Hippokration University Hospital of Athens from 2000 to 2005 were assessed in the current retrospective study and a statistical analysis was conducted. REsULTs： 30- and 90-d mortality rates were reported at 5.9% （2/34） and 14.7% （5/34）, respectively. significant correlation was demonstrated for the Model for End- stage Liver Disease （P30 = 0.094, P90 = 0.046） and the Maddrey Discriminant Function score （P30 = 0.033, P90 = 0.038） with 30- and 90-d mortality whereas a significant association was also established for alanine aminotrans- ferase （P = 0.057）, fibrin degradation products （P = 0.048） and C-reactive protein （P = 0.067） with 90-d mortality. For 30-d mortality the Area Under the Curve was 0.969 （95%CI： 0.902-1.036, P = 0.028） for the Model for End-stage Liver Disease score and 0.984 （95%CI： 0.942-1.027, P = 0.023） for the Maddrey Discriminant Function score with the optimal cut off point of 30.5 （sensitivity 1, specificity 0.937） and 108.68 （sensitivity 1, specificity 0.969）, respectively. Accordingly, for 90-d mortality the Area Under the Curve was 0.762 （95%CI： 0.559-0.965, P = 0.065） for the Model for End-stage Liver Disease score and 0.752 （95%CI： 0.465-1.038, P = 0.076） for the Maddrey Discriminant Function score with the optimal cut off point of 19 （sensitivity 0.6, specificity 0.6） and 92 （sensitivity 0.6, specificity 0.946）, respectively. The observed Kaplan Meier survival rates for different score-categories were compared with logrank tests and higher score values were correlated with a lower survival. CONCLUsION： Equivale

关键词： Alcoholic liver disease Alcoholic hepatitis Maddrey discriminant function score Model for end-stage liver disease score

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Holland＇s Method as a Material in Environmental Education

引用

Journal of Environmental science and Engineering(B) 2017年第9期6卷 484-488页

作者： Odysseas Kopsidas aspasia Karagiannopoulou Laboratory of simulation of Industrial Processes Department of Industrial Management and Technology University of PiraeusPiraeus 18534 Greece

In this work, the Holland＇s methodology is modified for the categorization of human personalities by including queries （in the corresponding questionnaire that serves as an evaluation tool） investigating its responders＇ attitude as regards his/her willingness to be professionally engaged with the natural or/and anthropogenic environment. The population used as representative sample consisted of 250 students following courses at high school and university level. The quantitative methods used were descriptive statistics, parametric and non-parametric statistics hypothesis （on causal relations） testing, categorical semantics, ontological mapping fuzzy sets and interval algebra. The results obtained showed relative significant internal consistency at macro-level for almost half of the interviewees, but the dependence of answers to environmental queries on the rest responds to the rest queries was insignificant, indicating lack of specific knowledge and clarification of the corresponding concepts at micro-level.

关键词： Environmental education Holland's theory questionnaire design hypothesis testing vocational typology.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Thermal Ablation in the Management of Adrenal Metastasis Originating from Non-small Cell Lung Cancer： A 5-year single-center Experience

引用

Chinese Medical Journal 2017年第17期130卷 2027-2032页

作者： Evanthia I Botsa Ioanna L Thanou aspasia T Papatheodoropoulou Loukas I Thanos First Pediatric Clinic National and Kapodistrian University of Athens Agia Sofia Children&#39 s Hospital Athens 11527 Greece Department of Medical Imaging and Interventional Radiology Sotiria General Hospital for Chest Diseases Athens 11527 Greece

Background：Treatment of adrenal metastasis from lung carcinoma may prolong survival in the selected ***,not all patients can undergo surgery;thus,minimally invasive ablation procedures such as radiofrequency ablation （RFA） and microwave ablation （MWA） have gained acceptance as alternative treatment *** study summarized a 5-year single-center experience regarding the evaluation of safety and efficacy of computed tomography （CT）-guided thermal ablation in the management of adrenal metastasis originating from non-small cell lung cancer （NsCLC）.Methods：The data of NsCLC patients ablated for adrenal metastasis at the Department of Diagnostic Imaging and Interventional Radiology,General Hospital sotiria,were retrospectively *** were divided into two groups：RFA group and MWA group according to the therapeutic *** blood tests included measurement of international normalized ratio,partial thromboplastin time,and platelet enumeration.A dual-phase contrast-enhanced spiral CT was performed immediately after the procedure to assess the immediate response after ablation and to screen for related ***-up was performed with CT or magnetic resonance imaging at 1,3,6 months and 1 year after ablation and every 6 months ***：A total of 99 ablation sessions in 71 patients with adrenal metastasis originating from NsCLC were included in the final ***-limited,postablation syndrome occurred in 16/99 （16.1%） of ablation *** procedures were technically *** postablation imaging showed no contrast enhancement of the ablated tumor in all ***-up imaging at 3 months revealed local tumor progression in 8 （22.8%） patients of the RFA group and 7 （19.4%） patients of MWA group,all of them underwent a second session *** 1-year assessment revealed local recurrence of the ablated tumor in six patients （17.1%） of RFA group and seven patients （19.4%） of MWA grou

关键词： Adrenal Metastasis Microwave Nonsmall Cell Lung Cancer Radiofrequency Ablation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of the red reflex: An overview for the pediatrician

引用

World Journal of Methodology 2021年第5期11卷 263-277页

作者： aspasia Toli Asli Perente Georgios Labiris Department of Ophthalmology University Hospital of AlexandroupolisAlexandroupolis 68100Greece

BACKGROUND Red reflex test(RRT)is a simple,non-invasive method that can be performed easily by pediatricians during the clinical examination in neonatal period,infancy and *** reflexes can lead to prompt diagnosis of several ocular disorders,with potentially severe consequences on patient’s vision,cognitive function and even *** To underline the contribution of pediatricians to early detection of vision and life threatening diseases by using RRT *** For the present systematic review,PubMed searches were performed using the key words“red reflex and newborn”;“red reflex and neonate”;“red reflex and complications”;“red reflex and necessity”;“red reflex and retinoblastoma”;“red reflex and congenital cataract”;“red reflex and glaucoma”;“red reflex and prematurity”;“red reflex and leukocoria”;“red reflex and blindness”;“red reflex sensitivity and specificity”;“red reflex and differential diagnosis”;“red reflex and guidelines”.The relevant articles were selected without language *** a full-text publication was not available,their English abstracts were *** some cases,studies from the reference lists of the selected articles provided useful *** research took place in september 2020,in the Ophthalmology Department of University Hospital of *** A total of 45 articles were selected according to the used key *** reviewing data from these articles,it is supported that red reflex remains an effective tool of undeniable importance for early detection of severe eye conditions,such as cataract,retinoblastoma,retinopathy of prematurity and *** literature reports some limitations of RRT,including a notable percentage of false positive tests,the inability to detect small,peripheral retinoblastomas and the lower sensitivity for posterior segment pathology,it is widely accepted that the benefits from the regular evaluation of the test on public health are ***,RRT

关键词： Red eye reflex Leukocoria Visual screening Newborn Prevention Pediatric examination

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：