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Biochemical analysis of granzyme H and elucidation of its structurally important residues involved in substrate and inhibitor binding

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Journal of Chinese Pharmaceutical Sciences 2012年第1期21卷 33-39页

作者： Naheed Z Razwi Rukhshan Khurshid Mahjabeen Saleem Sabiha Karim Saeed Ahmad Nagra asmat Salim Department of Biochemistry CMH Lahore Medical CollegeLahorePakistan Fatima Jinnah Medical College LahorePakistan Institute of Biochemistry and Biotechnology University of the PunjabLahorePakistan College of Pharmacy University of the PunjabLahore Institute of Chemistry University of the PunjabLahorePakistan Dr.Panjwani Center for Molecular Medicine and DrugResearch International Center for Chemical and Biological SciencesKarachi UniversityPakistan

Apoptotic cell death plays an important role in the maintenance of the normal physiological state and in the pathogenesis of *** exocytosis is the main pathway for the immune elimination of virus-infected cells and tumor cells by cytotoxic T lymphocytes and natural killer *** recent study,we have investigated the level of granzyme H in patients with breast cancer and in control subjects using enzymatic *** study also included the prediction of different sites of granzyme H that play a role in substrate and inhibitor recognition in apoptosis process by using 3D structural model of the *** research described the possible post-translational modification sites that may help the enzyme in immune elimination of tumor *** study shows that the level of granzyme H was reduced in patients when compared to normal control *** are a number of amino acids that function as substrate recognition sites in granzyme ***,inhibitors may inhibit their activity and affect the process of autolysis.

关键词： Autolysis Granzyme H Apoptosis Post translational modification

Spatio-Temporal Air Pollutant Characterization for Urban Areas

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Journal of Geoscience and Environment Protection 2022年第1期10卷 218-237页

作者： Nurainshafika Sahak Arnis asmat Noor Zaitun Yahaya School of Chemistry and Environment Faculty of Applied Sciences Universiti Teknologi MARA Selangor Malaysia Climate Change & Carbon Footprint Research Group Universiti Teknologi MARA Selangor Malaysia Faculty of Ocean Engineering Technology and Informatics Universiti Malaysia Terengganu Terengganu Malaysia

Urban pollution has now become increasingly recognized as an important determinant of air pollution in developed countries. The effect of urban air pollution in developing countries, on the other hand, has not been adequately addressed in the data Spatio-temporal time series. Thus, this study was intended to characterize the effect of urbanization on air pollution for an urbanized Klang Valley, Malaysia using Spatio-temporal data from 2008 to 2017. The Air Pollution Index (API) data and local pollutant concentration were employed to establish the links between urban air pollution. The analysis will be supported by determining the source of pollutants during the study period using Principal Component Analysis (PCA). The study identified that Carbon monoxide (CO), Nitrogen Dioxide (NO2), and Ozone (O3) are the major air pollution that has contributed to degrading air quality in the Klang Valley due to the vehicles, combustion process, and industries.

关键词： Urban Pollution Air Pollution Index (API) Spatio-Temporal Characterization Source of Pollutants Inverse Distance Weighted (IDW) Principal Component Analysis (PCA)

Anti-biogram and resistogram profiling of Aeromonas species isolated from Malaysian aquatic sources

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Journal of Coastal Life Medicine 2013年第2期 108-112页

作者： Olumide Adedokun Odeyemi asmat Ahmad School of Environment and Natural Resources Faculty of Science and TechnologyNational University of MalaysiaUKM BangiSelangorMalaysia School of Biosciences and Biotechnology Faculty of Science and TechnologyNational University of MalaysiaUKM BangiSelangorMalaysia

Objective:To investigate antibiotics and heavy metals resistance profile of Aeromonas species isolated from Kuala Gula and Kuala Sepetang,***:Isolated Aeromonas species were subjected to 12 antibiotics:penicillin G 10 units,tetracycline 30μg,novobiocin 5μg,nitrofurantoin 100μg,ampicillin 10μg,chloramphenicol 10μg,fluconazole 25μg,gentamicin 10μg,streptomycin 10μg and 25μg,kanamycin 30μg,and vancomycin 30μg and 5 heavy metals:MnSO_(4).H_(2)O,Cr(NO_(3)).9H2O,CuSO_(4),Pb(NO_(3))_(2),HgCl_(2).Results:Results from this study revealed that isolates from the two sources-displayed varied *** from Kuala Sepetang showed 91%,66%,61%,and 52%resistance to vancomycin,Novobiocin,streptomycin and gentamycin while Kuala Gula isolates showed 76%,93%,28%and 14%*** rate of resistance was shown to be against lead(Pb),Chromium(Cr),copper(Cu)and Manganese(Mn)with minimum inhibitory concentration ranging from 2560μg/mL to>5120μg/*** resistance to mercury was observed among isolates from Kuala ***:This study showed that there was widespread of both heavy metals and antibiotics resistance among Aeromonas isolates from the two marine sources with isolates from Kuala Sepetang showing more resistance thereby posing danger to both aquatic animals and human health.

关键词： Virulence Antibiotics profile Resistance Marine sources

Survival of Epidemic, Clinical, Faecal and Recreational Beach Enterococci Strains with Putative Virulence Genes in Marine and Fresh Waters

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Journal of Environmental Protection 2014年第6期5卷 482-492页

作者： asmat Ahmad Ayokunle Christopher Dada Gires Usup School of Biosciences and Biotechnology Universiti Kebangsaan Malaysia Bangi Malaysia School of Environmental & Natural Resource Sciences Faculty of Science & Technology Universiti Kebangsaan Malaysia Bangi Malaysia

Culturable faecal coliform, epidemic, clinical, faecal and recreational beach enterococci strains possessing putative virulence genes were enumerated over the course of 5 weeks to comparatively assess their persistence in tropical marine and fresh waters. For the clinical and epidemic strains tested, it took 2.38 ± 0.45 days for a 1-log reduction (T90) in marine water. A higher T90 average of 2.51 ± 0.08 was observed for the commensal and environmental strains. Generally, lower T90 values of 2.14 ± 0.26 and 2.15 ± 0.16 days respectively were observed for hospital and community acquired enterococci strains in fresh water mesocosms subjected to tropical ambient temperature. Beach water enterococci and enterococci recovered from faeces of humans survived for up to 20 days and 23 days respectively in fresh and marine waters. The epidemic strain, MMH594, an esp-positive clinical bacteremia isolate that previously caused multiple infections in a hospital ward outbreak fares favourably well in tropical marine and fresh aquatic environments. For enterococci, the decay rate was approximately 13% higher in fresh water than was observed for marine water. On the contrary, for E. coli, the decay rate was approximately 17% lower in fresh water than was observed in marine water. Generally, the whole, the population trends of E. coli and enterococci in fresh and marine water mesocosms did not reveal any evidence of growth. Our findings suggest that potentially pathogenic bacteria can resume active growth after three weeks of being harboured by the reservoir-beach sand and still pose threat to public health.

关键词： Clinical Enterococci Die-Off Beach Enterococci Die-Off Faecal Enterococci Die-Off Tropical Water Temperature Marine and Fresh Water Virulence

Heavy-Metal Tolerance and Antibiotic Susceptibility of Red Pigmented Bacteria Isolated from Marine Environment

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Natural Resources 2012年第4期3卷 171-174页

作者： Mahtab Jafarzade Suhaiza Mohamad Gires Usup asmat Ahmad School of Bioscience and Biotechnology Universiti Kebangsaan Malaysia Bangi Malaysia School of Environmental Science and Natural Resources Faculty of Science and Technology Universiti Kebangsaan Malaysia Bangi Malaysia

This study was undertaken to determine heavy metal resistance and antibiotic susceptibility of three non-pathogenic red pigmented bacteria namely WPRA3, SM11-3j and SC-G18, isolated from marine environments of Malaysia. The bacteria isolates were identified by 16S rRNA sequencing and by biochemical and morphological tests. The 16S rRNA gene sequences of all isolates showed ≥96% similarity to Serratia spp. Antibiotic susceptibility test of isolates was assayed according to the Kirby-Bauer disc diffusion method. All isolates were highly resistant to beta-lactam antibiotics, but were susceptible to quinolone antibiotics. Minimum inhibitory concentration (MIC) of nine heavy metals (Ni2+, Co2+, Cr3+, Zn2+, Mn2+, Pb2+, Hg2+, Cd2+ and Cu2+) against the bacteria isolates were determined via the plate-dilution method. The isolates exhibited resistance to Ni2+, Co2+, Cr3+ and Zn2+. Isolates WPRA3 and SM11-3j showed higher multiple tolerances to heavy metals. The results obtained indicate that bacteria from marine environments of Malaysia present interesting metabolic activities, which should be studied and explored for potential biotechnological applications.

关键词： Antibiotic Susceptibility Heavy Metal Resistance Serratia sp Marine Bacteria

Oscillations of a Punctual Charge in the Electric Field of a Charged Ring: A Comparative Study

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Journal of Electromagnetic Analysis and Applications 2013年第5期5卷 229-235页

作者： Najeeb Alam Khan asmat Ara Nasir Uddin Khan Nadeem Alam Khan Department of Mathematical Sciences University of Karachi Karachi Pakistan.

We applied multiple parameters method (MPM) to obtain natural frequency of the nonlinear oscillator with rational restoring force. A frequency analysis is carried out and the relationship between the angular frequency and the initial amplitude is obtained in analytical/numerical form. This equation is analyzed in three cases: the relativistic harmonic oscillator, a mass attached of a stretched elastic wire and oscillations of a punctual charge in the electric field of charged ring. The three and four parameters solutions are obtained. The results obtained are compared with the numerical solution, showing good agreement.

关键词： Oscillator Stretched Wire Parameters Electric Field

Hexanuclear Complex of Platinum(II) with Cleavage Product of Cystamine Dihydrochloride by β-Mercaptoethylamine

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Advances in Chemical Engineering and Science 2016年第1期6卷 29-33页

作者： asmat N. Azizova Dilqam B. Tagiyev Shmid G. Gasimov Khudayar I. Gasanov The Institute of Catalysis and Inorganic Chemistry Named after Acad. M. F. Nagiyev of the National Academy of Sciences Azerbaijan Baku Azerbaijan

Six-nuclear complexes of Platinum(II) with cleavage of a cystamine dihydrochloride by β-mercaptoethylamine with composition [Pt6(H2NCH2CH2S)8]Cl4·5H2O had been syntesized for the first time. Structure of the complex had been installed together with IKS- and XRD analysis. It has been established that each atom of platinum is surrounded by two atoms of sulfur and nitrogen due to bidentate coordination of a ligand. Only two of the six platinum atoms are on the same plane;other four atoms are in the different crossing planes. Four platinum atoms form adurable metal chelate cycles, which collapse over temperature 260℃. The results of IR spectroscopy confirmed with the RS-analysis.

关键词： Mercaptoamine Ligands Platinum Six-Nuclear Complexes Synthesis

Seroprevalence of Toxoplasma gondii infection in domestic animals of Mohmand agency,Pakistan

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Journal of Coastal Life Medicine 2013年第1期1卷 72-75页

作者： Mudassir Shah Muhammad Zahid Aftab Alam Sthanadar Pir asmat Ayesha Kausar Abdul Hamid Jan Department of Zoology Islamia College University PeshawarKPPakistan Department of Zoology University of PeshawarKPPakistan

Objective:To determine the prevalence of toxoplasmosis among domestic animals of Mohmand Agency,***:Indirect haemagglutination test was used to detect Toxoplasma gondii(***)antibodies in the ***:Out of 384 domestic animals,124(32.29%)were seropositive for antibodies of *** antibodies were detected in 56 out of 104 examined goats(53.84%).The seropositivity in male and female goats were 20(38.46%)and 36(69.23%)*** seropositivity of *** in sheep was 36%(n=100)while the prevalence in female sheep was higher(41.66%)as compared to male sheep(30.76%).A total of 8 out of 48 male cows were detected seropositive(16.66%)and 8 out of 32 female cows were detected seropositive(25%).Lowest prevalence was detected in buffaloes which was 16%(n=100).Out of 52 male buffaloes 4 were detected seropositive for *** antibodies(7.69%)while in female buffaloes was 25%(n=48).The seroprevalence of *** antibodies was higher in goats and lower in ***:The findings of the present study indicate that *** infection is high in domestic animals in Mohmand agency,Pakistan,which has implications for public health in this *** control strategies and suitable measures should be carried out rationally in this region,in order to lower the risk of exposure to ***.

关键词： Antibodies Domestic animals Seroprevalence Toxoplasma gondii

巴基斯坦波特瓦尔高原农业生态系统中灰鹧鸪(Francolinus pondicerianus)的种群生物学(英文)

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Avian Research 2012年第2期03卷 91-102页

作者： Iftikhar HUSSAIN asmat-un-NISA Sungum KHALIL Department of Wildlife Management PMAS-Arid Agriculture University

我们于2009年在巴基斯坦波特瓦尔高原地区对农业生态系统中灰鹧鸪(Francolinus pondicerianus)的种群生物学进行了研究。该地区是灰鹧鸪在巴基斯坦的重要分布区之一。灰鹧鸪在作物区和灌丛林地的密度分别为每公顷1.59±0.39和0.87±0.14... 详细信息

我们于2009年在巴基斯坦波特瓦尔高原地区对农业生态系统中灰鹧鸪(Francolinus pondicerianus)的种群生物学进行了研究。该地区是灰鹧鸪在巴基斯坦的重要分布区之一。灰鹧鸪在作物区和灌丛林地的密度分别为每公顷1.59±0.39和0.87±0.14只,并且两种生境中的密度在季节间均稍有浮动。灰鹧鸪在由Desmostachia bipinnata、Acacia modesta、Imperata cylindrical、枣树(Zizipus jujuba)及大戟属(Euphorbia)等植物组成的植被地面营巢。产卵期为春夏两季,平均产卵期长约6±0.36天(5–7天),平均窝卵数为7±0.36枚(6–8枚)。平均孵卵期为20.6±0.50天(19–22天)。所记录的42枚卵中,32枚成功孵化(成功率76.19%),平均孵化率为每窝5.33±1.22枚。离巢雏鸟数约为每窝3.83±0.83只(离巢率63.08%)。该鸟种为杂食性,亦食天牛。从该鸟的食物中鉴别出10个种类,包括 7 种植物:珍珠粟(Pennisetum typhoideum)、高粱(Sorghum bicolor)、假高粱(***)、牧豆树(Prosopis juliflora)、绿豆(Phaseolus radiates)、尖刺红花(Carthemus axycantha)及金合欢属(Acacia)某种植物,2种昆虫:家白蚁(Coptotermes formosanus)及红褐林蚁(Formica rufa),以及砂砾。

关键词：栖息地利用繁殖生物学食性雨养农业灌丛林