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Reproductive and Developmental Medicine 2018年第1期2卷 52-58页

作者： Christian Lee andersen Fei Zhao Xiao-Qin Ye Department of Physiology and Pharmacology College of Veterinary MedicineUniversity of GeorgiaAthensGA 30602USA Interdisciplinary Toxicology Program University of GeorgiaAthensGA 30602USA Reproductive Developmental Biology Group National Institute of Environmental Health SciencesDurhamNC 27709USA

Zearalenone(ZEA)is produced by Fusarium species and a common contaminant in *** and its metabolites,α-andβ-zearalenol,α-andβ-zearalanol,and zearalanone,are mycoestrogens that can interfere with estrogen *** levels of mycoestrogens reduced female fertility in farm animals and rodents,in which adverse effects of mycoestrogens on major events in female reproduction,including ovarian folliculogenesis,ovulation,ovarian steroidogenesis,fertilization,preimplantation embryo development and transport,embryo implantation,placentation,parturition,and lactation,have been reported in different experimental ***,we review the in vivo effects of mycoestrogens on the main events in female reproduction.

关键词： Female Reproduction Mycoestrogens Puberty Zearalenone

Treatment of Budd-Chiari syndrome with a focus on transjugular intrahepatic portosystemic shunt

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World Journal of Hepatology 2013年第1期5卷 38-42页

作者： Anders Bay Neumann Stine Degn andersen Dennis Tφnner Nielsen Peter Holland-Fischer Hendrik Vilstrup Henning Grφnbk Department of Medicine V (Gastroenterology and Hepatology) Aarhus University HospitalDK-8000 Aarhus CDenmark Department of Radiology R Aarhus University HospitalDK-8000 Aarhus CDenmark

AIM:To evaluate long-term complications and survival in patients with Budd-Chiari syndrome (BCS) referred to a Danish transjugular intrahepatic portosystemic shunt (TIPS) ***:Twenty-one consecutive patients from 1997-2008 were retrospectively included [15 women and 6 men,median age 40 years (range 17-66 years)].Eighteen Danish patients came from the 1.8 million catchment population of Aarhus University Hospital and three patients were referred from Scandinavian *** consisted of tests for underlying haematological,endocrinological,or hypercoagulative disorders parallel to initiation of specific treatment of ***:BCS was mainly caused by thrombophilic (33%) or myeloproliferative (19%) *** percents had symptoms for less than one week with ascites as the most prevalent *** (67%) were treated with TIPS and 7 (33%) were manageable with treatment of the underlying condition and *** median follow-up time for the TIPS-treated patients was 50 mo (range 15-117 mo),and none required subsequent liver *** control was achieved in all TIPS patients with a marked reduction in the dose of diuretics.A total of 14 TIPS revisions were needed,mostly of uncovered *** died during follow-up:One non-TIPS patient worsened after 6 mo and died in relation to transplantation,and one TIPS patient died 4 years after the TIPS-procedure,unrelated to ***:In our BCS cohort TIPS-treated patients have near-complete survival,reduced need for diuretics and compared to historical data a reduced need for liver transplantation.

关键词： Ascites Budd-Chiari syndrome Myeloproliferative disorder Thrombophilia Thrombosis Transjugular intrahepatic portosystemic shunt

Functional Magnetic Resonance Imaging Studies on Dopamine Receptor in Awake Normal and Parkinsonian Rhesus Monkeys

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Functional Magnetic Resonance Imaging Studies on Dopamine Re...

首届全国功能神经影像学和神经信息学研讨会

作者： Anders andersen Peter Hardy Don Gash Department of Anatomy ＆ Neurobiology Morris K. Udall Parkinson Disease Research Center of Excellence Magnetic Resonance Imaging and Spectroscopy Center College of Medicine University of Kentucky Lexington KY 40536 4. Shandong University College of Medicine Jinan 250012 China. ) Department of Anatomy ＆ Neurobiology

＜正＞ Functional magnetic resonance imaging （fMRI） is increasingly recognized as being a non-invasive way to perform pharmacological investigations in experimental animal models and patients with neurotransmitter deficits such as in Parkinson’s disease （PD）. Previously, we have demonstrated in normal rhesus monkeys that pharmacological MRI （phMRI, i. e. functional MRI using drugs to evoke CNS responses） can be used to map age-associated changes in the nigrostriatal system following dopaminergic stimulation （NeuroImage 14: 1159 ?1167, 2001）. In the present study, phMRI was used to map dopamine （DA） receptor-mediated neuronal activity, specifically the D1 and D2 receptors in the basal ganglia of hemiparkinsonian rhesus monkeys. Twelve female rhesus monkeys rendered hemiparkinsonian via unilateral infusion of MPTP into the right carotid artery were used in this study. Three sec and age-matched normal controls were used for comparison. Apomor-phine, a mixed D1/D2 receptor agonist, evoked strong activations seen in the MPTP-lesoned putamen and substantia nigra. In parallel, a significant increase in movement speed was seen in these animals, as quantified using an automated video -tracking system. In normal monkeys, apomorphine evoked a small deactivation in the putamen, while no changes were seen in the SN. Accordingly, motor speed remained unchanged compared to baseline levels, in response to apomorphine challenge. Results suggest that phMRI is capable to detect MPTP-induced changes in the basal ganglia with dopaminergic stimulation and also prove that phMRI may be a potential powerful tool for Parkinson’s disease research in human.

关键词： Functional magnetic resonance imaging Dopamine receptor Parkinson disease Monkey

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萨拉

疯狂英语（初中天地） 2007年第6期 26-29页

作者： Hans Christian andersen 洪馥芝

安徒生的童话我们一定读过不少,但其文学成就是多方面的,除了童话以外,还著有小说、剧本、游记以及诗和自传等。《萨拉》选自安徒生的游记《瑞典纪行》(Pictures of Sweden,1851),描写了他在这个宁静小镇的所见所想,并不乏对人生的思考。

关键词：安徒生天竺葵

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调皮的男孩

疯狂英语（初中天地） 2007年第2期 25-27页

作者： Hans Christian andersen 洪馥芝

爱情是什么?对于这个问题,想必每个人的答案都不尽相同。安徒生就用爱神丘比特比喻爱情,表达了他对爱情的理解。爱情就像个调皮的男孩,无处不在,一不留神,就会被丘比特的箭射中,堕入情网。但你可不要玩弄爱情,不然受伤的将是你自己。

关键词：丘比特坚信礼

升主动脉心外膜超声成像在冠状动脉旁路移植术中的价值

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中国医学影像技术 2005年第6期21卷 900-902页

作者：张宇虹 Kai andersen Runar Lundblad Halfdan Ihlen 大连医科大学附属二院超声科辽宁大连116027 挪威奥斯陆大学国家医院胸外科挪威奥斯陆0027 挪威奥斯陆大学国家医院胸外科挪威奥斯陆大学国家医院心内科超声实验室

目的　探讨心外膜超声技术在冠状动脉旁路移植术中检查升主动脉的临床意义。方法　应用心外膜超声探头在45例非体外循环旁路移植术中对升主动脉进行检查,判定是否形成粥样斑块及其程度,同时与术者触诊所得出的结果进行比较。术者根据斑... 详细信息

目的　探讨心外膜超声技术在冠状动脉旁路移植术中检查升主动脉的临床意义。方法　应用心外膜超声探头在45例非体外循环旁路移植术中对升主动脉进行检查,判定是否形成粥样斑块及其程度,同时与术者触诊所得出的结果进行比较。术者根据斑块部位及程度改变手术方法及方式。结果　45例中正常20例,动脉粥样斑块形成25例,其中轻度9 例、中度10例、重度6例。心外膜超声技术对升主动脉粥样斑块的检出率明显高于触诊检查。所有病例未发生围手术期中风。结论　应用心外膜超声技术可以较触诊更敏感地发现升主动脉粥样斑块形成,可以降低围手术期中风的发生率,具有重要的临床价值。

关键词：超声检查冠状动脉旁路移植术主动脉升

Effects of exercise on leukocytosis and blood hemostasis in 800 healthy young females and males

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World Journal of Experimental Medicine 2013年第1期3卷 11-20页

作者： Kristin L Sand Torun Flatebo Marian Berge andersen Azzam A Maghazachi Department of Physiology Institute of Basic Medical SciencesFaculty of MedicineUniversity of Oslo

AIM: To investigate the effects of exercise on healthy individuals of both genders. METHODS: This study lasted 6 years and involved about 800 healthy people. Individuals were divided into females and males and further sub-divided into two groups; in the first group individuals run(or skied in the winter time) and then rested for 3 h, whereas individuals in the second group intensely cycled for 5 min. The status of health was determined by measuring the sedimentation rate and the intensity of exercises by measuring the heart rate. Blood samples were collected before and after exercise. RESULTS: We observed that in the first group a significant increase of the total white blood cells, segmented neutrophils, band neutrophils, eosinophils and to a lesser extent lymphocytes but not monocytes in the blood circulation. However, all cell types were increased in the circulation after 5 min intense exercise. No differences in the pattern of cell increase were observed among the genders. Activated partial thromboplastin time(APTT) and D-dimer were also measured in the blood of individuals who cycled intensely for 5 min to determine the coagulation and fibrinolytic activities in the blood. APTT is reduced and D-dimer values significantly increased after intense exercise. However, APTT was statistically lower in males than females, whereas no differences in the D-dimer values were observed among the genders. CONCLUSION: Our results indicate that exercise whether leisure or strenuous affects leukocytosis and hemostasis in both genders. A major advantage of this study is the high numbers of individuals involved and the inclusion of both females and males values.

关键词： Exercise Leukocytosis Activated partial thromboplastin time D-dimer

Development of an instrument to identify symptoms potentially indicative of ovarian cancer in a primary care clinic setting

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Open Journal of Obstetrics and Gynecology 2012年第3期2卷 183-191页

作者： M. Robyn andersen Barbara A. Goff Kimberly A. Lowe Exponent Health Sciences Seattle Washington Molecular Diagnostics Program Fred Hutchinson Cancer Research Center Seattle USA School of Public Health University of Washington Seattle Washington

Background: Several recently published studies suggest that screening for symptoms could improve the early diagnosis of ovarian cancer. This report describes the development of a simple and reliable method of collecting symptom information in a primary care clinic. Methods: 1200 women, ages 40 - 87, completed several versions of a draft symptom index (SI) assessment form during their visits to a primary care clinic. Factors associated with a positive SI result were examined. Providers were surveyed about acceptability of the symptom screening procedures. Findings: Variation in the instructions provided to women influenced the rate at which women indicated having symptoms indicative of a positive SI, 5% had positive results when written instructions emphasized listing only current symptoms. Women coming to the clinic because of a current medical concern or problem did have higher rates of positive SI results, as did non-white women (p < 0.05). Acceptability by providers was high. Patients could independently complete the SI in under 5 minutes. One patient with a positive SI was diagnosed with ovarian cancer and none with a negative SI developed cancer. Interpretation: A quick paper and pencil form can be used to identify women with symptoms potentially indicative of ovarian cancer. Use of such a form for ovarian cancer screening purposes is acceptable to most women and providers in a primary care clinic setting.

关键词： Ovarian Cancer Symptoms

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