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Hidden army within:Harnessing the microbiome to improve cancer treatment outcomes

World Journal of Clinical Cases 2024年第28期12卷 6159-6164页

作者： Ippokratis Messaritakis Georgios Vougiouklakis asimina koulouridi Aris P Agouridis Nikolaos Spernovasilis Department of Microbiology German Oncology Center&Yiannoukas Labs LTDBioiatriki GroupLimassol 4108Cyprus Department of Internal Medicine German Oncology CenterLimassol 4108Cyprus Department of Oncology German Oncology CenterLimassol 4108Cyprus School of Medicine European University CyprusNicosia 2404Cyprus Department of Infectious Diseases German Oncology CenterLimassol 4108Cyprus

The gut microbiome has emerged as a critical player in cancer pathogenesis and treatment ***,an imbalance in the gut microbial community,impacts tumor initiation,progression,and therapy *** bacterial species have been associated with either promoting or inhibiting tumor growth,offering potential targets for therapeutic *** gut microbiome in-fluences the efficacy and toxicity of conventional treatments and cutting-edge immunotherapies,highlighting its potential as a therapeutic target in cancer ***,translating microbiome research into clinical practice requires addres-sing challenges such as standardizing methodologies,validating microbial bio-markers,and ensuring ethical ***,we provide a comprehensive overview of the gut microbiome's role in cancer highlighting the need for on-going research,collaboration,and innovation to harness its full potential for im-proving patient outcomes in *** current editorial aims to explore these insights and emphasizes the need for standardized methodologies,validation of microbial biomarkers,and interdisciplinary collaboration to translate microbiome research into clinical ***,it underscores ethical consider-ations and regulatory challenges surrounding the use of microbiome-based ***,this article advocates for ongoing research,collaboration,and innovation to realize the full potential of microbiome-guided oncology in impro-ving patient care and outcomes.

关键词： Gut microbiome Cancer treatment Immunotherapy Microbiome-based interventions Dysbiosis Precision oncology

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Extracorporeal organ support for critically ill patients:Overcoming the past,achieving the maximum at present,and redefining the future

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World Journal of Critical Care Medicine 2024年第2期13卷 19-28页

作者： Panagiotis Papamichalis Katerina G Oikonomou Maria Xanthoudaki asimina Valsamaki Apostolia-Lemonia Skoura Sophia K Papathanasiou Achilleas Chovas Intensive Care Unit General Hospital of LarissaLarissa 41221Greece Department of Transfusion Medicine University Hospital of LarissaLarissa 41110Greece Department of Internal Medicine General Hospital of LarissaLarissa 41221Greece

Extracorporeal organ support(ECOS)has made remarkable progress over the last few *** replacement therapy,introduced a few decades ago,was the first available application of *** subsequent evolution of ECOS enabled the enhanced support to many other organs,including the heart[veno-arterial extracorporeal membrane oxygenation(ECMO),slow continuous ultrafiltration],the lungs(veno-venous ECMO,extracorporeal carbon dioxide removal),and the liver(blood purification techniques for the detoxification of liver toxins).Moreover,additional indications of these methods,including the suppression of excessive inflammatory response occurring in severe disorders such as sepsis,coronavirus disease 2019,pancreatitis,and trauma(blood purification techniques for the removal of exotoxins,endotoxins,or cytokines),have *** organ support therapy is crucial since a vast majority of critically ill patients present not with a single but with multiple organ failure(MOF),whereas,traditional therapeutic approaches(mechanical ventilation for acute respiratory failure,antibiotics for sepsis,and inotropes for cardiac dysfunction)have reached the maximum efficacy and cannot be improved ***,several issues remain to be clarified,such as the complexity and cost of ECOS systems,standardization of indications,therapeutic protocols and initiation time,choice of the patients who will benefit most from these interventions,while evidence from randomized controlled trials supporting their use is still ***,these methods are currently a part of routine clinical practice in intensive care *** editorial presents the past,present,and future considerations,as well as perspectives regarding these *** better understanding of these methods,the pathophysiology of MOF,the crosstalk between native organs resulting in MOF,and the crosstalk between native organs and artificial organ support systems when applied sequentially or simultaneously,will lead t

关键词： Kidney-liver replacement therapy Heart-lung support Blood purification Native–artificial organ crosstalk Multiple organ support therapy Extracorporeal organ support

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The omega-3 and retinopathy of prematurity relationship

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International Journal of Ophthalmology(English edition) 2017年第2期10卷 300-305页

作者： Angelakis Malamas Angeliki Chranioti Christos Tsakalidis Stavros A Dimitrakos asimina Mataftsi Royal Victoria Infirmary Eye DepartmentNewcastle Upon TyneNE1 4LPUK First Department of Ophthalmology Aristotle University of ThessalonikiThessaloniki 54621Greece Second NICU and Neonatology Department Papageorgiou General HospitalAristotle University of ThessalonikiThessaloniki 56403Greece Second Department of Ophthalmology Aristotle University of ThessalonikiThessaloniki 56403Greece

The aim of this article is to examine the effect of omega-3（ω-3） long-chain polyunsaturated fatty acids（LCPUFAs） intake on retinopathy of prematurity（ROP） by reviewing the experimental and clinical trials conducted on animal models and *** demonstrate cytoprotective and cytotherapeutic actions contributing to a number of anti-angiogenic and neuroprotective mechanisms within the *** intake appears to have a beneficial effect on ischemia,oxidative stress,inflammation and cellular signaling mechanisms,influencing retinal cell gene expression and cellular differentiation.ω-3 LCPUFAs may modulate metabolic processes that activate molecules implicated in the pathogenesis of vasoproliferative and neurodegenerative retinal diseases such as ROP.

关键词： retinopathy ofprematurity omega-3

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Introduction of a digital near-vision reading test for normal and low vision adults:development and validation

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Eye and Vision 2020年第1期7卷 497-511页

作者： Georgios Labiris Eirini-Kanella Panagiotopoulou Eleftherios Chatzimichael Maria Tzinava asimina Mataftsi Konstantinos Delibasis Department of Ophthalmology University Hospital of AlexandroupolisDragana68100 AlexandroupolisGreece Department of Computer Science and Biomedical Informatics University of Thessaly35100LamiaGreece 2nd Department of Ophthalmology Aristotle University of Thessaloniki56429ThessalonikiGreece

Background:MNREAD is an advanced near-vision acuity chart that has already been translated and validated in Greek *** that no validated Greek digital near-vision test exists,our primary objective was to develop and validate a digital near-vision reading test based on the fundamental properties of the Greek printed MNREAD(MNREAD-GR).Methods:This is a prospective,comparative study.A digital near-vision chart was developed(Democritus Digital Acuity Reading Test-DDART)with text size calibration,audio recording for automatic reading timing,as well as automatic calculation of reading acuity(RA),maximum reading speed(MRS),critical print size(CPS)and reading accessibility index(ACC).Normal and low vision subjects participated in the validation process,responding to MNREAD-GR and DDART at the same day,at a 40 cm viewing *** in all parameters between the charts were compared with t-test and intraclass correlation coefficients(ICCs).Within 15 days,all participants responded again to DDART in a different set of sentences to assess its test-retest ***:One hundred patients(normal vision group-NVG:70 patients;low vision group-LVG:30 patients)responded to both reading ***-significant differences were detected for all parameters between DDART and MNREAD-GR except for MRS and ACC that were significantly higher in MNREAD-GR in NVG(p<0.01).NVG participants demonstrated sufficient ICCs that ranged from 0.854 to 0.963,while LVG demonstrated ICCs for RA,ACC,MRS and CPS equal to 0.986,0.894,0.794 and 0.723,*** parameters calculated with DDART demonstrated excellent test-retest reliability(ICCs:0.903-0.956).Conclusions:The proposed reading test presented comparable validity and repeatability to MNREAD-GR suggesting that it can be used both in normal and low vision Greek patients.

关键词： Digital near-vision chart Critical print size Reading acuity Reading speed Presbyopia Low vision

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Spasm of the near reflex:a common diagnostic dilemma?

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International Journal of Ophthalmology(English edition) 2021年第4期14卷 541-546页

作者： Eleni Papageorgiou Dimitrios Kardaras Eftychia Kapsalaki Efihymios Dardiotis asimina Mataftsi Evangelia E.Tsironi Department of Ophthalmology University Hospital of LarissaLarissa 41222Greece Department of Radiology University Hospital of LarissaLarissa 41222Greece Department of Neurology University Hospital of LarissaLarissa 41222Greece 2^(nd)Department of Ophthalmology Aristotle University of ThessalonikiThessaloniki 41222Greece

AIM:To report the clinical characteristics and diagnostic procedures used in patients with spasm of the near reflex(SNR),in order to present common investigation strategies and diagnostic ***:Retrospective case series of twenty-two patients,mainly children,with SNR or accommodation spasm(AS).AS was diagnosed on the basis of blurred vision and a difference of>2 dioptres between manifest and cycloplegic *** esotropia and miosis were present,the patients were diagnosed with *** patients underwent visual acuity testing,orthoptic evaluation,assessment of refraction before and after cycloplegia,and dilated *** diagnostic investigations,such as neuroimaging,lumbar puncture(LP),electrophysiology and blood tests,were also *** use among children was assessed in hours per ***:There were 19 female and 3 male patients(age range 7-33 y,median=10 y).Seventeen patients had AS and 5 patients had SNR,with episodic blurry vision and headaches being the most common *** neuroimaging was performed in six patients(27%),although only one had a history of brain *** of those patients underwent visual evoked potentials and three also underwent LP and received intravenous steroid *** majority of patients(90%)reported prolonged daily screen time(>2 h/d),and in 55%of cases there were concurrent social problems or psychological *** consisted of careful explanation of the condition,atropine1%eye drops and full cycloplegic correction by means of bifocal ***:The diagnosis of SNR and AS may be challenging,because symptoms are usually intermittent and nonspecific,and a large number of patients are often subjected to redundant and potentially time-consuming examinations and treatment,that may exaggerate the underlying psychological ***,detailed clinical testing and assessment of psychosocial profile is necessary,in order to avoid unnecessary *** sh

关键词： accommodative spasm bifocal glasses convergence spasm pseudomyopia spasm of the near reflex screen time

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Prevention,diagnostic evaluation,management and prognostic implications of liver disease in critically ill patients with COVID-19

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World Journal of Clinical Cases 2023年第3期11卷 514-527页

作者： asimina Valsamaki Maria Xanthoudaki Katerina G Oikonomou Panagiotis J Vlachostergios AntoniosPapadogoulas Periklis Katsiafylloudis Ioanna Voulgaridi Apostolia-Lemonia Skoura Apostolos Komnos Panagiotis Papamichalis Intensive Care Unit General Hospital of LarissaLarissa 41221Greece Division of Hematology and Medical Oncology Department of MedicineWeill Cornell MedicineNew YorkNY 10065United States Department of Microbiology General Hospital of LarissaLarissa 41221Greece Transfusion Medicine Department University Hospital of LarissaLarissa 41110Greece

Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2,broke out in December 2019 in Wuhan city of China and spread rapidly ***,by March 2020,the World Health Organization declared the disease a global *** from the respiratory system,various other organs of the human body are also seriously affected by the *** injury in patients with a severe form of COVID-19 is estimated to be 14.8%-53.0%.Elevated levels of total bilirubin,aspartate aminotransferase and alanine aminotransferase and low levels of serum albumin and prealbumin are the main laboratory *** with pre-existing chronic liver disease and cirrhosis are much more prone to develop severe liver *** literature review presented the recent scientific findings regarding the pathophysiological mechanisms responsible for liver injury in critically ill patients with COVID-19,the various interactions between drugs used to treat the disease and the function of the liver and the specific tests providing the possibility of early diagnosis of severe liver injury in these ***,it highlighted the burden that COVID-19 put on health systems worldwide and its effect on transplant programs and the care provided to critically ill patients in general and particularly to those with chronic liver disease.

关键词： Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2 Liver disease Intensive care unit Liver unit Prealbumin

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Implementation of Forest Policy in Greece in Relation to Biodiversity and Climate Change

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Open Journal of Ecology 2018年第3期8卷 174-191页

作者： Konstantinos Spanos Dionysios Gaitanis asimina Skouteri Panos Petrakis Ioannis Meliadis Hellenic Agricultural Organization General Directorate of Agricultural Research Forest Research Institute Thessaloniki Greece Hellenic Agricultural Organization General Directorate of Agricultural Research Institute of Mediterranean Forest Ecosys-tems Athens Greece

This is a review article based on literature (national and international) and empirical approach. A general overview on research priority areas on biodiversity and approaches and tools to provide information for forest policy implementation on biodiversity are briefly summarized. Challenges for biodiversity research and related policy in Europe and Greece are depicted. General information on forests, protected areas and forest management in Greece is also presented. Major actions and measures for conservation of forest biodiversity in Greece are described and analysed. The implementation of forest policy in Greece (including the adoption of International constitutional frame) in relation to biodiversity protection and climate change is also analysed. Priorities identified by the Strategic Plan of Rural Development 2007-2013 in Greece in order to adapt to climate change, are also presented. Furthermore, the National institutional framework (Legislation) and strategic targets for biodiversity conservation in Greece are synoptically presented. Finally, major conclusions and future challenges are highlighted.

关键词： Biodiversity Conservation Protected Areas Forest Policy Implementation Strategic Targets

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Gastroenterology and liver disease during COVID-19 and in anticipation of post-COVID-19 era: Current practice and future directions

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World Journal of Clinical Cases 2021年第19期9卷 4918-4938页

作者： Katerina G Oikonomou Panagiotis Papamichalis Tilemachos Zafeiridis Maria Xanthoudaki Evangelia Papapostolou asimina Valsamaki Konstantinos Bouliaris Michail Papamichalis Marios Karvouniaris Panagiotis J Vlachostergios Apostolia-Lemonia Skoura Apostolos Komnos Intensive Care Unit General Hospital of LarissaLarissa 41221ThessalyGreece Surgical Department General Hospital of LarissaLarissa 41221ThessalyGreece Department of Cardiology University Hospital of LarissaLarissa 41110ThessalyGreece Intensive Care Unit University Hospital of LarissaLarissa 41110ThessalyGreece Division of Hematology and Medical Oncology Department of MedicineWeill Cornell MedicineNew YorkNY 10065United States Transfusion Medicine Department University Hospital of LarissaLarissa 41110ThessalyGreece

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has emerged as a major threat to global public *** virus causes the clinical syndrome known as coronavirus disease 2019(COVID-19),in which multiple organs can get *** from manifestations of the respiratory system,which predominate,its clinical presentation is frequently accompanied by symptoms of the gastrointestinal(GI)tract and liver *** correlation of symptoms and abnormalities with disease severity is discussed,leading to ambiguous results from international ***,the disease infects patients with coexisting liver and GI disorders affecting both their health status and the availability of healthcare services provided to *** risk of transmission of the disease during aerosol-generating procedures has changed the diagnostic approach and follow-up algorithms for liver and GI *** the safety of both doctors and patients,telemedicine and distant evaluation have become everyday practice,whereas several routines and emergency visits at outpatient and emergency departments have been postponed or *** against SARS-CoV-2 is underway,providing hope to humanity and the expectation that the post-COVID-19 era is *** review aims to update knowledge about the manifestations of COVID-19 related to liver and GI diseases and the effect of the pandemic on the diagnostic and therapeutic procedures for these diseases with a special focus on how current practices have changed and what changes will possibly remain in the future.

关键词： COVID-19 SARS-CoV-2 Liver disease Gastroenterology practice Endoscopy

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Design of Monolithic Concrete Ground Floors

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Journal of Civil Engineering and Architecture 2014年第7期8卷 833-845页

作者： Alexandros D. Bantias Ioannis A. Tegos Theodoros A. Chrysanidis asimina M. Athanatopoulou Department of Civil Engineering School of Engineering Aristotle University of Thessaloniki Thessaloniki 54124 Greece

It is known that the slabs on soil constitute one of the most difficult types of structures despite their apparent simplicity. The objective of this paper is to give a general survey of the design of ground supported slabs with the interposition of a suitable subbase. A solution is proposed with the following characteristics：（1） complete suppression of joints; （2） conventional reinforcement with meshes in the upper and lower fiber of the slab in order to confront and distribute cracking that is caused by hindrance of free contractions and expansions; （3） effective confrontation of problems of bulging. The proposal is in effect on one hand for industrial floorings and on the other hand for concrete pavings with large durability requirement.

关键词： Ground slabs restraints durability jointless fatigue.

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Liver replacement therapy with extracorporeal blood purification techniques current knowledge and future directions

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World Journal of Clinical Cases 2023年第17期11卷 3932-3948页

作者： Panagiotis Papamichalis Katerina G Oikonomou asimina Valsamaki Maria Xanthoudaki Periklis Katsiafylloudis Evangelia Papapostolou Apostolia-Lemonia Skoura Michail Papamichalis Marios Karvouniaris Antonios Koutras Eleni Vaitsi Smaragdi Sarchosi Antonios Papadogoulas Dimitrios Papadopoulos Intensive Care Unit General Hospital of LarissaLarissa 41221ThessalyGreece Department of Transfusion Medicine University Hospital of LarissaLarissa 41110ThessalyGreece Department of Cardiology University Hospital of LarissaLarissa 41110ThessalyGreece Intensive Care Unit AHEPA University HospitalThessaloniki 54636Greece 1^(st) Department of Obstetrics and Gynecology General Hospital of Athens“ALEXANDRA”National and Kapodistrian University of AthensAthens 11528Greece Department of Anesthesiology University Hospital of LarissaLarissa 41110ThessalyGreece

Clinically,it is highly challenging to promote recovery in patients with acute liver failure(ALF)and acute-on-chronic liver failure(ACLF).Despite recent advances in understanding the underlying mechanisms of ALF and ACLF,standard medical therapy remains the primary therapeutic *** transplantation(LT)is considered the last option,and in several cases,it is the only intervention that can be ***,this intervention is limited by organ donation shortage or exclusion criteria such that not all patients in need can receive a *** option is to restore impaired liver function with artificial extracorporeal blood purification *** first such systems were developed at the end of the 20th century,providing solutions as bridging therapy,either for liver recovery or *** enhance the elimination of metabolites and substances that accumulate due to compromised liver *** addition,they aid in clearance of molecules released during acute liver decompensation,which can initiate an excessive inflammatory response in these patients causing hepatic encephalopathy,multiple-organ failure,and other complications of liver *** compared to renal replacement therapies,we have been unsuccessful in using artificial extracorporeal blood purification systems to completely replace liver function despite the outstanding technological evolution of these *** middle to high-molecular-weight and hydrophobic/protein-bound molecules remains extremely *** majority of the currently available systems include a combination of methods that cleanse different ranges and types of molecules and ***,conventional methods such as plasma exchange are being re-evaluated,and novel adsorption filters are increasingly being used for liver *** strategies are very promising for the treatment of liver ***,the best method,system,or device has not been developed yet,and its probability of

关键词： Liver failure Transplantation Blood purification Liver replacement therapy Artificial extracorporeal systems Transplant-free survival

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