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Drainage vs no drainage in secondary peritonitis with sepsis following complicated appendicitis in adults in the modern era of antibiotics

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World Journal of Gastrointestinal Surgery 2013年第11期5卷 300-305页

作者： Sheraz Ahmed Rather Shams UL Bari Ajaz A Malik asima khan Department of Surgery Sheri Kashmir Institute of Medical Sciences SouraSrinagarKashmir 190006India Department of General Surgery Sheri Kashmir Institute of Medical Sciences Medical College BeminaSrinagarKashmir 190006India Resident Accident and Emergency Sheri Kashmir Institute of Medical Sciences Medical College Bemina SrinagarKashmir 190006India

AIM: To compare the profile of postoperative outcome in secondary peritonitis with sepsis due to complicated appendicitis in two cohorts(drainage vs no-drainage) after appendicectomy in adults in the modern era of effective antibiotics. METHODS: A retrospective review of all adult patients who were operated for secondary peritonitis with sepsis due to complicated appendicitis was carried out. Total of 209 patients were identified from May 2005 to April 2009 with operative findings of gangrenous or perforated appendix. The patients were divided into two cohorts, those where prophylactic drainage was established(n = 88) and those where no drain was used(n = 121). Abdominal drain was removed oncethe drainage ceased or decreased(< 10-20 mL/d in closed system of drainage or when once daily dressing was minimally soaked in open system). Broad spectrum antibiotics to cover the gut flora were started in both cohorts at diagnosis and were stopped once septic features resolved. Peritoneal fluid for aerobic culture and sensitivity were routinely obtained intra operatively; however antibiotic regimens were not changed unless patient failed to respond to the antibiotics based on the institutional protocol. The co-morbidities and their influence on primary end points were noted. Immunocompromised patients, appendicitis complicated by inflammatory bowel disorder and tumors were excluded from the study. RESULTS: Disease stratification and other demographic features were comparable in both cohorts. There was zero mortality in drainage group while as one patient(0.82%) died in the non-drainage group. The median duration(in days) of hospital stay(6.5 vs 4); antibiotic use(5 vs 3.5); regular parental analgesic use(5 vs 3.5) and paralytic ileus(2.5 vs 2) was more common in the drainage group. Incidence of major wound infection in patients 14(15.9%) vs 22(18.18%) and residual intraabdominal sepsis(inter loop collection/abscess)-7(8%) vs 13(10.74%) requiring secondary intervention was not

关键词： Appendicitis Antibiotics Drainage Gangerenous Peritonitis

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Extraction of protein from churpi of yak milk origin:Size reduction,nutraceutical potential and as a wall material for resveratrol

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Food Bioscience 2022年第2期46卷 900-911页

作者： Asir Gani Nairah Noor Adil Gani Jenno Joseph-Leenose-Helen asima Shah Zanoor ul Ashraf Laboratory of Functional Food and Nutraceuticals Department of Food Science and TechnologyUniversity of KashmirSrinagar190006India

Resveratrol is a known anti-oxidant and anti-cancer *** low bioavailability and poor water solubility of resveratrol is a major barrier that restricts its usage in food *** overcome these problems,the study presents micro and nano encapsulation of resveratrol in casein micelles extracted from Himalayan cheese(Churpi).Resveratrol loaded casein microparticles(CS-rm)were obtained using emulsion-freeze ***,resveratrol loaded casein nanoparticles(CS-rn)were obtained using *** were characterized using dynamic light scattering(DLS),scanning electron microscopy(SEM)and attenuated total reflectance-fourier transform infrared spectroscopy(ATR-FTIR).DLS revealed hydrodynamic diameter of 71.24μm and 387.023 nm and zeta potential of-22.62 and-28.08 mV for CS-rm and *** confirmed the characteristic peaks of resveratrol at 965.4,1380.86,1586.66 and 1607 cm-1 confirmed successful micro and ***-rm displayed high encapsulation efficiency(52.32%)and swelling power(77.90 at pH 3 and 68.65 at pH 7.5)than *** micro and nanoencapsulation protected resveratrol in gastric conditions,however,CS-rn showed high release of resveratrol then CS-rm in simulated intestinal *** anti-oxidant and anti-cancer activity of resveratrol under simulated gastric and intestinal conditions(SGID)was significantly higher(p≤0.05)for CS-rn,showing that nanoencapsulation improved release and nutraceutical profile of *** loaded nano and micro casein particles can be used a source of fortified protein supplement in growing food and nutraceutical industry.

关键词： Casein Encapsulation efficiency In vitro release Anti-cancer

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Nd-doped NiFe_(2)O_(4) and its composite with CNTs to tune photocatalytic activity

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Journal of Rare Earths 2023年第12期41卷 1919-1928,I0004页

作者： Fatimah Mohammed AAlzahrani Amna Irshad Sonia Zulfiqar Z.A.Alrowaili Noor ul Ain asima Anwar Muhammad Farooq Warsi M.S.Al-Buriahi Department of Chemistry CollegeofSciencePrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabi Institute of Chemistry Baghdad-ul-Jadeed CampusThe Islamia University of BahawalpurBahawalpur6310Pakistan Department of Chemistry Faculty of ScienceUniversity of Ostrava30.Dubna 22Ostrava70103Czech Republic Department of Chemicaland Biological Engineering Iowa State UniversitySweeney Hall618 Bissll RoadAmesIowa 50011United States Department of Physics College of ScienceJouf UniversityPo.Box 2014SakakaSaudi Arabia Institute of Physics Baghdad-ul-Jadeed CampusThe Islamia University of BahawalpurBahawalpur63100Pakistan Department of Physics Sakarya UniversitySakaryaTurkey

Rare earth-doped spinel nano ferrites are attaining importance as heterogeneous nanocatalysts for the degradation of organic *** earth metal doping increases the electrical and optical properties,as well as the surface-to-volume ratio of the bare *** this work,NiFe_(2)O_(4)(NF) and Nd-NiFe_(2)O_(4)(NF-1) were successfully synthesized via the co-precipitation *** nanotubes(CNT)-based nanocomposite(NF-2) was prepared using the ultra-sonication *** prepared materials were analyzed via various physiochemical *** degradation efficiency of these materials was analyzed for the degradation of Rhodamine B,methylene blue,and benzoic acid,NF-2 shows the highest efficiency among all the prepared ***-2 shows 83.87%,90.80%,and 66.96% degradation of Rhodamine B,methylene blue,and benzoic acid,*** reason for the superior activity of NF-2 is the existence of rare earth Nd ions and *** surface area of NF increases due to the presence of carbon nanotubes and enhanced surface area provides more active sites for the degradation reaction.

关键词： XRD Carbon nanotubes Benzoic acid Photo-degradation Visible light Rare earths

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Cobalt and sulfur co-doped nano-size TiO_2 for photodegradation of various dyes and phenol

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Journal of Environmental Sciences 2015年第11期27卷 100-109页

作者： asima Siddiqa Dilshad Masih Dalaver Anjum Muhammad Siddiq KAUST Catalysis Center King Abdullah University of Science and Technology (KAUST) National Centre for Physics Quaid-i-Azam University Complex Chemistry Department Quaid-i-Azam University Imaging and Characterization Lab KAUST

Various compositions of cobalt and sulfur co-doped titania nano-photocatalyst are synthesized via sol–gel method. A number of techniques including X-ray diffraction（XRD）, ultraviolet–visible（UV–Vis）, Rutherford backscattering spectrometry（RBS）, thermal gravimetric analysis（TGA）Raman, N2 sorption, electron microscopy are used to examine composition, crystalline phase, morphology, distribution of dopants, surface area and optical properties o synthesized materials. The synthesized materials consisted of quasispherical nanoparticles of anatase phase exhibiting a high surface area and homogeneous distribution o dopants. Cobalt and sulfur co-doped titania demonstrated remarkable structural and optical properties leading to an efficient photocatalytic activity for degradation of dyes and phenol under visible light irradiations. Moreover, the effect of dye concentration catalyst dose and p H on photodegradation behavior of environmental pollutants and recyclability of the catalyst is also examined to optimize the activity of nano-photocatalys and gain a better understanding of the process.

关键词： Photocatalysis Nanoparticles Co-doped Ti O2 Dye degradation Phenol

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Deep Learning-Based Classification of Fruit Diseases:An Application for Precision Agriculture

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Computers, Materials & Continua 2021年第2期66卷 1949-1962页

作者： Inzamam Mashood Nasir asima Bibi Jamal Hussain Shah Muhammad Attique khan Muhammad Sharif Khalid Iqbal Yunyoung Nam Seifedine Kadry Department of Computer Science HITEC UniversityTaxila47040Pakistan Department of Computer Science COMSATS University IslamabadWah CampusWah Cantt47080Pakistan Department of Computer Science COMSATS University IslamabadAttock CampusAttockPakistan Department of Computer Science and Engineering Soonchunhyang UniversityAsanSouth Korea Department of Mathematics and Computer Science Faculty of ScienceBeirut Arab UniversityBeirutLebanon

Agriculture is essential for the economy and plant disease must be *** recognition of problems is important,but the manual inspection is slow,error-prone,and has high manpower and time *** intelligence can be used to extract fruit color,shape,or texture data,thus aiding the detection of ***,the convolutional neural network(CNN)techniques show a massive success for image classification *** extracts more detailed features and can work efficiently with large *** this work,we used a combined deep neural network and contour feature-based approach to classify fruits and their diseases.A fine-tuned,pretrained deep learning model(VGG19)was retrained using a plant dataset,from which useful features were ***,contour features were extracted using pyramid histogram of oriented gradient(PHOG)and combined with the deep features using serial based *** the fusion process,a few pieces of redundant information were added in the form of ***,a“relevance-based”optimization technique was used to select the best features from the fused vector for the final *** the use of multiple classifiers,an accuracy of up to 99.6%was achieved on the proposed method,which is superior to previous ***,our approach is useful for 5G technology,cloud computing,and the Internet of Things(IoT).

关键词： Agriculture deep learning feature selection feature fusion fruit classification

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Radical scavenging and antibacterial activity of Arnebia benthamii methanol extract

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Asian Pacific Journal of Tropical Medicine 2012年第10期5卷 766-772页

作者： Showkat A Ganie asima Jan Sabeera Muzaffar Bilal A Zargar Rabia Hamid M Afzal Zargar Department of Biochemistry University of Kashmir Department of Food Science and Technology University of Kashmir Department of Pharmaceutical Sciences University of Kashmir

Objective:To evaluate in vitro antioxidant and antibacterial activity of methanolic extract of Arnebia benthamii（***） whole ***:Plasmid damage was analyzed by agarose gell *** thymus DNA was monitored by TBARS ***, reducing power and lipid peroxidation was evaluated by using standard *** assay was monitored by disc diffusion ***:DPPH radical scavenging and hydroxyl radical scavenging potential of the plant revealed that the extract to be active radical ***(Fe3+-Fe2+) power and lipid peroxidation inhibition efficiency（TBARS assay） of the extract was also evaluated and the extract showed promising activity in preventing lipid peroxidation and might prevent oxidative damages to *** extract offered a significant protection against plasmid and calf thymus UNA damage induced by hydroxyl radicals. The extract was also evaluated on different bacterial strains and the maximum antibacterial activity was exhibited against Escherichia coli（***） when compared with standard drug. Conclusions:These findings demonstrate that the methanol extract of *** has excellent anti-oxidant activities and could be considered as a potential source of lead molecules for pharmaceutical industries.

关键词： Free radicals Lipid peroxidation DPPH TBARS DNA damage Antibacterial activity Arnebia benthamii

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Effect of Bisphosphonate on Osteoclast of Bone

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Forensic Medicine and Anatomy Research 2014年第3期2卷 56-62页

作者： Sarah Ralte asima Bhattacharyya Department of Anatomy North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS) Meghalaya India

Bisphosphonates are synthetic analogues of naturally occurring pyrophosphate molecule and are potent inhibitors of osteoclastic bone resorption. Bisphosphonates bind to hydroxyapatite crystals with high affinity and after incorporation by osteoclasts, the primary target cell, it inhibits osteoclastic bone resorption. The anti-resorptive effect has been shown to occur in organ culture as well as in-vivo, but the precise mechanism by which it exerts its bone resorbing effect is not yet fully understood. In vitro and in vivo studies have demonstrated that zoledronate is a more potent inhibitor of osteoclasts than earlier bisphosphonates. Bisphosphonates have now emerged as a leading therapeutic agent for the treatment of hypercalcaemia of malignancy, bone metabolic diseases, Paget’s disease and postmenopausal osteoporosis.

关键词： Osteoclast Bone Resorption Bisphosphonate Mechanism of Action

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联合国妇女署在保护巴基斯坦妇女权利方面的作用（2010-2019）

联合国妇女署在保护巴基斯坦妇女权利方面的作用（2010-2019）

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作者： asima Tanveer 吉林大学

学位级别：硕士

巴基斯坦的性别平等和妇女赋权问题已经成为巴基斯坦国内外共同关注的焦点。遗憾的是,这个焦点目前主要集中在巴基斯坦社会中妇女的必要权利方面。联合国妇女署（UN Women）和《消除对妇女一切形式歧视公约》（The Convention on the El... 详细信息

巴基斯坦的性别平等和妇女赋权问题已经成为巴基斯坦国内外共同关注的焦点。遗憾的是,这个焦点目前主要集中在巴基斯坦社会中妇女的必要权利方面。联合国妇女署（UN Women）和《消除对妇女一切形式歧视公约》（The Convention on the Elimination of All Forms of Discrimination against Women）促进了地区妇女权利提升并且促使国际社会和国家履行性别平等承诺,并将这些承诺纳入当地法律、政策和框架之中。在过去12年中,联合国妇女署通过提供技能培训、保险、小额信贷计划和市场联系等便利条件为巴基斯坦妇女提供了创造收益的机会,大约30,000名女性居家工作者和被排斥的妇女群体直接受益,这使得她们能够更加充分地参与到旁遮普省（Punjab）、信德省（Sindh）、俾路支省（Baluchistan）和开伯尔-普赫图赫瓦省（Khyber Pakhtunkhwa）等地区的经济发展中。联合国妇女署驻巴基斯坦办事处的使命是促进两性平等和妇女赋权。联合国妇女署和巴基斯坦政府以及民间团体合作,他们通过共同努力,尽力保证两性平等、社会经济发展和保护妇女权利。本论文的研究问题是“联合国妇女署在保护巴基斯坦妇女权利方面起到了什么作用?”一方面,联合国妇女署给巴基斯坦的妇女赋权带来了积极的影响,包括提供性别平等的教育,给巴基斯坦的妇女赋权,推动巴基斯坦政府改变妇女政策,改变巴基斯坦社会公众的性别观念;但另一方面,联合国妇女署在巴基斯坦依然面临着一些挑战,包括联合国体系的缺陷,联合国妇女署的社会问题,女性教育意识的缺失,巴基斯坦政府的政治压力,以及宗教和文化的障碍。该研究分析了巴基斯坦的性别平等（女权主义）和妇女自由的现状,并强调这一现状对妇女权利的伤害和剥削。女权主义（Feminism）主张促进男女平等,在权利平等的社会里,妇女可以依靠自己的选择在各行各业工作且不受到剥削。本研究许多有效的资料来源于社会活动家、联合国妇女署的官员和促进巴基斯坦两性平等和妇女赋权的政治人士。本研究主要探讨女权主义理论如何在保障巴基斯坦妇女权利方面发挥作用以及联合国妇女署为巴基斯坦妇女权利发展做出的贡献。笔者对相关政府官员、学者和致力于妇女权利的非政府组织官员进行了访谈。本研究分为五章。第一章阐述了论文的研究背景、研究问题、研究方法和关于联合国妇女署的文献综述。研究问题为联合国妇女署在保护巴基斯坦妇女权利方面起到什么作用。同时本章也探讨了论文的论点、局限性、研究方法和理论框架。并且这篇论文可以为学者理解和探索联合国妇女署在保护巴基斯坦妇女权利方面提供新的范式。第二章着重介绍联合国妇女署的历史发展的不同阶段。联合国妇女署是在联合国会员国的认可下,专门关注性别平等和妇女赋权问题的机构。联合国妇女署的主要宗旨和职能包括:支持政府间机构,如妇女地位委员会（Commission on the Status of Women）;帮助成员国实施相关妇女权利保护标准,向有需求的国家提供适当的技术和财政支持;协助联合国体系履行性别平等方面的承诺。第三章分析了联合国妇女署的积极影响。包括以下几个方面:第一,联合国妇女署为所有性别提供平等受教育的机会。教育是行使权利的必要条件,是男女老少能够参加社会、经济和政治生活和发展民主社会的基础。第二,促进巴基斯坦的妇女赋权。在巴基斯坦,妇女赋权面临许多问题,联合国妇女署通过帮助巴基斯坦妇女,包括最边缘化和最脆弱的妇女和女童,协助她们在社会各个层面,特别是在生殖权利方面,拥有知情权和决定权。第三,促进巴基斯坦政府改变对妇女的政策,并且热烈欢迎巴基斯坦加入和实现2030年性别平等议程目标。联合国妇女署与亚洲国家政府共同合作,提高妇女获得经济收入的机会,增加女童获得教育和保护的机会,打击性别暴力,并增强妇女的政治参与和公民参与。第四,改变巴基斯坦公众的社会不平等观念。性别不平等作为巴基斯坦一个根深蒂固的威胁,阻碍着其社会经济的进步。联合国妇女署致力于改变人们性别歧视的观念,废除性别不平等。第四章讨论了联合国妇女署在巴基斯坦面临的挑战。首先是联合国体系的不足,联合国的结构仍然存在着一定的缺陷。其次是巴基斯坦国内的社会问题所带来的挑战。巴基斯坦的国内法中有歧视妇女的规定,女性的政治决策权低于男性,相关的性别统计信息不透明且获取困难,国内的经济情况无法为女性提供平等机会。第三是巴基斯坦缺乏女性受教育的意识。受教育是每个男人和女人的权利,但在巴基斯坦,女性受教育比例非常低。还有很多家庭受到伊斯兰教的影响不喜欢男女同校,继而剥夺了女孩接受高等教育的机会。因此,政府必须加强教育意识的传播。第四是来自巴基斯坦政府的政治压力。妇女的政治参与是发展中国家的基本问题之一。目前,巴基斯坦国民议会为妇女保留了60个席位,目前共有7

关键词：联合国妇女署巴基斯坦性别平等女性赋权

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磁控溅射用于细微颗粒涂镀功能薄膜的新技术

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辽宁科技大学学报 2017年第2期40卷 126-132页

作者： Peter J Kelly David Sawtell Glen T West May Azzawi asima Farooq Marina Ratova 英国曼彻斯特城市大学科学与工程学院英国曼彻斯特M15GD

磁控溅射是一项成熟的技术,可用在各种基体上沉积高质量金属及陶瓷涂层。然而,此项技术一般并不适于涂镀微粒粒度为nm或μm到100μm的细微粒涂层。本文详述了一种可涂镀微粒粒径在上述范围的均匀功能薄膜的技术。在磁场下面安放的一个... 详细信息

磁控溅射是一项成熟的技术,可用在各种基体上沉积高质量金属及陶瓷涂层。然而,此项技术一般并不适于涂镀微粒粒度为nm或μm到100μm的细微粒涂层。本文详述了一种可涂镀微粒粒径在上述范围的均匀功能薄膜的技术。在磁场下面安放的一个碗状容器内放有微粒子,容器可以振动可使粒子均匀地振出碗边沉落到真空腔,薄膜沉积工艺为反应或非反应脉冲磁控溅射。Ti,Ti O2,Sn及Sn O2从单磁场源沉积,而Bi/W的氧化物从双磁场源沉积。用SEM,TEM和EDX,以及其它与应用相关的技术表征所沉积的微粒,以表明此项技术的潜在功能。

关键词：功能薄膜磁控溅射粒子沉积振动

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干细胞 proteome 上的 antiproliferative 代理人 ciclopirox olamine 处理的影响

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World Journal of Stem Cells 2013年第1期5卷 9-25页

作者： Gry H Dihazi asima Bibi Olaf Jahn Jessica Nolte Gerhard A Mueller Wolfgang Engel Hassan Dihazi Department of Nephrology and Rheumatology Georg-August University GoettingenD-37075 GoettingenGermany Proteomics Group Max-Planck-Institute of Experimental MedicineD-37075 GoettingenGermany Deutsche Forschungsgemeinschaft Research Center for Molecular Physiology of the Brain D-37073 Institute of Human Genetics Georg-August University GoettingenD-37073 GoettingenGermany

AIM:To investigate the proteome changes of stem cells due to ciclopirox olamine (CPX) treatment compared to control and retinoic acid treated cells. METHODS:Stem cells (SCs) are cells, which have the ability to continuously divide and differentiate into various other kinds of cells. Murine embryonic stem cells (ESCs) and multipotent adult germline stem cells (maG-SCs) were treated with CPX, which has been shown to have an antiproliferative effect on stem cells, and compared to stem cells treated with retinoic acid (RA),which is known to have a differentiating effect on stem cells. Classical proteomic techniques like 2-D gel electrophoresis and differential in-gel electrophoresis (DIGE) were used to generate 2D protein maps from stem cells treated with RA or CPX as well as from non-treated stem cells. The resulting 2D gels were scanned and the digitalized images were collated with the help of Delta 2D software. The differentially expressed proteins were analyzed by a MALDI-TOF-TOF mass spectrometer, and the identified proteins were investigated and categorized using bioinformatics. RESULTS:Treatment of stem cells with CPX, a synthetic antifungal clinically used to treat superficial mycoses, resulted in an antiproliferative effect in vitro, without impairment of pluripotency. To understand the mechanisms induced by CPX treatments which results in arrest of cell cycle without any marked effect on pluripotency, a comparative proteomics study was conducted. The obtained data revealed that the CPX impact on cell proliferation was accompanied with a significant alteration in stem cell proteome. By peptide mass fingerprinting and tandem mass spectrometry combined with searches of protein sequence databases, a set of 316 proteins was identified, corresponding to a library of 125 non-redundant proteins. With proteomic analysis of ESCs and maGSCs treated with CPX and RA, we could identify more than 90 single proteins, which were differently expressed in both cell lines. We cou

关键词： Stem cells Differentiation Hypusination Ciclopirox olamine Proteomics Retinoic acid

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