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Phytochemicals and cancer chemoprevention

Journal of Cancer Metastasis and Treatment 2020年第1期6卷 575-610页

作者： asim dave Falguni Parande Eun-Jung Park John M.Pezzuto Arnold&Marie Schwartz College of Pharmacy and Health Sciences Long Island UniversityBrooklynNY 11201USA College of Pharmacy and Health Sciences Western New England UniversitySpringfieldMA 01119-2684USA

The unending morbidity and mortality that results from cancer,as well as adverse reactions due to chemotherapy and the enormous economic burden of treatment and hospitalization,advocates for the necessity of chemopreventive *** chemoprevention refers to the use of agents capable of reversing,reducing,or slowing down the pathology of cancer at various ***,a few therapeutic drugs with relatively low toxicity(e.g.,tamoxifen,finasteride),and a sparse number of vaccines(hepatitis B,HPV),are used to prevent specific *** the general population,however,therapeutic options for cancer prevention are not ***,it is generally agreed that diet affects the genesis of cancer,and phytochemicals have the capacity of functioning as cancer chemoprevention *** is supported by epidemiological studies and clearly documented with animal models designed to mimic human ***,some public health strategies,such as recommendations for greater consumption of fruits and vegetables,reflect the merits of cancer ***,we focus on some well-established natural product cancer chemopreventive agents,including resveratrol(grapes),epigallocatechin-3-gallate(green tea),sulforaphane(cruciferous vegetables),anthocyanins(grapes and berries),curcumin(turmeric),silibinin(milk thistle),and lycopene(tomatoes).As aptly demonstrated by genomic analysis and other methods,the mechanistic underpinning is variable and *** addition,responses may be mediated through indirect mechanisms,such as interaction with the ***,ancillary applications of chemopreventive agents are worthy of consideration,such as management of sequelae induced by *** the loss of millions of cancer patients every year,it is obvious that negating malignant metastatic conditions remains of paramount *** meeting this objective,cancer chemoprevention offers great promise.

关键词： Chemoprevention phytochemicals resveratrol curcumin anthocyanins silibinin lycopene epigallocatechin-3-gallate anti-cancer activity

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