Phytochemicals and cancer chemoprevention
作者机构：Arnold&Marie Schwartz College of Pharmacy and Health SciencesLong Island UniversityBrooklynNY 11201USA College of Pharmacy and Health SciencesWestern New England UniversitySpringfieldMA 01119-2684USA
出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)
年 卷 期：2020年第6卷第1期
页 面：575-610页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported in part by the California Table Grape Commission
主 题：Chemoprevention phytochemicals resveratrol curcumin anthocyanins silibinin lycopene epigallocatechin-3-gallate anti-cancer activity
摘 要：The unending morbidity and mortality that results from cancer,as well as adverse reactions due to chemotherapy and the enormous economic burden of treatment and hospitalization,advocates for the necessity of chemopreventive *** chemoprevention refers to the use of agents capable of reversing,reducing,or slowing down the pathology of cancer at various ***,a few therapeutic drugs with relatively low toxicity(e.g.,tamoxifen,finasteride),and a sparse number of vaccines(hepatitis B,HPV),are used to prevent specific *** the general population,however,therapeutic options for cancer prevention are not ***,it is generally agreed that diet affects the genesis of cancer,and phytochemicals have the capacity of functioning as cancer chemoprevention *** is supported by epidemiological studies and clearly documented with animal models designed to mimic human ***,some public health strategies,such as recommendations for greater consumption of fruits and vegetables,reflect the merits of cancer ***,we focus on some well-established natural product cancer chemopreventive agents,including resveratrol(grapes),epigallocatechin-3-gallate(green tea),sulforaphane(cruciferous vegetables),anthocyanins(grapes and berries),curcumin(turmeric),silibinin(milk thistle),and lycopene(tomatoes).As aptly demonstrated by genomic analysis and other methods,the mechanistic underpinning is variable and *** addition,responses may be mediated through indirect mechanisms,such as interaction with the ***,ancillary applications of chemopreventive agents are worthy of consideration,such as management of sequelae induced by *** the loss of millions of cancer patients every year,it is obvious that negating malignant metastatic conditions remains of paramount *** meeting this objective,cancer chemoprevention offers great promise.
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