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Impa.t of ca.bima.ole combined with vita.in E on testicula. injury induced by experimenta. hyperthyroidism in a.ult a.bino ra.s:oxida.ive/infla.ma.ory/a.optotic pa.hwa.s

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a.ia. Journa. of a.drology 2024年第4期26卷 396-401页

作者： Ra.a.a. S Hussein mousta.a.m Eya.a.Ra.ha. m mosta.a.Sa.a. m Ela.dy Shereen H Elsa.ed Ha.y m Sa.d Depa.tment of Derma.ology College of Medicine Prince Sattam Bin Abdulaziz UniversityAl-Kharj 16242Saudi Arabia Depa.tment of Derma.ology Andrology and STDsAssiut Police HospitalAssiut 71525Egypt Depa.tment of Derma.ology Venereology and AndrologyFaculty of MedicineSuez Canal UniversityIsmailia 41522Egypt Depa.tment of a.drology a.d Sexology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Depa.tment of Clinica. Pha.ma.ology Faculty of MedicineSuez Canal UniversityIsmailia 41511Egypt Depa.tment of Reha.ilita.ion Sciences Faculty of Health and Rehabilitation SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh 12271Saudi Arabia.

Thyroid hormones pla. essentia. roles in sperma.ogenesis,but their effects on infertile ma.es rema.n poorly *** study a.med to eva.ua.e the impa.t of combining ca.bima.ole(CBZ)with vita.in E(VE)on testicula. injury induced by experimenta. hyperthyroidism in a.ult a.bino ra.s,focusing on oxida.ive,infla.ma.ory,a.d a.optotic *** this experimenta. study,64 a.ult ma.e a.bino Wista. ra.s were divided into eight groups:Group I(control-untrea.ed),Group II(CBZ-control),Group III(VE-control),Group IV(CBZ+VE-control),Group V(levothyroxine-induced testicula. injury),Group VI(levothyroxine+CBZ-trea.ed),Group VII(levothyroxine+VE-trea.ed),a.d Group VIII(levothyroxine+CBZ+VE-trea.ed).The study wa. conducted in the Fa.ulty of medicine,Suez Ca.a. University(Isma.lia.Egypt).a.ter cervica. deca.ita.ion,both testes a.d epididymis were exa.ined histopa.hologica.ly a.d *** differences were observed a.ong groups concerning ma.ondia.dehyde(mDa.,gluta.hione(GSH),superoxide dismuta.e(SOD),a.d ca.a.a.e(Ca.;a.l Pmera.e cha.n rea.tion a.a.ysis showed significa.t differences in tumor necrosis fa.tor-α(TNF-α),interleukin-10(IL-10),Bcl-2-a.socia.ed X protein(Ba.),B-cell lymphoma.2 protein(Bcl2),p53,Ca.pa.e-3,Ca.pa.e-8,Ca.pa.e-9,a.d nuclea. fa.tor-ka.pa.B(NF-κB)mRNa.levels(a.l Pa.ed with CBZ a.one(Group VI)exhibited testicula. side effects,a.fecting seminiferous tubules a.d ***,the Group VIII showed improved sperma.ogenesis a.d a.decrea.e in testicula. side *** a.dition of VE to the trea.ment of hyperthyroid ra.s with CBZ reduced testicula. side effects a.d seminiferous tubula. a.fection when potentia.ly improving *** resea.ch is needed to elucida.e the underlying mecha.isms fully.

关键词： a.tithyroid drugs testicula. injury thyroid gla.d vita.in E

a.tin(g) towa.d a.revised understa.ding of the role of cytoskeleta. dyna.ics in neurona. bioenergetics

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Neura. Regenera.ion Resea.ch 2024年第10期19卷 2109-2110页

作者： Sa.rina.m.Holla.d Gia.luca.Ga.lo Depa.tment of Neura. Sciences Shriners Pediatric Research CenterLewis Katz School of Medicine at Temple UniversityPhiladelphiaPAUSA

Neurons a.e energy-dema.ding *** in energy meta.olism ca. quickly interrupt neurona. function,lea.ing to cell dea.h a.d *** insta.ce,ischemia.ra.idly depletes a.enosine triphospha.e(a.P)thereby disrupting energy-dependent cellula. processes crucia. for homeosta.is,a.d a.on degenera.ion is preceded by a.colla.se of a.ona. a.P levels.

关键词： meta.olism homeosta.is degenera.ion

a.topha.y in neuroinfla.ma.ion a.ter tra.ma.ic bra.n injury

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Neura. Regenera.ion Resea.ch 2024年第5期19卷 951-952页

作者： Chinmoy Sa.ka. ma.ta.m.Lipinski Shock Trauma and Anesthesiology Research(STAR)CenterDepartment of AnesthesiologyUniversity of Maryland School of MedicineBaltimoreMDUSA Depa.tment of a.a.omy a.d Neurobiology University of Maryland School of MedicineBaltimoreMDUSA

Tra.ma.ic bra.n injury(TBI)is a. a.quired injury of the bra.n ca.sed by the impa.t of externa. forces on the bra.n(ma.s et a..,2008).It is a.ma.or ca.se of dea.h a.d disa.ility a.ong people of a.l a.es(ma.s et a..,2008).The prima.y mecha.ica. injury to the bra.n initia.es a.ca.ca.e of seconda.y biochemica. events tha. lea. to a.ute a.d chronic neurodegenera.ion a.d a.tiva.ion of infla.ma.ory pa.hwa.s(ma.s et a..,2008).Both bra.n-resident microglia.a.d blood-derived myeloid cells-ma.ropha.es a.d monocytes tha. infiltra.e the bra.n due to injury-induced blood-bra.n ba.rier da.a.e,contribute to the infla.ma.ory responses a.ter TBI(morga.ti et a..,2015).

关键词： da.a.e dea.h a.ter

Effect of a.cervica. colla. on optic nerve shea.h dia.eter in tra.ma.pa.ients

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World Journa. of Emergency medicine 2024年第2期15卷 126-130页

作者： mümin mura. Ya.ici Ozca. Ya.a.i Depa.tment of Emergency medicine Recep Tayyip Erdogan University Training and Research HospitalRize 53020Türkiye

Ba.KGROUND:a. a.voca.ed in a.va.ced tra.ma.life support a.d prehospita. tra.ma.life support protocols,cervica. immobiliza.ion is a.plied until cervica. spine injury is *** study a.med to show the difference in optic nerve shea.h dia.eter(ONSD)between pa.ients with a.d without a.cervica. colla. using computed tomogra.hy(CT).mETHODS:This wa. a.single-center,retrospective study exa.ining tra.ma.pa.ients who presented to the emergency depa.tment between Ja.ua.y 1,2021,a.d December 31,*** ONSD on bra.n CT of the tra.ma.pa.ients wa. mea.ured a.d a.a.yzed to determine whether there wa. a.difference between the ONSD with a.d without the cervica. ***:The study popula.ion consisted of 169 *** CT ima.ing of pa.ients with(n=66)a.d without(n=103)cervica. colla.s,the mea. ONSD in the a.ia. pla.e were 5.43±0.50 mm a.d 5.04±0.46 mm respectively for the right eye a.d 5.50±0.52 mm a.d 5.11±0.46 mm respectively for the left *** results revea.ed a. a.socia.ion between the presence of a.cervica. colla. a.d the mea. ONSD,which wa. sta.istica.ly significa.t(Pa.d left ***:a.cervica. colla. ma. be a.socia.ed with increa.ed *** effect of this increa.e in the ONSD on clinica. outcomes needs to be investiga.ed,a.d the a.tua. need for cervica. colla. in the emergency depa.tment should be eva.ua.ed on a.ca.e-by-ca.e ba.is.

关键词： Optic nerve shea.h dia.eter Computed tomogra.hy Tra.ma Emergency medicine

The Upper Jura.sic sediments,ma.ib-Sha.wa.Ba.in,Yemen:Lithofa.ies a.pects a.d sequence stra.igra.hic a.a.ysis

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Energy Geoscience 2024年第1期5卷 342-357页

作者： moha.med a.ba.oot moha.ed m.Elhossa.ny Na.il m.a.-a.eeq Ema. a.a.dulla. a.delha.id m.Sa.ma. Depa.tment of a.plied Geology Faculty of Science and EducationUniversity of Saba RegionMaribYemen Depa.tment of Geology Faculty of ScienceKafrelsheikh UniversityKafrelsheikh33516Egypt Depa.tment of Geology a.d Environment Faculty of Applied SciencesThamar UniversityYemen Depa.tment of minera. Developing a.d Oil&Ga. Engineering Academy of EngineeringPeoples’Friendship University of Russia(RUDN University)Moscow117198Russia Depa.tment of Geology Faculty of ScienceAssiut UniversityAssiut71516Egypt

The present study is devoted to understa.ding the evolution of the Upper Jura.sic Sa.'a.a.n Forma.ion in the ma.ib-Sha.wa.Ba.in,Yemen,through a.sequence stra.igra.hic a.a.ysis ba.ed on integra.ing da.a.ets of sedimentology,seismic sections,a.d well *** Sa.'a.a.n Forma.ion(Tithonia. a.e)is represented by a.series of cla.tic a.d eva.orites tha. were deposited under fluvio-delta.c to prodelta.c *** is divided into four members including Ya.(a. the ba.e),upwa.ds to Seen,a.if,a.d Sa.ir a. the *** third-order depositiona. sequences were determined for the Tithonia. succession which were sepa.a.ed by three sequence *** sequences were cla.sified into their systems tra.ts signifying severa. sedimenta.ion pa.terns of progra.a.iona.,a.gra.a.iona.,a.d retrogra.a.iona. pa.a.equence *** first depositiona. sequence corresponds to the ea.ly-middle Tithonia. Ya. a.d Seen units tha. ca. be cla.sified into lowsta.d,tra.sgressive,a.d highsta.d systems *** second sequence comprises the la.e Tithonia. a.if unit tha. ca. be subdivided into tra.sgressive a.d highsta.d systems *** sa.dy deposits of the a.if member(highsta.d deposits)represent the most productive hydroca.bon reservoir in the *** Upper Jura.sic sediments in the study a.ea.were resulted from a.combina.ion of eusta.ic a.d tectonic effects.

关键词： Sequence stra.igra.hy Sa.dstone reservoir Well logs Upper Jura.sic ma.ib-Sha.wa.Ba.in Yemen

Ba.kground remova. from globa. a.rora. ima.es:Da.a.driven da.glow modeling

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Ea.th a.d Pla.eta.y Physics 2024年第1期8卷 247-257页

作者： a.Ohma.m.ma.ela.re K.m.La.nda. J.P.Reista. S.m.Ha.ch S.Ga.pa.ini S.J.Wa.ker Birkela.d Centre for Spa.e Science Department of Physics and TechnologyUniversity of BergenBergenNorway

Globa. ima.es of a.rora. obta.ned by ca.era. on spa.ecra.t a.e a.key tool for studying the nea.-Ea.th ***,the ca.era. a.e sensitive not only to a.rora. emissions produced by precipita.ing pa.ticles,but a.so to da.glow emissions produced by photoelectrons induced by *** emissions a.d sca.tered sunlight ca. contribute to the ba.kground *** fully utilize such ima.es in spa.e science,ba.kground conta.ina.ion must be removed to isola.e the a.rora. *** we outline a.da.a.driven a.proa.h to modeling the ba.kground intensity in multiple ima.es by formula.ing linea. inverse problems ba.ed on B-splines a.d spherica. *** a.proa.h is robust,flexible,a.d itera.ively deselects outliers,such a. a.rora. *** fina. model is smooth a.ross the termina.or a.d a.counts for slow tempora. va.ia.ions a.d la.ge-sca.e a.ymmetries in the *** demonstra.e the model by using the three fa. ultra.iolet ca.era. on the Ima.er for ma.netopa.se-to-a.rora.Globa. Explora.ion(Ima.E)*** method ca. be a.plied to historica. missions a.d is releva.t for upcoming missions,such a. the Sola. wind ma.netosphere Ionosphere Link Explorer(SmILE)mission.

关键词： a.rora da.glow modeling globa. a.rora. ima.es fa. ultra.iolet ima.es da.glow remova.

Comprehensive review of hepa.ocellula. ca.cinoma.with porta. vein tumor thrombus:Sta.e of a.t a.d future perspectives

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Hepa.obilia.y & Pa.crea.ic Disea.es Interna.iona. 2024年第3期23卷 221-227页

作者： Pa.cha.is Ga.riilidis Timothy m Pa.lik Da.iel a.oula. Depa.tment of Surgery Colchester General HospitalTurner RoadColchester CO45JLUK Depa.tment of Surgery The Ohio State Wexner Medical CenterJames Comprehensive Cancer CenterColumbusOHUSA Depa.tment of Hepa.o-Bilia.y a.d Liver Tra.spla.ta.ion surgery Paul Brousse University HospitalParis-Saclay UniversityVillejuif 94800France

Ba.kground:Despite a.va.ces in the dia.nosis of pa.ients with hepa.ocellula. ca.cinoma.HCC),70%-80%of pa.ients a.e dia.nosed with a.va.ced sta.e *** vein tumor thrombus(PVTT)is a.ong the most ominous signs of a.va.ced sta.e disea.e a.d ha. been a.socia.ed with poor surviva. if *** sources:a.systema.ic sea.ch of mEDLINE(Pubmed),Emba.e,Cochra.e Libra.y a.d Da.a.a.e for Systema.ic Reviews(CDSR),Google Schola.,a.d Na.iona. Institute for Hea.th a.d Clinica. Excellence(NICE)da.a.a.es until December 2022 wa. conducted using free text a.d meSH terms:hepa.ocellula. ca.cinoma.porta. vein tumor thrombus,porta. vein thrombosis,va.cula. inva.ion,liver a.d/or hepa.ic resection,liver tra.spla.ta.ion,a.d systema.ic ***:Centers of surgica. excellence ha.e reported promising results rela.ed to the individua.ized surgica. ma.a.ement of porta. thrombus versus a.teria. chemoemboliza.ion or systemic *** elements to the individua.ized surgica. ma.a.ement of HCC a.d porta. thrombus include precise cla.sifica.ion of the porta. vein tumor thrombus,a.cura.e identifica.ion of the subgroups of pa.ients who ma. benefit from resection,a. well a. meticulous surgica. *** review a.dressed five specific a.ea.:(a.forma.ion of PVTT;(b)cla.sifica.ions of PVTT;(c)controversies rela.ed to clinica. guidelines;(d)surgica. trea.ments versus non-surgica. a.proa.hes;a.d(e)cha.a.teriza.ion of surgica. techniques correla.ed with cla.sifica.ions of ***:Current evidence from Chinese a.d Ja.a.ese high-volume centers demonstra.ed tha. pa.ients with HCC a.d a.socia.ed PVTT ca. be ma.a.ed with surgica. resection with a.cepta.le results.

关键词： Hepa.ectomy Liver surgery Liver neopla.ms Porta. vein tumor thrombus

Towa.ds implementa.ion of a.loy-specific thermo-fluid modelling for la.er powder-bed fusion of mg a.loys

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Journa. of ma.nesium a.d a.loys 2024年第6期12卷 2327-2344页

作者： moha.ma. Hoseini-a.ha. mika.l Ersson Peter Hedström Depa.tment of ma.eria. Science a.d Engineering KTH Royal Institute of TechnologyStockholmSE-10044 Sweden

multi-physics thermo-fluid modeling ha. been extensively used a. a. a.proa.h to understa.d melt pool dyna.ics a.d defect forma.ion a. well a. optimizing the process-rela.ed pa.a.eters of la.er powder-bed fusion(L-PBF).However,its ca.a.ilities for being implemented a. a.relia.le tool for ma.eria. design,where minor cha.ges in ma.eria.-rela.ed pa.a.eters must be a.cura.ely ca.tured,is still in *** the present resea.ch,first,a.thermo-fluid computa.iona. fluid dyna.ics(CFD)model is developed a.d va.ida.ed a.a.nst experimenta. *** the predicted ma.eria. properties of the pure mg a.d commercia. ZK60 a.d WE43 mg a.loys,pa.a.etric studies a.e done a.tempting to elucida.e how the difference in some of the ma.eria. properties,i.e.,sa.ura.ed va.or pressure,viscosity,a.d solidifica.ion ra.ge,ca. influence the melt pool *** is found tha. a.higher sa.ura.ed va.or pressure,a.socia.ed with the ZK60 a.loy,lea.s to a.deeper unsta.le keyhole,increa.ing the keyhole-induced porosity a.d eva.ora.ion ma.s *** viscosity a.d wider solidifica.ion ra.ge ca. increa.e the non-uniformity of tempera.ure a.d velocity distribution on the keyhole wa.ls,resulting in increa.ed keyhole insta.ility a.d forma.ion of ***,the WE43 a.loy showed the best beha.ior in terms of defect forma.ion a.d eva.ora.ion ma.s loss,providing theoretica. support to the extensive use of this a.loy in *** summa.y,this study suggests a. a.proa.h to investiga.e the effect of ma.eria.s-rela.ed pa.a.eters on L-PBF melting a.d solidifica.ion,which ca. be extremely helpful for future design of new a.loys suita.le for L-PBF.

关键词： mg a.loys La.er powder-bed fusion(L-PBF) melt pool dyna.ics Computa.iona. fluid dyna.ics Fluid flow

Ca.bon monoxide a. C1 Building Block in Fine Chemica. Synthesis

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Chinese Journa. of Chemistry 2024年第2期42卷 199-221页

作者： Rui m.B.Ca.rilho ma.io J.F.Ca.vete Ga.or mikle La.zlo Kolla. ma.iette m.Pereira University of Coimbra Coimbra Chemistry CentreDepartment of ChemistryRua Larga3004-535 CoimbraPortugal Depa.tment of Genera. a.d Inorga.ic Chemistry a.d ELKH-PTE Resea.ch Groupfor Selective Chemica. Syntheses University of PecsIfjusag utja 6H-7624 PecsHungary

Ca.bon monoxide(CO)ha. become one of the most releva.t a.d versa.ile renewa.le C1 building blocks for chemica. synthesis,especia.ly in the fine chemica.s industry,due to the development of efficient a.d selective ca.a.ysts for its *** this review,we present a.comprehensive critica. a.a.ysis of the la.t 10 yea.s litera.ure on the use of CO a. a.renewa.le feedstock for fine chemica.s *** review is orga.ized by type of ca.a.ytic rea.tion,na.ely a.kene a.d a.kyne ca.bonyla.ion,hydroformyla.ion,ca.bonyla.ion of a.yl ha.ides,ca.bonyla.ive cross-coupling a.d C-H *** exa.ples of the synthesis of releva.t building blocks a.d/or known pha.ma.eutica.s a.e *** is pla.ed on exa.ples of utilizing CO a. the C1 building block in one or more ca.a.ytic *** ca.a.yst used a.d the rea.tion conditions a.e consistently presented throughout a.l of the exa.ples.

关键词： Ca.bon monoxide Fine chemica.s Ca.bonyla.ion Hydroformyla.ion C-H functiona.iza.ion