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Nitric oxide and geriatrics:Implications in diagnostics and treatment of the elderly

Journal of Geriatric cardiology 2011年第4期8卷 230-242页

作者： ashley c torregrossa Mayank Aranke Nathan S Bryan Texas Therapeutics Institute Brown Foundation Institute of Molecular MedicineUniversity of Texas Health Science Center at Houston1825 Pressler St.530CHoustonTX 77030USA The University of Texas at Austin University StationAustinTX 78712USA The University of Texas Graduate School of Biomedical Sciences 6767 Bertner Av.HoustonTX 77030USA

The nation’s aging population is growing *** 2030,the number of adults age 65 and older will nearly double to 70 *** are living longer and older adults can now live for many years with multiple chronic illnesses but with a substantial cost to health *** percent of the Medicare population has at least five chronic conditions i.e.,hypertension,diabetes,arthritis,*** in experimental models and even humans reveal that constitutive production of nitric oxide(NO)is reduced with aging and this circumstance may be relevant to a number of diseases that plague the aging *** is a multifunctional signaling molecule,intricately involved with maintaining a host of physiological processes including,but not limited to,host defense,neuronal communication and the regulation of vascular *** is one of the most important signaling molecules in our body,and loss of NO function is one of the earliest indicators or markers of *** studies provide evidence that insufficient NO production is associated with all major cardiovascular risk factors,such as hyperlipidemia,diabetes,hypertension,smoking and severity of atherosclerosis,and also has a profound predictive value for disease progression including cardiovascular and Alzheimers *** plus years after its discovery and over 13 years since a Nobel Prize was awarded for its discovery,there have been no hallmark therapeutic breakthroughs or even NO based *** will review the current state of the science surrounding NO in the etiology of a number of different diseases in the geriatric *** these observations,it can be concluded that enzymatic production of NO declines steadily with increasing age in healthy human *** strategies to diagnose and treat NO insufficiency may provide enormous benefit to the geriatric patient.

关键词： nitrite nitrate cardiovascular disease Alzheimer’s disease bloodflow circulation

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collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity

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Bioactive Materials 2021年第12期6卷 4342-4359页

作者： Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan c.Simon Vera Hintze Sandra Franz Department of Dermatology Venerology und AllergologyLeipzig University04103LeipzigGermany Institute of Materials Science Max Bergmann Center for BiomaterialsTechnische Universitǎt Dresden01069DresdenGermany Biomaterials Department INNOVENT e.V.JenaGermany

Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic *** of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic *** we describe immunomodulatory hyaluronan/collagen(HA-Ac/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound *** sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in *** further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo *** a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the *** is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation *** in vivo translation,we designed HA-Ac/coll hydrogels allowing delivery of sHA into wounds over a period of at least one *** immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound *** sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure.

关键词： 4-6):sulfated hyaluronan Macrophages Immunomodulation chronic wounds Hydrogel Skin inflammation

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