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Impact of lockdown relaxation and implementation of the facecovering policy on mental health: A United Kingdom COVID-19 study

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World Journal of Psychiatry 2021年第12期11卷 1346-1365页

作者： Shanaya Rathod Saseendran Pallikadavath Elizabeth Graves Mohammad Mahbubur Rahman ashlea brooks Mustafa G Soomro Pranay Rathod Peter Phiri Department of Research and Development Southern Health NHS Foundation TrustSouthampton SO303JBHampshireUnited Kingdom Portsmouth-Brawijaya Centre for Global Health Population and PolicyUniversity of PortsmouthPortsmouth PO12DTUnited Kingdom School of Health and Care Professions University of PortsmouthPortsmouth PO12DTHampshireUnited Kingdom Mental Health Solent NHS TrustPortsmouth P036ADUnited Kingdom PPI PPI RepresentativeLondon SO303JBUnited Kingdom Primary Care Population Sciences and Medical EducationFaculty of MedicineUniversity of SouthamptonSouthampton SO165STUnited Kingdom

BACKGROUND Pandemic mitigation policies,such as lockdown,are known to impact on mental health of *** face covering under relaxed lockdown restrictions gives assurance of less transmission of airborne infection and has the potential to improve mental health of individuals affected by *** To examine the association of the lockdown relaxation and the implementation of the face covering policy on the mental health of the general population and subgroups in the United Kingdom using interrupted time series *** Using a web-based cross-sectional survey of 28890 United Kingdom adults carried out during May 1,2020 to July 31,2020,changes in mental health status using generalised anxiety disorder(GAD-7),and impact of events scale-revised(IES-R)scales are examined,at the dates of the first lockdown relaxation(July 4,2020)and the subsequent introduction of face covering(July 24,2020)in United Kingdom.A sharp regression discontinuity design is used to check discontinuities in mental health outcomes at policy-change *** Average GAD-7 scores of participants were 5.6,5.6 and 4.3 during the lockdown period,the lockdown relaxation phase and the phase of compulsory face covering,respectively,with lower scores indicating lower anxiety *** scores for IES-R were 17.3,16.8 and 13.4,with lower scores indicating less *** lockdown measures and subsequent introduction of face covering,on average,reduced GAD-7 by 0.513(95%CI:0.913-0.112)and 1.148(95%CI:1.800-0.496),*** reductions in IES-R were 2.620(95%CI:4.279-0.961)and 3.449(95%CI:5.725-1.172).These imply that both lockdown relaxation and compulsory face-covering have a positive association with mental health scores(GAD-7 and IES-R).CONCLUSION The differential impact of lockdown and relaxation on the mental health of population sub-groups is evident in this study with future implications for *** of face covering in public pl

关键词： COVID-19 Psychological impact Lockdown Face-covering Mental health Anxiety

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Effects of cumulative COVID-19 cases on mental health:Evidence from multi-country survey

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World Journal of Psychiatry 2023年第7期13卷 461-477页

作者： Shanaya Rathod Saseendran Pallikadavath Elizabeth Graves Mohammad M Rahman ashlea brooks Pranay Rathod Rachna Bhargava Muhammad Irfan Reham Aly Haifa Mohammad Saleh Al Gahtani Zahwa Salam Steven Wai Ho Chau Theone S E Paterson Brianna Turner Viktoria Gorbunova Vitaly Klymchuk Peter Phiri Department of Research and Innovation Southern Health NHS Foundation TrustSouthampton SO303JBUnited Kingdom Portsmouth-Brawijaya Centre for Global Health University of PortsmouthPortsmouth PO12UPUnited Kingdom Salford Business School University of SalfordSalford M54WTUnited Kingdom Patient and Public Involvement Southern Health NHS Foundation TrustSouthampton SO303JBUnited Kingdom Department of Psychiatry All India Institute of Medical SciencesNew Delhi 110029India Department of Mental Health Psychiatry and Behavioral SciencesPeshawar Medical CollegeRiphah International UniversityIslamabad 46000Pakistan Department of Clinical Services Ministry of HealthCairo 4262114Egypt College of Medicine and Medical Sciences Arabian Gulf UniversityBahrain 329Bahrain Peshawar Dental College Ripah International UniversityIslamabad 46000Pakistan Department of Psychiatry The Chinese University of Hong KongHong KongChina Department of Psychology University of VictoriaVictoria BC V8P 5C2Canada Department of Social Psychology Zhytomyr State UniversityZhytomyr 10002Ukraine National Psychological Association Mental Health for Ukraine ProjectEuropean Federation of Psychologists'AssociationGFAKyiv 04071Ukraine School of Psychology Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUnited Kingdom

BACKGROUND Depression and anxiety were both ranked among the top 25 leading causes of global burden of diseases in 2019 prior to the coronavirus disease 2019(COVID-19)*** pandemic affected,and in many cases threatened,the health and lives of millions of people across the globe and within the first year,global prevalence of anxiety and depression increased by 25%with the greatest influx in places highly affected by *** To explore the psychological impact of the pandemic and resultant restrictions in different countries using an opportunistic sample and online questionnaire in different phases of the *** A repeated,cross-sectional online international survey of adults,16 years and above,was carried out in 10 countries(United Kingdom,India,Canada,Bangladesh,Ukraine,Hong Kong,Pakistan,Egypt,Bahrain,Saudi Arabia).The online questionnaire was based on published approaches to understand the psychological impact of COVID-19 and the resultant *** standardised measures were included to explore levels of depression[patient health questionnaire(PHQ-9)],anxiety[generalized anxiety disorder(GAD)assessment],impact of trauma[the impact of events scale-revised(IES-R)],loneliness(a brief loneliness scale),and social support(The Multidimensional Scale of Perceived Social support).RESULTS There were two rounds of the online survey in 10 countries with 42866 participants in Round 1 and 92260 in Round *** largest number of participants recruited from the United Kingdom(112985 overall).The majority of participants reported receiving no support from mental health services throughout the *** study found that the daily cumulative COVID-19 cases had a statistically significant effect on PHQ-9,GAD-7,and IES-R *** scores significantly increased in the second round of surveys with the ordinary least squares regression results with regression discontinuity design specification(to control lockdown effects)confirming these ***

关键词： COVID-19 Mental health Global research International Pandemic Impact

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Storylines of family medicine Ⅳ:perspectives on practice—lenses of appreciation

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Family Medicine and Community Health 2024年第S3期12卷 33-42页

作者： William B Ventres Leslie A Stone Radeeb Akhtar Jeffrey M Ring Lucy M Candib Erick Messias Ronald M Epstein Marc Tunzi Amy L Lee Christopher P Morley Carina M Brown David Slawson Jill Konkin David G Campbell Ian Couper Susan Williams Robert brooks Lucie Walters Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Medicine and Community Health Icahn School of Medicine at Mount SinaiNew YorkNew YorkUSA Independent Health Psychologist Los AngelesCaliforniaUSA Family Medicine and Community Health UMass Chan Medical SchoolWorcesterMassachusettsUSA Psychiatry and Behavioral Neurosciences Saint Louis University School of MedicineSaint LouisMissouriUSA Family Medicine University of Rochester Medical CenterRochesterNew YorkUSA Family Medicine Residency Program Natividad Medical CenterSalinasCaliforniaUSA Family Medicine Tufts University School of MedicineBostonMassachusettsUSA Public Health and Preventive Medicine SUNY Upstate Medical UniversitySyracuseNew YorkUSA Cone Health Family Medicine Residency The University of North Carolina School of MedicineGreensboroNorth CarolinaUSA Family Medicine Atrium HealthCharlotteNorth CarolinaUSA Family Medicine University of Alberta Faculty of Medicine&DentistryEdmontonAlbertaCanada Cunninghame Arm Medical Centre Australian College of Rural and Remote MedicineLakes EntranceQueenslandAustralia Ukwanda Centre for Rural Health Stellenbosch University Faculty of Medicine and Health SciencesCape TownWestern CapeSouth Africa Adelaide Rural Clinical School The University of AdelaideAdelaideSouth AustraliaAustralia Department of Rural Health Broken Hill UniversityBroken HillNew South WalesAustralia Adelaide Rural Clinical School The University of Adelaide Faculty of Health and Medical SciencesMount GambierSouth AustraliaAustralia

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅳ:perspectives on practice—lenses of appreciation’,authors address the following themes:‘Relational connections in the doctor–patient partnership’,‘Feminism and family medicine’,‘Positive family medicine’,‘Mindful practice’,‘The new,old ethics of family medicine’,‘Public health,prevention and populations’,‘Information mastery in family medicine’and‘Clinical courage.’May readers nurture their curiosity through these essays.

关键词： thematic illustration doctor

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Prioritizing Strategies for Building the Resilience of Public Health Systems to Disasters Across Multiple Communities and Countries

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International Journal of Disaster Risk Science 2024年第1期15卷 1-17页

作者： Benjamin J.Ryan Mayumi Kako Shelby Garner Rok Fink Ismail Tayfur Jonathan Abrahams Sanjaya Bhatia Adriana Campelo Matthew Fendt Alicia Fontenot Nahuel Arenas Garcia Tim Hatch Ryoma Kayano LaShonda Malrey‑Horne Makiko MacDermot Md Moshiur Rahman Chaverle Noel Shuhei Nomura Jeremy P.Novak Maria Opazo Kendell Oliver Luciana Peters Sohel Rahman PerihanŞimşek Andrew Stricklin Raymond Swienton Bryan W.brooks Frist College of Medicine Belmont UniversityNashvilleTN 37212USA Department of Environmental Science Environmental Health Science ProgramCollege of Arts and SciencesBaylor UniversityWacoTX 76798USA Division of Nursing Science School of Biomedical and Health SciencesHiroshima UniversityHiroshima 734-8553Japan Gordon E.Inman College of Health Sciences and Nursing Belmont UniversityNashvilleTN 37212USA Faculty of Health Sciences University of Ljubljana1000 LjubljanaSlovenia Department of Emergency Medicine University of Health Sciences34668 IstanbulTurkey Monash University Accident Research Center MelbourneVIC 3800Australia Global Education and Training Institute United Nations Ofce for Disaster Risk ReductionIncheon 22004Republic of Korea Regional Ofce for the Americas and Caribbean United Nations Ofce for Disaster Risk ReductionPanama City 0843-03441Panama Engineering and Computer Science Baylor UniversityWacoTX 76798USA Department of Public Health Robbins College of Health and Human SciencesBaylor UniversityWacoTX 76798USA Alabama Department of Public Health MontgomeryAL 36092USA World Health Organization Centre for Health Development(WHO Kobe Centre) Kobe 651-0073Japan Waco-McLennan County Public Health District WacoTX 76707USA Department of Health Policy and Management School of MedicineKeio UniversityTokyo 160-8582Japan Department of Global Health Policy Graduate School of MedicineThe University of TokyoTokyo 113-0033Japan Tokyo Foundation for Policy Research Tokyo 106-6234Japan Global Development College BrisbaneQLD 4000Australia Municipality of Pudahuel 13124 PudahuelChile City Hall of Porto Alegre Porto Alegre 90010-170Brazil Ministry of Health and Family Welfare Government of the People’s Republic of BangladeshDhaka 1000Bangladesh Department of Emergency Aid and Disaster Management Trabzon University61335 TrabzonTurkey Department of Emergency Medicine UT SouthwesternDallasTX 75390USA

The COVID-19 pandemic highlighted the urgent need to strengthen public health *** response,the United Nations Disaster Risk Reduction(UNDRR) Public Health System Resilience Scorecard(Scorecard) was applied in workshops across multiple *** aim of our research was to explore the workshop findings to develop priority strategies for strengthening public health system *** conducted a workshop from 14 to 16 March 2023,at the UNDRR Global Education and Training Institute in Incheon,Republic of Korea.A sequential modified Delphi method was utilized to develop a set of prioritized resilience *** were drawn from 70 strategies identified from 13 distinct workshops in eight *** two surveys,23 strategies were *** received ratings of "High" or Very High" from89% of *** related to the inclusion of public health risks in emergency plans,integrating multidisciplinary teams into public health,enabling local transport mechanisms,and improving the ability to manage an influx of *** Scorecard provides an adaptable framework to identify and prioritize strategies for strengthening public health system *** leveraging this methodology,our study demonstrated how resilience strategies could inform disaster risk reduction funding,policies,and actions.

关键词： Health system resilience Public policy Resilience scorecard Workshops

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The tortuous path of lactate shuttle discovery:From cinders and boards to the lab and ICU

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Journal of Sport and Health Science 2020年第5期9卷 446-460页

作者： George A.brooks Exercise Physiology Laboratory Department of Integrative BiologyUniversity of California BerkeleyCA 94720-3140USA

Once thought to be a waste product of oxygen limited(anaerobic)metabolism,lactate is now known to form continuously under fully oxygenated(aerobic)*** shuttling between producer(driver)and consumer cells fulfills at least 3 purposes;lactate is:(1)a major energy source,(2)the major gluconeogenic precursor,and(3)a signaling *** Lactate Shuttle theory is applicable to diverse fields such as sports nutrition and hydration,resuscitation from acidosis and Dengue,treatment of traumatic brain injury,maintenance of glycemia,reduction of inflammation,cardiac support in heart failure and following a myocardial infarction,and to improve ***,dysregulated lactate shuttling disrupts metabolic flexibility,and worse,supports *** production in cancer(the Warburg effect)is involved in all main sequela for carcinogenesis:angiogenesis,immune escape,cell migration,metastasis,and self-sufficient *** history of the tortuous path of discovery in lactate metabolism and shuttling was discussed in the 2019 American College of Sports Medicine Joseph *** Lecture in Orlando,FL.

关键词： Anaerobic metabolism Exercise Glycolysis Oxidative metabolism Warburg Effect

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Applied biodiversity science in China in the global context

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National Science Review 2021年第7期8卷 62-65页

作者： Thomas M.brooks Xinsheng Zhang International Union for Conservation of Nature

In 2021, the city of Kunming in Yunnan Province, China,will host the fifteenth meeting of Conference of Parties of the Convention on Biological Diversity. The meeting is expected to be the pivotal moment at which the world’s governments agree on a new ‘Post-2020 Global Biodiversity Framework’(https://***/conferences/post2020). The framework is anticipated to be structured around a small number of outcome goals for 2050—a compelling case has been made that these should include explicit goals for ecosystems, species,genetic diversity and the contributions which nature makes to people [1].

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Does digit ratio （2D：4D） predict penile length？

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Asian Journal of Andrology 2011年第5期13卷 667-668页

作者： Denise brooks McQuade Department of Biology Skidmore College SaratogaSprings NY 12866 USA

Now advertized in at least one locale as the ＇sexy ratio＇ with the caption, ＇Your hands give away your hotness＇（http：//***/ #!5794008; accessed 3 May 2011）, an online summary of a recent study linking facial attractiveness to the ratio of the index and ring fingers1 indicates that digit ratio （2D：4D） research has reached mainstream culture. Digit ratio, most commonly the ratio of the index to ring fingers in humans, is sexually dimorphic （males have lower values than females） with greater differences on their right hand.

关键词： associations well established

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A study of process-induced grain structures during steady state and non-steady state electron-beam welding of a titanium alloy

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Journal of Materials Science & Technology 2022年第18期113卷 117-127页

作者： Yu Lu Richard Turner Jeffery brooks Hector Basoalto School of Metallurgy and Materials University of BirminghamBirminghamB152TTUnited Kingdom Department of Materials Science and Engineering The University of SheffieldMappin StreetSheffieldS13JDUnited Kingdom

A detailed microstructural characterisation of the emerging weld-line grain structure,for bead-upon-plate welds in Ti-6Al-4V(Ti64)of differing plate thickness,was *** microstructure studied was formed during both steady state and non-steady state sections within the weld path,with the non-steady state portion being taken from the end of the plate as the weld bead and heat source overhang the edge of the *** allows for the effects of welding process conditions on the microstructural evolution to be *** weld pool geometry and 3D tomography of the weld-induced defects have been *** characterisation of microstructure and texture for different welding parameters and for steady and non-steady states have been used to identify physical parameters for the microstructure predictions that are difficult to obtain *** different states significantly affect the weld crown shape and formation,weld toe,weld bead depth and ***,the heat affected zone(HAZ)re-mains *** the microstructural evolution,both the steady and non-steady states have similar microstructure and *** defects were observed in the steady state section of welds,but sub-surface spherical pores have been observed in the non-steady state section of a *** element modelling to simulate the thermal-metallurgical-mechanical fields within the steady and non-steady state sections of the welds was considered,and the cooling rates predicted within steady state and non-steady sections were interrogated to improve the theoretical understanding of the microstructure and defect formation differences in these Ti64 EB weld regions.

关键词： Electron-beam fusion welding Processing Microstructure Ti-6Al-4V

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Stability and orientation of cecropin P1 on maleimide self-assembled monolayer(SAM) surfaces and suggested functional mutations

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Chinese Chemical Letters 2015年第4期26卷 485-490页

作者： Shuai Wei Charles L.brooks Ⅲ Department of Chemistry University of Michigan Department of Biophysics University of Michigan

One of the main challenges of biosensor design is to understand the protein or peptide stability on the chip in high resolution structural detail. Since conventional experimental methods are limited by the resolution for their applications on surface tethered peptides/proteins, a recently developed coarse grained simulation method is employed to explore the peptide/surface interaction in residue-level resolution. This work shows how the coarse grained model successfully describes peptide-surface interactions by evaluating thermal stability of the peptide cecropin PI in bulk solution and on surfaces by physical adsorption and chemical tethering. The simulation also reproduces observations of peptide orientations on the self-assembled monolayer surface from earlier experimental work. Additionally, using knowledge obtained from the simulations, specific mutations are suggested and the desired structure and pose on the surface is obtained. In summary, this work sheds a light on the reasonable biosensor design that is ~uided by simulations.

关键词： Coarse grained simulationKB Go-like modelPeptide-surface interactionThermal stabilityOrientationMutation

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