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Ebola virus disease: Recent advances in diagnostics and therapeutics

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Asian Pacific Journal of Tropical Medicine 2019年第9期12卷 385-395页

作者： Supriya Jagga ashish ranjan sharma Chiranjib Chakraborty Sang-Soo Lee Institute for Skeletal Aging&Orthopedic Surgery Chuncheon Sacred Heart HospitalHallym UniversityChuncheon 24252 Republie of Korea Department of Biotechnology School of Life Science and BiotechnologyAdamas UniversityBarasat Barackpore RdKlltaWest Bengal 700126 lndia

Ebola virus disease(EVD)is associated with haemorrhagic fever in humans and nonhuman primates,with a high rate of fatality(up to 90%).Some outbreaks in human history have proven the lethality of *** recent epidemic of 2014 and 2015 in West Africa was the deadliest of all time(11 284 deaths).To understand the transmission dynamics,we have reviewed the epidemiology of EVD to *** absence of any licensed vaccines or approved drugs against Ebola virus(EBOV)further highlights the severity and crisis level of *** organizations(public and private)are making considerable efforts to develop novel therapeutic approaches or vaccines to contain the outbreak of EBOV ***,we summarized the various potential drugs and vaccines(undergoing multiple phases of clinical trials)that have arisen as an alternative against EBOV,and we highlighted the numerous issues and limitations hindering this ***,an increasing focus on strengthening the medical and civic health structure could provide speedy benefits in containing the spread of EVD,as well as offer a resilient foundation for the deployment of novel drugs and vaccines to the affected countries,once such drugs and vaccines become available.

关键词： Ebola virus Vaccines Therapeutics Ebola outbreaks Diagnostics Epidemiology Haemorrhagic fever

PPARγLBD and its ligand specificity reveal a selection of potential partial agonist:Molecular dynamics based T2D drug discovery initiative

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BIOCELL 2021年第4期45卷 953-961页

作者： BIDYUT MALLICK ashish ranjan sharma MANOJIT BHATTACHARYA SANG-SOO LEE CHIRANJIB CHAKRABORTY Department of Applied Science Galgotias College of Engineering and TechnologyKnowledge Park-IIGreater Noida201306India Institute for Skeletal Aging&Orthopedic Surgery Hallym University-Chuncheon Sacred Heart HospitalChuncheon-si24252Korea Department of Zoology Fakir Mohan UniversityVyasa ViharBalasore756020India Department of Biotechnology School of Life Science and BiotechnologyAdamas UniversityKolkata700126India

PPARγis a peroxisome proliferator-activated receptor(PPAR)family protein and is a target for type 2 diabetes(T2D).In this paper,we have performed a molecular docking analysis between ligand molecules(CID9816265,CID11608015,CID20251380,CID20251343,CID20556263,CID624491,CID42609928,and CID86287562)and PPARγto determine the ligand *** also helps to understand the ligand-binding domain(LBD)activity of PPARγduring the binding of the ***,a molecular dynamics simulation study was performed to determine the ligand biding stability in the PPARγ*** ligand specificity informed us about the potentiality of selecting a partial *** study also shows the binding conformation of Ceramicine B having hydrogen bonding affinity with a tricyclic polar head and stabilized theβ-sheet *** the other hand,the tricyclic polar head of nimbolide also formed hydrogen bonding(Ser342),but it shows a lesser degree of stabilization in theβ-sheet *** shows the binding conformation of partial agonist(PPARγ)in the Pocket-II of PPARγLBD,which has a significant role in stabilizing theβ-sheet *** might help to regulate ERK/Cdk5 mediated phosphorylation of *** study helps us understand the valid pose of a set of ligands confirmation and target protein conformation using docking and molecular dynamics *** in silico study will also help to initiate a drug discovery process of T2D.

关键词： PPARγ Partial agonist Molecular simulation T2D Drug discovery

Altered gut microbiota patterns in COVID-19:Markers for inflammation and disease severity

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World Journal of Gastroenterology 2022年第25期28卷 2802-2822页

作者： Chiranjib Chakraborty ashish ranjan sharma Manojit Bhattacharya Kuldeep Dhama Sang-Soo Lee School of Life Science and Biotechnology Adamas UniversityKolkata 700126India Institute for Skeletal Aging&Orthopaedic Surgery Hallym UniversityChuncheon-si 24252South Korea Department of Zoology Fakir Mohan UniversityBalasore 756020India Division of Pathology Indian Council of Agricultural Research(ICAR)-Indian Veterinary Research Institute(IVRI)Bareilly 243122Uttar PradeshIndia Institute for Skeletal Aging&Orthopedic Surgery Hallym UniversityChuncheon-si 24252South Korea

The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection leads to a severe respiratory illness and alters the gut microbiota,which dynamically interacts with the human immune *** alterations include decreased levels of beneficial bacteria and augmentation of opportunistic ***,we describe critical factors affecting the microbiota in coronavirus disease 2019(COVID-19)*** include,such as gut microbiota imbalance and gastrointestinal symptoms,the pattern of altered gut microbiota composition in COVID-19 patients,and crosstalk between the microbiome and the gut-lung axis/gut-brain-lung ***,we have illustrated the hypoxia state in COVID-19 associated gut microbiota *** role of ACE2 in the digestive system,and control of its expression using the gut microbiota is discussed,highlighting the interactions between the lungs,the gut,and the brain during COVID-19 ***,we address the gut microbiota in elderly or co-morbid patients as well as gut microbiota dysbiosis of in severe *** clinical trials to understand the role of probiotics in COVID-19 patients are listed in this *** inflammation is one of the major driving forces for COVID-19 symptoms and gut microbiome disruption and is associated with disease ***,understanding the role of the gut microbiota in immune modulation during SARS-CoV-2 infection may help improve therapeutic strategies for COVID-19 treatment.

关键词： COVID-19 Inflammation Gut microbiota Therapeutic

Anti-inflammatory effects of traditional mixed extract of medicinal herbs(MEMH)on monosodium urate crystal-induced gouty arthritis

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Chinese Journal of Natural Medicines 2017年第8期15卷 561-575页

作者： Ju-Suk Nam Supriya Jagga ashish ranjan sharma Joon-Hee Lee Jong Bong Park Jun-Sub Jung Sang-Soo Lee Institute For Skeletal Aging&Orthopedic Surgery Hallym University-Chuncheon Sacred Heart HospitalChuncheonGangwon-do24252Republic of Korea Institute of Natural Medicine College of MedicineHallym UniversityChucheonGangwon-do 24252Republic of Korea Hana Oriental Clinic ChucnheonGangwon-do 24433Republic of Korea

Korean oriental medicine prescription is widely used for the treatment of gouty diseases. In the present study, we investigated anti-inflammatory effects of modified Korean herbal formulation, mixed extract of medicinal herbs(MEMH), and its modulatory effects on inflammatory mediators associated with gouty arthritis. Both in vitro and in vivo studies were carried out to assess the anti-inflammatory efficacy of MEMH on monosodium urate(MSU) crystals-induced gouty inflammation. MSU crystals stimulated human chondrosarcoma cell line, SW1353, and human primary chondrocytes were treated with MEMH in vitro. The expression levels of pro-inflammatory mediators and metalloproteases were analyzed. The effect of MEMH on NFκB signaling pathway in SW1353 cells was examined. Effect of MEMH on the mR NA expression level of pro-inflammatory mediators and chemotactic factor from human monocytic cell line, THP-1, was also analyzed. The probable role of MEMH in the differentiation process of osteoblast like cells, SaO S-2, after MSU treatment was also observed. To investigate the effects of MEMH in vivo, MSU crystals-induced ankle arthritic model was established. Histopathological changes in affected joints and plasma levels of pro-inflammatory mediators(IL-1β and TNFα) were recorded. MEMH inhibited NFκB signaling pathway and COX-2 protein expression in chondrocytes. MSU-induced mR NA expressions of pro-inflammatory mediators and chemotactic cytokines were suppressed by MEMH. In MSU crystals-induced ankle arthritic mouse model, administration of MEMH relieved inflammatory symptoms and decreased the plasma levels of IL-1β and TNFα. The results indicated that MEMH can effectively inhibit the expression of inflammatory mediators in gouty arthritis, demonstrating its potential for treating gouty arthritis.

关键词： Gout Monosodium urate crystals Inflammation Chondrocyte Oriental medicine

The bacteriophage mu lysis system–A new mechanism of host lysis?

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BIOCELL 2021年第5期45卷 1175-1186页

作者： SAIKAT SAMANTA ashish ranjan sharma ABINIT SAHA MANOJ KUMAR SINGH ARPITA DAS MANOJIT BHATTACHARYA RUDRA PRASAD SAHA SANG-SOO LEE CHIRANJIB CHAKRABORTY Department of Biotechnology School of Life Science&BiotechnologyAdamas UniversityKolkata700126India Institute for Skeletal Aging&Orthopedic Surgery Hallym University-Chuncheon Sacred Heart HospitalChuncheon-si24252Korea Department of Zoology Fakir Mohan UniversityBalasore56020India

Bacteriophages are viruses that infect bacteria and can choose any one of the two alternative pathways for infection,i.e.,lysis or *** lysis is one of the conventional biological processes required to spread infection from one bacterium to *** analysis suggests that in the paradigm bacteriophage Mu,six proteins might be involved in host cell *** has a broad host range,and Mu-like phages were found in both Gram-negative and Gram-positive *** analysis of the genomes of Mu and Mu-like phages could be useful in elucidating the lysis mechanism in this group of phages.A detailed review of the various mechanisms of phage lysis and different proteins associated with the process will help researchers understand the phage biology and their life cycle in different *** recent increase in the number of multidrug-resistant(MDR)strains of bacteria and the usual long-term nature of new drug development has encouraged scientists to look for alternative strategies like phage therapy and the discovery of new lysis *** the lysis mechanism in the Mu-like phages could be exploited to develop alternative therapeutics to kill drug-resistant pathogenic *** this review article,we have analyzed the phage Mu-mediated host lysis system,which is unknown till now,and our analysis indicates a possibility of the existence of a new lysis mechanism operating in Mu.

关键词： Bacteriophage Mu Host cell lysis Endolysin Holin Spanin

Thermogram Adaptive Efficient Model for Breast Cancer Detection Using Fractional Derivative Mask and Hybrid Feature Set in the IoT Environment

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Computer Modeling in Engineering & Sciences 2022年第2期130卷 923-947页

作者： Ritam sharma JankiBallabh sharma ranjan Maheshwari Praveen Agarwal Rajasthan Technical University KotaRajasthan324010India Anand International College of Engineering Jaipur303012India Nonlinear Dynamics Research Center(NDRC) Ajman UniversityAjman20550United Arab Emirates International Center for Basic and Applied Sciences Jaipur302029India Institute of MathematicalModeling Almaty050000Kazakhstan

In this paper,a novel hybrid texture feature set and fractional derivative filter-based breast cancer detection model is *** paper also introduces the application of a histogram of linear bipolar pattern features(HLBP)for breast thermogram ***,breast tissues are separated by masking operation and filtered by Gr¨umwald–Letnikov fractional derivative-based Sobel mask to enhance the texture and rectify the noise.A novel hybrid feature set usingHLBP and other statistical feature sets is derived and reduced by principal component *** basis function kernel-based support vector machine is employed for detecting the abnormality in the *** performance parameters are calculated using five-fold cross-validation scheme using MATLAB 2015a simulation *** proposedmodel achieves the classification accuracy,sensitivity,specificity,and area under the curve of 94.44%,95.55%,92.22%,96.11%,respectively.A comparative investigation of different texture features with respect to fractional orderαto classify the breast malignancy is also *** proposed model is also compared with a few existing state-of-art schemes which verifies the efficacy of the *** orderαoffers extra adaptability in overcoming the limitations of thermal imaging techniques and assists radiologists in prior breast cancer *** proposed model is more generalized which can be used with different thermal image acquisition protocols and IoT based applications.

关键词： Thermal image breast cancer fractional derivative mask image texture analysis feature extraction radial basis function machine learning

Data mining-based algorithm for assortment planning

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Journal of Management Analytics 2020年第3期7卷 443-457页

作者： Praveen ranjan Srivastava Satyendra sharma Simran Kaur Information Technology Indian Institute of Management(IIM)RohatakRohtakIndia Operation and Supply Chain Birla Institute of Technology and Science(BITS)PilaniPilaniRajasthanIndia Computer Science Birla Institute of Technology and Science(BITS)PilaniPilaniRajasthanIndia

With increasing varieties and products,management of limited shelf space becomes quite difficult for ***,an efficient product assortment,which in turn helps to plan the organization of various products across limited shelf space,is extremely important for *** can be distinguished based on quality,price,brand,and other attributes,and decision needs to be made about an assortment of the products based on these *** efficient assortment planning improves the financial performance of the retailer by increasing profits and reducing operational *** techniques can be very effective in grouping products,stores,*** help managers solve the problem of assortment *** paper proposes data mining approaches for assortment planning for profit maximization with space,and cost constraints by mapping it into well-known knapsack problem.

关键词： Retail assortment SKU rationalization data mining

Gold nanoparticles： sonocatalytic synthesis using ethanolic extract of Andrographis paniculata and functionalization with polycaprolactone-gelatin composites

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Frontiers of Materials Science 2012年第3期6卷 236-249页

作者： Punuri Jayasekhar BABUA Sibyala SARANYA Pragya sharma ranjan TAMULI Utpal BORA Biomaterials and Tissue Engineering Laboratory Department of BiotechnologyIndian Institute of Technology GuwahatiGuwahatiAssam-781039India Biotech Hub Centre for the EnvironmentIndian Institute of Technology GuwahatiGuwahatiAssam-781039India Department of Biotechnology D.R.W.CollegeGudurSPS NelloreAndhra Pradesh-524101India

Gold nanoparticles （AuNPs） were synthesized by sonication using ethanolic leaf extract of Andrographis paniculata. We investigated the optimum parameters for AuNP synthesis and functionalization with polycaprolactone-gelatin （PCL-GL） composites. The AuNPs were characterized with various biophysical techniques such as TEM, XRD, FT-IR and EDX spectroscopy. TEM images showed that nanoparticles were spherical in shape with a size range from 5 to 75 nm. EDX analysis revealed the presence of molecular oxygen and carbon on the surface of AuNPs. The synthesized AuNPs were tested for their effect on HeLa （human cervical cancer） and MCF- 7 （human breast cancer） cell lines and found to be nontoxic and biocompatible, which are potential carriers for hydrophobic drugs.

关键词： sonocatalasis Andrographis paniculata functionalization crystal growth biomaterial PCL-GL composite

Translational products of adipose tissue-derived mesenchymal stem cells:Bench to bedside applications

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World Journal of Stem Cells 2021年第10期13卷 1360-1381页

作者： Shilpa sharma Sathish Muthu Madhan Jeyaraman Rajni ranjan Saurabh Kumar Jha Department of Pediatric Surgery All India Institute of Medical SciencesNew Delhi 110029India Indian Stem Cell Study Group LucknowUttar Pradesh 226010India Department of Orthopaedics Government Medical College and HospitalDindigulTamil Nadu 624304India Research Scholar Department of BiotechnologySchool of Engineering and TechnologyGreater NoidaSharda UniversityUttar Pradesh 201306India Department of Orthopaedics School of Medical Sciences and ResearchSharda UniversityGreater NoidaUttar Pradesh 201306India Department of Biotechnology School of Engineering and TechnologySharda UniversityGreater NoidaUttar Pradesh 201306India

With developments in the field of tissue engineering and regenerative medicine,the use of biological products for the treatment of various disorders has come into the limelight among researchers and *** all the available biological tissues,research and exploration of adipose tissue have become more *** tissue engineering aims to develop by-products and their substitutes for their regenerative and immunomodulatory *** use of biodegradable scaffolds along with adipose tissue products has a major role in cellular growth,proliferation,and *** tissue,apart from being the powerhouse of energy storage,also functions as the largest endocrine organ,with the release of various *** progenitor cells among the heterogeneous population in the adipose tissue are of paramount importance as they determine the capacity of regeneration of these *** results of adipose-derived stemcell assisted fat grafting to provide numerous growth factors and adipokines that improve vasculogenesis,fat graft integration,and survival within the recipient tissue and promote the regeneration of tissue are *** tissue gives rise to various by-products upon *** article highlights the significance and the usage of various adipose tissue by-products,their individual characteristics,and their clinical applications.

关键词： Adipose tissue Stem cells Fat graft Clinical applications Mesenchymal stem cells