Gold nanoparticles： sonocatalytic synthesis using ethanolic extract of Andrographis paniculata and functionalization with polycaprolactone-gelatin composites

作     者：Punuri Jayasekhar BABUA Sibyala SARANYA Pragya SHARMA Ranjan TAMULI Utpal BORA 

作者机构：Biomaterials and Tissue Engineering LaboratoryDepartment of BiotechnologyIndian Institute of Technology GuwahatiGuwahatiAssam-781039India Biotech HubCentre for the EnvironmentIndian Institute of Technology GuwahatiGuwahatiAssam-781039India Department of BiotechnologyD.R.W.CollegeGudurSPS NelloreAndhra Pradesh-524101India 

出 版 物：《Frontiers of Materials Science》 (材料学前沿（英文版）)

年 卷 期：2012年第6卷第3期

页      面：236-249页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 083201[工学-食品科学] 

基　　金：The Department of Biotechnology  Government of India (Project title “Establishment of Institutional Biotech hubs” (IBT hubs) by DBT) 

主　　题：sonocatalasis Andrographis paniculata functionalization crystal growth biomaterial PCL-GL composite 

摘      要：Gold nanoparticles （AuNPs） were synthesized by sonication using ethanolic leaf extract of Andrographis paniculata. We investigated the optimum parameters for AuNP synthesis and functionalization with polycaprolactone-gelatin （PCL-GL） composites. The AuNPs were characterized with various biophysical techniques such as TEM, XRD, FT-IR and EDX spectroscopy. TEM images showed that nanoparticles were spherical in shape with a size range from 5 to 75 nm. EDX analysis revealed the presence of molecular oxygen and carbon on the surface of AuNPs. The synthesized AuNPs were tested for their effect on HeLa （human cervical cancer） and MCF- 7 （human breast cancer） cell lines and found to be nontoxic and biocompatible, which are potential carriers for hydrophobic drugs.