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Anticonvulsant potential of rosuvastatin in combination with carbamazepine and valproate in animal models of epilepsy

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World Journal of Methodology 2025年第2期15卷 137-144页

作者： Vandana Tayal Akash Mandal Ijasul haque M Akhilesh Mishra Bhupinder S Kalra Vandana Roy Department of Pharmacology Maulana Azad Medical CollegeNew Delhi 110002India Department of Pharmacology MES Medical CollegePerintalmanna 679338KeralaIndia Department of Central Animal Facility Maulana Azad Medical CollegeNew Delhi 110002India

BACKGROUND Epilepsy impacts millions of people,with many not responding to existing *** evidence links neuroinflammatory processes to *** exhibit anti-inflammatory and neuroprotective properties,potentially offering antiepileptic *** To evaluate the anticonvulsant effects of rosuvastatin in animal models of *** Ninety-six albino mice were divided into 16 *** the maximal electroshock seizure(MES)model,eight groups received intraperitoneal vehicle,carbama-zepine,rosuvastatin,or a *** measured included seizure protection[tonic hind limb extension(THLE)],duration of THLE,seizure duration,and *** the pentylenetetrazol(PTZ)model,eight groups were pretreated with vehicle,valproate,rosuvastatin,or a combination,with outcomes measured as seizure latency,seizure duration,and *** In the MES model,rosuvastatin exhibited protection against THLE in a small percentage of *** shortens the duration of THLE in a dose-dependent ***,none of these were statistically significant com-pared to the control *** combination of rosuvastatin 10 mg/kg with carbamazepine 4 mg/kg resulted in a significant reduction in seizure duration compared to the control group,better than carbamazepine alone at 4 mg/kg and 6 mg/*** the PTZ model,rosuvastatin alone showed no significant effects on latency,duration of seizure,or ***,rosuvastatin 10 mg/kg combined with valproate 100 mg/kg significantly delayed the onset of seizures,seizure duration and mortality percentage,better than valproate alone at 100 mg/*** Rosuvastatin enhanced the anticonvulsant effects of carbamazepine and *** studies are required to explore the antiepileptic potential of rosuvastatin at various doses,durations,dosage forms,routes and models.

关键词： Antiepileptic Anticonvulsant Statins Rosuvastatin Maximal electroshock seizure Pentylenetetrazol

Dynamic analysis of buried pipeline with and without barrier system subjected to underground detonation

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Defence Technology（防务技术） 2023年第11期29卷 95-105页

作者： Chaidul haque Chaudhuri Deepankar Choudhury Department of Civil Engineering Indian Institute of Technology BombayMumbai400076India

Failure of pipe networks due to blast loads resulting from terrorist attacks or construction facilities, may cause economic loss, environmental pollution, source of firing or even it may lead to a disaster. The present work develops a closed-form solution of buried pipe with barrier system subjected to subsurface detonation. The solution is derived based on the concept of double-beam system. Euler Bernoulli's beams are used to simulate the buried pipe and the barrier system. Soil is idealized as viscoelastic foundation along with shear interaction between discrete Winkler springs(advanced soil model). The finite SineFourier transform is employed to solve the coupled partial differential equations. The solution is validated with past studies. A parametric study is conducted to investigate the influence of TNT charge weight, pipe material, damping ratio and TNT offset on the response of buried pipe with and without barrier system. Further a statistical analysis is carried out to get the significant soil and pipe input parameters. It is perceived that peak pipe displacements for both the cases(with and without barrier) are increases with increasing the weight of TNT charge and decreases with increasing the damping ratio and TNT offset. The deformation of pipe also varies with pipe material. Pipe safety against blast loads can be ensured by providing suitable barrier layer. The present study can be utilized in preliminary design stage as an alternative to expensive numerical analysis or field study.

关键词： Buried pipeline Subsurface detonation Analytical solution Viscoelastic foundation Protective barrier

Regional Impact of Cyclone Sidr in Bangladesh: A Multi-Sector Analysis

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International Journal of Disaster Risk Science 2016年第3期7卷 312-327页

作者： Afsana haque Sarwar Jahan Department of Urban and Regional Planning Bangladesh University of Engineering and Technology(BUET)

This research investigates the impact of cyclone Sidr on six regional economic systems of Bangladesh. The study uses secondary data on direct damages and corresponding changes in consumer spending and public/private investment expenditure. It employs input–output modeling and simulates the changes in national and regional output,income, and employment due to cyclone Sidr. Our findings indicate that coastal regions of Bangladesh—Barisal,Chittagong, and Khulna—are more vulnerable to cyclone disaster than are other parts of the country. The cycloneinduced loss of output is highest for Chittagong Division and income and employment losses are greatest in Barisal Division. The most affected sectors are housing services,agriculture, construction, and industrial activities. But sectoral losses vary widely across the regions. This research also finds that the present state of consumer spending and investment expenditure is not great enough to handle cyclone-induced output, income, and employment losses. It argues that investment decisions must consider regional patterns of output, income, and employment losses in different economic sectors to ensure cyclone-resilient development in Bangladesh.

关键词： Bangladesh Cyclone Sidr Input-output model Regional impact Sectoral impact

HbA_(1C) as a Biomarker of Non-alcoholic Fatty Liver Disease: Comparison with Anthropometric Parameters

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Journal of Clinical and Translational Hepatology 2021年第1期9卷 15-21页

作者： Muhammad Masroor Zeba haque Dow University of Health Sciences KarachiPakistan

Background and Aims:Multiple non-invasive methods including radiological,anthropometric and biochemical markers have been reported with variable *** present study assessed glycosylated hemoglobin(HbA1C)as a biomarker to predict non-alcoholic fatty liver disease(NAFLD)and its severity,compared with body mass index(BMI),waist to hip ratio(WHR)and waist circumference(WC)Methods:This case control study included 450 individuals,including 150 cases and 300 age-and gender-matched controls recruited from the Dow Radiology Institute on the basis of radiological findings of fatty infiltration on abdominal ultrasound through convenient ***,WHR and WC were measured according to standard ***1C was determined by turbidimetric inhibition immunoassay Results:Among the cases and controls,66%and 32%had HbA1C levels higher than 5.7%***1C and BMI were significantly associated with NAFLD[crude odds ratio(cOR)=4.12,2.88,2.25(overweight)and 4.32(obese)].WC was found to be significantly associated with NAFLD for both genders(cOR in males=5.50 and females=5.79,p<0.01).After adjustment for other parameters,HbA1C and WC were found to be significantly associated with NAFLD(aOR=3.40,p<0.001)along with WC in males(aOR=2.91,p<0.05)and in females(aOR=4.28,p<0.05).A significant rise in severity of hepatic steatosis was noted with increases in HbA1C,BMI and ***1C possessed a positive predictive value of 76%for the study population[0.76,confidence interval(CI):0.715-0.809],70.6%for males(0.706,CI:0.629-0.783)and 80%for females(0.80,CI:0.741-0.858).Conclusions:Higher than normal HbA1C and WC measurements possess a more than 70%potential to predict *** is the single risk factor that is strongly associated with NAFLD after adjustment for indices of body ***1C may be presented as a potential biomarker for NAFLD in examination with other anthropometric measures in the adult population.

关键词： NAFLD HbA_(1C) Biomarker Non-diabetic population Body weight measurements Body mass index(BMI) Waist circumference(WC)

Biosynthesis of Flower-Shaped CuO Nanostructures and Their Photocatalytic and Antibacterial Activities

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Nano-Micro Letters 2020年第2期12卷 224-234页

作者： Hafsa Siddiqui MSQureshi Fozia Zia haque Department of Physics Sha-Shib College of Science and ManagementBhopal 462030India Optical Nanomaterial Lab Department of PhysicsMaulana Azad National Institute of TechnologyBhopal 462003India

Copper oxide nanoflowers(CuO-NFs)have been synthesized through a novel green route using Tulsi leaves-extracted eugenol(4-allyl-2-methoxyphenol)as reducing *** results reveal the growth of crystalline singlephase CuO-NFs with monoclinic *** prepared CuO-NFs can effectively degrade methylene blue with 90%*** also show strong barrier against ***(27±2 mm)at the concentration of 100μg mL−1,while at the concentration of 25μg mL−1 weak barrier has been found against all examined bacterial *** results provide important evidence that CuO-NFs have sustainable performance in methylene blue degradation as well as bacterial organisms.

关键词： Copper oxide O.Sanctum Eugenol Biosynthesis Photocatalysis Antibacterial

Schamel equation in an inhomogeneous magnetized sheared flow plasma with q-nonextensive trapped electrons

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Chinese Physics B 2018年第2期27卷 428-434页

作者： Shaukat Ali Shan Qamar-ul-haque Theoretical Physics Division (TPD) PINSTECH

An investigation is carried out for understanding the properties of ion–acoustic（IA） solitary waves in an inhomogeneous magnetized electron-ion plasma with field-aligned sheared flow under the impact of q-nonextensive trapped electrons. The Schamel equation and its stationary solution in the form of solitary waves are obtained for this inhomogeneous plasma. It is shown that the amplitude of IA solitary waves increases with higher trapping efficiency（β）, while the width remains almost the same. Further, it is found that the amplitude of the solitary waves decreases with enhanced normalized drift speed, shear flow parameter and the population of the energetic particles. The size of the nonlinear solitary structures is calculated to be a few hundred meters and it is pointed out that the present results are useful to understand the solar wind plasma.

关键词： sheared flow plasma density inhomogeniety electron trapping

The effect of hemicellulose on the interparticle frictional behavior of lignocellulosic biomass particulates

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Particuology 2021年第2期19卷 16-22页

作者： Ekramul haque Ehite Eric Drumm Nourredine Abdoulmoumine Biosystems Engineering and Soil Science Department University of TennesseeKnoxvilleTN 37996USA Center for Renewable Carbon University of TennesseeKnoxvilleTN 37996USA

Lignocellulosic biomass material sourced from plants and herbaceous sources is considered as a prospective feedstock of inexpensive,potentially carbon-neutral *** biomass is structurally built on cellulose,hemicellulose,and lignin,which are present in varying concentrations based on the feedstock type and play distinct and not well understood mechanical functions in the flow *** frictional characteristics of lignocellulosic biomass particulates influence their flow behavior in ***,it is important to fundamentally investigate the relative contribution of cellulose,hemicellulose,and lignin to the frictional ***,these three biopolymers are interwoven into a complex matrix in the lignocellulosic biomass,thus making it hard to quantify the contribution of each *** this study,we selectively remove hemicellulose from switchgrass and investigate the effects of its diminishing concentration on the coefficient of *** observed that the angle of repose and,therefore,the coefficient of friction for a loose assembly of the control and treated switchgrass samples decrease with decreasing hemicellulose *** indicates the frictional resistance to flow for biomass particulate assemblies is at least proportional to the hemicellulose *** also established that the observed changes in the frictional behavior were not due to particle morphological characteristics.

关键词： Lignocellulosic biomass Frictional behavior Angle of repose Hot water extraction Switchgrass Hemicellulose removal

Geochemistry of Tertiary sandstones from southwest Sarawak,Malaysia: implications for provenance and tectonic setting

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Acta Geochimica 2016年第3期35卷 294-308页

作者： Nasim Ferdous Atikul haque Farazi Department of Geology University of Malaya

Tertiary sandstones collected from southwest Sarawak, Malaysia, were analyzed to decipher their provenance, weathering, and tectonic setting. The studied sandstones have a sublitharenite composition and are dominantly composed quartz with little mica and feldspar, and a small amount of volcanic fragments. These sand- stones were generally derived from quartz-rich recycled orogenic sources. They have relatively high SiO2 content with low Na20, CaO, MnO, and MgO contents. Values of Chemical Index of Alteration （CIA） of these rock samples vary from 71 to 93, with an average of 81, implying intense chemical alteration during weathering. A felsic igneous source is suggested by a low concentration of TiO2 com- pared to CIA, enrichment of Light Rare Earth Elements, depletion of Heavy Rare Earth Elements, and negative Eu anomalies. A felsic origin is further supported by a Eu/Eu＊ range of 0.65-0.85 and high Th/Sc, La/Sc, La/Co, and Th/ Co ratios. This work presents the first reported geochemical data of Tertiary sandstones of the Sarawak Basin. These data led us to conclude that the sandstones were dislodged from recycled orogenic sources and deposited in a slowly subsiding rifted basin in a passive continental tectonic setting.

关键词： Geochemistry Tertiary sandstone Provenance Tectonic setting SW Sarawak Malaysia

Investigation on Structure and Properties of Brass Casting

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Journal of Materials Science & Technology 2008年第3期24卷 299-301页

作者： M.M.haque A.A.Khan 53100 Kuala Lumpur Department of Manufacturing and Materials Engineering Kulliyyah of Engineering Gombak International Islamic University Malaysia(IIUM)

In this work,alpha(α)brass was poured in green sand mould and metallic chill mould at about 1050℃. Sand casting method and metallic chill casting method are representing the slow and fast cooling rates of the castings,*** slow cooling rate in the sand mould produces larger grains,while the metallic chill mould produces smaller grains in the *** the grain size decreases,the strength of the cast brass increases;micro-porosity in the casting decreases and the tendency for the casting to fracture during solidification ***,the faster cooling rate casting offers higher strength,density and hardness compared to the slow cooling rate casting.

关键词： Green sand Chill mould Micro-porosity Solidification