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Curcumin preconditioning enhances the efficacy of adipose-derived mesenchymal stem cells to accelerate healing of burn wounds

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Burns & Trauma 2021年第1期9卷 272-287页

作者： Maryam Azam Hafiz Ghufran Hira Butt Azra Mehmood Ramla Ashfaq asad M.Ilyas Muhammad R.Ahmad Sheikh Riazuddin National Centre of Excellence in Molecular Biology 87-West Canal Bank RoadUniversity of the PunjabLahorePakistan Jinnah Burn and Reconstructive Surgery Centre Maulana Shaukat Ali RdQuaid-i-Azam CampusLahorePakistan

Background:Following recent findings from our group that curcumin preconditioning augments the therapeutic efficacy of adipose-derived stem cells in the healing of diabetic wounds in rats,we aimed to investigate the regenerative effects of curcumin preconditioned adipose-derived mesenchymal stem cells(ASCs)for better recovery of acid inflicted burns in this ***:ASCs were preconditioned with 5μM curcumin for 24 hours and assessed for proliferation,migration,paracrine release potential and gene expression comparative to naive ***,the healing capacity of curcumin preconditioned ASCs(Cur-ASCs)versus naive ASCs was examined using acidic wounds in *** this,acid inflicted burns of 20 mm in diameter were made on the back of male Wistar ***,2×10^(6) cells of Cur-ASCs and naive ASCs were intradermally injected in the wound periphery(n=6)for comparison with an untreated saline ***-transplantation,wounds were macroscopically analysed and photographed to evaluate the percentage of wound closure and period of *** wound biopsies were excised and used for histological evaluation and expression analysis of wound healing markers at molecular level by quantitative PCR and western ***:We found that Cur-ASCs exhibited greater proliferation,migration and paracrine potential in ***,Cur-ASCs showed more effective recovery than naive ASCs as exhibited by gross morphology,faster wound closure and earlier ***’s trichrome and hematoxylin and eosin staining demonstrated the improved architecture of the healing burns,as evidenced by reduced infiltration of inflammatory cells,compact collagen and marked granulation in Cur-ASC treated *** these findings,molecular assessment showed significantly reduced expressions of pro-inflammatory factors(interleukin-1 beta,interleukin-6,tumor necrosis factor alpha)a with striking upsurge of an oxidative marker(superoxide dismutase 1),p

关键词： Adipose-derived stem cells Curcumin preconditioning Acidic burn Wound healing

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A Review of Particle Image Velocimetry for Fish Migration

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World Journal of Mechanics 2016年第4期6卷 131-149页

作者： S. M. Sayeed-Bin-asad T. Staffan Lundström A. G. Andersson J. Gunnar I. Hellström Division of Fluid and Experimental Mechanics Lule&#229 University of Technology Lule&#229 Sweden

Understanding the flow characteristic in fishways is crucial for efficient fish migration. Flow characteristic measurements can generally provide quantitative information of velocity distributions in such passages;Particle Image Velocimetry (PIV) has become one of the most versatile techniques to disclose flow fields in general and in fishways, in particular. This paper firstly gives an overview of fish migration along with fish ladders and then the application of PIV measurements on the fish migration process. The overview shows that the quantitative and detailed turbulent flow information in fish ladders obtained by PIV is critical for analyzing turbulent properties and validating numerical results.

关键词： Particle Image Velocimetry (PIV) Fish Migration Fishways

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用于交通标志检测的窗口大小聚类残差SSD模型

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湖南大学学报（自然科学版） 2019年第10期46卷 133-140页

作者：宋青松王兴莉张超陈禹宋焕生 KHATTAK asad Jan 长安大学信息工程学院

SSD通常被认为适合于求解小目标图像检测问题,但在特征表征和检测效率两方面还存在改进空间.提出一种聚类残差SSD模型,一方面将原始SSD模型中的VGG16基础网络替换为更深的ResNet50残差网络,以改善特征表征能力.另一方面采用K-均值聚类... 详细信息

SSD通常被认为适合于求解小目标图像检测问题,但在特征表征和检测效率两方面还存在改进空间.提出一种聚类残差SSD模型,一方面将原始SSD模型中的VGG16基础网络替换为更深的ResNet50残差网络,以改善特征表征能力.另一方面采用K-均值聚类算法取代盲目搜索机制,确定SSD中默认窗口的大小,以改善检测效率.针对德国交通标志检测数据集,模型获得了97.1%mAP和每幅图像0.07 s的检测速度.针对中国交通标志数据集,模型获得89.7%mAP和每幅图像0.08 s的检测速度.与原始SSD模型比较,本文所提模型的检测性能得到改善.

关键词：交通标志检测深度学习单拍多盒探测器(SSD) K-均值聚类

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Potential Antioxidant Activities Improve Salt Tolerance in Ten Varieties of Wheat (<i>Triticum aestivum</i>L.)

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American Journal of Plant Sciences 2013年第6期4卷 69-76页

作者： Aurangzeb Rao Syed Dilnawaz Ahmad Syed Mubashar Sabir Shahid Iqbal Awan asad Hussain Shah Syed Rizwan Abbas Saima Shafique Fareed Khan Atia Chaudhary Department of Chemistry University of the Poonch Rawalakot Pakistan. Department of Plant Breeding and Molecular Genetics Faculty of Agriculture University of the Poonch Rawalakot Pakistan Department of Plant Breeding and Molecular Genetics Faculty of Agriculture University of the Poonch Rawalakot Pakistan University of Azad Jammu and Kashmir Muzaffarabad Pakistan

The activity of antioxidative enzymes system is affected by salt stress, chlorophyll content (CHL), leaf relative water content (RWC), Na+ and K+ contents, their ratio and some oxidative stress indices were studied in leaves of ten bread wheat cultivarsSehar-06, Lu-26, NARC-09, BARC-09 and Pirsbak-09’(salt-tolerant) and Kaghan-94, Rohtas-90, Soughat-90, Shaheen-94 and Zardana-89’(salt-sensitive), grown under salinity treatments carried out in five levels (1 dS·m-1 as control, 2, 4, 8, 16 dS·m-1) via sodium chloride. Under high salt potency significant increase for activities of antioxidant enzymes such as ascorbate peroxidase (APX) and guiacol peroxidase (GPX), occured in salt tolerant varieties. Meanwhile, under salinity condition the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and (GPX) in sensitive cultivar were lower than control. Regarding (APX) activity there was no significant difference between salinity and control situation. Under salt stress membrane stability index (MSI) of both cultivars were negatively influenced. Hydrogen peroxide (H2O2) content of salinity sensitive cultivars was higher than control. Salt tolerant varieties had more amounts of K+ content, K+ and Na+ ratio, relative water content, yield and chlorophyll under salt conditions, and sensitive ones recorded higher Na+ content at tillering stage. The mechanism of salt stress might be achieved due to low lipid peroxidation, assumingly lower changes in membrane stability index and evasion of Na+ combination and amplified activity of antioxidant enzymes.

关键词： Antioxidant Enzymes Chlorophyll Content+/Na+ Ratio Relative Water Content Salinity Wheat

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Effect of Phytase Enzyme on Organs Growth Performance and Blood Profile of Broiler

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Advances in Enzyme Research 2021年第3期9卷 37-49页

作者： Fida Noor Baloch Hafeez Noor Baloch asad Ullah Khan Naseebullah Marri Baloch Ismail Anwer Baloch Nadir Khan Baloch Ayaz Qadir Qambrani Abdul Khalique Samejo Faculty of Animal Husbandry and Veterinary Sciences Sindh Agriculture University Tandojam Pakistan Shanxi Agricultural University Taigu China University of Veterinary & Animal Sciences Lahore Pakistan

Enzymes which are biological catalyst composed of amino acids with minerals and vitamins. The use of enzymes has many benefits in poultry diets include not only enhanced feed conversion and bird performance but also reduced output of excreta problems of environment. The present research work was conducted to evaluate the effect of phytase enzyme on growth performance and blood profile of broiler. Birds were arbitrarily separated into four groups, i.e. Group A (control) was offered 0 g/kg, 0.05 g/kg (group B), 0.075 g/kg (group C) and 0.025 g/kg (group D) phytase enzyme provided in broiler feed. Parameters which were selected in present research work as, feed intake, live body weight, feed conversion ratio, growth performance and blood profile. Results showed that the maximum chicken body weight was noted in group C and feed intake was minimum in group C, as compared to other groups. Feed conversion ratio was significantly (p < 0.05) higher in group C, followed by other groups the non-significantly variance founded respectively, the highest weight of liver, gizzard, heart, intestine were noted in treated group C comparatively, highest spleen weight was in group B and in group A (control) the minimum weight of spleen was noted and the average blood profile of broiler chicks in different groups, the white blood cells was significantly higher in group D followed by group A, group B and C. Red blood cells was significantly (P < 0.05) better in group C. Haemoglobin was significant differences in different groups of trial. A significant (P < 0.05) difference in Packed cells volume in group A followed by group B, C and D. Total protein in group A was minimum followed by group B, C and D, respectively. From the present study, it was concluded that supplementation of 0.075 g/kg phytase enzyme has a better effect on growth performance and blood profile of broiler.

关键词： Broiler Birds Phytase Enzyme Growth Performance and Blood Profile of Broiler

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甲状腺乳头状癌线粒体DNA D环区基因突变的临床意义

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江苏大学学报（医学版） 2017年第1期27卷 31-35页

作者： Muhammad asad Iqbal 刘嫣方林江薛娣钱炜江苏大学附属人民医院耳鼻咽喉－头颈外科江苏镇江212002 江苏大学附属人民医院中心实验室江苏镇江212002 江苏大学附属人民医院病理科江苏镇江212002

目的:探讨甲状腺乳头状癌线粒体DNA(mt DNA)D环区基因突变和线粒体微卫星不稳定及其与临床病理参数之间的相关性。方法:选取96例甲状腺乳头状癌石蜡组织标本,提取DNA并对mt DNA D环区序列行巢式PCR扩增,通过正反向直接测序对扩增产物基... 详细信息

目的:探讨甲状腺乳头状癌线粒体DNA(mt DNA)D环区基因突变和线粒体微卫星不稳定及其与临床病理参数之间的相关性。方法:选取96例甲状腺乳头状癌石蜡组织标本,提取DNA并对mt DNA D环区序列行巢式PCR扩增,通过正反向直接测序对扩增产物基因序列进行检测,利用Mitomaster软件将所测区的基因序列与剑桥标准系列(revised Cambridge reference sequence,r CRS)及相关数据库进行比对,分析D环区基因突变与临床病理参数之间的相关性。结果:采用巢式PCR成功扩增出91例甲状腺乳头状癌石蜡标本mt DNA D环区序列,扩增成功率达到94.8%;87例标本(90.6%)检测出突变位点35个,共255个突变,其中D310及D514区域存在微卫星不稳定;统计结果表明患者年龄、性别、肿瘤直径、TNM分期与mt DNA D环区突变个数无相关性(P>0.05)。结论:甲状腺乳头状癌mt DNA D环区基因存在高频突变,可能在甲状腺乳头状癌的发病中起重要作用。

关键词：甲状腺乳头状癌线粒体DNA D环区突变

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Smooth Sliding Mode Control for PEM Fuel Cell System

Smooth Sliding Mode Control for PEM Fuel Cell System

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第24届中国控制与决策会议

作者： S. Saqib H. Rizvi A. I. Bhatti Qudrat Khan Qadeer Ahmad asad Hameed Zahid Butt CASPR Dept.of Electronics Engineering Mohammad Ali Jinnah University

A smooth sliding mode control （SSMC） is applied to tackle the problem of PEM fuel cell system output voltage stabilization problems along with controlling oxygen excess ratio. The oxygen excess ratio is controlled in the inner control loop using PID while the regulation of output voltage is being treated in the outer loop through smooth sliding mode control. The control is applied on the validated nonlinear model of the PEM fuel cell system. The simulation results show that the scheme with SSM control provides same performance as compared to higher order sliding mode control （Super twisting Algorithm） in output voltage stabilization and also in minimizing the fuel consumption.

关键词： Smooth Sliding Mode Control PEM Fuel Cell System

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Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy

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World Journal of Gastroenterology 2006年第40期12卷 6515-6521页

作者： Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki Department of General Visceral and Thoracic Surgery University Medical Centre of Hamburg-Eppendorf Hamburg Germany Institute of Medical Biometry and Epidemiology University Medical Centre of Hamburg-Eppendorf Hamburg Germany Institute of Pathology University Medical Centre of Hamburg-Eppendorf Hamburg Germany Institute of Immunology University of Munich Munich Germany Institute of Tumor Biology University Medical Centre of Hamburg-Eppendorf Hamburg Germany

AIM： To study the prognostic value of adjuvant chemotherapy in patients with pancreatic, ductal adenocarcinoma. METHODS： Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three （41%） of the 106 patients were staged as pT1/2, 63 （59%） as pT3/4, 51 （48%） as pNo, and 55 （52%） as pN1. The study population included 59 （56%） patients exhibiting G1/2, and 47 （44%） patients with G3 tumors. Patients received no adjuvant chemoor radiation therapy and were followed up for a median of 12 （range： 3.5 to 139） mo.RESULTS： Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as ＂tumor free＂ by conventional histopathology in 73 （69%） out of the 106 patients. Twenty-nine （57%） of 51 patients staged histopathologically as pNo had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free （relative risk 2.92, P = 0.005） and overall （relative risk 2.49, P = 0.009） survival. CONCLUSION： The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports stratification of patients with may help to improve risk pancreatic cancer.

关键词： Pancreatic ductal adenocarcinoma Nodal microinvolvement Micrometastases

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Proliferation, Multiplication and Improvement of Micro-Propagation System for Mass Clonal Production of Rose through Shoot Tip Culture

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American Journal of Plant Sciences 2018年第2期9卷 296-310页

作者： Allah Jurio Khaskheli Muhammad Ibrahim Khaskheli Maqsood Ahmad Khaskheli Tahmina Shar Waqas Ahmad Umed Ali Lighari Muhammad Azeem Khaskheli asad Ali Khaskheli Faisal Hayat Makan Department of Biotechnology Sindh Agriculture University Tando Jam Pakistan Department of Plant Protection Sindh Agriculture University Tando Jam Pakistan State Key Laboratory of Rice Biology China National Rice Research Institute Hangzhou China Collage of Agriculture and Biotechnology China Agriculture University Beijing China Institute of Pomology Chinese Academy of Agriculture Sciences Xingcheng China Department of Animal Nutrition Sindh Agriculture University Tando Jam Pakistan

Present study was conducted to assess the regeneration potential and producing mass-clonal seedlings of Rose through shoot tip culture. A total of 40 explants were cultured on each of basal medium supplemented with different concentrations of BAP, NAA and GA. The observations on the survival rate, days taken to initiate the shoots, total number of shoots and length of shoots, initiation of roots, total number of root, length of roots and number of leaves were investigated. Rose regenerated on MS-Basal medium (control) without addition of growth hormones showed significantly (P < 0.05) lower survival rate and did not show shoots up to the end of experiments. MS-Basal medium supplemented with different concentrations of BAP, NAA and GA showed increasing rate of survival. MS-Basal medium supplemented with highest BAP, NAA and GA concentration (MS-SV) has taken least time to initiate the shoots, whilst supplemented in concentrations of 0.5 and/or 1.0 mg/L, respectively revealed more time. Rooted plants were transplanted into the substrate and acclimatized in the laboratory greenhouse (humid cavity). The acclimatization in the humid cavity showed optimistic effect on the number of survived plants.

关键词： Rose Tissue Culture Explants BAP NAA and GA

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应用ImageJ程序包进行材料显微组织图像处理、分析和可视化的一种框架(英文)

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中国体视学与图像分析 2012年第4期17卷 301-312页

作者： asad Ullah 刘国权王浩 Dil Faraz Khan Matiullah Khan 北京科技大学材料科学与工程学院北京100083 Department of Mathematics Karakoram International University Gilgit-Baltistan 北京科技大学新金属材料国家重点实验室北京100083

显微组织图像(例如胞、粒子与晶粒等)的数字图像处理、分割和分析,对于获取显微组织特征的三维信息非常重要。已有数种商用和共享程序包可以用于图像的处理和分析。"ImageJ"即其中之一,其长期广泛采用及其可扩展插件形式已使其成为许多... 详细信息

显微组织图像(例如胞、粒子与晶粒等)的数字图像处理、分割和分析,对于获取显微组织特征的三维信息非常重要。已有数种商用和共享程序包可以用于图像的处理和分析。"ImageJ"即其中之一,其长期广泛采用及其可扩展插件形式已使其成为许多不同应用领域科学家选用的工具。它包含了处理、分割、重建和可视化材料显微结构所需要的几乎所有基本的和最新的功能以及图像分析工具(例如‘Particle Analyzer’,‘3D object counter’,‘3D Roi Manager’),以用于成组粒子的复杂统计处理。虽然它在生物医学研究领域很受欢迎,被认为是一种有用的和有效的开放源码的图像处理与分析软件,但是在材料科学领域对其所知甚少。面向材料学界,本文尤其是那些没有图像处理和分析经验的材料科学与工程专业人员,在简要介绍ImageJ的基础上,提出了将其应用于在三维空间中处理、分割和分析显微组织结构连续切片图像的一个通用框架。

关键词：材料体视学显微组织系列截面图像 ImageJ 图像分割图像分析

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