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Sharing Song

小学生时代（大嘴英语） 2024年第9期 18-21页

作者： Pamela Love Laura montenegro(图) 不详

Sing a song of sharing Apples in a tree:Some for squirrels,and some for birds,And some of them for me.

关键词： some birds Apple

Immune response to inactivated bacterial vector carrying the recombinant K39 antigen of Leishmania infantum in mice

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Asian Pacific Journal of Tropical Biomedicine 2024年第5期14卷 199-206页

作者： Lucelina S.Araújo Bruno B.Silva Eduarda N.F.N.Santos Arnaldo S.Bezerra Samuel S.Frota as.is.r.montenegro Eridan O.P.T.Florean Maurício Fvan Tilburg Maria Izabel F.Guedes Laboratory of Biotechnology and Molecular Biology Northeast Biotechnology NetworkState University of CearáFortalezaBrazil Faculty of Veterinary Medicine State University of CearáFortalezaBrazil

Objective:To evaluate the immunological response elicited by an inactivated bacterial vector carrying the K39 antigen of Leishmania infantum,and a purified ***:Mice were subjected to the following treatments:(1)Purified recombinant K39(rK39)protein at a 20μg dose with complete Freund’s adjuvant;(2)Inactivated Escherichia coli(BL21 DE3)carrying the K39 protein at an equivalent total protein content of 200μg;(3)Inactivated bacteria lacking the K39 protein;(4)Non-immunized control *** monitoring was *** groups were challenged by intraperitoneal injection of 10^(7) Leishmania infantum *** euthanasia,the liver and spleen were collected to analyze the levels of TNF,IFN-γ,IL-12,IL-4,and ***:Mice immunized with purified rK39 or the inactivated bacterial vector carrying the K39 antigen of Leishmania infantum showed a long-lasting immune response with high levels of polyclonal antibodies specifically recognizing the recombinant *** IgG1 subclass was the predominant immunoglobulin;however,the induction of IgG2a and the profile of cytokines produced were indicative of the induction of a mixed-type ***:The inactivated bacterial vector carrying the K39 antigen,as well as the purified antigen can induce a long-lasting immune response in immunized mice,predominantly favouring a Th2 profile response.

关键词： Visceral leishmaniasis K39 Inactivated bacterial vector Vaccine Immune response Th1 Th2 Leishmania infantum

Noninvasive Ventilation Interfaces in the Treatment of Acute respiratory Insufficiency: A Critical review

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Open Journal of Emergency Medicine 2024年第3期12卷 95-103页

作者： Andréa Nóbrega Cirino Nogueira Chakira Torres Lima renata dos Santos Vasconcelos Suzy Maria montenegro Pontes Arnaldo Aires Peixoto Junior renan Magalhães montenegro Junior Clinical research Unit Walter Cantdio University Hospital Federal University of Cear/EBSERH Fortaleza Brazil

Background: Noninvasive ventilation (NIV) is an important therapeutic modality for the treatment of acute respiratory failure (ArF). In this review, we critically analyze randomized controlled trials on the most used NIV interfaces in the treatments of ArF. Methods: The searches were conducted in the Medline, Lilacs, PubMed, Cochrane, and Pedro databases from June to November 2021. The inclusion criteria were randomized clinical trials (rCTs) published from 2016 to 2021 in Portuguese, Spanish, or English and involving adults (aged ≥ 18 years). The eligibility criteria for article selection were based on the PICO strategy: Population—Adults with ArF;Intervention—NIV Therapy;Comparison—Conventional oxygen therapy, high-flow nasal cannula (HFNC) oxygen therapy, or NIV;Outcome—improvement in ArF. The search for articles and the implementation of the inclusion criteria were independently conducted by two researchers. results: Seven scientific articles involving 574 adults with ArF due to various causes, such as chest trauma, decompensated heart failure, coronavirus disease 2019 (COVID-19), and postoperative period, among others, were included. The interfaces cited in the studies included an oronasal mask, nasal mask, full-face mask, and helmet. In addition, some favorable outcomes related to NIV were reported in the studies, such as a reduction in the rate of orotracheal intubation and shorter length of stay in the ICU. Conclusions: The most cited interfaces in the treatment of ArF were the oronasal mask and the helmet.

关键词： Noninvasive Ventilation respiratory Insufficiency respiration Artificial Continuous Positive Airway Pressure

Association between Helicobacter pylori infection,mismatch repair,HEr2 and tumor-infiltrating lymphocytes in gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2487-2503页

作者： Carlos A Castaneda Miluska Castillo Luis A Bernabe Joselyn Sanchez Matteo Fassan Katherine Tello Ignacio Ivan Wistuba Ivan Chavez Passiuri Eloy ruiz Juvenal Sanchez Fernando Barreda Daniel Valdivia Yaqueline Bazan Milagros Abad-Licham Claudio Mengoa Hugo Fuentes Paola montenegro Ebert Poquioma raul Alatrista Claudio J Flores Luis Taxa Faculty of Health Sciences Universidad Cientifica del SurLima 15038Peru GECO PErU Grupo de Estudios Clinicos Oncologicos del PeruLima 15038Peru Department of research Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Faculty of Human Medicine Universidad Ricardo PalmaLima 15039Peru Department of Medicine Surgical Pathology&Cytopathology UnitUniversity of PaduaPadua 35121Italy Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Abdominal Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Medical Specialties Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Regional de Enfermedades Neoplasicas del NorteTrujillo 13001Peru Faculty of Human Medicine Universidad Privada Antenor OrregoTrujillo 13008Peru Department of Surgery Instituto Regional de Enfermedades Neoplasicas del SurArequipa 04002Peru Department of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Epidemiology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Unidad de Investigación Básica y Traslacional Oncosalud-AUNALima 15038Peru Faculty of Medicine Universidad San Martin de PorresLima 15008Peru

BACKGrOUND The influence of Helicobacter-pylori(***)infection and the characteristics of gastric cancer(GC)on tumor-infiltrating lymphocyte(TIL)levels has not been extensively *** of infiltrating-immune-cell subtypes as well as survival is necessary to obtain comprehensive *** To determine the rates of deficient mismatch-repair(dMMr),HEr2-status and *** infection and their association with TIL levels in *** Samples from 503 resected GC tumors were included and TIL levels were evaluated following the international-TILs-working-group recommendations with assessment of the intratumoral(IT),stromal(ST)and invasive-border(IB)*** density of CD3,CD8 and CD163 immune cells,and dMMr and HEr2-status were determined by immunohistochemistry(IHC).*** infection was evaluated by routine histology and quantitative PCr(qPCr)in a subset of *** dMMr was found in 34.4%,HEr2+in 5%and ***-positive in 55.7%of *** IT-TIL was associated with grade-3(P=0.038),while ST-TIL with grade-1(Precurrence(P=0.003).dMMr was associated with high TIL levels in the ST(P=0.019)and IB(P=0.01)compartments,and STCD3(P=0.049)and ST-CD8(P=0.05)***2-was associated with high IT-CD8(P=0.009).*** was associated with high IT-TIL levels(P=0.009)when assessed by routine-histology,and with high TIL levels in the 3 compartments(P=0.002-0.047)and CD8 density in the IT and ST compartments(P=0.001)when assessed by qPCr.A longer overall survival was associated with low IT-CD163(P=0.003)and CD8/CD3(P=0.001 in IT and P=0.002 in ST)and high IT-CD3(P=0.021),ST-CD3(P=0.003)and CD3/CD163(P=0.002).CONCLUSION TIL levels were related to dMMr and *** CD8/CD3 and high CD163/CD3 were associated with lower recurrence and longer survival.

关键词： Lymphocytes Macrophages Gastric cancer Helicobacter pylori HEr2 Mismatch repair

Wheel-rail contact model for railway vehicle-structure interaction applications:development and validation

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railway Engineering Science 2023年第3期31卷 181-206页

作者： P.A.montenegro r.Calçada CONSTrUCT-LESE Faculty of EngineeringUniversity of PortoRua Dr.Roberto Frias S/N4200-465 PortoPortugal

An enhancement in the wheel-rail contact model used in a nonlinear vehicle-structure interaction(VSI)methodology for railway applications is presented,in which the detection of the contact points between wheel and rail in the concave region of the thread-flange transition is implemented in a simplified *** presenting the enhanced formulation,the model is validated with two numerical applications(namely,the Manchester Benchmarks and a hunting stability problem of a sus-pended wheelset),and one experimental test performed in a test rig from the railway Technical research Institute(rTrI)in *** its finite element(FE)nature,and contrary to most of the vehicle multibody dynamic commercial software that cannot account for the infrastructure flexibility,the proposed VSI model can be easily used in the study of train-bridge systems with any degree of *** validation presented in this work proves the accuracy of the proposed model,making it a suitable tool for dealing with different railway dynamic applications,such as the study of bridge dynamics,train running safety under different scenarios(namely,earthquakes and crosswinds,among others),and passenger riding comfort.

关键词： Vehicle-structure interaction Wheel-rail contact Manchester Benchmarks Thread-flange transition Dynamic analysis Model validation

1D alignment of proteins and other nanoparticles by using reversible covalent bonds on cyclic peptide nanotubes

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Organic Chemistry Frontiers 2022年第5期9卷 1226-1233页

作者： Juan M.Priegue Iria Louzao Ivan Gallego Javier montenegro Juan r.Granja Singular research Centre in Chemical Biology and Molecular Materials (CIQUS)Organic Chemistry DepartmentUniversity of Santiago de Compostela(USC)15782 Santiago de CompostelaSpain

Self-assembling cyclic peptide nanotubes are supramolecular structures whose diameter and external surface properties are precisely *** this communication we describe a general strategy to align different molecules on... 详细信息

关键词： nanoparticles alignment surface

Effective parameter study for the facile and controlled growth of silver molybdate nano/micro rods

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Frontiers of Materials Science 2016年第4期10卷 375-384页

作者： Javier Esteban Enriquez montenegro Dinesh Pratap SINGH Department of Physics University of Santiago Chile Avenida Ecuador 3493 Estacion Central Santiago 9170124 Chile

Controlled growth of nano/micro structures by controlling the effective parameters is the basic requirement for the application point of view in various areas. Here we report the facile growth of silver molybdate nanolmicro rods by mixing the solution of silver nitrate and ammonium molybdate at ambient condition followed by hydrothermal treatment at various temperatures for 12 h. To achieve the goal for the synthesis of long, high yield and homogeneous nanorods various effective parameters have been studied to set the most effective conditions for the growth. Among possible effective parameters first the temperature of the furnace was set by warring the temperature and then at the set temperature the concentration of reactants （NH4）6Mo7O24 and silver nitrate are varied respect to each other. The pH and temperature values were monitored during the mixing of the reactants. Structurallmicrostructural characterization revealed the optimum condition of 150℃ of the furnace and the concentration of （NH4）sMo7O24 and silver nitrate as described in various tables.

关键词： silver molybdate nanorod Ag6Mo10O33 controlled growth silver nitrate

Overcast sky condition prevails on and influences the biometeorology of the tropical Andean Páramos

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Journal of Mountain Science 2023年第1期20卷 78-86页

作者： Paola montenegro-DÍAZ rolando CELLErIALVEAr Galo CArrILLO-rOJAS Departamento de recursos Hídricos y Ciencias Ambientales Universidad de CuencaCuenca010207Ecuador Facultad de Ingeniería Universidad de CuencaCuenca010207Ecuador Facultad de Ciencias Químicas Universidad de CuencaCuenca010207Ecuador

Clouds play a major role in modulating the biometeorological processes. We studied the influence of cloudiness on four biometeorological variables:daily air temperature(Tair), relative humidity(rH),reference evapotranspiration(ETr),and photosynthetic active radiation(PAr), recorded at four sites of Andean Páramos in southern Ecuador during 2.5 to 5.5 years. First, we quantified both the cloud cover percentage(Cloud%) creating cloud masks over the visible bands of Landsat 7 images and the sky condition(K_(T)) using the records of solar and extraterrestrial radiation. Second, we estimated KTfrom Cloud%. Finally, we quantified T_(air), rH, ET_(r), and PAr under clear, cloudy, and overcast K_(T) and their dependence on KT. The average Cloud% ranged between 65%–76%, and KTcorroborated the prevailing overcast sky(between 55% and 72.5% of the days) over the páramos. The proposed model performed well in the sites of calibration(r^(2)= 0.80;MBE = 0.00;rMSE = 0.05) and validation(r^(2)= 0.74;MBE =-0.07;rMSE = 0.11). The overcast sky diminished T_(air)(≤ 10℃), ET_(r)(≤ 1.6 mm day-1), and PAr(4 MJ m^(-2)day^(-1)) and increased rH(≥ 88%),while the variables showed the opposite behavior during the uncommon clear sky(≤ 5.5% of the days).Thus, mostly the dynamic of rH(r^(2)≥ 0.62), ETr(r^(2)≥ 0.85), and PAr(r2≥ 0.77) depended on K_(T). Hence,the prevailing overcast sky influenced the biometeorology of the páramos.

关键词： Cloudiness indicator Clearness index Satellite imagery Tropical Andes

Ecophysiological basis of the Jack-and-Master strategy:Taraxacum officinale(dandelion)as an example of a successful invader

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Journal of Plant Ecology 2018年第1期11卷 147-157页

作者： Marco A.Molina-montenegro Alejandro del Pozo Ernesto Gianoli Centro de Ecología Molecular y Aplicaciones Evolutivas en Agroecosistemas(CEM) Instituto de Ciencias BiológicasUniversidad de TalcaAvda.Lircay s/nTalcaChile Centro de Estudios Avanzados en ZonasÁridas(CEAZA) Facultad de Ciencias del MarUniversidad Católica del NorteLarrondo 1281CoquimboChile research Program“Adaptation of the Agriculture to Climate Change”PIEI A2C2 Universidad de TalcaTalcaChile Centro de Mejoramiento Genético y Fenómica Vegetal Facultad de Ciencias AgráriasUniversidad de TalcaAvda.Lircay s/nTalcaChile Departamento de Botánica Universidad de ConcepciónCasilla 160-CConcepciónChile Departamento de Biología Universidad de La SerenaCasilla 554La SerenaChile

Aims Successful invasive plants are often assumed to display significant levels of phenotypic *** possible strategies by which phenotypic plasticity may allow invasive plant species to thrive in changing environments have been suggested:(i)via plasticity in morphological or physiological traits,invasive plants are able to maintain a higher fitness than native plants in a range of environ-ments,including stressful or low-resource habitats:a‘Jack-of-all-trades’strategy;(ii)phenotypic plasticity allows the invader to better exploit resources available in low stress or favorable habitats,show-ing higher fitness than native ones:a‘Master-of-some’strategy and(iii)a combination of these abilities,the‘Jack-and-Master’*** We evaluated these strategies in the successful invader Taraxacum officinale in a controlled experiment mimicking natural environmen-tal *** set up three environmental gradients consisting of factorial arrays of two levels of temperature/light,temperature/water and light/water,*** compared several ecophysiologi-cal traits,as well as the reaction norm in fitness-related traits,in both *** and the closely related native Hypochaeris thrin-cioides subjected to these environmental *** Findings Overall,*** showed significantly greater accumulation of biomass and higher survival than the native ***,with this difference being more pronounced toward both ends of each *** also showed significantly higher plasticity than its native counterpart in several ecophysiological ***,*** exhibits a Jack-and-Master strategy as it is able to main-tain higher biomass and survival in unfavorable conditions,as well as to increase fitness when conditions are *** suggest that this strategy is partly based on ecophysiological responses to the environment,and that it may contribute to explaining the successful invasion of *** across diffe

关键词： biological invasion competition ecophysiological traits environmental gradients Taraxacum officinale