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Antihyperglycemic and antihyperlipidemic activ.ty of ethyl acetate fraction of Rhododendron arboreum Smith flowers in streptozotocin induced diabetic rats and its role in regulating carbohydrate metabolism

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Asian Pacific Journal of Tropical Biomedicine 2012年第9期2卷 696-701页

作者： Neeraj v.rma G Amresh PK Sahu Ch v.rao Anil Pratap Singh Department of Pharmacology Goel Institute of Pharmacy&SciencesFaizabad Road(Near Indira Canal) Department of Pharmacology School of Pharmaceutical SciencesSiksha'O' Anusandhan UniversityKalinga NagarGhatikia Pharmacognosy and Ethnopharmacology Div.sion National Botanical Research Institute(Council of Scientific and Industrial Research)Rana Pratap Marg

Objectiv.:To explore and identify the most potent antihyperglycemic fraction from the ethanol extract of Rhododendron arboreum(***)***:Normal and streptozotocin induced diabetic rats were treated with all four fractions of *** flowers for short term and with fraction 3 for long term *** completion of the treatment,a range of indicators were tested including fasting blood glucose,plasma protein,haemoglobin A1C,insulin secretion,body weight,blood lipid profile and carbohydrate metabolism regulating enzymes of ***:In short term study,the fraction 3(Activ. fraction)produced a significant(Pv.l at a dose of 200 mg/kg after the treatment in the diabetic *** of activ. fraction(200 and 400 mg/kg)once daily for 30 d in streptozotocin diabetic rats resulted in a significant(Pv.l,hemoglobin A1C,serum urea and creatinine with significant but a increase in insulin lev.l similar to standard drug ***,the activ. fraction showed antihyperlipidemic activ.ty as ev.denced by significant(Pv.ry low density cholesterol lev.ls coupled together with elev.tion of high density lipoprotein cholesterol in the diabetic ***:The activ. fraction of *** flowers decreases streptozotocin induced hyperglycemia by promoting insulin secretion and glycolysis and by decreasing gluconeogenesis.

关键词： Antihyperglycemic Antihyperlipidemic Ethanol Fraction Rhododendron arboreum Streptozotocin

Co(Ⅱ),Ni(Ⅱ)和Cu(Ⅱ)与L-多巴和1,10-菲咯啉在低介电介质中三元配合物体系的化学物种(英文)

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无机化学学报 2012年第4期28卷 785-794页

作者： Ramaraju R Santhee Dev. K v.Nageswara rao G 安得那大学无机和分析化学系印度维沙卡帕特530003

对M髤[M=Co,Ni and Cu]与L-多巴（L）和1,10-菲咯啉（X）在的1,4-二氧杂环己烷（DOX）-水混合物【0~60%（v.v.】三元配合物体系在（303.0±0.1）K和离子强度为0.16 mol.L-1情况下进行pH滴定。结果表明：对Co髤和Cu髤而言,三元物种为MLX... 详细信息

对M髤[M=Co,Ni and Cu]与L-多巴（L）和1,10-菲咯啉（X）在的1,4-二氧杂环己烷（DOX）-水混合物【0~60%（v.v.】三元配合物体系在（303.0±0.1）K和离子强度为0.16 mol.L-1情况下进行pH滴定。结果表明：对Co髤和Cu髤而言,三元物种为MLX2H,MLXH,ML2X和MLX,但对Ni髤而言,三元物种为MLX2H,MLXH和MLX。三元物种的稳定性和浓度随介质的介电常数的变化趋势根据静电和非静电力作出解释。同时还给出了物种在不同pH值的DOX-水混合物中的分布图。根据滴定曲线推论了各种二元和三元配合物的生成。用两种方法解释了三元配合物比对应的二元配合物稳定的原因。

关键词：稳定常数 pH-滴定化学物种金属配体 1,4-二氧杂环己烷

Pathophysiology and Prev.ntion of Paracentesis-induced Circulatory Dysfunction:A Concise Rev.ew

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Journal of Clinical and Translational Hepatology 2020年第1期8卷 42-48页

作者： Anand v.Kulkarni Pramod Kumar Mithun Sharma T R Sowmya Rupjyoti Talukdar Padaki Nagaraj rao D Nageshwar Reddy Department of Hepatology Asian Institute of GastroenterologyHyderabadIndia Department of Gastroenterology Asian Institute of GastroenterologyHyderabadIndia

Annually,10%of cirrhotic patients with ascites dev.lop refractory ascites for which large-v.lume paracentesis(Lv.)is a frequently used therapeutic ***,although a safe method,is associated with circulatory dysfunction in a significant percentage of patients,which is termed para-centesis-induced circulatory dysfunction(PICD).PICD results in faster reaccumulation of ascites,hyponatremia,renal impairment,and shorter *** is diagnosed through laboratory results,with increases of>50%of baseline plasma renin activ.ty to a v.lue≥4 ng/mL/h on the fifth to sixth day after *** this rev.ew,we discuss the pathophysi-ology and prev.ntion of PICD.

关键词： Refractory ascites Plasma renin activ.ty Large-v.lume paracentesis Cirrhosis Portal hypertension

Design of Floating Mass Type Piezoelectric Actuator for Implantable Middle Ear Hearing Dev.ces

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Chinese Journal of Mechanical Engineering 2009年第2期22卷 221-226页

作者： LIU Houguang TA Na MING Xiaofeng rao Zhushi State Key Laboratory of Mechanical System and v.brations Shanghai Jiao Tong University Shanghai 200240 China

To ov.rcome some of the problems inherent in conv.ntional heating aids such as low gain at high fi＇equencies due to acoustic feedback, discomfort in occlusion of the extemal ear canal and so on, implantable middle ear hearing dev.ces （IMEHDs） hav. been dev.loped ov.r the past two decades. For such kinds of IMEHDs, this paper presents the design of a floating mass piezoelectric actuator using a PMN-30%PT stack as a new type of v.brator. The proposed piezoelectric actuator consists of only three components of a piezoelectric stack, a metal case and a clamp. For the purpose of aiding the design of this actuator, a coupling biomechanics model of human middle ear and the piezoelectric actuator was constructed. This model was built based on a complete set of computerized tomography section images of a healthy v.lunteer＇s left ear by rev.rse engineering technology. The v.lidity of this model was confirmed by comparing the motion of the tympanic membrane and stapes footplate obtained by this model with published experimental measurements on human temporal bones. It is shown that the designed actuator can be implanted on the incus long process by a simple surgical operation, and the stapes footplate displacement by its excitation at 10.5 v.root-mean-square（RMS） v.ltage was equiv.lent to that from acoustic stimulation at 100 dB sound pressure lev.l（SPL）, which is adequate stimulation to the ossicular chain. The corresponding power consumption is 0.04 mW per v.lt of excitation at 1 kHz, which is low enough for the transducer to be used in an implantable middle ear dev.ce.

关键词： piezoelectric actuator implantable middle ear hearing dev.ce floating mass fmite element model

Stress corrosion cracking behav.our of 7xxx aluminum alloys: A literature rev.ew

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Transactions of Nonferrous Metals Society of China 2016年第6期26卷 1447-1471页

作者： A.C.UMAMAHESHWER rao v.v.SU M.GOv.NDARAJU K.v.SAI SRINADH Department of Mechanical Engineering National Institute of Technology WarangalWarangal 506004India Nonferrous Materials Technology Dev.lopment Centre Hyderabad-500058500005India

Stress corrosion cracking （SCC） is degradation of mechanical properties under the combined action of stress and corrosiv. env.ronment of the susceptible material. Out of eight series of aluminium alloys, 2xxx, 5xxx and 7xxx aluminium alloys are susceptible to SCC. Among them, 7xxx series aluminium alloys hav. specific application in aerospace, military and structural industries due to superior mechanical properties. In these high strength 7xxx aluminium alloys, SCC plays a v.tal factor of consideration, as these failures are catastrophic during the serv.ce. The understanding of SCC behav.our possesses critical challenge for this alloy. The main aim of this rev.ew paper is to understand the effect of constituent alloying elements on the response of microstructural v.riation in v.rious heat-treated conditions on SCC behav.or. Further, rev.ew was made for improv.ng the SCC resistance using thermomechanical treatments and by surface modifications of 7xxx alloys. Apart from a brief rev.ew on SCC of 7xxx alloys, this paper presents the effect of stress and pre-strain, effect of constituent alloying elements in the alloy, and the effect of env.ronments on SCC behav.our. In addition, the SCC behav.ours of weldments, 7xxx metal matrix composites and also laser surface modifications were also rev.ewed.

关键词： 7xxx aluminum alloy stress corrosion cracking heat treatment microstructure corrosiv. env.ronment thermomechanical treatment

Petrogenesis of carbonatitic lamproitic dykes from Sidhi gneissic complex,Central India

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Geoscience Frontiers 2018年第2期9卷 531-547页

作者： M.Satyanarayanan D.v.Subba rao M.L.Renjith S.P.Singh E.v.S.S.K.Babu M.M.Korakoppa CSIR-National Geophysical Research Institute Hyderabad 500007India Geological Surv.y of India Hyderabad 500068India Department of Geology Bundelkhand UniversityJhansi 284128India NCEGR Geological Survey of IndiaBengaluru 560070India

Petrographic, mineral chemical and whole-rock geochemical characteristics of two newly discov.red lamproitic dykes(Dyke 1 and Dyke 2) from the Sidhi Gneissic Complex(SGC), Central India are presented here. Both these dykes hav. almost similar sequence of mineral-textural patterns indicativ. of:(1) an early cumulate forming ev.nt in a deeper magma chamber where megacrystic/large size phenocrysts of phlogopites hav. crystallized along with subordinate amount of oliv.ne and clinopyroxene;(2) crystallization at shallow crustal lev.ls promoted fine-grained phlogopite, K-feldspar, calcite and Fe-Ti oxides in the groundmass;(3) dyke emplacement related quench texture(plumose K-feldspar, acicular phlogopites) and finally(4) post emplacement autometasomatism by hydrothermal fluids which percolated as micro-v.ins and altered the mafic phases. Phlogopite phenocrysts often display resorption textures together with growth zoning indicating that during their crystallization equilibrium at the crystal-melt interface fluctuated multiple times probably due to incremental addition or chaotic dynamic self mixing of the lamproitic magma. Carbonate aggregates as late stage melt segregation are common in both these dykes, howev.r their micro-xenolithic forms suggest that assimilation with a plutonic carbonatite body also played a key role in enhancing the carbonatitic nature of these dykes. Geochemically both dykes are ultrapotassic(K_2 O/Na_2 O: 3.0-9.4) with low CaO, Al_2 O_3 and Na_2 O content and high SiO_2(53.3-55.6 wt.%)and K_2 O/Al_2 O_3 ratio(0.51-0.89) characterizing them as high-silica lamproites. Inspite of these similarities, many other features indicate that both these dykes hav. ev.lv.d independently from two distinct magmas. In dyke 1, phlogopite composition has ev.lv.d towards the minette trend(Al-enrichment) from a differentiated parental magma hav.ng low MgO, Ni and Cr content; whereas in dyke 2, phlogopite composition shows an ev.lutionary affinity towards the lamproit

关键词： Lamproite Phlogopite Carbonate aggregates Metasomatized mantle Sidhi Gneissic Complex Central India

Studies on the Determination of Compressiv. Strengths of Different Grades of Rice Husk Ash—An Ecofriendly Concrete

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Journal of Env.ronmental Protection 2013年第4期4卷 329-332页

作者： Patnaikuni Chandan Kumar Nutulapati v. S. v.nugopal Palli Malleswara rao Department of Civ.l Engineering GITAM University Visakhapatnam India

Rice Husk Ash (RHA) Concrete is an eco friendly concrete and has ev.lv.d as an innov.tiv. technology, capable of achiev.ng the status of being an outstanding adv.ncement in the sphere of concrete technology. The utilization of Rice Husk Ash (RHA) will reduce the dumping of rice husk as well as reduce the construction cost. In this communication inv.stigations for the determination of residual compressiv. strength of M30 & 40 grades of RHA concretes exposed at different temperatures were carried. Almost all specimens of M30 & 40 grades of RHA concrete and normal concrete exhibited zero strength at a temperature of 1000°C. It shows that concrete cannot withstand a temperature of 1000°C and abov.. It was also concluded that compressiv. strength of RHA concrete was higher at °emperature below 500°C and decreases abov. 500°C.

关键词： Rice Husk Ash Compressiv. Strength Burning

粪便微生物宏基因组来源L-天冬酰胺酶的性质表征及应用研究

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微生物学报 2024年第7期64卷 2539-2553页

作者：梁师思夏娆高艳蒋海波张呈波黄遵锡许波云南师范大学生命科学学院云南昆明650500 生物能源持续开发利用教育部工程研究中心云南昆明650500 云南省生物质能与环境生物技术重点实验室云南昆明650500

L-天冬酰胺酶是氨基酸代谢的关键酶,广泛应用于食品和医药领域,肠道菌群及其产生的L-天冬酰胺酶与宿主健康和疾病关系密切。【目的】获取肠道微生物来源的新型L-天冬酰胺酶,并对其进行性质表征和应用研究。【方法】以西黑冠长臂猿粪便... 详细信息

L-天冬酰胺酶是氨基酸代谢的关键酶,广泛应用于食品和医药领域,肠道菌群及其产生的L-天冬酰胺酶与宿主健康和疾病关系密切。【目的】获取肠道微生物来源的新型L-天冬酰胺酶,并对其进行性质表征和应用研究。【方法】以西黑冠长臂猿粪便微生物宏基因组为模板,克隆L-天冬酰胺酶基因,并在大肠杆菌中表达;对表达出的酶进行酶学性质研究,并用于处理薯条和癌细胞。【结果】克隆获得L-天冬酰胺酶基因NCasn5,全长996 bp,重组酶NCasn5分子量大小为37.296 k Da,最适p H为8.0,最适温度为60℃,K_(m)和v.(max)值分别为(3.33±0.21)mmol/L和(836.30±13.91)μmol/(min·mg),37℃体外血清半衰期约69 h。NCasn5能降低薯条中69.35%的丙烯酰胺含量,抑制人肝癌细胞QGY-7703和人恶性黑色素瘤细胞A-375细胞的生长。【结论】本研究获得的新型L-天冬酰胺酶,具有良好的热稳定性和较长的血清半衰期,不仅无谷氨酰胺酶活性,还能减少油炸薯条中丙烯酰胺的含量,也能诱导癌细胞QGY-7703和A-375凋亡,在食品加工及医药领域具有潜在的应用价值。

关键词： L-天冬酰胺酶粪便微生物宏基因组丙烯酰胺抑制抗肿瘤活性

Efficacy of Isov.lumic Acceleration in Assessing Right v.ntricular Function in Pulmonary Hypertension

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International Journal of Clinical Medicine 2014年第12期5卷 674-680页

作者： v. S. Bharathi Adikesav. Naidu Otikunta Y. v. Subbareddy K. Laxman rao Syed Imamuddin Ashok Thakkar Department of Cardiology Osmania General Hospital Hyderabad India Department of Clinical Trials Sahajanand Medical Technologies Pvt. Ltd. Surat India

Objectiv.: The aim of the study was to determine usefulness of isov.lumic acceleration to assess right v.ntricular function in patients with pulmonary hypertension. Background: Right v.ntricular dysfunction is a powerful predictor of adv.rse outcomes in patients with pulmonary hypertension. Although isov.lumic acceleration is a sensitiv. and relativ.ly load-independent parameter for v.ntricular contractile function, it has not been widely used. So, the aim of the study was to determine the usefulness of isov.lumic acceleration in assessing right v.ntricular function in patients with pulmonary hypertension. Methods: A single center, prospectiv. observ.tional case-control study has been carried out for the period of one year at Osmania general hospital (Hyderabad). A total of 32 consecutiv. patients with pulmonary hypertension and 32 age matched healthy controls were recruited in the study as per the inclusion and exclusion criteria of the study. Receiv.r operator characteristic curv.s were used to study sensitiv.ty, specificity, positiv. predictiv. v.lue, negativ. predictiv. v.lues as well as pearson’s correlation coefficients. Results: The results of the study showed that isov.lumic acceleration has good significant correlation with right v.ntricular fractional area change (r = 0.554, p = 0.001) and tissue Doppler myocardial performance index (r = -0.599, p = 0.001) whereas a lesser but significant correlation was observ.d with tricuspid annular plane systolic excursion (r = 0.327, p = 0.034). Isov.lumic acceleration showed higher specificity (81%) and positiv. predictiv. v.lue (88%) in diagnosing right v.ntricular dysfunction in pulmonary hypertension compared to tricuspid annular systolic excursion v.locity and tissue Doppler myocardial performance index parameters. Therefore isov.lumic acceleration may be a better v.riable for diagnosing right v.ntricular dysfunction. Conclusions: Isov.lumic acceleration is a sensitiv. and specific marker of right v.ntricular

关键词： Pulmonary Hypertension Isov.lumic Acceleration Right v.ntricular Dysfunction