检索结果-南通市图书馆

SCN1A rs6732655A/T polymorphism:Diagnostic and therapeutic insights for drug-resistant epilepsy

World Journal of Experimental Medicine 2024年第3期14卷 72-79页

作者： Aroop Viswas Pradeep K Dabla Dharmsheel Shrivastav Swapan Gupta Manisha Yadav Subhash Yadav Bidhan chandra Koner Department of Biochemistry Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Department of Neurology Govind Ballabh Pant Institute of Postgraduate Medical Education and ResearchNew Delhi 110002DelhiIndia Multi-disciplinary Research Unit Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia Department of Biotechnology Amity University GwaliorGwalior 474005Madhya PradeshIndia Department of Biochemistry Maulana Azad Medical CollegeNew Delhi 110002DelhiIndia

BACKGROUND A significant subset of individuals with epilepsy fails to respond to currently available antiepileptic drugs,resulting in heightened mortality rates,psychosocial challenges,and a diminished quality of *** factors,particularly within the SCN1A gene,and the pro-inflammatory cytokine response is important in intricating the drug resistance in idiopathic epilepsy *** this extended study,we determined the correlation of rs6732655A/T single nucleotide polymorphism to understand the causative association of SCN1A gene with epilepsy drug resistance and inflammatory *** To find the correlation of SCN1A gene rs6732655A/T polymorphism with the drug-resistant epilepsy and inflammatory *** The study enrolled 100 age and sex-matched patients of both drug-resistant and drug-responsive epilepsy *** analysed the rs6732655A/T polymorphism to study its association and causative role in drug-resistant epilepsy cases using restriction fragment length polymorphism *** diagnostic performance of interleukin(IL)-1β,IL-6,and high mobility group box 1(HMGB1)protein levels was evaluated in conjunction with genotypic outcome receiver operating characteristic *** AT and AA genotypes of rs6732655 SCN1A gene polymorphism were associated with higher risk of drug resistance *** biomarkers IL-6,IL1βand HMGB1 demonstrated diagnostic potential,with cutoff values of 4.63 pg/mL,59.52 pg/mL and 7.99 ng/mL,respectively,offering valuable tools for epilepsy ***,specific genotypes(AA and AT)were found to be linked to the elevated levels of IL-1βand IL-6 and potentially reflecting increased oxidative stress and neuro-inflammation in drug-resistant cases supporting the previous reported outcome of high inflammatory markers response in drug resistance *** SCN1A genotypes AA and AT are linked to higher drug-resistant epilepsy *** findings underscore the potential influence of inflammation

关键词： Epilepsy Drug resistance SCN1A gene Pro-inflammatory cytokines Genetic factors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Correlation of neutrophil to lymphocyte ratio to severity of coronary artery disease and in-hospital clinical outcomes in patients with acute coronary syndrome: A prospective observational study

引用

Journal of Acute Disease 2024年第1期13卷 14-19页

作者： Vinodhkumar Kandibendla GThiruvikrama Prakash Subash chandra Bose Prafull Dhewle Department of Cardiology Prakriya HospitalsNagasandraBangloreIndia Department of Cardiology E.S.HospitalVillupuramTamil NaduIndia Department of Cardiology Government Medical CollegeAnanthapuramuAndhra PradeshIndia Department of Cardiology Shrikrishna Hrudayalaya HospitalNagpurMaharashtraIndia

Objective:To explore correlation of neutrophil-to-lymphocyte ratio(NLR)to severity of coronary artery disease(CAD)and in-hospital clinical outcomes in patients with acute coronary syndrome(ACS).Methods:In this prospective and observational study,we recruited 500 patients with *** all the eligible patients,demographic details were collected,and laboratory parameters were *** CAD severity was evaluated in terms of the number of involved *** NLR was calculated based on neutrophils and lymphocytes and the correlation of various risk factors and severity and outcome of CAD was ***:77.2%of Patients was male,and 52%of the patients aged between 55-70 *** on the type of ACS,396 out of 500 patients had ST-elevation myocardial *** ascending trend in the white blood cell levels and NLR value was noted as the severity of the ACS increased and the highest white blood cell levels and NLR was noted among classⅣ*** mean NLR value among the non-survivors were higher compared to the survivors(9.52±5.72 vs.4.76±2.36;P<0.01).Receiver operating curve showed that the cut-off NLR value was 5.76 with a sensitivity of 75.0%and a specificity of 77.3%.Conclusions:The NLR can be used as an independent prognostic marker in *** elevated NLR value serves as a reliable predictor for short-term complications,notably in-hospital mortality.

关键词： Acute coronary syndrome Coronary artery disease Coronary vessels Hospital mortality Lymphocytes Neutrophils Prognosis Risk factors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinically adaptable machine learning model to identify early appreciable features of diabetes

引用

Intelligent Medicine 2024年第1期4卷 22-32页

作者： Nurjahan Nipa Mahmudul Hasan Riyad Shahriare Satu Walliullah Koushik chandra Howlader Mohammad Ali Moni Department of Information and Communication Technology Bangabandhu Sheikh Mujibur Rahman Digital UniversityBangladeshKaliakairGazipur1750 Bangladesh Department of Applied Mathematics Noakhali Science and Technology UniversityNoakhali3814Bangladesh Department of Management Information Systems Noakhali Science and Technology UniversityNoakhali3814Bangladesh Department of Computer Science and Telecommunication Engineering Noakhali Science and Technology UniversityNoakhali3814Bangladesh Department of Computer Science North Dakota State UniversityFargo58105NDUnited States School of Health and Rehabilitation Sciences Faculty of Health and Behavioural SciencesThe University of QueenslandSt LuciaQLD 4072Australia

Objective Diabetes mellitus is a serious disease where the body of affected patients are failed to produce enough insulin that causes an abnormality of blood *** disease happens for a number of reasons including modern lifestyle,lethargic attitude,unhealthy food consumption,family history,age,overweight,*** aim of this study was to propose a machine learning based prediction model that detected diabetes at the *** In this work,we collected 520 patients records from the University of California,Irvine(UCI)machine learning repository of Sylhet Diabetes Hospital,***,a similar questionnaire of that hospital was followed and assembled 558 patients records from all over Bangladesh through this ***,we accumulated patient records of these two *** the next step,these datasets were cleaned and applied thirty five state-of-arts classifiers such as logistic regression(LR),K nearest neighbors(KNN),support vector classifier(SVC),Nave Byes(NB),decision tree(DT),random forest(RF),stochastic gradient descent(SGD),Perceptron,AdaBoost,XGBoost,passive aggressive classifier(PAC),ridge classifier(RC),Nu-support vector classifier(NuSVC),linear support vector classifier(LSVC),calibrated classifier CV(CCCV),nearest centroid(NC),Gaussian process classifier(GPC),multinomial NB(MNB),complement NB,Bernoulli NB(BNB),categorical NB,Bagging,extra tree(ET),gradiant boosting classifier(GBC),Hist gradiant boosting classifier(HGBC),one vs rest classifier(OVsRC),multi-layer perceptron(MLP),label propagation(LP),label spreading(LS),stacking,ridge classifier CV(RCCV),logistic regression CV(LRCV),linear discriminant analysis(LDA),quadratic discriminant analysis(QDA),and light gradient boosting machine(LGBM)to explore best stable predictive *** performance of the classifiers has been measured using five metrics such as accuracy,precision,recall,F1-score,and area under the receiver operating ***,these outcomes were interpret

关键词： Diabetes Early features Machine learning Classification

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A multiwavelength view of a classical T Tauri star CV Cha

引用

Research in Astronomy and Astrophysics 2019年第1期19卷 75-86页

作者： Jeewan chandra pandey Subhajeet Karmakar Arti Joshi Saurabh Sharma Shashi Bhushan pandey Anil Kumar pandey Aryabhatta Research Institute of Observational Sciences (ARIES)

Using long-term optical, ultraviolet(UV) and X-ray data, we present a study of a classical T Tauri star CV Cha. The V-band light curve obtained from the All Sky Automated Survey(ASAS) shows short as well as long-term variability. The short-term variability could be due to rotational modulation of CV Cha. We derive the rotational period of 3.714 ± 0.001 d for CV Cha. UV light curves obtained from Swift also show the variations. X-ray light curves from XMM-Newton and Swift do not show any significant short as well as long-term variability. However, the light curve from chandra appears to be variable, which could be due to the emergence of flaring activities. X-ray spectra from all observations are explained well by the single temperature plasma of 0.95 keV with X-ray luminosity of 1030.4erg s-1in the 0.5–7.5 keV energy band. It appears that variability in optical and UV bands could be due to the presence of both hot and cool spots on the surface, while X-ray emission is dominated by magnetic processes.

关键词： stars:activity stars:individual(CV Cha) stars:pre-main sequence stars:variable:T Tauri X-ray:stars

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Need for operational simplicity and timely disbursal of benefits—a qualitative exploration of the implementation of a direct benefit transfer scheme for persons with tuberculosis in India

引用

Infectious Diseases of Poverty 2024年第3期13卷 58-72页

作者： Malu Mohan Jeromie W.V.Thangaraj Sumit pandey G.Sri Lakshmi Priya Sivavallinathan Arunachalam Rahul Sharma Hemant Deepak Shewade B.Aishwarya K.Afeeq Afsana Khatoon B.Gokulvijay Gude Sireesha Kavita chandra S.Nandhakumar Prince Samuel C.Nanditha Viswanathan Devika Shanmugasundaram Raghuram Rao Manoj V.Murhekar Kathiresan Jeyashree Indian Council of Medical Research-National Institute of Epidemiology R-127TNHBAyapakkamChennaiTamil Nadu 600077India TB Support Network WHO Country Office for IndiaNew DelhiIndia Central Tuberculosis Division Government of IndiaNew DelhiIndia

Background Ni-kshay Poshan Yojana(NPY)is a direct benefit transfer scheme of the Government of India introduced in 2018 to support the additional nutritional requirements of persons with TB(PwTB).Our recent nationwide evaluation of implementation and utilization of NPY using programmatic data of PwTB from nine randomly selected Indian states,reported a 70%coverage and high median delay in benefit *** undertook a qualitative study between January and July 2023,to understand the detailed implementation process of NPY and explore the enablers and barriers to effective implementation and utilization of the NPY *** We followed a grounded theory approach to inductively develop theoretical explanations for social phenomena through data generated from multiple *** conducted 36 in-depth interviews of national,district and field-level staff of the National Tuberculosis Elimination Programme(NTEP)and NPY beneficiaries from 30 districts across nine states of India,selected using theoretical *** analytical framework developed through inductive coding of a set of six interviews,guided the coding of the subsequent *** and themes emerged through constant comparison and the data collection continued until theoretical *** Stakeholders perceived NPY as a beneficial *** political commitment from the state administration,mainstreaming of NTEP work with the district public healthcare delivery system,availability of good geographic and internet connectivity and state-specific grievance redressal mechanisms and innovations were identified as enablers of ***,the complex,multi-level benefit approval process,difficulties in accessing banking services,perceived inadequacy of benefits and overworked human resources in the NTEP were identified as barriers to implementation and *** The optimal utilization of NPY is enabled by strong political commitment and challenged by its length

关键词： National Tuberculosis Elimination Programme Nutritional status Direct benefit transfer Implementation Cash transfer scheme Grounded theory India

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Extreme exposure of fluoride and arsenic contamination in shallow coastal aquifers of the Ganges delta,transboundary of the Indo-Bangladesh region

引用

Geoscience Frontiers 2024年第1期15卷 286-303页

作者： Dipankar Ruidas Subodh chandra Pal Tanmoy Biswas Asish Saha Abu Reza Md.Towfiqul Islam Department of Geography The University of BurdwanPurba BardhamanWest Bengal 713104India Department of Disaster Management Begum Rokeya UniversityRangpur 5400Bangladesh Department of Development Studies Daffodil International UniversityDhaka 1216Bangladesh

Globally,shallow aquifer groundwater(GW)has been severely affected in recent decades for both geogenic and anthropogenic *** hydro-geochemical characteristics of the GW change inconsistently with the addition of unwanted inorganic trace elements into the GW aquifer of the Indo-Bangladesh delta region(IBDR),such as arsenic(As)along with fluoride(F-)*** GW can have a negative impact on drinking water supplies and agricultural *** pollution can have serious adverse effects on the environment and human ***,the GW quality of this region is deteriorating progressively,and human health threatening by various life-threatening ***,the current study concentrated on the GW quality evaluation and prediction of possible health issues in the IBDR due to elevated contamination of As along with F-within GW aquifers by considering sixteen *** survey-based statistical methods such as entropy quality index(EWQI)combined with health risk index(HRI)was implemented for evaluating the As and F-sensitivity with the help of correlation testing and principal component *** study's outcome explains that a substantial portion of the IBDR has been vastly experiencing inferior GW quality,environmental issues,and health-related problems in dry and wet seasons,correspondingly for As and *** diagram verified the suitability of water that almost 55%of GW across the study area’s aquifers are unfit for drinking as well as cultivation of *** analysis and the Monte Carlo simulation method were also applied to assess the contaminant's concentration level and probable health risk *** present study concludes that the elevated exposure of As and F-pollution has to be monitored regularly and prevent unwanted GW contamination through implementing sustainable approaches and policies to fulfil the sustainable development goal 6(SDG-6)till 2030,ensuring the most basic human right of clean,safe,and hy

关键词： Indo-Bangladesh delta Entropy quality index Health risk index Monte Carlo simulation SDG-6

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Textile dyeing wastewater negatively influences the hematological profile and reproductive health of male Swiss albino mice

引用

Asian pacific Journal of Reproduction 2024年第4期13卷 169-177页

作者： Taimur Islam Nusrat Binte Rafique Mohosina Mou Dipu Roy Robius Sani Sadi Ziban chandra Das Anup Kumar Talukder Minhaz Ahmed Mizanur Rahman Golam Haider Department of Pathobiology Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Department of Gynecology Obstetrics and Reproductive HealthBangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Department of Agroforestry and Environment Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Department of Physiology and Pharmacology Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh

Objective:To determine the effects of textile dyeing industrial wastewater on the hematological parameters and reproductive health including histoarchitecture of male gonad(testes)of ***:Twenty-four Swiss albino mice at 4-weeks old were divided into four groups(n=6 per group).Mice of group 1 supplied with normal drinking water were served as the control *** of group 2,3 and 4 were supplied normal drinking water mixed with textile dyeing wastewater at 5%,10% and 20% concentration,*** completing 24 weeks of treatment,different hematological profile,weight of testes,gonadosomatic index(GSI),sperm concentration and morphology were ***,histopathological changes in testes were ***:Hematocrit value and hemoglobin concentrations were decreased in all groups of wastewater-treated mice compared to the control ***,weight of testes,GSI and sperm concentration were decreased significantly in wastewater-treated mice in comparison to the control *** percentage of morphologically healthy epididymal sperm was significantly reduced in wastewater-treated *** examination revealed degenerative changes in seminiferous tubules,a smaller number of spermatogenic cells,elongation of seminiferous tubules and degenerative changes of seminiferous tubules in wastewater-treated ***:Textile dyeing wastewater has harmful effects on hematological profile and reproductive health of male mice.

关键词： Textile dyeing wastewater Gonads Hematology Histopathology Mice

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

采用解析和数值方法分析浮动式矩形浮箱的波浪诱导载荷研究

引用

哈尔滨工程大学学报（英文版） 2024年第1期23卷 113-126页

作者： Sarat chandra Mohapatra Iuri Baldaconi da Silva Bispo Yuchan Guo C.Guedes Soares Center for Marine Technology and Ocean Engineering(CENTEC) Instituto Superior TécnicoUniversidade de LisboaLisboa 1049-001Portugal

A three-dimensional mathematical hydrodynamic model associated with surface wave radiation by a floating rectangular box-type structure due to heave,sway,and roll motions in finite water depth is investigated based on small amplitude water wave theory and linear structural *** analytical expressions for the radiation potentials,wave forces,and hydrodynamic coefficients are presented based on matched eigenfunction expansion method(MEFEM).The correctness of the analytical results of wave forces is compared with the construction of a numerical model using the open-source boundary element method code *** addition,the present result is compared with the existing published experimental results available in the *** effects of the different design parameters on the floating box-type rectangular structure are studied by analyzing the vertical wave force,horizontal wave force,torque,added mass,and damping coefficients due to the heave,sway,and roll motions,and the comparison analysis between the forces is also analyzed in ***,the effect of reflection and transmission coefficients by varying the structural width and drafts are analyzed.

关键词： Mathematical model MEFEM Box-type structure BEM code NEMOH Wave forces

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Carcinogenic Helicobacter pylori in gastric pre-cancer and cancer lesions: Association with tobacco-chewing

引用

World Journal of Gastroenterology 2014年第22期20卷 6860-6868页

作者： arvind pandey Satyendra chandra Tripathi Sutapa Mahata Kanchan Vishnoi Shirish Shukla Sri Prakash Misra Vatsala Misra Suresh Hedau Ravi Mehrotra Manisha DwivediZ Alok C Bharti Divisionof Molecular Oncology Institute of Cytology and Preventive Oncology (ICMR)Noida 201301India Center for Biotechnology University of AllahabadAllahabad 211002India Clinical Cancer Prevention-Research UT MD Anderson Cancer CenterHoustonTX 77030United States Department of Gastroenterology MLN Medical CollegeAllahabad 211002India Department of Pathology MLN Medical CollegeAllahabad 211002India

AIM: To investigate the low gastric cancer incidence rate relative to the highly prevalent Helicobacter pylori (H. pylori) infection; data relevant to H. pylori infection during gastric carcinogenesis in Indian patien... 详细信息

关键词： UreC CagA Dysplasia Intestinal metaplasia Gastric adenocarcinoma Tobacco chewing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Productivity status of traditional agrisilviculture system on northern and southern aspects in mid-hill situation of Garhwal Himalaya,India

引用

Journal of Forestry Research 2009年第2期20卷 137-143页

作者： arvind Bijalwan chandra Mohan Sharma V. K. Sah College of Forestry and Environment Allahabad Agricultural Institute- Deemed University Department of Botany H.N.B. Garhwal University Department of Forest Ecology College of Forestry and Hill Agriculture G. B. Pant University of Agriculture and Technology

The productivity of traditional agrisilviculture system(agricultural crops + trees) was investigated in the northern and southern aspects of mid-hill situation in Garhwal Himalaya, Uttarakhand, India during the 2004?2006.A total of 19 tree species were studied in both northern and southern aspects, out of which 17 tree species were selected in northern aspect and 12 tree species in southern aspect for phytosociological characteristic analysis of trees in agrisilvicultural *** most dominant tree species are Grewia optiva, Celtis australis and Melia azedarach and successively grown under traditional agrisilviculture *** results show that the annual productivity of all tree species was 3 775 kg·ha-1·a-1 in northern aspect(site-N) and 3 101 kg·ha-1·a-1 in southern aspect(site-S).*** had the highest productivity in both site-N and site-S among the tree species, followed by ***, Quercus leucotrichophora and *** dominant agricultural crops were Eleusine coracana in summer cereals, Phaseolus vulgaris in summer pulses-oilseeds and Triticum aestivum in the winter season in the *** average biological productivity of agricultural crops in northern aspect was about 16% higher than that in southern aspect under traditional agrisilviculture *** sole agricultural crop productivity(without trees) in northern aspect was also higher than that in southern *** obvious difference in annual productivity of trees and agriculture crops was observed between northern aspect and southern *** overall productivity in traditional agrisilviculture system(crop + tree) was 24%(in northern aspect) and 21%(in southern aspect) higher than that in sole cropping system.

关键词： traditional agrisilviculture system sole agricultural system productivity phytosociology sole crop importance value index

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：