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Effect of structure and function of paraoxonase-1(PON-1)on organophosphate pesticides metabolism

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BIOCELL 2020年第3期44卷 363-370页

作者： HAZAEL RAMIRO CEJA-GÁLVEZ ERANDIS DHENI TORRES-SÁNCHEZ JUAN HERIBERTO TORRES-JASSO arturo VILLALOBOS ORNELAS JOEL SALAZAR-FLORES Department of Medical and Life Sciences University Center of La CiénegaUniversity of Guadalajara(CUCI-UdeG)OcotlánCP 47810Mexico Department of Biological Sciences University Center of the CoastUniversity of Guadalajara(CUCosta-UdeG)Puerto VallartaCP 48280Mexico

Paraoxonase-1(PON1)is an important enzyme in various pathologies such as pesticide poisoning,diabetes,atherosclerosis,neuronal disorders,and cancer,due to its multifunctional activity since it acts on different ***,one of its main functions is the hydrolysis of organophosphate(OP)compounds from pesticides that cause fatal poisoning at the level of the central nervous system(CNS).The objective of this review was to investigate whether the structure,genetics,and function of PON1 affect the metabolism of organophosphate pesticides or other *** was selected from articles in the database PubMed–NCBI(https://***/pubmed/)with a publication date between 2011 and *** enzymatic activity of PON1 can be modified depending on its chemical structure since there are different genetic polymorphisms that change PONI morphologies or the levels of expression in the *** leads to differences in susceptibilities to organophosphate pesticide *** results of this review reveal that phenotypic variants of PON1 have differences in affinities for OP substrates.

关键词： PON1 Pesticides Organophosphorus toxicity

Metaheuristic post-optimization of the NIST repository of covering arrays

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CAAI Transactions on Intelligence Technology 2017年第1期2卷 31-38页

作者： Jose Torres-Jimenez arturo Rodriguez-Cristerna CINVESYAV-Yamaulipas Information Technology Laboratory Km. 5.5 Carretera Cd. Victoria Yamaulipas Mexico

Construction of Covering Arrays （CA） with minimum possible number of rows is challenging. Often the available CA have redundant combinatorial interaction that could be removed to reduce the number of rows. This paper addresses the problem of removing redundancy of CA using a metaheuristic post- optimization （MPO） approach. Our approach consists of three main components： a redundancy detector （RD）; a row reducer （RR）; and a missing-combinations reducer （MCR）. The MCR is a metaheuristic component implemented using a simulated annealing algorithm. MPO was instantiated with 21,964 CA taken from the National Institute of Standards and Technology （NIST） repository. It is a remarkable result that this instantiation of MPO has delivered 349 new upper bounds for these CA.

关键词： Covering arrays NIST repository of covering arrays Metaheuristic post-processing algorithms

Research on representative brand and operation mode of second-hand clothing in Europe

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服饰导刊 2020年第3期9卷 23-32页

作者： Ying Tang arturo Dell'Acqua Bellavitis Key Laboratory of Science&Technology of Eco-Textile Jiangnan UniversityWuxi 214122 China Politecnico di Milano School of DesignMilan 20158 Italy

In order to study the current situation and operation mode of second-hand clothing brand in Europe,this paper makes a field investigation on the second-hand clothing shops in European *** classification of the inspected shops,five representative brands with certain popularity and influence and different operation modes in Europe are selected out from high-grade antique boutiques,non-profit charity organizations,professional retailers and middle-grade consignment shops in the second-hand clothing *** paper analyzes and discusses the development history of stores,the source of goods,the form of stores,and the operation mode,so as to provide a reference for the development and standardization of the second-hand clothing market in China.

关键词： Europe second-hand clothing brand operation mode

Selection of patients with hepatocellular carcinoma for livertransplantation:Past and future

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World Journal of Hepatology 2016年第1期8卷 58-68页

作者： arturo Soriano Aranzazu Varona Rajesh Gianchandani Modesto Enrique Moneva Javier Arranz Antonio Gonzalez Manuel Barrera Liver Transplantation Unit University Hospital Nuestra Señora de CandelariaSanta Cruz38010 Santa Cruz de TenerifeSpain

The aim of liver transplantation(LT) for hepatocellular carcinoma(HCC) is to ensure a rate of disease-free survival similar to that of patients transplanted due to benign disease. Therefore, we are forced to adopt strict criteria when selecting candidates for LT and prioritizing patients on the waiting list(WL), to have clarified indications for bridging therapy for groups at risk for progression or recurrence, and to establish certain limits for downstaging therapies. Although the Milan criteria(MC) remain the standard and most employed criteria for indication of HCC patients for LT by far, in the coming years, criteria will be consolidated that take into account not only data regarding the size/volume and number of tumors but also their biology. This criteria will mainly include the alpha fetoprotein(AFP) values and, in view of their wide variability, any of the published logarithmic models for the selection of candidates for LT. Bridging therapy is necessary for HCC patients on the WL who meet the MC and have the possibility of experiencing a delay for LT greater than 6 mo or any of the known risk factors for recurrence. It is difficult to define single AFP values that would indicate bridging therapy(200, 300 or 400 ng/m L); therefore, it is preferable to rely on the criteria of a French AFP model score > 2. Other single indications for bridging therapy include a tumor diameter greater than 3 cm, more than one tumor, and having an AFP slope greater than 15 ng/m L per month or > 50 ng/m L for three months during strict monitoring while on the WL. When considering the inclusion of patients on the WL who do not meet the MC, it is mandatory to determine their eligibility for downstaging therapy prior to inclusion. The upper limit for this therapy could be one lesion up to 8 cm, 2-3 lesions with a total tumor diameter up to 8 cm, or a total tumor volume of 115 cm^3. Lastly, liver allocation and the prioritization of patients with HCC onthe WL should take into account

关键词： Hepatocarcinoma Liver transplantation Alpha fetoprotein Patient selection Prioritization Waiting list Bridging therapy Allocation Downstaging

Variability in mentum deformities of Tanytarsus larvae(Diptera,Chironomidae)in a metal rich basin in Northern Mexico

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Water Biology and Security 2022年第2期1卷 1-9页

作者： Orestes Carlos Bello-Gonzalez Perla Alonso-EguíaLis Cesar arturo Ilizaliturri Hernandez Norman Mercado-Silva Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de MorelosCuernavacaMorelosMexico Instituto Mexicano de Tecnología del Agua JiutepecMorelosMexico Facultad de Medicina-Centro de Investigacion Aplicada en Ambiente y Salud Universidad Autonoma de San Luis PotosíCoordinacion para la Aplicacion de la Ciencia y la Tecnología-(CIACyT-CIAAS)San Luis PotosíMexico

Mentum deformities in chironomids have been commonly used as indicators of metal contamination in freshwater *** of these deformities suggests sublethal effects and can provide early signals of environmental *** anthropogenic metal pollution is known to lead to an increase in deformities in chironomids,natural background deformity incidence information is key to their effective use as biomonitoring *** we explore the incidence of deformities from 5000 Tanytarsus(Diptera,Chironomidae)menta in relation to water physicochemical,and sediment metal(Al,As,Cu,Fe,Mn,Pb,Zn)concentration data from numerous sites in the naturally metal-rich Sonora River(NW Mexico)obtained over a two-year *** metal concentrations were found in the upper *** salinity,total suspended solids and conductivity were found in the lower *** As and Cu were occasionally found above published threshold effect levels(TEL).The proportion of deformities(%D)was low(2.1%)and a generalized linear model only explained 25.36%of%D variability among samples;this model included several physicochemical *** only metal significantly related to deformities was *** significant spatial and temporal variability in all metal concentrations and other physicochemical parameters in the basin,we were unable to explain a strong relationship between metal concentration and deformity *** results,based on consistent%D quantification from 5000 samples from a single taxon,suggest that natural variation in metal concentrations,even when statistically significant,is not associated with notable variations in the incidence of deformities.

关键词： Macroinvertebrate Pollution Sonora river Desert river Copper Arsenic

Parkinson’s disease and diabetes mellitus: common mechanisms and treatment repurposing

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Neural Regeneration Research 2022年第8期17卷 1652-1658页

作者： Carmen M.Labandeira arturo Fraga-Bau David Arias Ron Elena Alvarez-Rodriguez Pablo Vicente-Alba Javier Lago-Garma Ana I.Rodriguez-Perez Department of Clinical Neurology Hospital Alvaro CunqueiroUniversity Hospital ComplexVigoSpain Laboratory of Cellular and Molecular Neurobiology of Parkinson’s Disease Research Center for Molecular Medicine and Chronic Diseases(CIMUS)IDISUniversity of Santiago de CompostelaSantiago de CompostelaSpain Department of Clinical Oncology University Hospital ComplexOurenseSpain Department of Endocrinology Hospital MeixoeiroUniversity Hospital ComplexVigoSpain Networking Research Center on Neurodegenerative Diseases(CiberNed) MadridSpain

In the last decade,attention has become greater to the relationship between neurodegeneration and abnormal insulin signaling in the central nervous system,as insulin in the brain is implicated in neuronal survival,plasticity,oxidative stress and *** mellitus and Parkinson’s disease are both aging-associated diseases that are turning into epidemics *** mellitus and insulin resistance not only increase the possibility of developing Parkinson’s disease but can also determine the prognosis and progression of Parkinsonian ***,there are no available curative or disease modifying treatments for Parkinson’s disease,but the role of insulin and antidiabetic medications in neurodegeneration opens a door to treatment repurposing to fight against Parkinson’s disease,both in diabetic and nondiabetic Parkinsonian ***,it is essential to comprehend how a frequent and treatable disease such as diabetes can influence the progression of neurodegeneration in a challenging disease such as Parkinson’s ***,we review the present evidence on the connection between Parkinson’s disease and diabetes and the consequential implications of the existing antidiabetic molecules in the severity and development of Parkinsonism,with a particular focus on glucagon-like peptide-1 receptor agonists.

关键词： antidiabetic diabetes mellitus dopamine exenatide glucagon-like peptide-1 insulin neurodegeneration neuroinflammation Parkinson’s disease repurposing

LA Phillyrea iatifolia *** TERRITORIO BRESCIANO

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Natural Disaster Reduction in China 1983年第1期 73-92页

作者： arturo CRESCINI Centro Studi Naturalistici Bresciani

SOMMARIO-Sono elencate le stazioni bresciane della Phillyrea latifolia L.(s.l.),Viene posto in evidenzail componente floristico della stazione di monte Fratta(colli orientali bresciani)e i relativi aspetti vegetazio-nali,mettendo in risalto il carattere termo-xerofilo delle stazioni pedemontane della Phillyrea latifolia.A list of the stations of the territory around Brescia of Phillyrea latifolia L.(s.l.)is given *** flora of the station of monte Fratta(eastern hills of Brescia),the respective aspects of the vegetationand the character thermo-xerophilous of the stations of Phillyrea latifolia,are pointed out.

关键词： FOU LA Phillyrea iatifolia L.NEL TERRITORIO BRESCIANO As

Polymorphisms in oxidative pathway related genes and susceptibility to inflammatory bowel disease

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World Journal of Gastroenterology 2017年第47期23卷 8300-8307页

作者： Nezha Senhaji Sellama Nadifi Younes Zaid Aurora Serrano Daniel arturo Leon Rodriguez Nadia Serbati Mehdi Karkouri Wafaa Badre Javier Martín Laboratory of Genetic and Molecular Pathology Faculty of Medicine and Pharmacy of CasablancaHassanⅡUniversity Mohammed VI University of Health Sciences Instituto de Parasitología y Biomedicina López-Neyra Consejo Superior de Investigaciones Científicas Department of Pathology CHU Ibn Rochd Department of Gastroenterology CHU Ibn Rochd

AIM To investigate whether common variants in the oxidative pathway genes influence inflammatory bowel disease(IBD) risk among Moroccan patients. METHODS The distribution of(TAAA)n_rs12720460 and(CCTTT)n_rs3833912 NOS2 A microsatellite repeats, HIF-1 A_rs11549467 and NFKB1-94 ins/delA TTG_rs28362491 was analyzed in 507 subjects grouped in 199 IBD and 308 healthy controls. Genotyping was performed withpolymerase chain reaction-fluorescent method and the TaqMan~? allelic discrimination *** The allele and genotype frequencies of HIF1 A_ rs11549467, NFKB1_rs28362491 and NOS2 A_(TAAA)n did not differ significantly between patients and controls. Analysis of NOS2 A_(CCTTT)n markers evidenced differences between patients and healthy controls. A preferential presence of the(CCTTT)8(P = 0.02; OR = 1.71, 95%CI: 1.07-2.74),(CCTTT)14(P = 0.02; OR = 1.71, 95%CI: 1.06-2.76) alleles in IBD,(CCTTT)8(P = 0.008; OR = 1.95, 95%CI: 1.17-3.23) in CD and(CCTTT)7(P = 0.009; OR = 7.61, 95%CI: 1.25-46.08),(CCTTT)11(P = 0.05; OR = 0.51, 95%CI: 0.25-1.01),(CCTTT)14(P = 0.02; OR = 2.05, 95%CI: 1.07-3.94),(CCTTT)15(P = 0.01; OR = 2.25, 95%CI: 1.16-4.35) repeats in UC patients indicated its possible association with higher disease risk which need to be confirmed in a larger sample size. CONCLUSION Our results suggest that the NOS2 A_(CCTTT)n gene variations may influence IBD susceptibility in the Moroccan population.

关键词： HIF1A NFKB1 NOS2A Inflammatory bowel disease Moroccan patients

Monolithically printed all-organic flexible photosensor active matrix

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npj Flexible Electronics 2023年第1期7卷 504-512页

作者： Luis arturo Ruiz-Preciado Sanghoon Baek Noah Strobel Kai Xia Mervin Seiberlich Sung-min Park Uli Lemmer Sungjune Jung Gerardo Hernandez-Sosa Light Technology Institute Karlsruhe Institute of TechnologyEngesserstr.1376131 KarlsruheGermany InnovationLab Speyererstr.469115 HeidelbergGermany Department of Convergence IT Engineering Pohang University of Science and Technology77 Cheongam-RoPohang 37673Republic of Korea Institute of Microstructure Technology Karlsruhe Institute of TechnologyHermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany Department of Materials Science and Engineering Pohang University of Science and Technology77 Cheongam-RoPohang 37673Republic of Korea

Upcoming technologies in the fields of flexible electronics require the cost-efficient fabrication of complex circuitry in a streamlined *** printing techniques such as inkjet printing can enable such applications thanks to their inherent freedom of design permitting the mask-free deposition of multilayer optoelectronic devices without the need for subtracting *** we present an active matrix sensor array comprised of 100 inkjet-printed organic thin film transistors(OTFTs)and organic photodiodes(OPDs)monolithically integrated onto the same ultrathin *** the OTFTs and OPDs exhibited high-fabrication yield and state-of-the-art performance after the integration *** scaling of the OPDs,we achieved integrated pixels with power consumptions down to 50 nW at one of the highest sensitivities reported to date for an all-organic integrated ***,we demonstrated the application potential of the active matrix by static and dynamic spatial sensing of optical signals.

关键词： matrix printing multilayer