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Game changer:How Janus kinase inhibitors are reshaping the landscape of ulcerative colitis mana

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World Journal of Gastroenterology 2024年第35期30卷 3942-3953页

作者： Antonio M Caballero-Mateos Guillermo arturo Cañadas-de la Fuente Department of Gastroenterology and Hepatology San Cecilio University HospitalGranada 18014Spain Department of Nursing Faculty of Health SciencesUniversity of GranadaGranada 18004Spain

Recent advancements in the treatment landscape of ulcerative colitis(UC)have ushered in a new era of possibilities,particularly with the introduction of Janus kinase(JAK)-signal transducer and activator of transcription *** novel agents offer a paradigm shift in UC management by targeting key signaling pathways involved in inflammatory *** approved JAK inhibitors(JAKis),such as tofacitinib,filgotinib,and upadacitinib,clinicians now have powerful tools to modulate immune responses and gene expression,potentially revolutionizing the treatment algorithm for *** trials have demonstrated the efficacy of JAKis in inducing and maintaining remission,presenting viable options for patients who have failed conventional ***-world data support the use of JAKis not only as first-line treatments but also in subsequent lines of therapy,particularly in patients with aggressive disease phenotypes or refractory to biologic *** rapid onset of action and potency of JAKis have broadened the possibilities in the management strategies of UC,offering timely relief for patients with active disease and facilitating personalized treatment *** safety concerns,including cardiovascular risks and infections,ongoing research and post-marketing surveillance will continue to refine our understanding of the risk-benefit profile of JAKis in UC management.

关键词： Ulcerative colitis Janus kinase inhibitors Filgotinib Tofacitinib Upadacitinib

Influence of previous plane of nutrition on molecular mechanisms regulating the expression of urea and water metabolism related genes in the rumen and kidney of finishing crossbred Angus steers

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Animal Nutrition 2024年第2期17卷 232-243页

作者： Aghata E.Moreira da Silva arturo Macias Franco Bradley S.Ferguson Mozart A.Fonseca College of Agriculture Biotechnology&Natural Resources University of Nevada Department of Animal and Range Sciences Clayton Livestock Research Center New Mexico State University

This study aimed to understand how molecular mechanisms controlling water and urea metabolism at the finishing phase can be affected by previous plane of nutrition of crossbred Angus beef steers. Twentyfour(n = 24) animals were randomly distributed into either a moderate(MP) or high plane of nutrition during the background phase for 85 d. Animals were then blocked by their previous plane and were moved onto a 105-d finishing phase in a 2 × 2 factorial arrangement. The forage-finished group received only high-quality alfalfa hay, whereas the grain-fed group received a high grain diet(80% whole corn and20% alfalfa hay). By the end of the finishing phase, animals were harvested and tissue samples from the rumen and kidney were collected. Changes in gene expression of aquaporins(AQP)-2,-3,-4,-7, ATP1A1,ATP1B1, SGK1, CLIC1(kidney and rumen), UT-A1(kidney only) and UT-B(rumen only), were assayed via real-time q PCR; 18S r RNA was used as an endogenous control. One-way ANOVA followed by Tukey's post hoc analysis was conducted. When animals were from MP, forage-finishing increased the relative abundance of AQP3(P ≤ 0.05), AQP7(P ≤ 0.05), ATP1B1(P ≤ 0.05), and SGK1(P ≤ 0.05) in the kidney when compared to grain-fed animals. In the rumen, for the MP group, AQP7 was differentially expressed in both treatments at the finishing phase(P ≤ 0.01), with forage-finished steers having the highest expression of AQP7. For the MP group, UT-B had a tendency of presenting a higher expression on grainfed animals(P = 0.075). Overall, these results suggest that previous plane can impact expression of genes associated with water and urea metabolism during the finishing phase, namely AQP3, AQP7, ATP1B1, and SGK1 in the kidney, and AQP7 and UT-B in the rumen. The greatest impact observed on gene expression changes of investigated genes at the finishing phase was reflective of animals backgrounded on the moderate previous plane.

关键词： Gene expression Aquaporin Sodium channel Urea transporter

Radiomics and artificial intelligence applications in pediatric brain tumors

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World Journal of Pediatrics 2024年第8期20卷 747-763页

作者： Francesco Pacchiano Mario Tortora Chiara Doneda Giana Izzo Filippo Arrigoni Lorenzo Ugga Renato Cuocolo Cecilia Parazzini Andrea Righini arturo Brunetti Department of Precision Medicine University of Campania“L.Vanvitelli”CasertaItaly Department of Advanced Biomedical Sciences University of Naples“Federico II”Via Pansini 580131NaplesItaly Department of Head and Neck Neuroradiology UnitAORN MoscatiAvellinoItaly Department of Pediatric Radiology and Neuroradiology V.Buzzi Children’s HospitalMilanItaly Department of Medicine Surgery and DentistryUniversity of SalernoBaronissiItaly

Background The study of central nervous system(CNS)tumors is particularly relevant in the pediatric population because of their relatively high frequency in this demographic and the significant impact on disease-and treatment-related morbidity and *** both morphological and non-morphological magnetic resonance imaging techniques can give important information concerning tumor characterization,grading,and patient prognosis,increasing evidence in recent years has highlighted the need for personalized treatment and the development of quantitative imaging parameters that can predict the nature of the lesion and its possible *** this purpose,radiomics and the use of artificial intelligence software,aimed at obtaining valuable data from images beyond mere visual observation,are gaining increasing *** brief review illustrates the current state of the art of this new imaging approach and its contributions to understanding CNS tumors in *** sources We searched the PubMed,Scopus,and Web of Science databases using the following key search terms:(“radiomics”AND/OR“artificial intelligence”)AND(“pediatric AND brain tumors”).Basic and clinical research literature related to the above key research terms,i.e.,studies assessing the key factors,challenges,or problems of using radiomics and artificial intelligence in pediatric brain tumors management,was *** A total of 63 articles were *** included ones were published between 2008 and *** nervous tumors are crucial in pediatrics due to their high frequency and impact on disease and *** serves as the cornerstone of neuroimaging,providing cellular,vascular,and functional information in addition to morphological features for brain *** can provide a quantitative approach to medical imaging analysis,aimed at increasing the information obtainable from the pixels/voxel grey-level values and their ***“radiomic workflow”in

关键词： Machine learning Neuroradiology Pediatric brain tumors Radiomics

DNA metabarcoding reveals seasonal changes in diet composition across four arthropod-eating lizard species(Phrynosomatidae:Sceloporus)

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Integrative Zoology 2024年第3期19卷 480-495页

作者： Mauricio HERNÁNDEZ Stephanie HEREIRA-PACHECO Antton ALBERDI Aníbal H.DÍAZ DE LA VEGA-PÉREZ arturo ESTRADA-TORRES Sergio ANCONA Yendi E.NAVARRO-NOYA Doctorado en Ciencias Biológicas Centro Tlaxcala de Biología de la ConductaUniversidad Autónoma de TlaxcalaTlaxcalaMexico Estación Científica La Malinche Centro Tlaxcala de Biología de la ConductaUniversidad Autónoma de TlaxcalaTlaxcalaMexico Center for Evolutionary Hologenomics The Globe InstituteUniversity of CopenhagenCopenhagenDenmark Consejo Nacional de Ciencia y Tecnología-Centro Tlaxcala de Biología de la Conducta Universidad Autónoma de TlaxcalaTlaxcalaMexico Departamento de Ecología Evolutiva Instituto de EcologíaUniversidad Nacional Autónoma de MéxicoMexico CityMexico Laboratorio de Interacciones Bióticas Centro de Investigación en Ciencias BiológicasUniversidad Autónoma de TlaxcalaSan Felipe IxtacuixtlaTlaxcalaMexico

Diet composition and its ecological drivers are rarely investigated in coexisting closely related *** used a molecular approach to characterize the seasonal variation in diet composition in four spiny lizard species inhabiting a mountainous *** metabarcoding revealed that the lizards Sceloporus aeneus,***,***,and *** mostly consumed arthropods of the orders Hemiptera,Araneae,Hymenoptera,and *** terrestrial lizards *** and *** mostly predated ants and spiders,whereas the arboreal–saxicolous *** and saxicolous *** largely consumed grasshoppers and *** taxonomic and phylogenetic diversity of the prey was higher during the dry season than the rainy season,likely because reduced prey availability in the dry season forced lizards to diversify their diets to meet their nutritional *** and phylogenetic composition varied seasonally depending on the species,but only dietary composition varied with *** dietary turnover was greater in *** than in ***,suggesting site-specific seasonal variability in prey availability;no other differences among species were ***,which lives at the highest altitude in our study site,displayed interseasonal variation in diet *** differences were correlated with the species’feeding strategies and elevational distribution,which likely contributed to the coexistence of these lizard species in the studied geographic area and beyond.

关键词： arthropod-eating lizards diet breadth environmental barcoding mountainous ecosystem seasonal dietary shifts

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“一带一路”倡议对企业创新的影响

“一带一路”倡议对企业创新的影响

作者： William arturo Romero Osorio 华东师范大学

学位级别：硕士

Complications Associated with Autologous Fat Transfer: Case Report and Literature Review

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Modern Plastic Surgery 2024年第1期14卷 1-8页

作者： Bryan Armando Morales Eslava Carlos Emiliano García Cordova Antoine arturo Lagunes Gasca Department of Surgery Hospital Regional Petróleos Mexicanos Villahermosa Tabasco Mexico Department of Surgery Hospital Central Sur Petróleos Mexicanos Mexico City Mexico

Undoubtedly, since its appearance, the interest and use of autologous fat transfer (AFT) as a breast reconstruction technique have been increasing, becoming one of the main surgical alternatives for aesthetic breast augmentation. This increase in its popularity has led to the development of new technologies to increase its efficacy and safety, however, it has inherently implied the inadequate use of this procedure, mainly when performed by unqualified medical personnel. We present the case of a patient with complications following a breast AFT for aesthetic purposes, performed by a general practitioner without a specialty in plastic and reconstructive surgery.

关键词： Breast Breast Reconstruction Breast Surgery Autologous Fat Transfer Intramammary Abscess

Emerging melt quality control solution technologies for aluminium melt

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China Foundry 2009年第4期6卷 358-365页

作者： arturo Pascual Foseco Foundry(China)Co. Ltd.2002 Leishing International Plaza1319 Yan'an RoadShanghaiChinaJr

The newly developed ＂MTS 1500＂ Melt Treatment System is performing the specifically required melt treatment operations like degassing, cleaning, modification and/or grain refinement by an automated process in one step and at the same location. This linked process is saving time, energy and metal losses allowing - by automated dosage of the melt treatment agents - the production of a consistent melt quality batch after batch. By linking the MTS Metal Treatment System with sensors operating on-line in the melt, i.e., with a hydrogen sensor ＂Alspek H＂, a fully automated control of parts of the process chain like degassing is possible. This technology does guarantee a pre-specified and documented melt quality in each melt treatment batch. Furthermore, to ensure that castings are consistent and predictable there is a growing realization that cdtical parameters such as metal cleanliness must be measured prior to casting. There exists accepted methods for measuring the cleanliness of an aluminum melt but these can be both slow and costly. A simple, rapid and meaningful method of measuring and bench marking the cleanliness of an aluminum melt has been developed to offer the foundry a practical method of measuring melt cleanliness. This paper shows the structure and performance of the integrated MTS melt treatment process and documents achieved melt quality standards after degassing, cleaning, modification and grain refinement operations under real foundry conditions. It also provides an insight on a melt cleanliness measuring device ＂Alspek MQ＂ to provide foundry men better tools in meeting the increasing quality and tighter specification demand from the industry.

关键词： melt quality aluminum casting melt treatment cleanliness measuring

Introduction of Dr. Andrew V Schally

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Asian Journal of Andrology 2015年第6期17卷 923-924页

作者： arturo Mendoza-Valdes UROLOGO Hospital Medica Sur Puente dePiedra 150 T2-625 Col. Toriello Guerra Tlalpan14050Mexico DF.

Ifirst met Dr. Andrew V Schally （PhD, MDhc （Multi）, DSc, Distinguished Medical Research Scientist, U.S. Department of Veterans Affairs Professor of Pathology and Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida, USA） many years ago, probably around the beginning of the 1990＇s in one of his visits to Mexico City （Figure 1）. He has many friends in my country since some of the investigations that led to the development of the LHRH agonists were made in a couple of Mexican hospitals in collaboration with some outstanding Mexican physicians that I will mention later. In that time, I was the head of the Department of Urology of the Mexican National Cancer Institute and our Director, Dr. Jaime de la Garza, invited him for a meeting. I was surprised by his humbleness, intelligence and easy going personality, in spite of being a Nobel Prize scientist.

关键词： Introduction Andrew Schally

Usability perceptions and beliefs about smart thermostats by chi-square test, signal detection theory, and fuzzy detection theory in regions of Mexico

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Frontiers in Energy 2019年第3期13卷 522-538页

作者： Pedro PONCE Therese PEFFER arturo MOLINA Tecnologico de Monterrey calle del puente 222 MexicoMexico CityNon-US/Non-Canadian 64849Mexico California Institute for Energy and Environment University of California BerkeleyBerkeleyCA 94720USA

It is well known that smart thermostats (STs) have become key devices in the implementation of smart homes;thus, they are considered as primary elements for the control of electrical energy consumption in households. Moreover, energy consumption is drastically affected when the end users select unsuitable STs or when they do not use the STs correctly. Furthermore, in future, Mexico will face serious electrical energy challenges that can be considerably resolved if the end users operate the STs in a correct manner. Hence, it is important to carry out an in-depth study and analysis on thermostats, by focusing on social aspects that influence the technological use and performance of the thermostats. This paper proposes the use of a signal detection theory (SDT), fuzzy detection theory (FDT), and chi-square (CS) test in order to understand the perceptions and beliefs of end users about the use of STs in Mexico. This paper extensively shows the perceptions and beliefs about the selected thermostats in Mexico. Besides, it presents an in-depth discussion on the cognitive perceptions and beliefs of end users. Moreover, it shows why the expectations of the end users about STs are not met. It also promotes the technological and social development of STs such that they are relatively more accepted in complex electrical grids such as smart grids.

关键词： thermostats perceptions beliefs signal detection theory (SDT) fuzzy signal detection theory (FSDT) chi-square (CS) test