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S53G SNP in Cathepsin B: Can Be Used as a Molecular Biomarker to Breast Cancer?

Open Journal of Genetics 2022年第4期12卷 43-56页

作者： Letícia Cristina Dalzy Castro Danielle queiroz Calcagno Carlos eduardo de Melo Amaral Luiz Carlos Santana da silva Programa de Pós-graduaç ã o em Oncologia e Ciências Médicas Universidade Federal do Pará Belém Brasil Laboratório de erros Inatos do Metabolismo Universidade Federal do Pará Belém Brasil Núcleo de Pesquisa em Oncologia Universidade Federal do Pará Belém Brasil Fundaç ã o Centro de Hematologia e Hemoterapia do Pará Belém Brasil

Cathepsin B (CTS B) is a proteolytic enzyme that participates in several important biological processes. However, when it is altered can be involved in development of breast cancer, a disease with high incidence and mortality rate among women. Many studies have shown a correlation between high CTS B expression and breast tumor. Furthermore, it has been shown that the SNP rs1803250 (S53G) leads to structural and functional changes in protein that can make it pathogenic. The present study aimed to evaluate a possible association of SNP rs1803250 (S53G) with breast cancer. For this, real-time PCR was performed on a sample collected in the State of Pará, with 127 patients and 122 controls. The SNP frequency in this region was 0.12, according to a research project in progress that aims to identify Amerindians molecular alterations. This indicates that the SNP is found in region with a distribution close to worldwide frequency of 0.09. Our results showed that the SNP was in Hardy-Weinberg equilibrium in collected sample, but C variant allelic frequency was 0.08 in both patients and control groups, which is extremely similar to global average. Moreover, homozygotes CC was not found in the sample and SNP genotypes frequency in patients and control groups was not significantly different. In addition, statistical analysis showed that the SNP did not have to correlate with tumor subtypes nor with tumor staging. Therefore, according to the analyzed sample, the SNP rs1803250 has no association with breast cancer and it cannot be considered a molecular biomarker for breast cancer.

关键词： Cathepsin B Polymorphism Breast Cancer

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electrification and decarbonization: a critical review of interconnected sectors, policies, and sustainable development goals

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energy Storage and Saving 2023年第4期2卷 615-630页

作者： Icaro B.Boa Morte Ofelia de queiroz F.Araújo Claudia R.V.Morgado Jose Luiz de Medeiros Universidade Federal do Rio de Janeiro Rio de JaneiroRJ 21941-909Brazil

Climate actions(SDG-13)aim at limiting global warming by targeting carbon emissions *** the energy industry recognized as a significant CO_(2) emitter,SDG-13 policies mostly translate energy transition to renewables(SDG-7)and the electrification of end-users,both energy-demanding sectors and society(cities,households,and mobility).The double-layered actions parallel the classical“cascade control”employed in industrial *** achieving deep decarbonization,the ambitious net-zero emissions(NZe),large-scale deployment of renewables demand storage,with hydrogen as a prominent chemical storage alternative,and carbon capture&storage(CCS)for hard-to-electrify *** developments need policy and capital investments,and geopolitics and resource availability challenge and offer *** decarbonization and electrification have multiple realization paths and impact the industrial metabolism,SDGs are interconnected with synergies and *** of SDGs by policymakers is necessary for resilience and robustness in achieving climate goals within a systems dynamics *** critical review identifies niches in decarbonization and electrification,enlightening the industrial metabolism under the lens of SDGs.

关键词： Climate policies energy policies decarbonization electrification Systems dynamics Industrial Metabolism

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Optimal cytokinin/auxin balance for indirect shoot organogenesis of eucalyptus cloeziana and production of ex vitro rooted micro-cuttings

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Journal of Forestry Research 2022年第5期33卷 1573-1584页

作者： Leandro silva de Oliveira Gilvano ebling Brondani Letícia Vaz Molinari Rafaella Zanetti Dias Gustavo Leal Teixeira Antônio Natal Gonçalves Marcílio de Almeida Institute of Agricultural Science Federal University of Minas GeraisUniversity Campus1000Universitária Ave.Montes ClarosMG 39404-547Brazil Laboratory of In Vitro Culture of Forest Species Department of Forestry SciencesFederal University of LavrasUniversity CampusCentral AvenueLavrasMG 37200-900Brazil department of Biological Sciences “Luiz de Queiroz”College of AgricultureUniversity of São Paulo(ESALQ/USP)University Campus11Pádua Dias AvenuePiracicabaSP 13418-900Brazil

Shoot organogenesis is critical for the shortening of long breeding cycles and circumvent the barrier of cloning mature eucalyptus cloeziana *** enables large-scale production of plants from transformed *** study evaluates the effect ofα-naphthaleneacetic acid(NAA),thidiazuron(TDZ)and benzylaminopurine(BAP)on the organogenesis of *** from hypocotyls and cotyledonary *** the induction stage,hypocotyls and cotyledonary leaves were established in a Murashige and Skoog(MS)culture medium supplemented with NAA or *** tissues were cultivated in a MS culture medium containing only BAP or different concentrations of BAP/NAA in the differentiation *** buds were multiplied in vitro and elongated in a WPM culture medium supplemented with 0.89μM BAP and 0.05μM *** leaves exhibited the best in vitro *** induction of adventitious buds occurred only in calluses induced from *** the differentiation stage,4.4μM BAP treatment promoted an increase of adventitious bud ***-cuttings from regenerated shoots were acclimatized and rooted ex vitro in *** results confirm the establishment of an efficient protocol for the in vitro regeneration of *** by indirect organogenesis,providing new insights regarding cloning of this species.

关键词： Micropropagation Recalcitrant species Plant growth regulator explants source

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Correlation between Intestinal Health and Coccidiosis Prevalence in Broilers during Different Seasons of the Year in Brazil from 2012 to 2018

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Food and Nutrition Sciences 2024年第3期15卷 179-198页

作者： Fabio Luis Gazoni Gabriela Miotto Galli Marcel Manente Boiago Lenita Moura Stefani Aline Zampar Marco A. Juárez-estrada Guillermo Tellez-Isaias Aleksandro S. da silva Animal Health and Reproduction Veterinary Medicine Graduate Program Federal University of Santa Maria (UFSM) Santa Maria Brazil Animal Science Graduate Program Federal University of Rio Grande do Sul (UFRGS) Porto Alegre Brazil Animal Science Graduate Program Santa Catarina State University (UDESC) Chapecó Brazil departamento de Medicina y Zootecnia de Aves Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autonoma de Mexico Ciudad Universitaria Ciudad de Mexico Mexico department of Poultry Science Division of Agriculture University of Arkansas Fayetteville AR USA

Coccidiosis is a disease caused by intracellular protozoan parasites, specifically belonging to the genus eimeria. These parasites target the gastrointestinal tract in different types of hosts, causing sores in the intestinal lining. The presence of these lesions reduces the animal’s ability to digest and absorb nutrients, significantly impacting their overall performance. The current study aimed to explore the potential correlation between seasonal variations and the incidence of eimeria spp-induced lesions in broiler chickens’ gastrointestinal tracts in Brazil from 2012 to 2018. A total of 8,607 broiler chickens, aged 14 to 42 days, were sampled from 103 poultry integrated companies in Brazil to conduct intestinal health examinations. The sampling process involved selecting 3 to 6 chickens from each poultry house for examination. The assessment included various abnormalities such as shedding of intestinal cells and excessive fluid and mucus presence, thickening and tension of the intestines, food movement, roughened mucosal surface resembling a Turkish towel in the small intestine, tissue death, duodenal inflammation, intestinal inflammation, gizzard erosion, presence of worms and bedding material, and ingestion of mealworms. During the seasons, winter exhibited the highest average occurrence of eimeria maxima microorganisms at 52.83%, with e. acervulina following closely at 26.42% in second place. In spring, e. maxima had an occurrence of 11.31%, while in fall, e. tenella had the lowest occurrence at 6.74%. When analyzing the seasonal occurrence of eimeria, it was observed that e. maxima micro was more common during winter compared to summer (P = 0.0491). However, no discernible variation was observed in the occurrence of the remaining species across different seasons. Research findings suggest that subclinical coccidiosis is most prevalent during the winter season in Brazil. Likewise, clinical disease caused by e. acervulina is also prevalent during this time. I

关键词： eimeria epidemiology Intestinal Pathology Broiler Chickens Brazil

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Modeling unmanned aerial vehicle system for identifying foci of arboviral disease with monitoring system

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International Journal of Modeling, Simulation, and Scientific Computing 2022年第3期13卷 98-120页

作者： John David S.Belem Hidalyn Theodory C.M.Souza Alvaro Sobrinho Lenardo Chaves e.silva Helder Fernando de Araujo Oliveira Federal Rural University of the Semiarid BR-233s/n Cara´ubasRio Grande do Norte 59780-000Brazil Federal Rural University of the Semiarid BR-226s/n Pau dos FerrosRio Grande do Norte 59900-000Brazil Federal University of the Agreste of Pernambuco Avenida Bom Pastor s/nGaranhuns Pernambuco 55292-270Brazil

People who live in low-income and hard-to-reach regions are usually the most affected ones by high incidences of arboviral diseases,increasing morbidity and mortality rates,and public health *** present the modeling of hardware and software components of an unmanned aerial vehicle(UAV)system by mathematical tools,focusing on monitoring foci of arboviral diseases transmitted by Aedes aegypti mosquito,e.g.,Zika,Chikungunya,and *** used restriction equations and the colored Petri nets formal modeling language to represent the flight dynamics and the software components of the system,*** evaluated the specification of desired behaviors of the monitoring system using simulations and the model checking *** results showed the completeness and correctness of the *** design of such a system is challenging due to the potential risks to people and the ***,this study provides insights into the development of an UAV system for such an application *** monitoring system has the potential of improving the efficiency in identifying foci of arboviral diseases.

关键词： System modeling unmanned aerial vehicle colored Petri nets flight dynamics arboviral diseases

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Retention of eucalyptus harvest residues reduces soil compaction caused by deep subsoiling

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Journal of Forestry Research 2022年第2期33卷 643-651页

作者： Raphael Oliveira de Melo AymbiréAngeletti da Fonseca Nairam Félix de Barros Raphael Bragança Alves Fernandes Rafael da silva Teixeira Iago Nery Melo Ricardo Previdente Martins Soil Science department Universidade Federal de ViçosaViçosaMinas GeraisBrazil BRACeLL Company AlagoinhasBahiaBrazil

eucalyptus harvesting,forwarding and soil tillage operations are among the main causes for compaction of forest soils,with potential impacts on *** concern is especially important in areas with soils that are naturally compacted(fragipans and duripans).In these soils,tillage operations include the use of subsoilers that can reach depths of more than one meter and require heavy tractors that exert high pressure on the *** of the ways to try to minimize the effect of this compaction is by retaining harvest *** objective of this study was to evaluate the impacts of eucalyptus harvesting on soil physical attributes,as well as to determine the potential of different types of residue management to reduce compaction from the soil tillage *** experiments were conducted in the same area with a Yellow *** the first experiment,compaction caused by mechanized harvesting with harvester+forwarder was *** the second experiment,different managements of harvest residues were examined as potential modifiers of soil compaction during tillage for new *** this,three managements systems were tested:(1)retention of all harvest residues and litter from the previous rotation(HR+L),(2)retention of litter from the previous rotation(L),and(3)removal of harvest residues and litter from the previous rotation(WR).Before and after harvest,sampling was carried out in the planting rows and inter-rows,and after tillage,samples were collected in the traffic line of the subsoiler-tractor *** both experiments,undisturbed soil samples were collected from the center of the 0-10,10-20,20-40,40-60,and 60-100 cm layers to determine soil density and total *** each period and site of evaluation,mechanical resistance to penetration up to the 60-cm depth was also *** harvesting operation increased soil density at 0-10 and 60-100 cm depths only in the *** of harvest residues and litter(HR+L)after harvesting avoi

关键词： Soil penetration resistance Harvester+forwarder Soil tillage Soil density Cohesive soils

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Techno-functionality of fisetin-enriched yoghurt fermented with Lactobacillus acidophilus bio-capsules produced via osmoporation

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Systems Microbiology and Biomanufacturing 2022年第4期2卷 743-749页

作者： eduardo Wagner Vasconcelos de Andrade Sebastien Dupont Laurent Beney edilene Souza da silva Roberta Targino Hoskin Márcia Regina da silva Pedrini Bioprocess Laboratory Chemical Engineering DepartmentUniversidade Federal do Rio Grande do NorteLagoa NovaNatalRN 59078-900Brazil Laboratory of Bioactive Compounds Chemical Engineering DepartmentUniversidade Federal do Rio Grande do NorteLagoa NovaNatalRN 59078-900Brazil UMR Procédés Alimentaires et Microbiologiques(PAM UMR A 02.102)Univ.Bourgogne Franche-ComtéAgroSup Dijon21000 DijonFrance

Osmoporation is a novel encapsulation approach for bioactive compounds based on the osmoresistance mechanisms of microbial *** the best of our knowledge,this is the first study investigating the production of fisetin-enriched yoghurt using Lactobacillus acidophilus-based bio-capsules via osmoporation as the starter *** showed that the milk acidification with fisetin-loaded *** progressed at a slower pace due to complex mechanisms induced by osmopo-ration and internalized *** fermentation using fisetin bio-capsules reached a maximum acidification rate of 0.18 pH units/h after 23 h and pH 4.6 was achieved after 32 ***,the antioxidant activity of yoghurts produced with fisetin bio-capsules did not change during cold storage,while the antioxidant activity of yoghurt produced with non-encapsulated fisetin was reduced by 2.5-fold after 28 ***,this study shows that fisetin osmoporation using *** is a versatile encapsulation bioprocess that enables the delivery of preserved phytoactives into fermented foods like *** strategy has the potential to be extended to other applications in the dairy industry using lactic acid bacteria as both the encapsulation matrix and fermentation agent.

关键词： Cell-based carriers Probiotic bacteria Dairy fermented products Food biotechnology Functional foods

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Performance Parameters:demobilization Antibiotic Resistant Bacteria(ARB)and Carrying Genes(ARG)in Wastewater Disinfection

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Journal of environmental Science and engineering(B) 2024年第1期13卷 1-8页

作者： Solange Kazue Utimura denise Crocce Romano espinosa Marcio Luís Busi da silva elisabete de Santis Braga Pedro Jose Alvarez department of Chemical engineering USPR.do LagoSão Paulo 25005508-080Brazil department of Physical Chemical and Geological OceanographyUSPPraça do Oceanográfico 191SPBrazil department of Civil and environmental engineering Rice University6100 Main St.HoustonTexas 77005USA

The UV irradiation is used for removing Antibiotic Resistant Bacteria(ARB)and Antibiotic Resistance Genes(ARG)from wastewater *** are viruses that infect within bacteria,are recognized for bacterial *** influence of some parameters in quantification and performance influencing of pathogen demobilization could be considered in disinfection of *** comparison of Polyvalent phage(Ne1)versus Coliphage(Ne4)in suppressing a bacterium escherichia coli(NDM-1:b-lactam-resistant)with UV irradiation was observed the efficacy in reduction of cells in the disinfection and parameter *** results with the effect of UV-C irradiation on NDM-1 infected with 1%of Ne4 showed a decrease of cells from 8×10^(6)to 2×10^(5)in 60 min with UV-C *** NDM1(***)was infected with 1%of Ne4(Polyvalent Phage)under magnetic stirring for 1 h,the cells count was 8×10^(6).After 1 h in UV-C e×posure,the cells number reached 3×10^(5).The NDM1 that was e×posed in 1 h of UV-C irradiation and then was infected with 1%of *** counting were done 24 h after this *** cells were e×posed in UV-C and showed a reduction in the number of cells from 1×10^(8)to 4×10^(5)after 60 *** results indicate that bacteriophages can mitigate bacteria species,and combined the conventional water disinfection technologies that can support the microbial safety control strategies.

关键词： Antibiotic Resistant Bacteria(ARB) Antibiotic Resistance Genes(ARG) wastewater treatment disinfection escherichia coli(e.coli).

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PtRu nanoparticles supported on noble carbons for ethanol electrooxidation

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Journal of energy Chemistry 2022年第3期31卷 168-180,I0006页

作者： Alberto Rodríguez-Gómez enrico Lepre Luz Sánchez-silva Nieves López-Salas Ana Raquel de la Osa Faculty of Chemical Sciences and Technologies University of Castilla-La ManchaEnrique Costa Novella Building.Avda.Camilo Jose Cela1213071 Ciudad RealSpain Colloid Chemistry department Max Planck Institute of Colloids and InterfacesAm Mühlenberg 114476 PotsdamGermany

In this work,three cytosine derived nitrogen doped carbonaceous materials(noble carbons,NCs)with different atomic C/N ratios and porous networks have been synthesized and used as supports for Pt Ru electrocatalysts in the ethanol oxidation reaction(eOR)for clean hydrogen ***,the metal phase and the carbon support play critical roles in the electrocatalysts final *** NPs size distribution was obtained over supports with low atomic C/N ratios(i.e.,4 and 6)and defined porosity(i.e.,1701 m^(2)g^(-1)for Pt Ru/CNZ and 1834 m^(2)g^(-1)for Pt Ru/CLZ,respectively).In contrast,a lower C/N ratio and poor porous network(i.e.,65 m^(2)g^(-1),Pt Ru/CLK)led to the largest particle size and fostered an increase of the alloying degree between Pt and Ru NPs(i.e.,3%for C/N~6 and 28%for C/N~3).electrochemical active surface area was found to increase with decreasing NPs size and the alloy extent,due to a higher availability of Pt active *** degradation tests showed that Pt Ru/NCs outperform similar to Pt Ru NPs on commercial carbon pointing at the stabilizing effect of *** Ru/CNZ exhibited the best electrochemical performance(i.e.,69.1 m A mgPt-1),outperforming Pt Ru/CLZ and Pt Ru/CLK by3-and 9-fold,respectively,due to a suitable compromise between particle sizes,degree of alloy,textural properties and elemental *** anodes were scaled-up to a proton exchange membrane cell and Pt Ru/CNZ was proved to provide the best electrocatalytic activity(262 m A cm^(-2)and low energy requirements),matching the values obtained by the state of the art of eOR electrocatalysts.

关键词： Noble carbon Cytosine H2 production ethanol electrooxidation PtRu anode PeM cell

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Novel therapeutic strategies targeting mitochondria as a gateway in neurodegeneration

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Neural Regeneration Research 2023年第5期18卷 991-995页

作者： Diogo Trigo Jose Joao Vitoria Odete A.B.da Cruz e silva Neuroscience and Signalling Laboratory Institute of Biomedicine(iBiMED)Department of Medical SciencesUniversity of AveiroAveiroPortugal

In recent years, multiple disciplines have focused on mitochondrial biology and contributed to understanding its relevance towards adult-onset neurodegenerative disorders. These are complex dynamic organelles that have a variety of functions in ensuring cellular health and homeostasis. The plethora of mitochondrial functionalities confers them an intrinsic susceptibility to internal and external stressors(such as mutation accumulation or environmental toxins), particularly so in long-lived postmitotic cells such as neurons. Thus, it is reasonable to postulate an involvement of mitochondria in aging-associated neurological disorders, notably neurodegenerative pathologies including Alzheimer’s disease and Parkinson’s disease. On the other hand, biological effects resulting from neurodegeneration can in turn affect mitochondrial health and function, promoting a feedback loop further contributing to the progression of neuronal dysfunction and cellular death. This review examines state-of-the-art knowledge, focus on current research exploring mitochondrial health as a contributing factor to neuroregeneration, and the development of therapeutic approaches aimed at restoring mitochondrial homeostasis in a pathological setting.

关键词： Alzheimer’s disease axon energy homeostasis glymphatic system mitochondria mitostasis neurodegeneration neuroregeneration Parkinson’s disease therapeutical strategies

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